Herms, Jochen

Candlish M, Hofmann J, Brösamle D, Haessler A, DeMeglio M, Skodras A, Tushev G, De Biasi ES, Günther S, Wiegandt R, Theis H, De Domenico E, Hermann NS, Breunig P, Sauerland C, Nilsson KPR, Beyer MD, Looso M, Windbergs M, Roeber S, Herms J, Neher JJ, Chiocchetti AG, Hefendehl JK. Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology. J Neuroinflammation. 2026 Jun 9. doi: 10.1186/s12974-026-03897-x. Epub ahead of print. PMID: 42265753.
Chen X, Li S, Neubauer A, Li X, Mao W, Brendel M, Liu J, Zhang M, Yang C, Xu R, Liu J, Shan B, Yuan J, Liu C, Herms J, Zou C. Glucose hypometabolism and hyperphosphorylated Tau synergistically drive neuronal necroptosis. Neuron. 2026 Apr 22:S0896-6273(26)00265-5. doi: 10.1016/j.neuron.2026.03.035. Epub ahead of print. PMID: 42025167.
DeMeglio M, De Biasi ES, Breunig P, Candlish M, Sauerland C, Günther S, Kawase H, Peguera B, Bohnstaedt C, Herms J, Neubauer A, Neher JJ, Nilsson PR, Hu J, Hille S, Müller O, Acker-Palmer A, Hammock BD, Underhill TM, Junek S, Offermanns S, Fleming I, Hefendehl JK. Soluble epoxide hydrolase drives neurovascular dysfunction in a model of amyloidosis. Brain. 2026 May 22:awag184. doi: 10.1093/brain/awag184. Epub ahead of print. PMID: 42170924.
Gaur N, Angerer C, Gunes ZI, Ancau M, Wang M, Riemenschneider H, Hurler CA, Mungwa S, Lüningschrör P, Zhiti A, Steinbach R, Briese M, Srivastava M, Plaas M, Hermann A, Sendtner M, Jäkel S, Edbauer D, Herms J, Liebscher S, Grosskreutz J, Brill MS. Constitutive neuronal expression and disease-associated upregulation of chitinases in amyotrophic lateral sclerosis. Brain. 2026 Feb 28:awag083. doi: 10.1093/brain/awag083. Epub ahead of print. PMID: 41762671.
Gnörich J, Kusche-Palenga J, Palleis C, Neubauer A, Frontzkowski L, Jäck A, Kling A, Bauer T, Eyob H, Probst K, Roemer-Cassiano SN, Bernhardt AM, Katzdobler S, Marth L, Zaganjori M, Hopfner F, Zwergal A, Häckert J, Rullmann M, Sabri O, Barthel H, Stöcklein S, Werner RA, Simons M, Levin J, Herms J, Franzmeier N, Höglinger GU, Brendel M; German Imaging Initiative for Tauopathies (GII4T). Longitudinal monitoring of tau aggregation in progressive supranuclear palsy with [18F]PI-2620 PET. Alzheimers Dement. 2026 Feb;22(2):e71195. doi: 10.1002/alz.71195. PMID: 41736364; PMCID: PMC12932912.
Klimmt J, Cardoso Gonçalves C, Montgomery JV, Müller SA, Bublitz M, Filser S, Paeger L, Nuscher B, Dannert A, Roeber S, Pravata V, Schifferer M, Shrouder JJ, Schulz N, González-Gallego J, Cappello S, Misgeld T, Plesnila N, Beltrán E, Herms J, De Domenico E, Beyer MD, Schultze JL, Haass C, Lichtenthaler SF, Carraro C, Paquet D. A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes. Nat Neurosci. 2026 Aug 4. doi: 10.1038/s41593-026-02367-0. Epub ahead of print. PMID: 42552384.
Quattrone A, Bianco MG, Vescio B, Chimento I, Sacilotti A, Oliveti C, Arcuri PP, Stanà C, Tinelli E, Sabatini U, Kaasinen V, Franzmeier N, Stefanis L, Velonakis G, Boxer A, Constantinides VC, Höglinger GU, Quattrone A; PASSPORT Study Group; AL-108-231 Investigators; TAUROS MRI Investigators; DescribePSP group; AL-108-231 Study Group; Tau Restoration on PSP (TAUROS) MRI Investigators; DESCRIBE-PSP Study Group [i.a. Dichgans M, Perneczky R, Levin J, Priller J, Lingor P, Herms J]. Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study. Radiology. 2026 Jun;319(3):e251394. doi: 10.1148/radiol.251394. PMID: 42227858.
Rumpf SL, Strübing FL, Nalbach K, Vargiu CM, Berg G, Lichtenthaler SF, Parchi P, Gao P, Chen W, Brendel M, Gnörich JS, Bernhardt A, Dias Rodrigues L, Höglinger GU, Herms J, Koeglsperger T. Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies. Nat Commun. 2026 Jul 21;17(1):6976. doi: 10.1038/s41467-026-74961-6. PMID: 42481480; PMCID: PMC13392254.
Vöglein J, Arzberger T, Ebner I, Herms J, Roeber S, Ruf V, Danek A, Giese A, Höglinger GU, Levin J. Accuracy of clinical diagnosis in neurodegenerative diseases - a study of 455 autopsy cases. J Neurol. 2026 Feb 20;273(2):156. doi: 10.1007/s00415-026-13680-w. PMID: 41721140; PMCID: PMC12923403.

Baiardi S, Vargiu CM, Appleby BS, Barria M, Bentivenga GM, Calì I, Carlà B, Cohen M, Giese A, Herms J, Kortelainen AM, Ladogana A, Mammana A, Ritchie D, Windl O, Capellari S, Parchi P. The Phenotypic Spectrum of Sporadic Creutzfeldt-Jakob Disease Cortical Subtype. Ann Neurol. 2025 Dec 22. doi: 10.1002/ana.78117. Epub ahead of print. PMID: 41424290.
Neubauer A, Weissenbrunner D, Pekrun S, Roeber S, Ruf V, Feyen P, Strübing FL, Herms J. Alpha-synuclein deposition patterns in Alzheimer's disease: association with cortical amyloid beta and variable tau load. Acta Neuropathol. 2025 Oct 30;150(1):46. doi: 10.1007/s00401-025-02952-w. PMID: 41165827; PMCID: PMC12575528.
