Publications Alumni
Bernhagen, Jürgen
- Zhang L, Antabi MA, Mattar J, El Bounkari O, Fang R, Waegemann K, Bode FJ, Stösser S, Hermann P, Liman TG, Nolte CH, Ikenberg B, Bernkopf K, Petzold GC, Bernhagen J, Dichgans M, Georgakis MK; DEMDAS Investigators. Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study. Eur Stroke J. 2026 Jan 1;11(1):23969873251360145. doi: 10.1093/esj/23969873251360145. PMID: 41614521.
- Asare Y, Yan G, Schlegl C, Prestel M, van der Vorst EPC, Teunissen AJP, Aronova A, Tosato F, Naser N, Caputo J, Prevot G, Azzun A, Wefers B, Wurst W, Schneider M, Forne I, Bidzhekov K, Naumann R, van der Laan SW, Brandhofer M, Cao J, Roth S, Malik R, Tiedt S, Mulder WJM, Imhof A, Liesz A, Weber C, Bernhagen J, Dichgans M. A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis. Immunity. 2025 Jan 22:S1074-7613(25)00026-3. doi: 10.1016/j.immuni.2025.01.003. Epub ahead of print. PMID: 39879983.
El Bounkari O, Zan C, Yang B, Ebert S, Wagner J, Bugar E, Kramer N, Bourilhon P, Kontos C, Zarwel M, Sinitski D, Milic J, Jansen Y, Kempf WE, Sachs N, Maegdefessel L, Ji H, Gokce O, Riols F, Haid M, Gerra S, Hoffmann A, Brandhofer M, Avdic M, Bucala R, Megens RTA, Willemsen N, Messerer D, Schulz C, Bartelt A, Harm T, Rath D, Döring Y, Gawaz M, Weber C, Kapurniotu A, Bernhagen J. An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis. Nat Commun. 2025 Mar 7;16(1):2297. doi: 10.1038/s41467-025-57540-z. PMID: 40055309; PMCID: PMC11889166.
- Georgakis MK, Malik R, Bounkari OE, Hasbani NR, Li J, Huffman JE, Shakt G, Tack RWP, Kimball TN, Asare Y, Morrison AC, Tsao NL, Judy R, Mitchell BD, Xu H, Montasser ME, Do R, Kenny EE, Loos RJF, Terry JG, Carr JJ, Bis JC, Psaty BM, Longstreth WT, Young KA, Lutz SM, Cho MH, Broome J, Khan AT, Wang FF, Heard-Costa N, Seshadri S, Vasan RS, Palmer ND, Freedman BI, Bowden DW, Yanek LR, Kral BG, Becker LC, Peyser PA, Bielak LF, Ammous F, Carson AP, Hall ME, Raffield LM, Rich SS, Post WS, Tracy RP, Taylor KD, Guo X, Mahaney MC, Curran JE, Blangero J, Clarke SL, Haessler JW, Hu Y, Assimes TL, Kooperberg C, Bernhagen J, Anderson CD, Damrauer SM, Zand R, Rotter JI, de Vries PS, Dichgans M. Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk. Genome Med. 2025 Mar 21;17(1):27. doi: 10.1186/s13073-025-01456-2. PMID: 40119478; PMCID: PMC11929344.
- Hornung S, Vogl DP, Naltsas D, Dalla Volta B, Ballmann M, Marcon B, Syed MMK, Wu Y, Spanopoulou A, Feederle R, Heidrich L, Bernhagen J, Koeglsperger T, Höglinger GU, Rammes G, Lashuel HA, Kapurniotu A. Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein. Angew Chem Int Ed Engl. 2025 Jan 17:e202422834. doi: 10.1002/anie.202422834. Epub ahead of print. PMID: 39822034.
- Konieczny MJ, Omarov M, Zhang L, Malik R, Richardson TG, Baumeister SE, Bernhagen J, Dichgans M, Georgakis MK. The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases. Commun Biol. 2025 Jan 10;8(1):34. doi: 10.1038/s42003-025-07453-w. PMID: 39794498; PMCID: PMC11724035.
- Li Y, Leberzammer J, Blanchet X, Duan R, Lacy M, Triantafyllidou V, Eckardt V, Briem E, Jung AS, Su R, Guerra J, Jansen Y, Hristov M, Enard W, Bernhagen J, Weber C, Atzler D, Bartelt A, Döring Y, Santovito D, Kaltner H, Ludwig AK, von Hundelshausen P. Galectin-1 induces macrophage immunometabolic reprogramming, modulates T cell immunity and attenuates atherosclerotic plaque formation. Atherosclerosis. 2025 Dec 4;413:120608. doi: 10.1016/j.atherosclerosis.2025.120608. Epub ahead of print. PMID: 41391258.
