Höglinger, Günter
Bernhardt AM, Palleis C, Höglinger GU. Reply to: "Biomarker-Based Corticobasal Syndrome Classification: The Added Value of Deep Phenotyping and Population Diversity". Mov Disord. 2026 Apr 15. doi: 10.1002/mds.70306. Epub ahead of print. PMID: 41982093.
Brendel M, Barthel H, Höglinger GU. Biologic Definition of Parkinson Disease: A Pivotal Role for Molecular Imaging. J Nucl Med. 2026 Apr 22:jnumed.125.271573. doi: 10.2967/jnumed.125.271573. Epub ahead of print. PMID: 42020151.
- Dorneich JS, Gernert JA, Zimmermann H, Tagnin L, Zeinaki M, Sanzo L, Vogler L, Kaufmann E, Dargvainiene J, Leypoldt F, Bischof GN, Perneczky R, Rauchmann BS, Lindner S, Höglinger GU, Werner RA, Kerschensteiner M, Kümpfel T, Brendel M, Thaler FS. [18F]Fluorodeprenyl-D2 PET as a Tool to Monitor Disease Activity in GAD65-Ab Autoimmune Encephalitis. Ann Clin Transl Neurol. 2026 Mar 24. doi: 10.1002/acn3.70377. Epub ahead of print. PMID: 41876947.
- Eckenweber S, Völter F, Franzmeier N, Palleis C, Wagemann O, Weidinger E, Katzdobler S, Wlasich E, Sandkühler K, Böning G, Gnörich J, Scheifele M, Eckenweber F, Janowitz D, Kurz C, Perneczky R, Bürger K, Danek A, Höglinger G, Levin J, Brendel M, Schönecker S. Additive value of early-phase β-Amyloid-PET for the differential diagnosis of non-Alzheimer's disease dementia. Neuroimage Clin. 2026 Feb 9;49:103963. doi: 10.1016/j.nicl.2026.103963. Epub ahead of print. PMID: 41690259.
- Fanciulli A, Leys F, Höglinger G, Jost WH. How to treat cardiovascular autonomic failure in Parkinson's disease. J Neural Transm (Vienna). 2026 Jan 3. doi: 10.1007/s00702-025-03096-7. Epub ahead of print. PMID: 41484430.
Gnörich J, Kusche-Palenga J, Palleis C, Neubauer A, Frontzkowski L, Jäck A, Kling A, Bauer T, Eyob H, Probst K, Roemer-Cassiano SN, Bernhardt AM, Katzdobler S, Marth L, Zaganjori M, Hopfner F, Zwergal A, Häckert J, Rullmann M, Sabri O, Barthel H, Stöcklein S, Werner RA, Simons M, Levin J, Herms J, Franzmeier N, Höglinger GU, Brendel M; German Imaging Initiative for Tauopathies (GII4T). Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI-2620 PET. Alzheimers Dement. 2026 Feb;22(2):e71195. doi: 10.1002/alz.71195. PMID: 41736364; PMCID: PMC12932912.
Gröger R, Englert AL, Lalia M, de Weerd L, Rovere M, Kunze L, Palumbo G, Wind-Mark K, Fixemer S, Roemer-Cassiano SN, Franzmeier N, Höglinger G, Zwergal A, Tahirovic S, Werner RA, Brendel M, Gnörich J. Assessment of early-phase [18F]florbetaben images as a proxy for brain metabolism in mouse models of Alzheimer's disease. J Cereb Blood Flow Metab. 2026 Mar 10:271678X261420082. doi: 10.1177/0271678X261420082. Epub ahead of print. PMID: 41808245; PMCID: PMC12979222.
- Häfner F, Bernhardt A, Goldschagg N, Hopfner F, Gnörich J, Brendel M, Levin J, Strupp M, Höglinger G. Dementia with lewy bodies and Alzheimer´s Disease overlap syndrome with PSP-like phenotype caused by co-pathologies - a case report. J Neurol. 2026 Jan 6;273(1):62. doi: 10.1007/s00415-025-13592-1. PMID: 41493613.
- Höglinger G, Vandenberghe W, Woitalla D, Corvol JC, Van Tricht H, Ewen C, Van Den Steen B, Rebollo Mesa I, Germani M, Garric E, Arnould T, Jose J, Strong N, De Bruyn S, Buchanan TJ. Safety, tolerability and biomarker results of bepranemab in participants with progressive supranuclear palsy: a randomised, multicentre, double-blind, placebo-controlled, phase 1b trial. BMJ Neurol Open. 2026 Feb 26;8(1):e001396. doi: 10.1136/bmjno-2025-001396. PMID: 41789119; PMCID: PMC12958890.
Kassubek J, Höglinger GU, Zůza A, Kreiser K, Roselli F; DESCRIBE-PSP Study Group; Müller HP. Hypothalamic atrophy in progressive supranuclear palsy, assessed by convolutional neural network-based automatic segmentation. J Neurol. 2026 Mar 11;273(3):201. doi: 10.1007/s00415-026-13718-z. PMID: 41811373; PMCID: PMC12979338.
- Möhn N, Grote-Levi L, Bonifacius A, Tischer-Zimmermann S, Nay S, Jendretzky KF, Sassmann ML, Karacondi K, Zent M, Konen FF, Sühs KW, Meuth SG, Pawlitzki M, Warnke C, Ayzenberg I, Schneider R, Helmchen C, Brüggemann N, Klebe S, Hildner M, Grefkes C, Nitsch L, Hühnchen P, Böltz S, Alt L, Tumani H, Kleinschnitz C, Pul R, Grauer O, Clifford D, Gnanapavan S, Wicklein R, Perpoint T, Beudel M, Del Bello A, Rauer S, Wiendl H, Jelcic I, Gasnault J, Cimini E, Antinori A, Pinnetti C, Pourcher V, Weiss N, Lambert N, Maecker-Kolhoff B, Höglinger GU, Zahraeifard S, Cortese I, Eiz-Vesper B, Martin-Blondel G, Skripuletz T; Immunotherapy for PML Study Group. Virus-Specific T Cells and Response to Checkpoint Inhibitors in Progressive Multifocal Leukoencephalopathy. JAMA Neurol. 2026 Jan 20:e255318. doi: 10.1001/jamaneurol.2025.5318. Epub ahead of print. PMID: 41557340; PMCID: PMC12820779.
Pakula V, Dorneich JS, Frontzkowski L, Bartos LM, Fearns N, Roemer-Cassiano SN, Lindner S, Zwergal A, Kaufmann E, Höglinger G, Franzmeier N, Werner RA, Vollmar C, Rémi J, Brendel M, Gnörich J. Detection of Focal Lesions in Epilepsy with [18F]UCB-H Synaptic Vesicle Protein 2A PET Imaging. J Nucl Med. 2026 Apr 2:jnumed.125.271505. doi: 10.2967/jnumed.125.271505. Epub ahead of print. PMID: 41927278.
Quattrone A, Bianco MG, Vescio B, Chimento I, Sacilotti A, Oliveti C, Arcuri PP, Stanà C, Tinelli E, Sabatini U, Kaasinen V, Franzmeier N, Stefanis L, Velonakis G, Boxer A, Constantinides VC, Höglinger GU, Quattrone A; PASSPORT Study Group; AL-108-231 Investigators; TAUROS MRI Investigators; DescribePSP group; AL-108-231 Study Group; Tau Restoration on PSP (TAUROS) MRI Investigators; DESCRIBE-PSP Study Group [i.a. Dichgans M, Perneczky R, Levin J, Priller J, Lingor P, Herms J]. Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study. Radiology. 2026 Jun;319(3):e251394. doi: 10.1148/radiol.251394. PMID: 42227858.