Wang H, Chang TS, Dombroski BA, Cheng PL, Si YQ, Tucci A, Patil V, Valiente-Banuet L, Li C, Farrell K, Mclean C, Molina-Porcel L, Rajput A, De Deyn PP, Le Bastard N, Gearing M, Donker Kaat L, Van Swieten JC, Dopper E, Ghetti BF, Newell KL, Troakes C, de Yébenes JG, Rábano-Gutierrez A, Meller T, Oertel WH, Respondek G, Stamelou M, Arzberger T, Roeber S, Müller U, Hopfner F, Pastor P, Brice A, Durr A, Le Ber I, Beach TG, Serrano GE, Hazrati LN, Litvan I, Rademakers R, Ross OA, Galasko D, Boxer AL, Miller BL, Seeley WW, Van Deerlin VM, Lee EB, White CL 3rd, Morris HR, de Silva R, Crary JF, Goate AM, Friedman JS, Compta Y, Leung YY, Coppola G, Naj AC, Wang LS; PSP Genetics Study Group [i.a. Herms J]; Dalgard C, Dickson DW, Höglinger GU, Tzeng JY, Geschwind DH, Schellenberg GD, Lee WP. Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells. Mov Disord. 2025 Mar 8. doi: 10.1002/mds.30150. Epub ahead of print. PMID: 40055946.
Wilkens I, Bebermeier S, Heine J, Ruf VC, Compta Y, Molina Porcel L, Troakes C, Vamanu A, Downes S, Irwin DJ, Cohen J, Lee EB, Nilsson CF, Englund EM, Nemati M, Katzdobler S, Levin J, Bernhardt AM, Pantelyat A, Seemiller J, Berger S, Van Swieten JC, Dopper EGP, Rozemuller AJM, Kovacs GG, Bendahan N, Lang AE, Herms J, Höglinger GU, Hopfner F. Multiple System Atrophy Without Dysautonomia: An Autopsy-Confirmed Study. Neurology. 2025 Dec 9;105(11):e214316. doi: 10.1212/WNL.0000000000214316. Epub 2025 Nov 13. PMID: 41232058; PMCID: PMC12615010.
Zu J, Li C, Cui M, Liu X, Pan Z, Li X, Zhang F, Gentz J, Mitteregger-Kretzschmar G, Herms J, Shi Y. Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer's disease model. Brain. 2025 Dec 15:awaf462. doi: 10.1093/brain/awaf462. Epub ahead of print. PMID: 41396874.

Chatterjee M, Özdemir S, Fritz C, Möbius W, Kleineidam L, Mandelkow E, Biernat J, Doğdu C, Peters O, Cosma NC, Wang X, Schneider LS, Priller J, Spruth E, Kühn AA, Krause P, Klockgether T, Vogt IR, Kimmich O, Spottke A, Hoffmann DC, Fliessbach K, Miklitz C, McCormick C, Weydt P, Falkenburger B, Brandt M, Guenther R, Dinter E, Wiltfang J, Hansen N, Bähr M, Zerr I, Flöel A, Nestor PJ, Düzel E, Glanz W, Incesoy E, Bürger K, Janowitz D, Perneczky R, Rauchmann BS, Hopfner F, Wagemann O, Levin J, Teipel S, Kilimann I, Goerss D, Prudlo J, Gasser T, Brockmann K, Mengel D, Zimmermann M, Synofzik M, Wilke C, Selma-González J, Turon-Sans J, Santos-Santos MA, Alcolea D, Rubio-Guerra S, Fortea J, Carbayo Á, Lleó A, Rojas-García R, Illán-Gala I, Wagner M, Frommann I, Roeske S, Bertram L, Heneka MT, Brosseron F, Ramirez A, Schmid M, Beschorner R, Halle A, Herms J, Neumann M, Barthélemy NR, Bateman RJ, Rizzu P, Heutink P, Dols-Icardo O, Höglinger G, Hermann A, Schneider A. Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS. Nat Med. 2024 Jun;30(6):1771-1783. doi: 10.1038/s41591-024-02937-4. Epub 2024 Jun 18. PMID: 38890531; PMCID: PMC11186765.
Dinkel L, Hummel S, Zenatti V, Malara M, Tillmann Y, Colombo A, Monasor LS, Suh JH, Logan T, Roth S, Paeger L, Hoffelner P, Bludau O, Schmidt A, Müller SA, Schifferer M, Nuscher B, Njavro JR, Prestel M, Bartos LM, Wind-Mark K, Slemann L, Hoermann L, Kunte ST, Gnörich J, Lindner S, Simons M, Herms J, Paquet D, Lichtenthaler SF, Bartenstein P, Franzmeier N, Liesz A, Grosche A, Bremova-Ertl T, Catarino C, Beblo S, Bergner C, Schneider SA, Strupp M, Di Paolo G, Brendel M, Tahirovic S. Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease. Sci Transl Med. 2024 Dec 4;16(776):eadl4616. doi: 10.1126/scitranslmed.adl4616. Epub 2024 Dec 4. PMID: 39630885.
Englert B, Roeber S, Arzberger T, Ruf V, Windl O, Herms J. Fast-track neuropathological screening for neurodegenerative diseases. Free Neuropathol. 2024 Aug 6;5:5-16. doi: 10.17879/freeneuropathology-2024-5643. PMID: 39118598; PMCID: PMC11309573.
Farrell K, Humphrey J, Chang T, Zhao Y, Leung YY, Kuksa PP, Patil V, Lee WP, Kuzma AB, Valladares O, Cantwell LB, Wang H, Ravi A, De Sanctis C, Han N, Christie TD, Afzal R, Kandoi S, Whitney K, Krassner MM, Ressler H, Kim S, Dangoor D, Iida MA, Casella A, Walker RH, Nirenberg MJ, Renton AE, Babrowicz B, Coppola G, Raj T, Höglinger GU, Müller U, Golbe LI, Morris HR, Hardy J, Revesz T, Warner TT, Jaunmuktane Z, Mok KY, Rademakers R, Dickson DW, Ross OA, Wang LS, Goate A, Schellenberg G, Geschwind DH; PSP Genetics Study Group [i.a. Herms J]; Crary JF, Naj A. Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nat Commun. 2024 Sep 9;15(1):7880. doi: 10.1038/s41467-024-52025-x. PMID: 39251599; PMCID: PMC11385559.
Gnörich J, Koehler M, Wind-Mark K, Klaus C, Zatcepin A, Palumbo G, Lalia M, Monasor LS, Beyer L, Eckenweber F, Scheifele M, Gildehaus FJ, von Ungern-Sternberg B, Barthel H, Sabri O, Bartenstein P, Herms J, Tahirovic S, Franzmeier N, Ziegler S, Brendel M. Towards multicenter β-amyloid PET imaging in mouse models: A triple scanner head-to-head comparison. Neuroimage. 2024 Jul 26;297:120748. doi: 10.1016/j.neuroimage.2024.120748. Epub ahead of print. PMID: 39069223.