- Seidel F, Morrison MC, Arnoldussen I, Verweij V, Ebert S, Attema J, de Ruiter C, van Duyvenvoorde W, Snabel J, Geenen B, Franco A, Gart E, Bernhagen J, Wiesmann M, Kleemann R, Kiliaan AJ. Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice impacts adipokine secretion, plasma free fatty acids, and improves cerebrovascular health. PLoS One. 2025 Oct 17;20(10):e0333024. doi: 10.1371/journal.pone.0333024. PMID: 41105609; PMCID: PMC12533877.
- Spiller L, Zhang L, Gerra S, Stoppe C, Scheiermann P, Calandra T, Lolis E, Panstruga R, Bernhagen J, Hoffmann A. In vivo synergistic enhancement of MIF-mediated inflammation in acute lung injury by the plant ortholog Arabidopsis MDL1. FASEB J. 2025 Mar 31;39(6):e70489. doi: 10.1096/fj.202403301R. PMID: 40134325; PMCID: PMC11937861.
- Crespo-Avilan GE, Hernandez-Resendiz S, Ramachandra CJ, Ungureanu V, Lin YH, Lu S, Bernhagen J, El Bounkari O, Preissner KT, Liehn EA, Hausenloy DJ. Metabolic reprogramming of immune cells by mitochondrial division inhibitor-1 to prevent post-vascular injury neointimal hyperplasia. Atherosclerosis. 2024 Jan 14;390:117450. doi: 10.1016/j.atherosclerosis.2024.117450. Epub ahead of print. PMID: 38266625.
- Immler R, Nussbaumer K, Doerner A, El Bounkari O, Huber S, Abisch J, Napoli M, Schmidt S, Margraf A, Pruenster M, Rohwedder I, Lange-Sperandio B, Mall MA, de Jong R, Ohnmacht C, Bernhagen J, Voehringer D, Marth JD, Frommhold D, Sperandio M. CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2319057121. doi: 10.1073/pnas.2319057121. Epub 2024 Apr 30. PMID: 38687790.
- Windisch R, Soliman S, Hoffmann A, Chen-Wichmann L, Danese A, Vosberg S, Bravo J, Lutz S, Kellner C, Fischer A, Gebhard C, Redondo Monte E, Hartmann L, Schneider S, Beier F, Strobl CD, Weigert O, Peipp M, Schündeln M, Stricker SH, Rehli M, Bernhagen J, Humpe A, Klump H, Brendel C, Krause DS, Greif PA, Wichmann C. Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2312499121. doi: 10.1073/pnas.2312499121. Epub 2024 Jun 10. PMID: 38857395.
- Asare Y, Stoppe C, Bernhagen J (2023). Tracing the failing heart: dual genetic fate mapping for target identification. Signal Transduct Target Ther. 2023 Aug 4;8(1):287. doi: 10.1038/s41392-023-01564-8. PMID: 37537182; PMCID: PMC10400625.
- Breidung D, Megas IF, Freytag DL, Bernhagen J, Grieb G. The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective. Biomedicines. 2023 Dec 19;12(1):2. doi: 10.3390/biomedicines12010002. PMID: 38275363; PMCID: PMC10813530.
- Ebert S, Zang L, Ismail N, Otabil M, Fröhlich A, Egea V, Ács S, Hoeberg M, Berres ML, Weber C, Moreira JMA, Ries C, Bernhagen J, El Bounkari O (2023). Tissue Inhibitor of Metalloproteinases-1 Interacts with CD74 to Promote AKT Signaling, Monocyte Recruitment Responses, and Vascular Smooth Muscle Cell Proliferation. Cells. 2023 Jul 20;12(14):1899. doi: 10.3390/cells12141899. PMID: 37508563; PMCID: PMC10378328.
- Krammer C, Yang B, Reichl S, Besson-Girard S, Ji H, Bolini V, Schulte C, Noels H, Schlepckow K, Jocher G, Werner G, Willem M, El Bounkari O, Kapurniotu A, Gokce O, Weber C, Mohanta S, Bernhagen J (2023). Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice. FASEB J. 2023 Mar;37(3):e22752. doi: 10.1096/fj.202200056R. PMID: 36794636.