Tagnin L, Dorneich JS, Zeinaki M, Vogler L, Sanzo L, Gnörich JS, Katzdobler S, Masouris I, Jäck A, Bernhardt AM, Rauchmann BS, Stoecklein S, Simmet M, Joseph E, Lindner S, Koglin N, Mueller A, Stephens AW, Bischof GN, Frontzkowski LK, Franzmeier N, Werner RA, Gernert JA, Hopfner F, Höglinger GU, Perneczky R, Kurz C, Kümpfel T, Kerschensteiner M, Thaler FS, Levin J, Brendel M. Feasibility of short imaging protocols for [18F]fluordeprenyl-D2 PET in autoimmune encephalitis and multiple system atrophy. Eur J Nucl Med Mol Imaging. 2026 May 28. doi:10.1007/s00259-026-07932-0. Epub ahead of print. PMID: 42203967.
- Vöglein J, Arzberger T, Ebner I, Herms J, Roeber S, Ruf V, Danek A, Giese A, Höglinger GU, Levin J. Accuracy of clinical diagnosis in neurodegenerative diseases - a study of 455 autopsy cases. J Neurol. 2026 Feb 20;273(2):156. doi: 10.1007/s00415-026-13680-w. PMID: 41721140; PMCID: PMC12923403.
Wagemann O, Götz C, Wlasich E, Sandkühler K, Prix C, Stockbauer A, Marth L, Jäck A, Halbgebauer S, Tumani H, Höglinger GU, Levin J, Nübling G. Combining blood biomarkers and the German version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-G) for diagnosing cognitive decline in Down syndrome. Alzheimers Dement. 2026 Mar;22(3):e71296. doi: 10.1002/alz.71296. PMID: 41859776.
- Ye L, Seidler L, Chemodanow D, Respondek G, Niesmann C, Wilkens I, Klietz M, Höglinger GU, Kopp B. Executive anosognosia in progressive supranuclear palsy versus Parkinson's disease. Front Neurol. 2026 Feb 2;17:1744979. doi: 10.3389/fneur.2026.1744979. PMID: 41704890; PMCID: PMC12907162.
Zhu Z, Steward A, Dehsarvi A, Roemer-Cassiano SN, Dewenter A, Biel D, Hirsch F, Frontzkowski L, Pescoller J, Klonowski M, Gnörich J, Pontecorvo MJ, Shcherbinin S, Schöll M, Buckley R, Ossenkoppele R, Xie F, Guo T; Alzheimer's Disease Neuroimaging Initiative; Höglinger G, Brendel M, Franzmeier N. Defining patient-centered amyloid PET thresholds for the onset of tauopathy in Alzheimer's disease. Alzheimers Dement. 2026 Jan;22(1):e71064. doi: 10.1002/alz.71064. PMID: 41485137; PMCID: PMC12765405.
- Bauer T, Brendel M, Zaganjori M, Bernhardt AM, Jäck A, Stöcklein S, Scheifele M, Levin J, van Eimeren T, Drzezga A, Sabri O, Barthel H, Perneczky R, Höglinger G, Franzmeier N, Gnörich J; German Imaging Initiative for Tauopathies (GII4T). Pragmatic algorithm for visual assessment of 4-Repeat tauopathies in [18F]PI-2620 PET Scans. Neuroimage. 2025 Jan 9;306:121001. doi: 10.1016/j.neuroimage.2025.121001. Epub ahead of print. PMID: 39798829.
- Bernhardt AM, Longen S, Trossbach SV, Rossi M, Weckbecker D, Schmidt F, Jäck A, Katzdobler S, Fietzek UM, Weidinger E, Palleis C, Ruf V, Baiardi S, Parchi P, Höglinger GU, Matthias T, Levin J, Giese A. A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson's disease. Acta Neuropathol. 2025 Feb 20;149(1):20. doi: 10.1007/s00401-025-02853-y. PMID: 39976789; PMCID: PMC11842418.
Biel D, Steward A, Dewenter A, Dehsarvi A, Zhu Z, Roemer-Cassiano SN, Frontzkowski L, Hirsch F, Palleis C, Höglinger G, Brendel M, Franzmeier N; Alzheimer's Disease Neuroimaging Initiative (ADNI). A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease. Alzheimers Dement. 2025 Oct;21(10):e70783. doi: 10.1002/alz.70783. PMID: 41126448; PMCID: PMC12545699.
Chua OWH, Duan L, Bothe SH, Evsyukov V, Moebius C, Bickle M, Höglinger GU, Höllerhage M. Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity. Cell Death Discov. 2025 Dec 12. doi: 10.1038/s41420-025-02901-2. Epub ahead of print. PMID: 41387695.
Corvol JC, Obadia MA, Moreau C, Mariani LL, Brandel JP, Devos D, Sambin S, Carrière N, Höglinger G, Lebouteux M, Mangone G, Callizot N, Blondel A, Defert O, Estrella C, Karapet A, Verwaerde P, Defebvre L. AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open-Label Extension on Safety, Biomarkers, and Disease Progression. Mov Disord. 2025 Sep 27. doi: 10.1002/mds.70049. Epub ahead of print. PMID: 41014124.
- Courade JP, Zetterberg H, Höglinger GU, Dewachter I. The evolving landscape of Alzheimer's disease therapy: From Aβ to tau. Cell. 2025 Dec 24;188(26):7337-7354. doi: 10.1016/j.cell.2025.11.033. PMID: 41448139.
Crook H, Franzmeier N, Rahmouni N, Gnörich JS, Fryer TD, Hong YT, Roemer-Cassiano SN, Palleis C, Strauss A, Jones PS, Aigbirhio FI, Hopewell R, Rauchmann BS, Massarweh G, Perneczky R, Levin J, Höglinger GU, Rowe JB, O'Brien JT, Rosa-Neto P, Brendel M, Malpetti M. Comparing and combining TSPO-PET tracers in tauopathies. Eur J Nucl Med Mol Imaging. 2025 Oct 20. doi: 10.1007/s00259-025-07579-3. Epub ahead of print. PMID: 41114734.
Falkenburger B, Fanciulli A, Pötter-Nerger M, van Eimeren T, Classen J, Höglinger G, Redecker C, Winkler J, Klucken J. Clinical utility of digital technologies in Parkinson's disease. J Neural Transm (Vienna). 2025 Nov 12. doi: 10.1007/s00702-025-03062-3. Epub ahead of print. PMID: 41222710.
- Fanciulli A, Sixel-Döring F, Buhmann C, Krismer F, Hermann W, Winkler C, Woitalla D, Jost WH; German Parkinson’s Guideline Group [i.a. Levin J]; Trenkwalder C, Höglinger G. Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology. J Neurol. 2025 Jan 3;272(1):90. doi: 10.1007/s00415-024-12730-5. PMID: 39751950; PMCID: PMC11698777.
- Franzmeier N, Roemer-Cassiano SN, Bernhardt AM, Dehsarvi A, Dewenter A, Steward A, Biel D, Frontzkowski L, Zhu Z, Gnörich J, Pescoller J, Wagner F, Hirsch F, de Bruin H, Ossenkoppele R, Palleis C, Strübing F, Schöll M, Levin J, Brendel M, Höglinger GU. Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's disease. Mol Neurodegener. 2025 Mar 18;20(1):31. doi: 10.1186/s13024-025-00822-3. PMID: 40098057; PMCID: PMC11916967.
Gernert JA, Sanzo L, Zimmermann H, Thaler FS, Vogler L, Gnörich JS, Tagnin L, Lindner S, Kugelmann B, Schaefer R, Bischof GN, Katzdobler S, Werner RA, Höglinger GU, Levin J, Franzmeier N, Rauchmann B, Perneczky R, Kerschensteiner M, Kümpfel T, Brendel M. [18F]fluorodeprenyl-D2 PET can detect and monitor astrogliosis in anti-LGI1-IgG autoimmune encephalitis. Eur J Nucl Med Mol Imaging. 2025 Sep 26. doi: 10.1007/s00259-025-07531-5. Epub ahead of print. PMID: 41003762.
Gesierich B, Sander L, Pirpamer L, Meier DS, Ruberte E, Amann M, Sinnecker T, Huck A, de Leeuw FE, Maillard P, Moy S, Helmer KG; MarkVCID Consortium; Levin J, Höglinger GU; PROMESA Study Group; Kühne M, Bonati LH, Kuhle J, Cattin P, Granziera C, Schlaeger R, Duering M. Extended Technical and Clinical Validation of Deep Learning-Based Brainstem Segmentation for Application in Neurodegenerative Diseases. Hum Brain Mapp. 2025 Feb 15;46(3):e70141. doi: 10.1002/hbm.70141. PMID: 39936343; PMCID: PMC11815323.