Jensen I, Heine J, Ruf VC, Compta Y, Porcel LM, Troakes C, Vamanu A, Downes S, Irwin D, Cohen J, Lee EB, Nilsson C, Englund E, Nemati M, Katzdobler S, Levin J, Pantelyat A, Seemiller J, Berger S, van Swieten J, Dopper E, Rozenmuller A, Kovacs GG, Bendahan N, Lang AE, Herms J, Höglinger G, Hopfner F. Impact of Magnetic Resonance Imaging Markers on the Diagnostic Performance of the International Parkinson and Movement Disorder Society Multiple System Atrophy Criteria. Mov Disord. 2024 Jun 7. doi: 10.1002/mds.29879. Epub ahead of print. PMID: 38847384.
Kaiser L, Quach S, Zounek AJ, Wiestler B, Zatcepin A, Holzgreve A, Bollenbacher A, Bartos LM, Ruf VC, Böning G, Thon N, Herms J, Riemenschneider MJ, Stöcklein S, Brendel M, Rupprecht R, Tonn JC, Bartenstein P, von Baumgarten L, Ziegler S, Albert NL. Enhancing predictability of IDH mutation status in glioma patients at initial diagnosis: a comparative analysis of radiomics from MRI, [18F]FET PET, and TSPO PET. Eur J Nucl Med Mol Imaging. 2024 Feb 24. doi: 10.1007/s00259-024-06654-5. Epub ahead of print. PMID: 38396261.
Medina-Luque J, Piechocinski P, Feyen P, Sgobio C, Herms J. Striatal dopamine neurotransmission is altered in age- and region-specific manner in a Parkinson's disease transgenic mouse. Sci Rep. 2024 Jan 2;14(1):164. doi: 10.1038/s41598-023-49600-5. PMID: 38167878; PMCID: PMC10761704.
Rong Z, Mai H, Ebert G, Kapoor S, Puelles VG, Czogalla J, Hu S, Su J, Prtvar D, Singh I, Schädler J, Delbridge C, Steinke H, Frenzel H, Schmidt K, Braun C, Bruch G, Ruf V, Ali M, Sühs KW, Nemati M, Hopfner F, Ulukaya S, Jeridi D, Mistretta D, Caliskan ÖS, Wettengel JM, Cherif F, Kolabas ZI, Molbay M, Horvath I, Zhao S, Krahmer N, Yildirim AÖ, Ussar S, Herms J, Huber TB, Tahirovic S, Schwarzmaier SM, Plesnila N, Höglinger G, Ondruschka B, Bechmann I, Protzer U, Elsner M, Bhatia HS, Hellal F, Ertürk A. Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19. Cell Host Microbe. 2024 Nov 26:S1931-3128(24)00438-4. doi: 10.1016/j.chom.2024.11.007. Epub ahead of print. PMID: 39615487.
Ruch F, Gnörich J, Wind K, Köhler M, Zatcepin A, Wiedemann T, Gildehaus FJ, Lindner S, Boening G, von Ungern-Sternberg B, Beyer L, Herms J, Bartenstein P, Brendel M, Eckenweber F. Validity and value of metabolic connectivity in mouse models of β-amyloid and tauopathy. Neuroimage. 2024 Jan 6;286:120513. doi: 10.1016/j.neuroimage.2024.120513. Epub ahead of print. PMID: 38191101.
Slemann L, Gnörich J, Hummel S, Bartos LM, Klaus C, Kling A, Kusche-Palenga J, Kunte ST, Kunze LH, Englert AL, Li Y, Vogler L, Katzdobler S, Palleis C, Bernhardt A, Jäck A, Zwergal A, Hopfner F, Roemer-Cassiano SN, Biechele G, Stöcklein S, Bischof G, van Eimeren T, Drzezga A, Sabri O, Barthel H, Respondek G, Grimmer T, Levin J, Herms J, Paeger L, Willroider M, Beyer L, Höglinger GU, Roeber S, Franzmeier N, Brendel M. Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies. Acta Neuropathol. 2024 Nov 24;148(1):70. doi: 10.1007/s00401-024-02834-7. PMID: 39580770; PMCID: PMC11586312.
Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, Brösamle D, Wendeln AC, Osei-Sarpong C, Heindl S, Liesz A, Stoecklein S, Biechele G, Finze A, Eckenweber F, Lindner S, Rominger A, Bartenstein P, Willem M, Tahirovic S, Herms J, Buerger K, Simons M, Haass C, Rupprecht R, Riemenschneider MJ, Albert NL, Beyer M, Neher JJ, Paeger L, Levin J, Höglinger GU, Perneczky R, Ziegler SI, Brendel M. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease. Mol Neurodegener. 2024 Sep 5;19(1):64. doi: 10.1186/s13024-024-00752-6. PMID: 39238030; PMCID: PMC11375924.

Albert NL, Nelwan DV, Fleischmann DF, Quach S, von Rohr K, Kaiser L, Teske N, Unterrainer LM, Bartos LM, Ruf VC, Brendel M, Riemenschneider MJ, Wetzel C, Herms J, Rupprecht R, Thon N, Tonn JC, Belka C, Bartenstein P, von Baumgarten L, Niyazi M, Unterrainer M, Holzgreve A (2023). Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH-Wild-Type Glioblastoma. J Nucl Med. 2023 Aug 3:jnumed.122.265247. doi: 10.2967/jnumed.122.265247. Epub ahead of print. PMID: 37536737.
Ballweg A, Klaus C, Vogler L, Katzdobler S, Wind K, Zatcepin A, Ziegler SI, Secgin B, Eckenweber F, Bohr B, Bernhardt A, Fietzek U, Rauchmann BS, Stoecklein S, Quach S, Beyer L, Scheifele M, Simmet M, Joseph E, Lindner S, Berg I, Koglin N, Mueller A, Stephens AW, Bartenstein P, Tonn JC, Albert NL, Kümpfel T, Kerschensteiner M, Perneczky R, Levin J, Paeger L, Herms J, Brendel M (2023). [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data. J Neuroinflammation. 2023 Mar 11;20(1):68. doi: 10.1186/s12974-023-02749-2. PMID: 36906584; PMCID: PMC10007845.