- Prapiadou S, Živković L, Thorand B, George MJ, van der Laan SW, Malik R, Herder C, Koenig W, Ueland T, Kleveland O, Aukrust P, Gullestad L, Bernhagen J, Pasterkamp G, Peters A, Hingorani AD, Rosand J, Dichgans M, Anderson CD, Georgakis MK (2023). Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis. Circulation. 2023 Dec 28. doi: 10.1161/CIRCULATIONAHA.123.064974. Epub ahead of print. PMID: 38152968.
- Spiller L, Manjula R, Leissing F, Basquin J, Bourilhon P, Sinitski D, Brandhofer M, Levecque S, Gerra S, Sabelleck B, Zhang L, Feederle R, Flatley A, Hoffmann A, Panstruga R, Bernhagen J, Lolis E (2023). Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells. Sci Signal. 2023 Nov 21;16(812):eadg2621. doi: 10.1126/scisignal.adg2621. Epub 2023 Nov 21. PMID: 37988455.
- Tian Y, Milic J, Monasor LS, Chakraborty R, Wang S, Yuan Y, Asare Y, Behrends C, Tahirovic S, Bernhagen J (2023). The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model. Cell Mol Life Sci. 2023 Aug 19;80(9):262. doi: 10.1007/s00018-023-04911-8. PMID: 37597109; PMCID: PMC10439869.
- Vasella M, Wolf S, Francis EC, Grieb G, Pfister P, Reid G, Bernhagen J, Lindenblatt N, Gousopoulos E, Kim BS (2023). Involvement of the Macrophage Migration Inhibitory Factor (MIF) in Lipedema. Metabolites. 2023 Oct 23;13(10):1105. doi: 10.3390/metabo13101105. PMID: 37887430; PMCID: PMC10608777.
- Asare Y, Shnipova M, Živković L, Schlegl C, Tosato F, Aronova A, Brandhofer M, Strohm L, Beaufort N, Malik R, Weber C, Bernhagen J, Dichgans M (2022). IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses. Signal Transduct Target Ther. 2022 Oct 19;7(1):355. doi: 10.1038/s41392-022-01189-3. PMID: 36257930; PMCID: PMC9579124.
- Brandhofer M, Hoffmann A, Blanchet X, Siminkovitch E, Rohlfing AK, El Bounkari O, Nestele JA, Bild A, Kontos C, Hille K, Rohde V, Fröhlich A, Golemi J, Gokce O, Krammer C, Scheiermann P, Tsilimparis N, Sachs N, Kempf WE, Maegdefessel L, Otabil MK, Megens RTA, Ippel H, Koenen RR, Luo J, Engelmann B, Mayo KH, Gawaz M, Kapurniotu A, Weber C, von Hundelshausen P, Bernhagen J (2022). Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation. Cell Mol Life Sci. 2022 Sep 12;79(10):512. doi: 10.1007/s00018-022-04539-0. PMID: 36094626; PMCID: PMC9468113.
- Brandhofer M, Bernhagen J (2022). Cytokine aerobics: Oxidation controls cytokine dynamics and function. Structure. 2022 Jun 2;30(6):787-790. doi: 10.1016/j.str.2022.05.005. PMID: 35660241
- Georgakis MK, Bernhagen J, Heitman LH, Weber C, Dichgans M (2022). Targeting the CCL2-CCR2 axis for atheroprotection. Eur Heart J. 2022 Mar 7:ehac094. doi: 10.1093/eurheartj/ehac094. Epub ahead of print. PMID: 35253053.
- Kapurniotu A, Bernhagen J (2022). Lasso-grafted designer cytokines. Nat Biomed Eng. 2022 Nov 24. doi: 10.1038/s41551-022-00974-3. Epub ahead of print. PMID: 36424466.
- Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, Förstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ertürk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D'Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR (2022). Neuroimmune cardiovascular interfaces control atherosclerosis. Nature. 2022 May;605(7908):152-159. doi: 10.1038/s41586-022-04673-6. Epub 2022 Apr 27. PMID: 35477759.
- Taş K, Volta BD, Lindner C, El Bounkari O, Hille K, Tian Y, Puig-Bosch X, Ballmann M, Hornung S, Ortner M, Prem S, Meier L, Rammes G, Haslbeck M, Weber C, Megens RTA, Bernhagen J, Kapurniotu A (2022). Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly. Nat Commun. 2022 Aug 25;13(1):5004. doi: 10.1038/s41467-022-32688-0. PMID: 36008417; PMCID: PMC9411207.