Grand TS, Ren S, Thokala P, Zanigni S, Åström DO, Bidani A, Höglinger G, Poewe W, Krismer F, Regnier S; EMSA-SG Natural History Study Investigators. Cost-Effectiveness Modelling of Multiple System Atrophy for Early Health Technology Assessment. Pharmacoecon Open. 2025 Oct 31. doi: 10.1007/s41669-025-00609-8. Epub ahead of print. PMID: 41171337.
Höglinger G, Lingor P, Höllerhage M, Trenkwalder C. Treatment Options for Motor Fluctuations in Parkinson's Disease. Mov Disord. 2025 Oct 28. doi: 10.1002/mds.70107. Epub ahead of print. PMID: 41147599.
- Hornung S, Vogl DP, Naltsas D, Dalla Volta B, Ballmann M, Marcon B, Syed MMK, Wu Y, Spanopoulou A, Feederle R, Heidrich L, Bernhagen J, Koeglsperger T, Höglinger GU, Rammes G, Lashuel HA, Kapurniotu A. Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein. Angew Chem Int Ed Engl. 2025 Jan 17:e202422834. doi: 10.1002/anie.202422834. Epub ahead of print. PMID: 39822034.
Klietz M, Pannewitz-Makaj K, Baacke F, Wegner F, Höllerhage M, Krey L, Ye L, Schrader C, Höglinger GU, Warnecke T. Dysphagia in Multiple System Atrophy Does Not Correlate with Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein. Mov Disord. 2025 Oct 11. doi: 10.1002/mds.70092. Epub ahead of print. PMID: 41074579.
Lázaro DF, Amen T, Gerhardt E, Song C, Burns R, Kruse N, Santos PI, Milovanovic D, Höglinger G, Mollenhauer B, Luk KC, Lee VM, Outeiro TF. Synphilin-1 modulates alpha-synuclein assembly, release and uptake. NPJ Parkinsons Dis. 2025 Nov 20;11(1):326. doi: 10.1038/s41531-025-01144-3. PMID: 41266386; PMCID: PMC12635182.
Outeiro TF, Höglinger G, Lang AE, Vieira TCRG. Protein misfolding: understanding biology to classify and treat synucleinopathies. J Neural Transm (Vienna). 2025 Feb 11. doi: 10.1007/s00702-025-02889-0. Epub ahead of print. PMID: 39932548.
Palleis C, Bernhardt AM, Weidinger E, Fietzek UM, Jäck A, Katzdobler S, Gnörich J, Bauer T, Franzmeier N, Perneczky R; German Imaging Initiative for Tauopathies (GII4T); Brendel M, Levin J, Höglinger GU. A Biomarker-Based Classification of Corticobasal Syndrome. Mov Disord. 2025 Oct 6. doi: 10.1002/mds.70070. Epub ahead of print. PMID: 41048081.
- Porsche S, Klietz M, Greten S, Piot IA, Jensen I, Wegner F, Ye L, Krey L, Höllerhage M, Pötter-Nerger M, Zeitzschel M, Hagena K, Kassubek J, Süß P, Winkler J, Berg D, Paschen S, Tönges L, Gruber D, Gandor F, Jost WH, Kühn AA, Claus I, Warnecke T, Pedrosa DJ, Eggers C, Trenkwalder C, Classen J, Schwarz J, Schnitzler A, Krause P, Schneider A, Brandt M, Falkenburger B, Zerr I, Bähr M, Weidinger E, Levin J, Katzdobler S, Düzel E, Glanz W, Teipel S, Kilimann I, Prudlo J, Gasser T, Brockmann K, Spottke A, Esser A, Petzold GC, Respondek G, Höglinger GU. A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy. Mov Disord Clin Pract. 2025 Jan 27. doi: 10.1002/mdc3.14348. Epub ahead of print. PMID: 39868903.
Quattrone A, Franzmeier N, Höglinger GU. Reply to: Utility of Progression Rate Since Symptom Onset in Predicting Subsequent Survival in Progressive Supranuclear Palsy. Mov Disord. 2025 Nov 17. doi: 10.1002/mds.70124. Epub ahead of print. PMID: 41243832.
Quattrone A, Franzmeier N, Levin J, Petzold GC, Spottke A, Brosseron F, Falkenburger B, Prudlo J, Gasser T; DESCRIBE‐PSP Group, The ProPSP Group; Höglinger GU. Prospective Multicenter Evaluation of the MDS "Suggestive of PSP" Diagnostic Criteria. Mov Disord. 2025 Jan 10. doi: 10.1002/mds.30112. Epub ahead of print. PMID: 39797511.
- Reese R, Koeglsperger T, Schrader C, Tönges L, Deuschl G, Kühn AA, Krack P, Schnitzler A, Storch A, Trenkwalder C, Höglinger GU; German Parkinson‘s Guideline Group. Invasive therapies for Parkinson's disease: an adapted excerpt from the guidelines of the German Society of Neurology. J Neurol. 2025 Feb 22;272(3):219. doi: 10.1007/s00415-025-12915-6. PMID: 39985674; PMCID: PMC11846738.
- Roemer-Cassiano SN, Wagner F, Evangelista L, Rauchmann BS, Dehsarvi A, Steward A, Dewenter A, Biel D, Zhu Z, Pescoller J, Gross M, Perneczky R, Malpetti M, Ewers M, Schöll M, Dichgans M, Höglinger GU, Brendel M, Jäkel S, Franzmeier N. Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease. Sci Transl Med. 2025 Jan 22;17(782):eadp2564. doi: 10.1126/scitranslmed.adp2564. Epub 2025 Jan 22. PMID: 39841807.
Sadikoglou E, Domingo-Fernández D, Savytska N, Fernandes N, Rizzu P, Illarionova A, Strauß T, Schwarz SC, Kodamullil A, Höglinger GU, Dhingra A, Gasser T, Heutink P. Chr:17q21.31 locus risk haplotype H1 susceptibility to ferroptosis is mediated by endolysosomal pathway. Cell Death Dis. 2025 Nov 13;16(1):828. doi: 10.1038/s41419-025-08147-1. PMID: 41238560; PMCID: PMC12618564.
- Scheifele M, Gnörich J, Schröder E, Kunte SC, Ells Z, Hagen J, Katzdobler S, Palleis C, Bernhardt A, Jäck A, Franzmeier N, Fischer M, Levin J, Höglinger GU, Werner RA, Brendel M. Feasibility of a single-day protocol for SPECT and PET assessment of dopamine transporter availability, cardiac innervation and metabolic patterns in patients with movement disorders. Eur J Nucl Med Mol Imaging. 2025 Mar 11. doi: 10.1007/s00259-025-07188-0. Epub ahead of print. PMID: 40064709.
Steward A, Dewenter A, Hirsch F, Roemer-Cassiano SN, Zhu Z, Dehsarvi A, Biel D, Klonowski M, Frontzkowski L, Palleis C, Gnörich J, Dichgans M, Höglinger G, Brendel M, Franzmeier N. ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner. Brain. 2025 Dec 18:awaf463. doi: 10.1093/brain/awaf463. Epub ahead of print. PMID: 41410687.
- Völter F, Eckenweber S, Scheifele M, Eckenweber F, Hirsch F, Franzmeier N, Kreuzer A, Griessl M, Steward A, Janowitz D, Palleis C, Bernhardt A, Vöglein J, Stockbauer A, Rauchmann BS, Schöberl F, Wlasich E, Buerger K, Wagemann O, Perneczky R, Weidinger E, Höglinger G, Levin J, Brendel M, Schönecker S. Correlation of early-phase β-amyloid positron-emission-tomography and neuropsychological testing in patients with Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2025 Feb 28. doi: 10.1007/s00259-025-07175-5. Epub ahead of print. PMID: 40019578.