Bartos LM, Kirchleitner SV, Kolabas ZI, Quach S, Beck A, Lorenz J, Blobner J, Mueller SA, Ulukaya S, Hoeher L, Horvath I, Wind-Mark K, Holzgreve A, Ruf VC, Gold L, Kunze LH, Kunte ST, Beumers P, Park HE, Antons M, Zatcepin A, Briel N, Hoermann L, Schaefer R, Messerer D, Bartenstein P, Riemenschneider MJ, Lindner S, Ziegler S, Herms J, Lichtenthaler SF, Ertürk A, Tonn JC, von Baumgarten L, Albert NL, Brendel M (2023). Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution. Sci Adv. 2023 Oct 27;9(43):eadi8986. doi: 10.1126/sciadv.adi8986. Epub 2023 Oct 27. PMID: 37889970; PMCID: PMC10610915.
Gnörich J, Reifschneider A, Wind K, Zatcepin A, Kunte ST, Beumers P, Bartos LM, Wiedemann T, Grosch M, Xiang X, Fard MK, Ruch F, Werner G, Koehler M, Slemann L, Hummel S, Briel N, Blume T, Shi Y, Biechele G, Beyer L, Eckenweber F, Scheifele M, Bartenstein P, Albert NL, Herms J, Tahirovic S, Haass C, Capell A, Ziegler S, Brendel M (2023). Depletion and activation of microglia impact metabolic connectivity of the mouse brain. Neuroinflammation. 2023 Feb 24;20(1):47. doi: 10.1186/s12974-023-02735-8. PMID: 36829182; PMCID: PMC9951492.
Harrer P, Mirza-Schreiber N, Mandel V, Roeber S, Stefani A, Naher S, Wagner M, Gieger C, Waldenberger M, Peters A, Högl B, Herms J, Schormair B, Zhao C, Winkelmann J, Oexle K (2023). Epigenetic Association Analyses and Risk Prediction of RLS. Mov Disord. 2023 May 22. doi: 10.1002/mds.29440. Epub ahead of print. PMID: 37212434.
Koeglsperger T, Rumpf SL, Schließer P, Struebing FL, Brendel M, Levin J, Trenkwalder C, Höglinger GU, Herms J (2023). Neuropathology of incidental Lewy body & prodromal Parkinson's disease. Mol Neurodegener. 2023 May 12;18(1):32. doi: 10.1186/s13024-023-00622-7. PMID: 37173733; PMCID: PMC10182593.
Kunze LH, Ruch F, Biechele G, Eckenweber F, Wind-Mark K, Dinkel L, Feyen P, Bartenstein P, Ziegler S, Paeger L, Tahirovic S, Herms J, Brendel M (2023). Long-Term Pioglitazone Treatment Has No Significant Impact on Microglial Activation and Tau Pathology in P301S Mice. Int J Mol Sci. 2023 Jun 14;24(12):10106. doi: 10.3390/ijms241210106. PMID: 37373253; PMCID: PMC10298936.
Pratsch K, Unemura C, Ito M, Lichtenthaler SF, Horiguchi N, Herms J (2023). New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo. Int J Mol Sci. 2023 Jul 31;24(15):12283. doi: 10.3390/ijms241512283. PMID: 37569661; PMCID: PMC10418759.
Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, Farny D, Michaelsen M, Nuscher B, Schmidt MK, Flatley A, Schepers A, Gruijs da Silva LA, Zhou Q, Klopstock T, Liesz A, Arzberger T, Herms J, Feederle R, Gendron TF, Dormann D, Edbauer D (2023). Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. Acta Neuropathol Commun. 2023 Jul 11;11(1):112. doi: 10.1186/s40478-023-01592-z. PMID: 37434215; PMCID: PMC10334564.
Schließer P, Struebing FL, Northoff BH, Kurz A, Rémi J, Holdt L, Höglinger GU, Herms J, Koeglsperger T (2023). Detection of a Parkinson's Disease-Specific MicroRNA Signature in Nasal and Oral Swabs. Mov Disord. 2023 Jun 29. doi: 10.1002/mds.29515. Epub ahead of print. PMID: 37382573.
Tauber CV, Schwarz SC, Rösler TW, Arzberger T, Gentleman S, Windl O, Krumbiegel M, Reis A, Ruf VC, Herms J, Höglinger GU (2023). Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue. Acta Neuropathol Commun. 2023 Mar 11;11(1):40. doi: 10.1186/s40478-023-01534-9. PMID: 36906636; PMCID: PMC10008602.
Vogler L, Ballweg A, Bohr B, Briel N, Wind K, Antons M, Kunze LH, Gnörich J, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Boening G, Ziegler SI, Levin J, Zwergal A, Höglinger GU, Herms J, Brendel M (2023). Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [18F]UCB-H PET imaging. Neuroimage Clin. 2023 Jul 26;39:103484. doi: 10.1016/j.nicl.2023.103484. Epub ahead of print. PMID: 37541098.
Weidner L, Lorenz J, Quach S, Braun FK, Rothhammer-Hampl T, Ammer LM, Vollmann-Zwerenz A, Bartos LM, Dekorsy FJ, Holzgreve A, Kirchleitner SV, Thon N, Greve T, Ruf V, Herms J, Bader S, Milenkovic VM, von Baumgarten L, Menevse AN, Hussein A, Sax J, Wetzel CH, Rupprecht R, Proescholdt M, Schmidt NO, Beckhove P, Hau P, Tonn JC, Bartenstein P, Brendel M, Albert NL, Riemenschneider MJ (2023). Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages. Acta Neuropathol Commun. 2023 Sep 11;11(1):147. doi: 10.1186/s40478-023-01651-5. PMID: 37697350; PMCID: PMC10496331.

Blume T, Deussing M, Biechele G, Peters F, Zott B, Schmidt C, Franzmeier N, Wind K, Eckenweber F, Sacher C, Shi Y, Ochs K, Kleinberger G, Xiang X, Focke C, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Baumann K, Adelsberger H, Rominger A, Cumming P, Willem M, Dorostkar MM, Herms J, Brendel M (2022). Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition. Front Aging Neurosci. 2022 Mar 30;14:854031. doi: 10.3389/fnagi.2022.854031. PMID: 35431893; PMCID: PMC9007038.
Blume T, Filser S, Sgobio C, Peters F, Neumann U, Shimshek D, Saito T, Saido TC, Brendel M, Herms J (2022). β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice. Front Aging Neurosci. 2022 Jul 22;14:909586. doi: 10.3389/fnagi.2022.909586. PMID: 35936777; PMCID: PMC9354544.