- Thavayogarajah T, Sinitski D, Bounkari OE, Torres-Garcia L, Lewinsky H, Harjung A, Chen HR, Panse J, Vankann L, Shachar I, Bernhagen J, Koschmieder S (2022). CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia. Exp Hematol. 2022 Sep 9:S0301-472X(22)00681-6. doi: 10.1016/j.exphem.2022.08.005. Epub ahead of print. PMID: 36096455.
- Zan C, Yang B, Brandhofer M, El Bounkari O, Bernhagen J (2022). D-dopachrome tautomerase in cardiovascular and inflammatory diseases-A new kid on the block or just another MIF? FASEB J. 2022 Nov;36(11):e22601. doi: 10.1096/fj.202201213R. PMID: 36269019.
- Živković L, Asare Y, Bernhagen J, Dichgans M, Georgakis MK (2022). Pharmacological Targeting of the CCL2/CCR2 Axis for Atheroprotection: A Meta-Analysis of Preclinical Studies. Arterioscler Thromb Vasc Biol. 2022 Apr 7:101161ATVBAHA122317492. doi: 10.1161/ATVBAHA.122.317492. Epub ahead of print. PMID: 35387476.
- Bernhagen J (2021). A new cytokine target for chronic obstructive pulmonary disease?. EBioMedicine. 2021 Jul 9;69:103479. doi: 10.1016/j.ebiom.2021.103479. Epub ahead of print. PMID: 34252695.
- Bleilevens C, Soppert J, Hoffmann A, Breuer T, Bernhagen J, Martin L, Stiehler L, Marx G, Dreher M, Stoppe C, Simon TP (2021). Macrophage Migration Inhibitory Factor (MIF) Plasma Concentration in Critically Ill COVID-19 Patients: A Prospective Observational Study. Diagnostics (Basel). 2021 Feb 17;11(2):332. doi: 10.3390/diagnostics11020332. PMID: 33671433; PMCID: PMC7922575.
- Dobersch S, Rubio K, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Günther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D, Barreto G (2021). Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation. Nat Commun. 2021 Feb 16;12(1):1072. doi: 10.1038/s41467-021-21227-y. PMID: 33594057.
- Gruner K, Leissing F, Sinitski D, Thieron H, Axstmann C, Baumgarten K, Reinstädler A, Winkler P, Altmann M, Flatley A, Jaouannet M, Zienkiewicz K, Feussner I, Keller H, Coustau C, Falter-Braun P, Feederle R, Bernhagen J, Panstruga R (2021). Chemokine-like MDL proteins modulate flowering time and innate immunity in plants. J Biol Chem. 2021 Mar 30:100611. doi: 10.1016/j.jbc.2021.100611. Epub ahead of print. PMID: 33798552.
- Heinrichs D, Brandt EF, Fischer P, Köhncke J, Wirtz TH, Guldiken N, Djudjaj S, Boor P, Kroy D, Weiskirchen R, Bucala R, Wasmuth HE, Strnad P, Trautwein C, Bernhagen J, Berres ML (2021). Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations. Cells. 2021 Jan 28;10(2):252. doi: 10.3390/cells10020252. PMID: 33525493.
- Hofmann E, Soppert J, Ruhl T, Gousopoulos E, Gerra S, Storti G, Tian Y, Brandhofer M, Schweizer R, Song SY, Lindenblatt N, Pallua N, Bernhagen J, Kim BS (2021). The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia. Front Physiol. 2021 Jul 21;12:638448. doi: 10.3389/fphys.2021.638448. PMID: 34366876; PMCID: PMC8334873.
- Ives A, Le Roy D, Théroude C, Bernhagen J, Roger T, Calandra T (2021). Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway. FASEB J. 2021 May;35(5):e21418. doi: 10.1096/fj.202001605R. PMID: 33774873.
- Megas IF, Simons D, Kim BS, Stoppe C, Piatkowski A, Fikatas P, Fuchs PC, Bastiaanse J, Pallua N, Bernhagen J, Grieb G (2021). Macrophage Migration Inhibitory Factor-An Innovative Indicator for Free Flap Ischemia after Microsurgical Reconstruction. Healthcare (Basel). 2021 May 21;9(6):616. doi: 10.3390/healthcare9060616. PMID: 34063809.
- Schindler L, Zwissler L, Krammer C, Hendgen-Cotta U, Rassaf T, Hampton MB, Dickerhof N, Bernhagen J (2021). Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. J Leukoc Biol. 2021 Feb 10. doi: 10.1002/JLB.3A0420-242RRR. Epub ahead of print. PMID: 33565160.