- Wagemann O, Brendel M, Franzmeier N, Nübling G, Gnörich J, Zaganjori M, Prix C, Stockbauer A, Wlasich E, Loosli SV, Sandkühler K, Frontzkowski L, Höglinger G, Levin J. Feasibility and potential diagnostic value of [18F]PI-2620 PET in patients with down syndrome and Alzheimer's disease: a case series. Front Neurosci. 2025 Jan 6;18:1505999. doi: 10.3389/fnins.2024.1505999. PMID: 39834700; PMCID: PMC11744071.
- Wang H, Chang TS, Dombroski BA, Cheng PL, Si YQ, Tucci A, Patil V, Valiente-Banuet L, Li C, Farrell K, Mclean C, Molina-Porcel L, Rajput A, De Deyn PP, Le Bastard N, Gearing M, Donker Kaat L, Van Swieten JC, Dopper E, Ghetti BF, Newell KL, Troakes C, de Yébenes JG, Rábano-Gutierrez A, Meller T, Oertel WH, Respondek G, Stamelou M, Arzberger T, Roeber S, Müller U, Hopfner F, Pastor P, Brice A, Durr A, Le Ber I, Beach TG, Serrano GE, Hazrati LN, Litvan I, Rademakers R, Ross OA, Galasko D, Boxer AL, Miller BL, Seeley WW, Van Deerlin VM, Lee EB, White CL 3rd, Morris HR, de Silva R, Crary JF, Goate AM, Friedman JS, Compta Y, Leung YY, Coppola G, Naj AC, Wang LS; PSP Genetics Study Group [i.a. Herms J]; Dalgard C, Dickson DW, Höglinger GU, Tzeng JY, Geschwind DH, Schellenberg GD, Lee WP. Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells. Mov Disord. 2025 Mar 8. doi: 10.1002/mds.30150. Epub ahead of print. PMID: 40055946.
Wilkens I, Bebermeier S, Heine J, Ruf VC, Compta Y, Molina Porcel L, Troakes C, Vamanu A, Downes S, Irwin DJ, Cohen J, Lee EB, Nilsson CF, Englund EM, Nemati M, Katzdobler S, Levin J, Bernhardt AM, Pantelyat A, Seemiller J, Berger S, Van Swieten JC, Dopper EGP, Rozemuller AJM, Kovacs GG, Bendahan N, Lang AE, Herms J, Höglinger GU, Hopfner F. Multiple System Atrophy Without Dysautonomia: An Autopsy-Confirmed Study. Neurology. 2025 Dec 9;105(11):e214316. doi: 10.1212/WNL.0000000000214316. Epub 2025 Nov 13. PMID: 41232058; PMCID: PMC12615010.
- Bernhardt AM, Nemati M, Boros FA, Hopfner F, Levin J, Mollenhauer B, Winkler J, Zerr I, Zunke F, Höglinger G. α-Synuclein Seed Amplification Assays from Blood-Based Extracellular Vesicles in Parkinson's Disease: An Evaluation of the Evidence. Mov Disord. 2024 Jul 11. doi: 10.1002/mds.29923. Epub ahead of print. PMID: 38989741.
- Biechele G, Rauchmann BS, Janowitz D, Buerger K, Franzmeier N, Weidinger E, Guersel S, Schuster S, Finze A, Harris S, Lindner S, Albert NL, Wetzel C, Rupprecht R, Rominger A, Palleis C, Katzdobler S, Burow L, Kurz C, Zaganjori M, Trappmann LK, Goldhardt O, Grimmer T, Haeckert J, Keeser D, Stoecklein S, Morenas-Rodriguez E, Bartenstein P, Levin J, Höglinger GU, Simons M, Perneczky R, Brendel M. Associations between sex, body mass index and the individual microglial response in Alzheimer's disease. J Neuroinflammation. 2024 Jan 23;21(1):30. doi:10.1186/s12974-024-03020-y. PMID: 38263017; PMCID: PMC10804830.
- Bischof GN, Brendel M, Barthel H, Theis H, Barbe M, Bartenstein P, Claasen J, Danek A, Höglinger G, Levin J, Marek K, Neumaier B, Palleis C, Patt M, Rullmann M, Saur D, Schroeter ML, Seibyl J, Song M, Stephens A, Sabri O, Drzezga A, van Eimeren T; German Imaging Initiative for Tauopathies. Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [18F]PI-2620. J Nucl Med. 2024 Apr 4:jnumed.123.265930. doi: 10.2967/jnumed.123.265930. Epub ahead of print. PMID: 38575191.
- Brendel M, Guedj E, Yakushev I, Morbelli S, Höglinger GU, Tolboom N, Verger A, Albert NL, Cecchin D, Fernandez PA, Fraioli F, Traub-Weidinger T, Van Weehaeghe D, Barthel H. Neuroimaging biomarkers in the biological definition of Parkinson's disease and dementia with Lewy bodies - EANM position on current state, unmet needs and future perspectives. Eur J Nucl Med Mol Imaging. 2024 Jun 22. doi: 10.1007/s00259-024-06803-w. Epub ahead of print. PMID: 38907856.
- Brendel M, Parvizi T, Gnörich J, Topfstedt CE, Buerger K, Janowitz D, Rauchmann BS, Perneczky R, Kurz C, Mehrens D, Kunz WG, Kusche-Palenga J, Kling AB, Buchal A, Nestorova E, Silvaieh S, Wurm R, Traub-Weidinger T, Klotz S, Regelsberger G, Rominger A, Drzezga A, Levin J, Stögmann E, Franzmeier N, Höglinger GU. Aβ status assessment in a hypothetical scenario prior to treatment with disease-modifying therapies: Evidence from 10-year real-world experience at university memory clinics. Alzheimers Dement (Amst). 2024 Nov 22;16(4):e70031. doi: 10.1002/dad2.70031. PMID: 39583651; PMCID: PMC11582924.
Buchert R, Huppertz HJ, Wegner F, Berding G, Brendel M, Apostolova I, Buhmann C, Poetter-Nerger M, Dierks A, Katzdobler S, Klietz M, Levin J, Mahmoudi N, Rinscheid A, Quattrone A, Rogozinski S, Rumpf JJ, Schneider C, Stoecklein S, Spetsieris PG, Eidelberg D, Sabri O, Barthel H, Wattjes MP, Höglinger G; Alzheimer’s Disease Neuroimaging Initiative. Added value of FDG-PET for detection of progressive supranuclear palsy. J Neurol Neurosurg Psychiatry. 2024 Aug 8:jnnp-2024-333590. doi: 10.1136/jnnp-2024-333590. Epub ahead of print. PMID: 39107038.
Chatterjee M, Özdemir S, Fritz C, Möbius W, Kleineidam L, Mandelkow E, Biernat J, Doğdu C, Peters O, Cosma NC, Wang X, Schneider LS, Priller J, Spruth E, Kühn AA, Krause P, Klockgether T, Vogt IR, Kimmich O, Spottke A, Hoffmann DC, Fliessbach K, Miklitz C, McCormick C, Weydt P, Falkenburger B, Brandt M, Guenther R, Dinter E, Wiltfang J, Hansen N, Bähr M, Zerr I, Flöel A, Nestor PJ, Düzel E, Glanz W, Incesoy E, Bürger K, Janowitz D, Perneczky R, Rauchmann BS, Hopfner F, Wagemann O, Levin J, Teipel S, Kilimann I, Goerss D, Prudlo J, Gasser T, Brockmann K, Mengel D, Zimmermann M, Synofzik M, Wilke C, Selma-González J, Turon-Sans J, Santos-Santos MA, Alcolea D, Rubio-Guerra S, Fortea J, Carbayo Á, Lleó A, Rojas-García R, Illán-Gala I, Wagner M, Frommann I, Roeske S, Bertram L, Heneka MT, Brosseron F, Ramirez A, Schmid M, Beschorner R, Halle A, Herms J, Neumann M, Barthélemy NR, Bateman RJ, Rizzu P, Heutink P, Dols-Icardo O, Höglinger G, Hermann A, Schneider A. Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS. Nat Med. 2024 Jun;30(6):1771-1783. doi: 10.1038/s41591-024-02937-4. Epub 2024 Jun 18. PMID: 38890531; PMCID: PMC11186765.