Briel N, Ruf VC, Pratsch K, Roeber S, Widmann J, Mielke J, Dorostkar MM, Windl O, Arzberger T, Herms J, Struebing FL (2022). Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration. Acta Neuropathol. 2022 Aug 17. doi: 10.1007/s00401-022-02483-8. Epub ahead of print. PMID: 35976433.
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Rupprecht R, Wetzel CH, Dorostkar M, Herms J, Albert NL, Schwarzbach J, Schumacher M, Neumann ID (2022). Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders? Mol Psychiatry. 2022 Apr 20. doi: 10.1038/s41380-022-01561-3. Epub ahead of print. PMID: 35444254.
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Biechele G, Sebastian Monasor L, Wind K, Blume T, Parhizkar S, Arzberger T, Sacher C, Beyer L, Eckenweber F, Gildehaus FJ, von Ungern-Sternberg B, Willem M, Bartenstein P, Cumming P, Rominger A, Herms J, Lichtenthaler S, Haass C, Tahirovic S, Brendel M (2021). Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease. J Nucl Med. 2021 May 20:jnumed.120.261858. doi: 10.2967/jnumed.120.261858. Epub ahead of print. PMID: 34016733.
Biechele G, Blume T, Deussing M, Zott B, Shi Y, Xiang X, Franzmeier N, Kleinberger G, Peters F, Ochs K, Focke C, Sacher C, Wind K, Schmidt C, Lindner S, Gildehaus FJ, Eckenweber F, Beyer L, von Ungern-Sternberg B, Bartenstein P, Baumann K, Dorostkar MM, Rominger A, Cumming P, Willem M, Adelsberger H, Herms J, Brendel M (2021). Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation. Theranostics. 2021 Aug 19;11(18):8964-8976. doi: 10.7150/thno.64022. PMID: 34522221; PMCID: PMC8419052.
Blumenstock S, Sun F, Klaus C, Marinković P, Sgobio C, Paeger L, Liebscher S, Herms J (2021). Cortical circuit dysfunction in a mouse model of alpha-synucleinopathy in vivo. Brain Commun. 2021 Nov 15;3(4):fcab273. doi: 10.1093/braincomms/fcab273. PMID: 34877534; PMCID: PMC8643497.
Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A (2021). Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. Elife. 2021 Apr 13;10:e59826. doi: 10.7554/eLife.59826. PMID: 33845942.
Joshi P, Riffel F, Kumar S, Villacampa N, Theil S, Parhizkar S, Haass C, Colonna M, Heneka MT, Arzberger T, Herms J, Walter J (2021). TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits. Acta Neuropathol Commun. 2021 Oct 18;9(1):168. doi: 10.1186/s40478-021-01263-x. PMID: 34663480; PMCID: PMC8522217.
Korzhova V, Marinković P, Njavro JR, Goltstein PM, Sun F, Tahirovic S, Herms J, Liebscher S (2021). Long-term dynamics of aberrant neuronal activity in awake Alzheimer's disease transgenic mice. Commun Biol. 2021 Dec 7;4(1):1368. doi: 10.1038/s42003-021-02884-7. PMID: 34876653.
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Sun F, Salinas AG, Filser S, Blumenstock S, Medina-Luque J, Herms J, Sgobio C (2021). Impact of α-synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology. Brain Pathol. 2021 Nov 21:e13036. doi: 10.1111/bpa.13036. Epub ahead of print. PMID: 34806235.
Tang Q, Gao P, Arzberger T, Höllerhage M, Herms J, Höglinger G, Koeglsperger T (2021). Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion. Cell Death Dis. 2021 Sep 17;12(10):854. doi: 10.1038/s41419-021-04138-0. PMID: 34535638.
Vöglein J, Kostova I, Arzberger T, Röber S, Schmitz P, Simons M, Ruf V, Windl O, Herms J, Dieterich M, Danek A, Höglinger GU, Giese A, Levin J (2021). First symptom guides diagnosis and prognosis in neurodegenerative diseases - a retrospective study of autopsy proven cases. Eur J Neurol. 2021 Mar 4. doi: 10.1111/ene.14800. Epub ahead of print. PMID: 33662165.
Vöglein J, Kostova I, Arzberger T, Noachtar S, Dieterich M, Herms J, Schmitz P, Ruf V, Windl O, Roeber S, Simons M, Höglinger GU, Danek A, Giese A, Levin J (2021). Seizure prevalence in neurodegenerative diseases - a study of autopsy proven cases. Eur J Neurol. 2021 Sep 2. doi: 10.1111/ene.15089. Epub ahead of print. PMID: 34472165.PMC8161006.
Willroider M, Roeber S, Horn AKE, Arzberger T, Scheifele M, Respondek G, Sabri O, Barthel H, Patt M, Mishchenko O, Schildan A, Mueller A, Koglin N, Stephens A, Levin J, Höglinger GU, Bartenstein P, Herms J, Brendel M, Beyer L (2021). Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [ 18 F]PI-2620. Front Neurol. 2021 Jul 2;12:684523. doi: 10.3389/fneur.2021.684523. PMID: 34276540; PMCID: PMC8282895.
Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, Palleis C, Rauchmann BS, Gildehaus FJ, Lindner S, Spitz C, Franzmeier N, Baumann K, Rominger A, Bartenstein P, Ziegler S, Drzezga A, Respondek G, Buerger K, Perneczky R, Levin J, Höglinger GU, Herms J, Haass C, Brendel M (2021). Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases. Sci Transl Med. 2021 Oct 13;13(615):eabe5640. doi: 10.1126/scitranslmed.abe5640. Epub 2021 Oct 13. PMID: 34644146.

Beyer L, Nitschmann A, Barthel H, van Eimeren T, Unterrainer M, Sauerbeck J, Marek K, Song M, Palleis C, Respondek G, Hammes J, Barbe MT, Onur Ö, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens AW, Roeber S, Herms J, Bötzel K, Levin J, Classen J, Höglinger GU, Bartenstein P, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M (2020). Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. Eur J Nucl Med Mol Imaging. 2020 Apr 21. doi: 10.1007/s00259-020-04788-w. [Epub ahead of print]
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Biechele G, Wind K, Blume T, Sacher C, Beyer L, Eckenweber F, Franzmeier N, Ewers M, Zott B, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Tahirovic S, Willem M, Bartenstein P, Cumming P, Rominger A, Herms J, Brendel M (2020). Microglial Activation in the Right Amygdala-Entorhinal-Hippocampal Complex is Associated with Preserved Spatial Learning in AppNL-G-F mice. Neuroimage. 2020 Dec 29:117707. doi: 10.1016/j.neuroimage.2020.117707. Epub ahead of print. PMID: 33385560.