- Schindler L, Smyth LCD, Bernhagen J, Hampton MB, Dickerhof N (2021). Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils. Redox Biol. 2021 Mar 30;41:101946. doi: 10.1016/j.redox.2021.101946. Epub ahead of print. PMID: 33823474.
- Stowe AM, Bernhagen J (2021). Role of the immune system for conditioning in cerebrovascular diseases. Cond Med. 2021 Feb;4(1):1-2. PMID: 34095776; PMCID: PMC8177088.
- Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R (2021). MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model. J Clin Invest. 2021 Dec 1;131(23):e127171. doi: 10.1172/JCI127171. PMID: 34850744; PMCID: PMC8631602.
- Wirtz TH, Saal A, Bergmann I, Fischer P, Heinrichs D, Brandt EF, Koenen MT, Djudjaj S, Schneider KM, Boor P, Bucala R, Weiskirchen R, Bernhagen J, Trautwein C, Berres ML (2021). Macrophage migration inhibitory factor exerts pro-proliferative and anti-apoptotic effects via CD74 in murine hepatocellular carcinoma. Br J Pharmacol. 2021 Jul 11. doi: 10.1111/bph.15622. Epub ahead of print. PMID: 34250589.
- Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M (2020). Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability. Circ Res. 2020;10.1161/CIRCRESAHA.120.316743. doi:10.1161/CIRCRESAHA.120.316743 [published online ahead of print, 2020 Jun 17].
- Asare Y, Koehncke J, Selle J, Simsekyilmaz S, Jankowski J, Shagdarsuren G, Gessner JE, Bernhagen J, Shagdarsuren E (2020). Differential Role for Activating FcγRIII in Neointima Formation After Arterial Injury and Diet-Induced Chronic Atherosclerosis in Apolipoprotein E-Deficient Mice. Front Physiol. 2020;11:673. Published 2020 Jun 17. doi:10.3389/fphys.2020.00673
- Averdunk L, Bernhagen J, Fehnle K, Surowy H, Lüdecke HJ, Mucha S, Meybohm P, Wieczorek D, Leng L, Marx G, Leaf DE, Zarbock A, Zacharowski K, On Behalf Of The RIPHeart Study Collaborators, Bucala R, Stoppe C (2020). The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery. J Clin Med. 2020 Sep 11;9(9):E2936. doi: 10.3390/jcm9092936. PMID: 32932965.
- Hoffmann A, Zwißler LC, El Bounkari O, Bernhagen J (2020). Studying the Pro-Migratory Effects of MIF. Methods Mol Biol. 2020;2080:1-18. doi: 10.1007/978-1-4939-9936-1_1
- Hoffmann A, Bernhagen J (2020). Revisiting the secretion mechanism(s) of macrophage migration inhibitory factor-welcome to the "UPS club". Immunol Cell Biol. 2020;10.1111/imcb.12388. doi:10.1111/imcb.12388 [published online ahead of print, 2020 Sep 7]
- Kim BS, Breuer B, Arnke K, Ruhl T, Hofer T, Simons D, Knobe M, Ganse B, Guidi M, Beier JP, Fuchs PC, Pallua N, Bernhagen J, Grieb G (2020). The effect of the macrophage migration inhibitory factor (MIF) on excisional wound healing in vivo. J Plast Surg Hand Surg. 2020 Apr 11:1-8. doi: 10.1080/2000656X.2019.1710710. [Epub ahead of print]
- Kim BS, Tilstam PV, Arnke K, Leng L, Ruhl T, Piecychna M, Schulte W, Sauler M, Frueh FS, Storti G, Lindenblatt N, Giovanoli P, Pallua N, Bernhagen J, Bucala R (2020). Differential regulation of macrophage activation by the MIF cytokine superfamily members MIF and MIF-2 in adipose tissue during endotoxemia. FASEB J. 2020 Jan 21. doi: 10.1096/fj.201901511R. [Epub ahead of print]
- Kontos C, El Bounkari O, Krammer C, Sinitski D, Hille K, Zan C, Yan G, Wang S, Gao Y, Brandhofer M, Megens RTA, Hoffmann A, Pauli J, Asare Y, Gerra S, Bourilhon P, Leng L, Eckstein HH, Kempf WE, Pelisek J, Gokce O, Maegdefessel L, Bucala R, Dichgans M, Weber C, Kapurniotu A, Bernhagen J (2020). Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting. Nat Commun. 2020 Nov 25;11(1):5981. doi: 10.1038/s41467-020-19764-z. PMID: 33239628.