- Chopra A, Lang AE, Höglinger G, Outeiro TF. Towards a biological diagnosis of PD. Parkinsonism Relat Disord. 2024 Mar 6:106078. doi: 10.1016/j.parkreldis.2024.106078. Epub ahead of print. PMID: 38472075.
- Costa MFD, Rösler TW, Höglinger GU. Exploring the neuroprotective potential of Nrf2-pathway activators against annonacin toxicity. Sci Rep. 2024 Aug 29;14(1):20123. doi: 10.1038/s41598-024-70837-1. PMID: 39209951; PMCID: PMC11362529.
- de Boer EMJ, de Vries BS, Van Hecke W, Mühlebner A, Vincken KL, Mol CP, van Rheenen W, Westeneng HJ, Veldink JH, Höglinger GU, Morris HR, Litvan I, Raaphorst J, Ticozzi N, Corcia P, Vandenberghe W, Pijnenburg YAL, Seelaar H, Ingre C, Van Damme P, van den Berg LH, van de Warrenburg BPC, van Es MA. Diagnosing primary lateral sclerosis: a clinico-pathological study. J Neurol. 2024 Dec 12;272(1):46. doi: 10.1007/s00415-024-12816-0. PMID: 39666071.
Dilcher R, Wall S, Groß M, Katzdobler S, Wagemann O, Palleis C, Weidinger E, Fietzek U, Bernhardt A, Kurz C, Ferschmann C, Scheifele M, Zaganjori M, Gnörich J, Bürger K, Janowitz D, Rauchmann BS, Stöcklein S, Bartenstein P, Villemagne V, Seibyl J, Sabri O, Barthel H, Perneczky R, Schöberl F, Zwergal A, Höglinger GU, Levin J, Franzmeier N, Brendel M. Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies. Alzheimers Dement. 2024 Sep 12. doi: 10.1002/alz.14185. Epub ahead of print. PMID: 39263969.
- Farrell K, Humphrey J, Chang T, Zhao Y, Leung YY, Kuksa PP, Patil V, Lee WP, Kuzma AB, Valladares O, Cantwell LB, Wang H, Ravi A, De Sanctis C, Han N, Christie TD, Afzal R, Kandoi S, Whitney K, Krassner MM, Ressler H, Kim S, Dangoor D, Iida MA, Casella A, Walker RH, Nirenberg MJ, Renton AE, Babrowicz B, Coppola G, Raj T, Höglinger GU, Müller U, Golbe LI, Morris HR, Hardy J, Revesz T, Warner TT, Jaunmuktane Z, Mok KY, Rademakers R, Dickson DW, Ross OA, Wang LS, Goate A, Schellenberg G, Geschwind DH; PSP Genetics Study Group [i.a. Herms J]; Crary JF, Naj A. Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nat Commun. 2024 Sep 9;15(1):7880. doi: 10.1038/s41467-024-52025-x. PMID: 39251599; PMCID: PMC11385559.
- Ferschmann C, Messerschmidt K, Gnörich J, Barthel H, Marek K, Palleis C, Katzdobler S, Stockbauer A, Fietzek U, Finze A, Biechele G, Rumpf JJ, Saur D, Schroeter ML, Rullmann M, Beyer L, Eckenweber F, Wall S, Schildan A, Patt M, Stephens A, Classen J, Bartenstein P, Seibyl J, Franzmeier N, Levin J, Höglinger GU, Sabri O, Brendel M, Scheifele M; German Imaging Initiative for Tauopathies (GII4T). Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies. Eur J Nucl Med Mol Imaging. 2024 Feb 17. doi: 10.1007/s00259-024-06637-6. Epub ahead of print. PMID: 38366196.
- Germani M, Rebollo Mesa I, Buchanan TJ, De Bruyn S, Gasalla T, Van Tricht HLG, Ewen C, Golbe LI, Boxer A, Höglinger G. Combined Assessment of Function and Survival to Demonstrate the Effect of Treatment on Progressive Supranuclear Palsy. Mov Disord. 2024 Oct 29. doi: 10.1002/mds.30027. Epub ahead of print. PMID: 39470015.
- Gewily M, Plan EL, Yousefi E, König F, Posch M, Hopfner F, Höglinger G, Karlsson MO. Quantitative Comparisons of Progressive Supranuclear Palsy Rating Scale Versions Using Item Response Theory. Mov Disord. 2024 Aug 29. doi: 10.1002/mds.30001. Epub ahead of print. PMID: 39206961.
- Graessner H, Reinhard C, Bäumer T, Baumgärtner A, Brockmann K, Brüggemann N, Bültmann E, Erdmann J, Heise K, Höglinger G, Hüning I, Kaiser FJ, Klein C, Klopstock T, Krägeloh-Mann I, Kraemer M, Luedtke K, Mücke M, Musacchio T, Nadke A, Osmanovic A, Ritter G, Röse K, Schippers C, Schöls L, Schüle R, Schulz JB, Sproß J, Stasch E, Wunderlich G, Münchau A. Recommendations for optimal interdisciplinary management and healthcare settings for patients with rare neurological diseases. Orphanet J Rare Dis. 2024 Feb 13;19(1):62. doi: 10.1186/s13023-024-03023-1. PMID: 38347616; PMCID: PMC10863275.
Hagen JM, Scheifele M, Zacherl MJ, Katzdobler S, Bernhardt A, Brendel M, Levin J, Höglinger GU, Clauß S, Kääb S, Todica A, Boening G, Fischer M. Diagnostic Efficacy of 123Iodo-Metaiodobenzylguanidine SPECT/CT in Cardiac vs. Neurological Diseases: A Comparative Study of Arrhythmogenic Right Ventricular Cardiomyopathy and α-Synucleinopathies. Diagnostics (Basel). 2024 Dec 26;15(1):24. doi: 10.3390/diagnostics15010024. PMID: 39795552; PMCID: PMC11720076.
- Hopfner F, Höglinger G; German Parkinson’s Guidelines Group [i.a. Levin J, Lingor P]; Trenkwalder C. Definition and diagnosis of Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology. J Neurol. 2024 Sep 19. doi: 10.1007/s00415-024-12687-5. Epub ahead of print. PMID: 39297986.
- Höglinger G; German Parkinson’s Guidelines Committee [i.a. Levin J, Lingor P]; Trenkwalder C. Diagnosis and treatment of Parkinson´s disease (guideline of the German Society for Neurology). Neurol Res Pract. 2024 Jun 6;6(1):30. doi: 10.1186/s42466-024-00325-4. PMID: 38845028; PMCID: PMC11157782.
- Höglinger G, Jost WH. Every generation got its own disease. J Neural Transm (Vienna). 2024 May 2. doi: 10.1007/s00702-024-02767-1. Epub ahead of print. PMID: 38693462.
- Höglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE. A biological classification of Parkinson's disease: the SynNeurGe research diagnostic criteria. Lancet Neurol. 2024 Feb;23(2):191-204. doi: 10.1016/S1474-4422(23)00404-0. Erratum in: Lancet Neurol. 2024 Mar;23(3):e7. PMID: 38267191.
- Höglinger GU, Boxer AL, Lang AE. Clinical versus biomarker-based diagnosis of neurocognitive disorders. Lancet Neurol. 2024 Aug;23(8):765-766. doi: 10.1016/S1474-4422(24)00274-6. PMID: 39030034.
- Höglinger GU, Lang AE. The why and how of the SynNerGe criteria of Parkinson´s disease. J Neural Transm (Vienna). 2024 Jun 25. doi: 10.1007/s00702-024-02797-9. Epub ahead of print. PMID: 38916622.
- Höglinger GU, Lang AE. SynNeurGe: The road ahead for a biological definition of Parkinson's disease. J Parkinsons Dis. 2024 Dec 8:1877718X241298194. doi: 10.1177/1877718X241298194. Epub ahead of print. PMID: 39973492.