Brendel M, Barthel H, van Eimeren T, Marek K, Beyer L, Song M, Palleis C, Gehmeyr M, Fietzek U, Respondek G, Sauerbeck J, Nitschmann A, Zach C, Hammes J, Barbe MT, Onur O, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens A, Roeber S, Herms J, Bötzel K, Classen J, Bartenstein P, Villemagne V, Levin J, Höglinger GU, Drzezga A, Seibyl J, Sabri O (2020). Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy. JAMA Neurol. 2020 Nov 1;77(11):1408-1419. doi: 10.1001/jamaneurol.2020.2526.
Briel N, Pratsch K, Roeber S, Arzberger T, Herms J (2020). Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration. Brain Pathol. 2020 Oct 22:e12914. doi: 10.1111/bpa.12914. Epub ahead of print. PMID: 33089580.
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Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M, Brendel M, Haass C, Franzmeier N (2020). Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. EMBO Mol Med. 2020;e12308. doi:10.15252/emmm.202012308 [published online ahead of print, 2020 Aug 10]
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Sacher C, Blume T, Beyer L, Biechele G, Sauerbeck J, Eckenweber F, Deussing M, Focke C, Parhizkar S, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Baumann K, Tahirovic S, Kleinberger G, Willem M, Haass C, Bartenstein P, Cumming P, Rominger A, Herms J, Brendel M (2020). Asymmetry of fibrillar plaque burden in amyloid mouse models. J Nucl Med. 2020;jnumed.120.242750. doi:10.2967/jnumed.120.242750 [published online ahead of print, 2020 May 15].
Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, Lichtenthaler SF. Tahirovic S (2020). Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 2020;9:e54083. Published 2020 Jun 8. doi:10.7554/eLife.54083

Blumenstock S, Angelo MF, Peters F, Dorostkar MM, Ruf VC, Luckner M, Crux S, Slapakova L, Arzberger T, Claverol S, Herzog E, Herms J (2019). Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy. Acta Neuropathol. 2019 Aug 26. doi: 10.1007/s00401-019-02063-3. [Epub ahead of print]
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Delaidelli A, Jan A, Herms J, Sorensen PH. Translational control in brain pathologies: biological significance and therapeutic opportunities. Acta Neuropathol. 2019 Apr;137(4):535-555. doi: 10.1007/s00401-019-01971-8. Epub 2019 Feb 9. PMID: 30739199.
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Marinković P, Blumenstock S, Goltstein PM, Korzhova V, Peters F, Knebl A, Herms J (2019). In vivo imaging reveals reduced activity of neuronal circuits in a mouse tauopathy model. Brain. 2019 Mar 7. pii: awz035. doi: 10.1093/brain/awz035. [Epub ahead of print]
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Sacher C, Blume T, Beyer L, Peters F, Eckenweber F, Sgobio C, Deussing M, Albert NL, Unterrainer M, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Brzak I, Neumann U, Saito T, Saido TC, Bartenstein P, Rominger A, Herms J, Brendel M (2019). Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model. J Nucl Med. 2019 Jul 13. pii: jnumed.119.227322. doi: 10.2967/jnumed.119.227322. [Epub ahead of print]
Tan Y, Sgobio C, Arzberger T, Machleid F, Tang Q, Findeis E, Tost J, Chakroun T, Gao P, Höllerhage M, Bötzel K, Herms J, Höglinger G, Koeglsperger T (2019). Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease. Acta Neuropathol. 2019 Nov 25. doi: 10.1007/s00401-019-02099-5. [Epub ahead of print]
Yin C, Ackermann S, Ma Z, Mohanta SK, Zhang C, Li Y, Nietzsche S, Westermann M, Peng L, Hu D, Bontha SV, Srikakulapu P, Beer M, Megens RTA, Steffens S, Hildner M, Halder LD, Eckstein HH, Pelisek J, Herms J, Roeber S, Arzberger T, Borodovsky A, Habenicht L, Binder CJ, Weber C, Zipfel PF, Skerka C, Habenicht AJR (2019). ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat Med. 2019 Jan 28. doi: 10.1038/s41591-018-0336-8. [Epub ahead of print]

Albani A, Pérez-Rivas LG, Dimopoulou C, Zopp S, Colón-Bolea P, Roeber S, Honegger J, Flitsch J, Rachinger W, Buchfelder M, Stalla GK, Herms J, Reincke M, Theodoropoulou M (2018). The USP8 mutational status may predict long-term remission in patients with Cushing's disease. Clin Endocrinol (Oxf). 2018 Jun 29. doi: 10.1111/cen.13802. [Epub ahead of print]
Blume T, Filser S, Jaworska A, Blain JF, Koenig G, Moschke K, Lichtenthaler SF, Herms J (2018). BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines. Front Aging Neurosci. 2018 Jul 26;10:229. doi: 10.3389/fnagi.2018.00229. eCollection 2018.
Blume T, Focke C, Peters F, Deussing M, Albert NL, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Ozmen L, Baumann K, Barteinstein P, Rominger A, Herms J, Brendel M (2018). Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. J Neuroinflammation. 2018 Nov 6;15(1):307. doi: 10.1186/s12974-018-1347-6.
Brendel M, Yousefi BH, Blume T, Herz M, Focke C, Deussing M, Peters F, Lindner S, von Ungern-Sternberg B, Drzezga A, Bartenstein P, Haass C, Okamura N, Herms J, Yakushev I, Rominger A (2018). Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology. Front Aging Neurosci. 2018 Jun 7;10:174. doi: 10.3389/fnagi.2018.00174. eCollection 2018.
Brendel M, Jaworska A, Overhoff F, Blume T, Probst F, Gildehaus FJ, Bartenstein P, Haass C, Bohrmann B, Herms J, Willem M, Rominger A (2018). Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation. Theranostics. 2018 Sep 9;8(18):4957-4968. doi: 10.7150/thno.27868. eCollection 2018.
Crux S, Herms J, Dorostkar MM (2018). Tcf4 regulates dendritic spine density and morphology in the adult brain. PLoS One. 2018 Jun 22;13(6):e0199359. doi: 10.1371/journal.pone.0199359. eCollection 2018.