- Krammer C, Kontos C, Dewor M, Hille K, Dalla Volta B, El Bounkari O, Taş K, Sinitski D, Brandhofer M, Megens RTA, Weber C, Schultz JR, Bernhagen J, Kapurniotu A (2020). A MIF-derived cyclopeptide that inhibits MIF binding and atherogenic signaling via the chemokine receptor CXCR2. Chembiochem. 2020 Oct 30. doi: 10.1002/cbic.202000574. Epub ahead of print. PMID: 33125165.
- Sinitski D, Gruner K, Bernhagen J, Panstruga R (2020). Studying Plant MIF/D-DT-Like Genes and Proteins (MDLs). Methods Mol Biol. 2020;2080:249-261. doi: 10.1007/978-1-4939-9936-1_22.
- Wirtz TH, Reuken PA, Jansen C, Fischer P, Bergmann I, Backhaus C, Emontzpohl C, Reißing J, Brandt EF, Koenen MT, Schneider KM, Schierwagen R, Brol MJ, Chang J, Zimmermann HW, Köse-Vogel N, Eggermann T, Kurth I, Stoppe C, Bucala R, Bernhagen J, Praktiknjo M, Stallmach A, Trautwein C, Trebicka J, Bruns T, Berres ML (2020). Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis. JHEP Rep. 2020 Dec 17;3(2):100221. doi: 10.1016/j.jhepr.2020.100221. PMID: 33659891; PMCID: PMC7890204.
- Aftabizadeh M, Tatarek-Nossol M, Andreetto E, El Bounkari O, Kipp M, Beyer C, Latz E, Bernhagen J, Kapurniotu A (2019). Blocking inflammasome activation caused by β-amyloid peptide (Aβ) and islet amyloid polypeptide (IAPP) through an IAPP mimic. ACS Chem Neurosci. 2019 Jul 11. doi: 10.1021/acschemneuro.9b00260. [Epub ahead of print]
- Bernhagen J (2019). Protective cardiac conditioning by an atypical cytokine. Clin Sci (Lond). 2019 Apr 18;133(8):933-937. doi: 10.1042/CS20190036. Print 2019 Apr 30.
- Bernhagen J (2019). Separating cytokine twins with a small molecule. J Biol Chem. 2019 Dec 6;294(49):18532-18533. doi: 10.1074/jbc.H119.011749.
- Kapurniotu A, Gokce O, Bernhagen J (2019). The Multitasking Potential of Alarmins and Atypical Chemokines. Front Med (Lausanne). 2019 Jan 23;6:3. doi: 10.3389/fmed.2019.00003. eCollection 2019.
- Michelet C, Danchin EGJ, Jaouannet M, Bernhagen J, Panstruga R, Kogel KH, Keller H, Coustau C (2019). Cross-Kingdom Analysis of Diversity, Evolutionary History, and Site Selection within the Eukaryotic Macrophage Migration Inhibitory Factor Superfamily. Genes (Basel). 2019 Sep 24;10(10). pii: E740. doi: 10.3390/genes10100740.
- Milic J, Tian Y, Bernhagen J (2019). Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases. Biomolecules. 2019 Jun 5;9(6). pii: E217. doi: 10.3390/biom9060217.
- Sinitski D, Kontos C, Krammer C, Asare Y, Kapurniotu A, Bernhagen J (2019). Macrophage Migration Inhibitory Factor (MIF)-Based Therapeutic Concepts in Atherosclerosis and Inflammation. Thromb Haemost. 2019 Feb 4. doi: 10.1055/s-0039-1677803. [Epub ahead of print]
- Sinitski D, Gruner K, Brandhofer M, Kontos C, Winkler P, Reinstädler A, Bourilhon P, Xiao Z, Cool RH, Kapurniotu A, Dekker FJ, Panstruga R, Bernhagen J (2019). Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs. J Biol Chem. 2019 Dec 6. pii: jbc.RA119.009716. doi: 10.1074/jbc.RA119.009716. [Epub ahead of print]
- Tilstam PV, Soppert J, Hemmers C, Harlacher E, Döring Y, van der Vorst EPC, Schulte C, Alampour-Rajabi S, Theelen W, Asare Y, de Winther MPJ, Lawrence T, Bernhagen J, Schober A, Zernecke A, Jankowski J, Weber C, Noels H (2019). Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice. Atherosclerosis. 2019 Nov 2;292:23-30. doi: 10.1016/j.atherosclerosis.2019.10.023. [Epub ahead of print]
- Wirtz TH, Fischer P, Backhaus C, Bergmann I, Brandt EF, Heinrichs D, Koenen MT, Schneider KM, Eggermann T, Kurth I, Stoppe C, Bernhagen J, Bruns T, Fischer J, Berg T, Trautwein C, Berres ML (2019). Genetic Variants in the Promoter Region of the Macrophage Migration Inhibitory Factor are Associated with the Severity of Hepatitis C Virus-Induced Liver Fibrosis. Int J Mol Sci. 2019 Jul 31;20(15). pii: E3753. doi: 10.3390/ijms20153753.