- Höllerhage M, Becktepe J, Classen J, Deuschl G, Ebersbach G, Hopfner F, Lingor P, Löhle M, Maaß S, Pötter-Nerger M, Odin P, Woitalla D; German Parkinson’s Guidelines Group [i.a. Levin J]; Trenkwalder C, Höglinger GU. Pharmacotherapy of motor symptoms in early and mid-stage Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology. J Neurol. 2024 Aug 29. doi: 10.1007/s00415-024-12632-6. Epub ahead of print. PMID: 39207521.
Jensen I, Bebermeier S, Stiel S, Höglinger GU, Klietz M. Reply to: "A Short Progressive Supranuclear Palsy Quality of Life Scale: Data from the PSP-NET". Mov Disord. 2024 Dec;39(12):2307-2308. doi: 10.1002/mds.30049. PMID: 39699258.
- Jensen I, Heine J, Ruf VC, Compta Y, Porcel LM, Troakes C, Vamanu A, Downes S, Irwin D, Cohen J, Lee EB, Nilsson C, Englund E, Nemati M, Katzdobler S, Levin J, Pantelyat A, Seemiller J, Berger S, van Swieten J, Dopper E, Rozenmuller A, Kovacs GG, Bendahan N, Lang AE, Herms J, Höglinger G, Hopfner F. Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria. Mov Disord. 2024 Jun 7. doi: 10.1002/mds.29879. Epub ahead of print. PMID: 38847384.
- Jensen I, Stiel S, Bebermeier S, Schrag A, Greten S, Doll-Lee J, Wegner F, Ye L, Heine J, Krey L, Höllerhage M, Süß P, Winkler J, Berg D, Paschen S, Tönges L, Gruber D, Gandor F, Jost WH, Kühn AA, Claus I, Warnecke T, Pedrosa DJ, Eggers C, Trenkwalder C, Classen J, Schwarz J, Pötter-Nerger M, Kassubek J, Schnitzler A, Höglinger GU, Klietz M. A Short Progressive Supranuclear Palsy Quality of Life Scale. Mov Disord. 2024 Jul 26. doi: 10.1002/mds.29936. Epub ahead of print. PMID: 39056204.
- Katzdobler S, Nübling G, Klietz M, Fietzek UM, Palleis C, Bernhardt AM, Wegner F, Huber M, Rogozinski S, Schneider LS, Spruth EJ, Beyle A, Vogt IR, Brandt M, Hansen N, Glanz W, Brockmann K, Spottke A, Hoffmann DC, Peters O, Priller J, Wiltfang J, Düzel E, Schneider A, Falkenburger B, Klockgether T, Gasser T, Nuscher B, Haass C, Höglinger G, Levin J. GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA). J Neurol. 2024 Sep 10. doi: 10.1007/s00415-024-12647-z. Epub ahead of print. PMID: 39254698.
- Lang AE, Höglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ. Initial biological classification of Lewy body diseases: No consensus on terminology. Alzheimers Dement. 2024 Dec 28. doi: 10.1002/alz.14449. Epub ahead of print. PMID: 39732512.
- Levin J, Baiardi S, Quadalti C, Rossi M, Mammana A, Vöglein J, Bernhardt A, Perrin RJ, Jucker M, Preische O, Hofmann A, Höglinger GU, Cairns NJ, Franklin EE, Chrem P, Cruchaga C, Berman SB, Chhatwal JP, Daniels A, Day GS, Ryan NS, Goate AM, Gordon BA, Huey ED, Ibanez L, Karch CM, Lee JH, Llibre-Guerra J, Lopera F, Masters CL, Morris JC, Noble JM, Renton AE, Roh JH, Frosch MP, Keene CD, McLean C, Sanchez-Valle R, Schofield PR, Supnet-Bell C, Xiong C, Giese A, Hansson O, Bateman RJ, McDade E; Dominantly Inherited Alzheimer Network; Parchi P. α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden. Alzheimers Dement. 2024 Apr 26. doi: 10.1002/alz.13818. Epub ahead of print. PMID: 38666355.
Mahmoudi R, Greten S, Veith Sanches L, Krey L, Ulaganathan S, Höglinger GU, Heck J, Wegner F, Klietz M. Impact of the Anticholinergic Burden on Disease-Specific Symptoms in Parkinsonian Syndromes. Brain Sci. 2024 Aug 11;14(8):805. doi: 10.3390/brainsci14080805. PMID: 39199497; PMCID: PMC11352570.
- Malpetti M, Roemer SN, Harris S, Gross M, Gnörich J, Stephens A, Dewenter A, Steward A, Biel D, Dehsarvi A, Wagner F, Müller A, Koglin N, Weidinger E, Palleis C, Katzdobler S, Rupprecht R, Perneczky R, Rauchmann BS, Levin J, Höglinger GU, Brendel M, Franzmeier N. Neuroinflammation Parallels 18F-PI-2620 Positron Emission Tomography Patterns in Primary 4-Repeat Tauopathies. Mov Disord. 2024 Jul 18. doi: 10.1002/mds.29924. Epub ahead of print. PMID: 39022835.
- Marvian AT, Strauss T, Tang Q, Tuck BJ, Keeling S, Rüdiger D, Mirzazadeh Dizaji N, Mohammad-Beigi H, Nuscher B, Chakraborty P, Sutherland DS, McEwan WA, Köglsperger T, Zahler S, Zweckstetter M, Lichtenthaler SF, Wurst W, Schwarz S, Höglinger G. Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons. Mol Neurodegener. 2024 Dec 31;19(1):100. doi: 10.1186/s13024-024-00786-w. PMID: 39736627; PMCID: PMC11686972.
Meindl M, Zatcepin A, Gnörich J, Scheifele M, Zaganjori M, Groß M, Lindner S, Schaefer R, Simmet M, Roemer S, Katzdobler S, Levin J, Höglinger G, Bischof AC, Barthel H, Sabri O, Bartenstein P, Saller T, Franzmeier N, Ziegler S, Brendel M. Assessment of [18F]PI-2620 Tau-PET Quantification via Non-Invasive Automatized Image Derived Input Function. Eur J Nucl Med Mol Imaging. 2024 May 8. doi: 10.1007/s00259-024-06741-7. Epub ahead of print. PMID: 38717592.
- Möhn N, Grote-Levi L, Wattjes MP, Bonifacius A, Holzwart D, Hopfner F, Nay S, Tischer-Zimmermann S, Saßmann ML, Schwenkenbecher P, Sühs KW, Mahmoudi N, Warnke C, Zimmermann J, Hagin D, Goudeva L, Blasczyk R, Koch A, Maecker-Kolhoff B, Eiz-Vesper B, Höglinger G, Skripuletz T. Directly Isolated Allogeneic Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy. JAMA Neurol. 2024 Oct 7:e243324. doi: 10.1001/jamaneurol.2024.3324. Epub ahead of print. PMID: 39374035; PMCID: PMC11459361.
- Nay S, Möhn N, Grote-Levi L, Bonifacius A, Saßmann ML, Karacondi K, Tischer-Zimmermann S, Pöter H, Mahmoudi N, Wattjes MP, Maecker-Kolhoff B, Höglinger G, Eiz-Vesper B, Skripuletz T. Combined treatment with allogeneic Epstein-Barr- and human polyomavirus 1 specific T-cells in progressive multifocal leukoencephalopathy and EBV infection: a case report. Ther Adv Neurol Disord. 2024 May 28;17:17562864241253917. doi: 10.1177/17562864241253917. PMID: 38813521; PMCID: PMC11135084.
- Palleis C, Franzmeier N, Weidinger E, Bernhardt AM, Katzdobler S, Wall S, Ferschmann C, Harris S, Schmitt J, Schuster S, Gnörich J, Finze A, Biechele G, Lindner S, Albert NL, Bartenstein P, Sabri O, Barthel H, Rupprecht R, Nuscher B, Stephens AW, Rauchmann BS, Perneczky R, Haass C, Brendel M, Levin J, Höglinger GU. Association of Neurofilament Light Chain, [18F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology. 2024 Jan 9;102(1):e207901. doi: 10.1212/WNL.0000000000207901. Epub 2023 Dec 14. PMID: 38165362.