Deussing M, Blume T, Vomacka L, Mahler C, Focke C, Todica A, Unterrainer M, Albert NL, Lindner S, von Ungern-Sternberg B, Baumann K, Zwergal A, Bartenstein P, Herms J, Rominger A, Brendel M (2018). Data on specificity of [18F]GE180 uptake for TSPO expression in rodent brain and myocardium. Data Brief. 2018 May 5;19:331-336. doi: 10.1016/j.dib.2018.04.133. eCollection 2018 Aug.
Luckner M, Burgold S, Filser S, Scheungrab M, Niyaz Y, Hummel E, Wanner G, Herms J (2018). Label-free 3D-CLEM Using Endogenous Tissue Landmarks. iScience. 2018 Aug 31;6:92-101. doi: 10.1016/j.isci.2018.07.012. Epub 2018 Jul 20.
Peters F, Salihoglu H, Rodrigues E, Herzog E, Blume T, Filser S, Dorostkar M, Shimshek DR, Brose N, Neumann U, Herms J (2018). BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology. Acta Neuropathol. 2018 Jan 11. doi: 10.1007/s00401-017-1804-9. [Epub ahead of print]
Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C (2018). The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Mol Neurodegener. 2018 Sep 6;13(1):49. doi: 10.1186/s13024-018-0280-6.
Zhu K, Peters F, Filser S, Herms J (2018). Consequences of Pharmacological BACE Inhibition on Synaptic Structure and Function. Biol Psychiatry. 2018 Jun 23. pii: S0006-3223(18)31515-4. doi: 10.1016/j.biopsych.2018.04.022. [Epub ahead of print]

Ahlfeld J, Filser S, Schmidt F, Wefers AK, Merk DJ, Glaß R, Herms J, Schüller U (2017). Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex. Sci Rep. 2017 Jul 21;7(1):6137. doi: 10.1038/s41598-017-06150-x.
Blazquez-Llorca L, Valero-Freitag S, Rodrigues EF, Merchán-Pérez Á, Rodríguez JR, Dorostkar MM, DeFelipe J, Herms J (2017). High plasticity of axonal pathology in Alzheimer's disease mouse models. Acta Neuropathol Commun. 2017 Feb 7;5(1):14. doi: 10.1186/s40478-017-0415-y.
Blumenstock S, Rodrigues EF, Peters F, Blazquez-Llorca L, Schmidt F, Giese A, Herms J (2017). Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex. EMBO Mol Med. 2017 Mar 28. pii: e201607305. doi: 10.15252/emmm.201607305. [Epub ahead of print]
Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, Haass C, Herms J, Rominger A (2017). Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Front Neuroanat. 2017 Jan 20;10:127. doi: 10.3389/fnana.2016.00127. eCollection 2016.
Brendel M, Focke C, Blume T, Peters F, Deussing M, Probst F, Jaworska A, Overhoff F, Albert N, Lindner S, von Ungern-Sternberg B, Bartenstein P, Haass C, Kleinberger G, Herms J, Rominger A (2017). Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life-Span of Wild-Type Mice: A PET Study. J Nucl Med. 2017 Jul 13. pii: jnumed.117.195107. doi: 10.2967/jnumed.117.195107. [Epub ahead of print]
Deussing M, Blume T, Vomacka L, Mahler C, Focke C, Todica A, Unterrainer M, Albert NL, Lindner S, von Ungern-Sternberg B, Baumann K, Zwergal A, Bartenstein P, Herms J, Rominger A, Brendel M (2017). Coupling between physiological TSPO expression in brain and myocardium allows stabilization of late-phase cerebral [18F]GE180 PET quantification. Neuroimage. 2017 Oct 5;165:83-91. doi: 10.1016/j.neuroimage.2017.10.006. [Epub ahead of print]
Herms J, Schön C (2017). In vivo imaging of retinal neurodegeneration at the single cell level in humans. Brain. 2017 Jun 1;140(6):1542-1543. doi: 10.1093/brain/awx100.
Montagna E, Dorostkar MM, Herms J (2017). The Role of APP in Structural Spine Plasticity. Front Mol Neurosci. 2017 May 10;10:136. doi: 10.3389/fnmol.2017.00136. eCollection 2017.

Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A (2016). microPET imaging of tau pathology with [18F]-THK5117 in two transgenic mouse models. J Nucl Med. 2016 Feb 11. pii: jnumed.115.163493. [Epub ahead of print]
Brendel M, Probst F, Jaworska A, Overhoff F, Korzhova V, Albert N, Beck R, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Kleinberger G, Haass C, Herms J, Rominger A (2016). Glial activation and glucose metabolism in a transgenic amyloid mouse model: a triple tracer PET study. J Nucl Med. 2016 Feb 18. pii: jnumed.115.167858. [Epub ahead of print]
Herms J, Dorostkar MM (2016). Dendritic spine pathology in neurodegenerative diseases. Annu Rev Pathol. 2016 Feb 22. [Epub ahead of print]
Overhoff F, Brendel M, Jaworska A, Korzhova V, Delker A, Probst F, Focke C, Gildehaus FJ, Carlsen J, Baumann K, Haass C, Bartenstein P, Herms J, Rominger A (2016). Automated spatial brain normalization and hindbrain white matter reference tissue give improved [(18)F]-florbetaben PET quantitation in Alzheimer's model mice. Front Neurosci. 2016 Feb 29;10:45. doi: 10.3389/fnins.2016.00045. eCollection 2016.
Ovsepian SV, Blazquez-Llorca L, Freitag SV, Rodrigues EF, Herms J (2016). Ambient Glutamate Promotes Paroxysmal Hyperactivity in Cortical Pyramidal Neurons at Amyloid Plaques via Presynaptic mGluR1 Receptors. Cereb Cortex. 2016 Sep 6. [Epub ahead of print]
Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S (2016). Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Hum Mol Genet. 2016 Jan 5. pii: ddv639. [Epub ahead of print]
Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J (2016). Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biol Psychiatry. 2016 Dec 26. pii: S0006-3223(16)33157-2. doi: 10.1016/j.biopsych.2016.12.023. [Epub ahead of print]
Zou C, Shi Y, Ohli J, Schüller U, Dorostkar MM, Herms J (2016). Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer's disease. Acta Neuropathol. 2016 Jan 2. [Epub ahead of print]
Zou C, Crux S, Marinesco S, Montagna E, Sgobio C, Shi Y, Shi S, Zhu K, Dorostkar MM, Müller UC, Herms J. (2016). Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D-serine homeostasis. EMBO J. 2016 Aug 29. pii: e201694085. [Epub ahead of print]

Blazquez-Llorca L, Hummel E, Zimmerman H, Zou C, Burgold S, Rietdorf J, Herms J (2015). Correlation of two-photon in vivo imaging and FIB/SEM microscopy. J Microsc. 2015 Mar 18. doi: 10.1111/jmi.12231. [Epub ahead of print]
Brendel M, Jaworska A, Grießinger E, Rötzer C, Burgold S, Gildehaus FJ, Carlsen J, Cumming P, Baumann K, Haass C, Steiner H, Bartenstein P, Herms J, Rominger A (2015). Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models. PLoS One. 2015 Feb 23;10(2):e0116678. doi: 10.1371/journal.pone.0116678. eCollection 2015
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A (2015). Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment. Mol Psychiatry. 2015 Jun 9. doi: 10.1038/mp.2015.74. [Epub ahead of print]
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A (2015). Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET. Mol Psychiatry. 2015 Oct;20(10):1141. doi: 10.1038/mp.2015.146.