- Bernhagen J (2018). "Remote" myokine protects from pulmonary ischemia/reperfusion injury by a surprising "proximal" control mechanism. Ann Transl Med. 2018 Jul;6(13):275. doi: 10.21037/atm.2018.05.45.
- Georgakis MK, Gill D, Rannikmae K, Traylor M, Anderson CD, Lee JM, Kamatani Y, Hopewell JC, Worrall BB, Bernhagen J, Sudlow CL, Malik R, Dichgans M (2018). Genetically Determined Levels of Circulating Cytokines and Risk of Stroke: Role of Monocyte Chemoattractant Protein-1. Circulation. 2018 Sep 26. doi: 10.1161/CIRCULATIONAHA.118.035905. [Epub ahead of print]
- Hertelendy J, Reumuth G, Simons D, Stoppe C, Kim BS, Stromps JP, Fuchs PC, Bernhagen J, Pallua N, Grieb G. Macrophage Migration Inhibitory Factor - A Favorable Marker in Inflammatory Diseases? Curr Med Chem. 2018 Feb 13;25(5):601-605. doi: 10.2174/0929867324666170714114200. PMID: 28714387.
- Lacy M, Kontos C, Brandhofer M, Hille K, Gröning S, Sinitski D, Bourilhon P, Rosenberg E, Krammer C, Thavayogarajah T, Pantouris G, Bakou M, Weber C, Lolis E, Bernhagen J, Kapurniotu A (2018). Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4. Sci Rep. 2018 Mar 26;8(1):5171. doi: 10.1038/s41598-018-23554-5.
- Mattugini N, Merl-Pham J, Petrozziello E, Schindler L, Bernhagen J, Hauck SM, Götz M (2018). Influence of white matter injury on gray matter reactive gliosis upon stab wound in the adult murine cerebral cortex. Glia. 2018 Mar 24. doi: 10.1002/glia.23329. [Epub ahead of print]
- Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A (2018). Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke. Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.
- Schmitz C, Noels H, El Bounkari O, Straussfeld E, Megens RTA, Sternkopf M, Alampour-Rajabi S, Krammer C, Tilstam PV, Gerdes N, Bürger C, Kapurniotu A, Bucala R, Jankowski J, Weber C, Bernhagen J (2018). Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis. FASEB J. 2018 Mar 15:fj201800058R. doi: 10.1096/fj.201800058R. [Epub ahead of print]
- Seifert HA, Benedek G, Nguyen H, Gerstner G, Zhang Y, Kent G, Vandenbark AA, Bernhagen J, Offner H (2018). Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells. Metab Brain Dis. 2018 Jun 18. doi: 10.1007/s11011-018-0266-7. [Epub ahead of print]
- Soppert J, Kraemer S, Beckers C, Averdunk L, Möllmann J, Denecke B, Goetzenich A, Marx G, Bernhagen J, Stoppe C (2018). Soluble CD74 Reroutes MIF/CXCR4/AKT-Mediated Survival of Cardiac Myofibroblasts to Necroptosis. J Am Heart Assoc. 2018 Sep 4;7(17):e009384. doi: 10.1161/JAHA.118.009384.
- Spanopoulou A, Heidrich L, Chen HR, Frost C, Hrle D, Malideli E, Hille K, Grammatikopoulos A, Bernhagen J, Zacharias M, Rammes G, Kapurniotu A (2018). Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements. Angew Chem Int Ed Engl. 2018 Jun 16. doi: 10.1002/anie.201802979. [Epub ahead of print]
- Stoppe C, Averdunk L, Goetzenich A, Soppert J, Marlier A, Kraemer S, Vieten J, Coburn M, Kowark A, Kim BS, Marx G, Rex S, Ochi A, Leng L, Moeckel G, Linkermann A, El Bounkari O, Zarbock A, Bernhagen J, Djudjaj S, Bucala R, Boor P (2018). The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery. Sci Transl Med. 2018 May 16;10(441). pii: eaan4886. doi: 10.1126/scitranslmed.aan4886.