- Pötter-Nerger M, Löhle M, Höglinger G; German Parkinson‘s Guideline Group. Akinetic crisis and withdrawal syndromes: guideline "Parkinson's disease" of the German Society of Neurology. J Neurol. 2024 Aug 27. doi: 10.1007/s00415-024-12649-x. Epub ahead of print. PMID: 39192030.
- Quattrone A, Franzmeier N, Huppertz HJ, Klietz M, Roemer SN, Boxer AL, Levin J, Höglinger GU; AL‐108‐231 Investigators, the Tauros MRI Investigators, the PASSPORT Study Group, the DESCRIBE‐PSP Group. Magnetic Resonance Imaging Measures to Track Atrophy Progression in Progressive Supranuclear Palsy in Clinical Trials. Mov Disord. 2024 Jun 2. doi: 10.1002/mds.29866. Epub ahead of print. PMID: 38825840.
- Roemer SN, Brendel M, Gnoerich J, Malpetti M, Zaganjori M, Quattrone A, Gross M, Steward A, Dewenter A, Wagner F, Dehsarvi A, Ferschmann C, Wall S, Palleis C, Rauchmann BS, Katzdobler S, Jaeck A, Stockbauer A, Fietzek UM, Bernhardt AM, Weidinger E, Zwergal A, Stoecklein S, Perneczky R, Barthel H, Sabri O, Levin J, Hoeglinger GU, Franzmeier N. Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies. Brain. 2024 Jun 6:awae174. doi: 10.1093/brain/awae174. Epub ahead of print. PMID: 38842726.
- Rong Z, Mai H, Ebert G, Kapoor S, Puelles VG, Czogalla J, Hu S, Su J, Prtvar D, Singh I, Schädler J, Delbridge C, Steinke H, Frenzel H, Schmidt K, Braun C, Bruch G, Ruf V, Ali M, Sühs KW, Nemati M, Hopfner F, Ulukaya S, Jeridi D, Mistretta D, Caliskan ÖS, Wettengel JM, Cherif F, Kolabas ZI, Molbay M, Horvath I, Zhao S, Krahmer N, Yildirim AÖ, Ussar S, Herms J, Huber TB, Tahirovic S, Schwarzmaier SM, Plesnila N, Höglinger G, Ondruschka B, Bechmann I, Protzer U, Elsner M, Bhatia HS, Hellal F, Ertürk A. Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19. Cell Host Microbe. 2024 Nov 26:S1931-3128(24)00438-4. doi: 10.1016/j.chom.2024.11.007. Epub ahead of print. PMID: 39615487.
- Schoenmakers DH, van den Berg S, Timmers L, Adang LA, Bäumer T, Bosch A, van de Casteele M, Datema MR, Dekker H, Donnelly C, Driessens MHE, Graessner H, Greger V, Haddad T, Höglinger GU, van den Hout H, Jonker C, Langeveld M, Lambert LJ, Neacy E, Nieuwland M, Klockgether T, van der Knaap MS, Papadopoulou A, Plueschke K, van Rijn S, Rosenberg N, Saunier-Vivar EF, Dos Santos Vieira B, Hollak CEM, Goettsch WG, Wolf NI. Framework for Multistakeholder Patient Registries in the Field of Rare Diseases: Focus on Neurogenetic Diseases. Neurology. 2024 Sep 24;103(6):e209743. doi: 10.1212/WNL.0000000000209743. Epub 2024 Aug 22. PMID: 39173102.
- Schönecker S, Martinez-Murcia FJ, Denecke J, Franzmeier N, Danek A, Wagemann O, Prix C, Wlasich E, Vöglein J, Loosli SV, Brauer A, Górriz Sáez JM, Bouzigues A, Russell LL, Foster PH, Ferry-Bolder E, van Swieten JC, Jiskoot LC, Seelaar H, Sanchez-Valle R, Laforce R Jr, Graff C, Galimberti D, Vandenberghe R, de Mendonça A, Tiraboschi P, Santana I, Gerhard A, Sorbi S, Otto M, Pasquier F, Ducharme S, Butler C, Le Ber I, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Rohrer JD; Genetic Frontotemporal Dementia Initiative (GENFI); Priller J, Höglinger GU, Levin J. Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia. Neurology. 2024 Oct 22;103(8):e209569. doi: 10.1212/WNL.0000000000209569. Epub 2024 Sep 16. PMID: 39284109; PMCID: PMC11399068.
- Slemann L, Gnörich J, Hummel S, Bartos LM, Klaus C, Kling A, Kusche-Palenga J, Kunte ST, Kunze LH, Englert AL, Li Y, Vogler L, Katzdobler S, Palleis C, Bernhardt A, Jäck A, Zwergal A, Hopfner F, Roemer-Cassiano SN, Biechele G, Stöcklein S, Bischof G, van Eimeren T, Drzezga A, Sabri O, Barthel H, Respondek G, Grimmer T, Levin J, Herms J, Paeger L, Willroider M, Beyer L, Höglinger GU, Roeber S, Franzmeier N, Brendel M. Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies. Acta Neuropathol. 2024 Nov 24;148(1):70. doi: 10.1007/s00401-024-02834-7. PMID: 39580770; PMCID: PMC11586312.
- Veith Sanches L, Greten S, Doll-Lee J, Rogozinski SM, Heine J, Krey L, Ulaganathan S, Jensen I, Höllerhage M, Sani SS, Höglinger GU, Wegner F, Klietz M. SEND-PD in Parkinsonian Syndromes: Results of a Monocentric Cross-Sectional Study. Neuropsychiatr Dis Treat. 2024 Oct 1;20:1849-1859. doi: 10.2147/NDT.S474584. PMID: 39372876; PMCID: PMC11453152.
- Volkmann H, Höglinger GU, Grön G, Bârlescu LA; DESCRIBE-PSP study group; Müller HP, Kassubek J. MRI classification of progressive supranuclear palsy, Parkinson disease and controls using deep learning and machine learning algorithms for the identification of regions and tracts of interest as potential biomarkers. Comput Biol Med. 2024 Dec 10;185:109518. doi: 10.1016/j.compbiomed.2024.109518. Epub ahead of print. PMID: 39662313.
- Walter U, Loewenbrück KF, Dodel R, Storch A, Trenkwalder C, Höglinger G; German Parkinson Guideline Group. Systematic review-based guideline "Parkinson's disease" of the German Society of Neurology: diagnostic use of transcranial sonography. J Neurol. 2024 Jul 4. doi: 10.1007/s00415-024-12502-1. Epub ahead of print. PMID: 38963440.
- Wuehr M, Peto D, Fietzek UM, Katzdobler S, Nübling G, Zaganjori M, Brendel M, Levin J, Höglinger GU, Zwergal A. Low-intensity vestibular noise stimulation improves postural symptoms in progressive supranuclear palsy. J Neurol. 2024 May 9. doi: 10.1007/s00415-024-12419-9. Epub ahead of print. PMID: 38722328.
- Ye L, Greten S, Wegner F, Doll-Lee J, Krey L, Heine J, Gandor F, Vogel A, Berger L, Gruber D, Levin J, Katzdobler S, Peters O, Dashti E, Priller J, Spruth EJ, Kühn AA, Krause P, Spottke A, Schneider A, Beyle A, Kimmich O, Donix M, Haussmann R, Brandt M, Dinter E, Wiltfang J, Schott BH, Zerr I, Bähr M, Buerger K, Janowitz D, Perneczky R, Rauchmann BS, Weidinger E, Düzel E, Glanz W, Teipel S, Kilimann I, Wurster I, Brockmann K, Hoffmann DC, Klockgether T, Krause O, Heck J; PROMESA study group; Höglinger GU, Klietz M. The comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis. J Neurol. 2024 Feb 14. doi: 10.1007/s00415-024-12207-5. Epub ahead of print. PMID: 38353748.