Dorostkar MM, Zou C, Blazquez-Llorca L, Herms J (2015). Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities. Acta Neuropathol. 2015 Jul;130(1):1-19. doi: 10.1007/s00401-015-1449-5. Epub 2015 Jun 11.
Jung CK, Keppler K, Steinbach S, Blazquez-Llorca L, Herms J (2015). Fibrillar amyloid plaque formation precedes microglial activation. PLoS One. 2015 Mar 23;10(3):e0119768. doi: 10.1371/journal.pone.0119768. eCollection 2015.
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C (2015). η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. 2015 Aug 31. doi: 10.1038/nature14864. [Epub ahead of print]
Zou C, Montagna E, Shi Y, Peters F, Blazquez-Llorca L, Shi S, Filser S, Dorostkar MM, Herms J (2015). Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease. Acta Neuropathol. 2015 Apr 11. [Epub ahead of print]

Burgold S, Filser S, Dorostkar MM, Schmidt B, Herms J (2014). In vivo imaging reveals sigmoidal growth kinetic of beta-amyloid plaques. Acta Neuropathol Commun. 2014 Mar 28;2(1):30. [Epub ahead of print]
Dorostkar MM, Burgold S, Filser S, Barghorn S, Schmidt B, Anumala UR, Hillen H, Herms J (2014). Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model. Brain. 2014 Oct 3. pii: awu280. [Epub ahead of print]
Filser S, Ovsepian SV, Masana M, Blazquez-Llorca L, Brandt Elvang A, Volbracht C, Müller MB, Jung CK, Herms J (2014). Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions. Biol Psychiatry. 2014 Oct 29. pii: S0006-3223(14)00793-8. doi: 10.1016/j.biopsych.2014.10.013. [Epub ahead of print]
Honarnejad K, Daschner A, Gehring AP, Szybinska A, Giese A, Kuznicki J, Bracher F, Herms J (2014). Identification of tetrahydrocarbazoles as novel multifactorial drug candidates for treatment of Alzheimer's disease. Transl Psychiatry. 2014 Dec 16;4:e489. doi: 10.1038/tp.2014.132.
Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T (2014). An assay to image neuronal microtubule dynamics in mice. Nat Commun. 2014 Sep 12;5:4827. doi: 10.1038/ncomms5827
Neuner J, Ovsepian SV, Dorostkar M, Filser S, Gupta A, Michalakis S, Biel M, Herms J (2014). Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Nat Commun. 2014 May 28;5:3915. doi: 10.1038/ncomms4915.
Neuner J, Filser S, Michalakis S, Biel M, Herms J (2014). A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network. Sci Rep. 2014 Feb 3;4:3931. doi: 10.1038/srep03931
Ochs SM, Dorostkar MM, Aramuni G, Schön C, Filser S, Pöschl J, Kremer A, Van Leuven F, Ovsepian SV, Herms J (2014). Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin. Mol Psychiatry. 2014 Jun 10. doi: 10.1038/mp.2014.55. [Epub ahead of print]

Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A (2013). Impact of Partial Volume Effect Correction on Cerebral β-Amyloid Imaging in APP-Swe Mice using [18F]-Florbetaben PET. Neuroimage. 2013 Sep 19. pii: S1053-8119(13)00953-1. doi: 10.1016/j.neuroimage.2013.09.017. [Epub ahead of print]
Hoffmann NA, Dorostkar MM, Blumenstock S, Goedert M, Herms J (2013). Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice. Acta Neuropathol Commun. 2013 Dec 17;1(1):82. doi: 10.1186/2051-5960-1-82.
Honarnejad K, Kirsch AK, Daschner A, Szybinska A, Kuznicki J, Herms J (2013). FRET-Based Calcium Imaging: A Tool for High-Throughput/Content Phenotypic Drug Screening in Alzheimer Disease. J Biomol Screen. 2013 Dec;18(10):1309-20. doi: 10.1177/1087057113502672
Honarnejad K, Daschner A, Giese A, Zall A, Schmidt B, Szybinska A, Kuznicki J, Herms J (2013). Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease. PLoS One. 2013 Nov 15;8(11):e80645. doi: 10.1371/journal.pone.0080645
Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, Herms J (2013). Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease. J Cell Mol Med. (2013) Feb 5. doi: 10.1111/jcmm.12008. [Epub ahead of print]
Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C (2013). hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathol (2013) Feb 5. [Epub ahead of print]
Ovsepian SV, Herms J (2013). Drain of the brain: low-affinity p75 neurotrophin receptor affords a molecular sink for clearance of cortical amyloid β by the cholinergic modulator system. Neurobiol Aging. 2013 Jun 5. pii: S0197-4580(13)00203-0. doi: 10.1016/j.neurobiolaging.2013.05.005. [Epub ahead of print]
Ovsepian SV, Antyborzec I, O'Leary VB, Zaborszky L, Herms J, Oliver Dolly J (2013). Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons. Brain Struct Funct. 2013 May 29. [Epub ahead of print]
Ovsepian SV, Herms J (2013). Cholinergic neurons-keeping check on amyloid β in the cerebral cortex. Front Cell Neurosci. 2013 Dec 11;7:252. doi: 10.3389/fncel.2013.00252.
Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtiger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, Haass C, Bartenstein P (2013). Longitudinal Assessment of Cerebral β-Amyloid Deposition in Mice Overexpressing Swedish Mutant β-Amyloid Precursor Protein Using 18F-Florbetaben PET. J Nucl Med. 2013 May 31. [Epub ahead of print]

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