- Ye L, Sani SS, Veith Sanches L, Krey LFM, Wegner F, Höllerhage M, Schrader C, Höglinger G, Klietz M. Acute Levodopa Challenge in Atypical Parkinsonism: Comprehensive Analysis of Individual Motor Responses. Brain Sci. 2024 Sep 29;14(10):991. doi: 10.3390/brainsci14100991. PMID: 39452005; PMCID: PMC11506334.
- Yousefi E, Gewily M, König F, Höglinger G, Hopfner F, Karlsson MO, Ristl R, Zehetmayer S, Posch M. Efficiency of multivariate tests in trials in progressive supranuclear palsy. Sci Rep. 2024 Oct 26;14(1):25581. doi: 10.1038/s41598-024-76668-4. PMID: 39462124; PMCID: PMC11514033.
Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, Brösamle D, Wendeln AC, Osei-Sarpong C, Heindl S, Liesz A, Stoecklein S, Biechele G, Finze A, Eckenweber F, Lindner S, Rominger A, Bartenstein P, Willem M, Tahirovic S, Herms J, Buerger K, Simons M, Haass C, Rupprecht R, Riemenschneider MJ, Albert NL, Beyer M, Neher JJ, Paeger L, Levin J, Höglinger GU, Perneczky R, Ziegler SI, Brendel M. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease. Mol Neurodegener. 2024 Sep 5;19(1):64. doi: 10.1186/s13024-024-00752-6. PMID: 39238030; PMCID: PMC11375924.
- El Bouhaddani S, Höllerhage M, Uh HW, Moebius C, Bickle M, Höglinger G, Houwing-Duistermaat J. Statistical integration of multi-omics and drug screening data from cell lines. PLoS Comput Biol. 2024 Jan 31;20(1):e1011809. doi: 10.1371/journal.pcbi.1011809. PMID: 38295113; PMCID: PMC10878536.
- Greten S, Wegner F, Jensen I, Krey L, Rogozinski S, Fehring M, Heine J, Doll-Lee J, Pötter-Nerger M, Zeitzschel M, Hagena K, Pedrosa DJ, Eggers C, Bürk K, Trenkwalder C, Claus I, Warnecke T, Süß P, Winkler J, Gruber D, Gandor F, Berg D, Paschen S, Classen J, Pinkhardt EH, Kassubek J, Jost WH, Tönges L, Kühn AA, Schwarz J, Peters O, Dashti E, Priller J, Spruth EJ, Krause P, Spottke A, Schneider A, Beyle A, Kimmich O, Donix M, Haussmann R, Brandt M, Dinter E, Wiltfang J, Schott BH, Zerr I, Bähr M, Buerger K, Janowitz D, Perneczky R, Rauchmann BS, Weidinger E, Levin J, Katzdobler S, Düzel E, Glanz W, Teipel S, Kilimann I, Prudlo J, Gasser T, Brockmann K, Hoffmann DC, Klockgether T, Krause O, Heck J, Höglinger GU, Klietz M (2023). The comorbidity and co-medication profile of patients with progressive supranuclear palsy. J Neurol. 2023 Oct 6. doi: 10.1007/s00415-023-12006-4. Epub ahead of print. PMID: 37803149.
- Stockbauer A, Beyer L, Huber M, Kreuzer A, Palleis C, Katzdobler S, Rauchmann BS, Morbelli S, Chincarini A, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Garibotto V, Nicastro N, Lathuilière A, Lemstra AW, van Berckel BNM, Pilotto A, Padovani A, Ochoa-Figueroa MA, Davidsson A, Camacho V, Peira E, Bauckneht M, Pardini M, Sambuceti G, Aarsland D, Nobili F, Gross M, Vöglein J, Perneczky R, Pogarell O, Buerger K, Franzmeier N, Danek A, Levin J, Höglinger GU, Bartenstein P, Cumming P, Rominger A, Brendel M (2023). Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission. Eur J Nucl Med Mol Imaging. 2023 Nov 16. doi: 10.1007/s00259-023-06493-w. Epub ahead of print. PMID: 37971501.
- Vöglein J, Kostova I, Arzberger T, Röber S, Schmitz P, Simons M, Ruf V, Windl O, Herms J, Dieterich M, Danek A, Höglinger GU, Giese A, Levin J (2021). First symptom guides diagnosis and prognosis in neurodegenerative diseases - a retrospective study of autopsy proven cases. Eur J Neurol. 2021 Mar 4. doi: 10.1111/ene.14800. Epub ahead of print. PMID: 33662165.
- Vöglein J, Kostova I, Arzberger T, Noachtar S, Dieterich M, Herms J, Schmitz P, Ruf V, Windl O, Roeber S, Simons M, Höglinger GU, Danek A, Giese A, Levin J (2021). Seizure prevalence in neurodegenerative diseases - a study of autopsy proven cases. Eur J Neurol. 2021 Sep 2. doi: 10.1111/ene.15089. Epub ahead of print. PMID: 34472165.PMC8161006.
- Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, Palleis C, Rauchmann BS, Gildehaus FJ, Lindner S, Spitz C, Franzmeier N, Baumann K, Rominger A, Bartenstein P, Ziegler S, Drzezga A, Respondek G, Buerger K, Perneczky R, Levin J, Höglinger GU, Herms J, Haass C, Brendel M (2021). Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases. Sci Transl Med. 2021 Oct 13;13(615):eabe5640. doi: 10.1126/scitranslmed.abe5640. Epub 2021 Oct 13. PMID: 34644146.
- Jecmenica Lukic M, Kurz C, Respondek G, Grau-Rivera O, Compta Y, Gelpi E, Troakes C; Barcelona Brain Bank collaborative group, the MDS-endorsed PSP study group; van Swieten JC, Giese A, Roeber S, Arzberger T, Höglinger G. Copathology in Progressive Supranuclear Palsy: Does It Matter? Mov Disord. 2020 Jun;35(6):984-993. doi: 10.1002/mds.28011. Epub 2020 Mar 3. PMID: 32125724.
- Bonham LW, Karch CM, Fan CC, Tan C, Geier EG, Wang Y, Wen N, Broce IJ, Li Y, Barkovich MJ, Ferrari R, Hardy J, Momeni P, Höglinger G, Müller U, Hess CP, Sugrue LP, Dillon WP, Schellenberg GD, Miller BL, Andreassen OA, Dale AM, Barkovich AJ, Yokoyama JS, Desikan RS; International FTD-Genomics Consortium (IFGC); International Parkinson’s Disease Genetics Consortium (IPDGC); International Genomics of Alzheimer’s Project (IGAP). CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry. 2018 Apr 11;8(1):73. doi: 10.1038/s41398-017-0049-7. PMID: 29636460; PMCID: PMC5893558.
- Jabbari E, Woodside J, Tan MMX, Shoai M, Pittman A, Ferrari R, Mok KY, Zhang D, Reynolds RH, de Silva R, Grimm MJ, Respondek G, Müller U, Al-Sarraj S, Gentleman SM, Lees AJ, Warner TT, Hardy J, Revesz T, Höglinger GU, Holton JL, Ryten M, Morris HR. Variation at the TRIM11 locus modifies progressive supranuclear palsy phenotype. Ann Neurol. 2018 Oct;84(4):485-496. doi: 10.1002/ana.25308. Epub 2018 Sep 15. PMID: 30066433; PMCID: PMC6221133.
- Karch CM, Wen N, Fan CC, Yokoyama JS, Kouri N, Ross OA, Höglinger G, Müller U, Ferrari R, Hardy J, Schellenberg GD, Sleiman PM, Momeni P, Hess CP, Miller BL, Sharma M, Van Deerlin V, Smeland OB, Andreassen OA, Dale AM, Desikan RS; International Frontotemporal Dementia (FTD)–Genomics Consortium, International Collaboration for Frontotemporal Dementia, Progressive Supranuclear Palsy (PSP) Genetics Consortium, and International Parkinson’s Disease Genomics Consortium. Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA Neurol. 2018 Jul 1;75(7):860-875. doi: 10.1001/jamaneurol.2018.0372. PMID: 29630712; PMCID: PMC6043387.