- Asare Y, Ommer M, Azombo FA, Alampour-Rajabi S, Sternkopf M, Sanati M, Gijbels MJ, Schmitz C, Sinitski D, Tilstam PV, Lue H, Gessner A, Lange D, Schmid JA, Weber C, Dichgans M, Jankowski J, Pardi R, de Winther MP, Noels H, Bernhagen J (2017). Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo. Proc Natl Acad Sci U S A. 2017 Mar 14. pii: 201618411. doi: 10.1073/pnas.1618411114. [Epub ahead of print]
- Jumpertz S, Hennes T, Asare Y, Schütz AK, Bernhagen J (2017). CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells. Cell Signal. 2017 Feb 13. pii: S0898-6568(17)30053-0. doi: 10.1016/j.cellsig.2017.02.013. [Epub ahead of print]
- Kim BS, Tilstam PV, Springenberg-Jung K, Boecker AH, Schmitz C, Heinrichs D, Hwang SS, Stromps JP, Ganse B, Kopp R, Knobe M, Bernhagen J, Pallua N, Bucala R (2017). Characterization of adipose tissue macrophages and adipose-derived stem cells in critical wounds. PeerJ. 2017 Jan 4;5:e2824. doi: 10.7717/peerj.2824. eCollection 2017.
- Kim BS, Ott V, Boecker AH, Stromps JP, Paul NE, Alharbi Z, Cakmak E, Bernhagen J, Bucala R, Pallua N (2017). The Effect of Antiseptics on Adipose-Derived Stem Cells. Plast Reconstr Surg. 2017 Mar;139(3):625-637. doi: 10.1097/PRS.0000000000003125.
- Paul NE, Denecke B, Kim BS, Dreser A, Bernhagen J, Pallua N (2017). The effect of mechanical stress on the proliferation, adipogenic differentiation and gene expression of human adipose-derived stem cells. J Tissue Eng Regen Med. 2017 Jan 17. doi: 10.1002/term.2411. [Epub ahead of print]
- Schindler L, Dickerhof N, Hampton MB, Bernhagen J (2017). Post-translational regulation of macrophage migration inhibitory factor: Basis for functional fine-tuning. Redox Biol. 2017 Dec 6;15:135-142. doi: 10.1016/j.redox.2017.11.028. [Epub ahead of print]
- Brocks T, Fedorchenko O, Schliermann N, Stein A, Moll UM, Seegobin S, Dewor M, Hallek M, Marquardt Y, Fietkau K, Heise R, Huth S, Pfister H, Bernhagen J, Bucala R, Baron JM, Fingerle-Rowson G (2016). Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin. FASEB J. 2016 Oct 19. pii: fj.201600860R. [Epub ahead of print]
- Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Bøtker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernández-Reséndiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT (2016). From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Res Cardiol. 2016 Nov;111(6):69. Epub 2016 Oct 14.
- Kim BS, Jacobs D, Emontzpohl C, Goetzenich A, Soppert J, Jarchow M, Schindler L, Averdunk L, Kraemer S, Marx G, Bernhagen J, Pallua N, Schlemmer HP, Simons D, Stoppe C (2016). Myocardial ischemia induces SDF-1α release in cardiac surgery patients. J Cardiovasc Transl Res. 2016 Apr 7. [Epub ahead of print]
- Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R (2016). D-dopachrome tautomerase in adipose tissue inflammation and wound repair. J Cell Mol Med. 2016 Sep 7. doi: 10.1111/jcmm.12936. [Epub ahead of print]
- Kim B-S, Stoppe C, Grieb G, Leng L, Sauler M, Assis D, Simons D, Boecker A H, Schulte W, Piecychna M, Hager S, Bernhagen J, Pallua N, Bucala R (2016). The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn. Burns. 2016 May 18. pii: S0305-4179(16)00062-0. DOI: 10.1016/j.burns.2016.02.005. [Epub ahead of print]
- Kim B-S, Gaul C, Paul NE, Dewor M, Stromps J-P, Hwang S S, Nourbakhsh M, Bernhagen J, Rennekampff H-O, Pallua N(2016). The effect of lipoaspirates on human keratinocytes. Aesthetic Surgery Journal. 2016 May 31. pii: sjw049. DOI: http://dx.doi.org/10.1093/asj/sjw049. [Epub ahead of print]
- Noels H, Bernhagen J (2016). Editorial: The CXCR4 ligand/receptor family and the DPP4 protease in high-risk cardiovascular patients. Front Immunol. 2016 Feb 19;7:58. doi: 10.3389/fimmu.2016.00058. eCollection 2016.
- Pasqualon T, Lue H, Tillmann S, Pruessmeyer J, Jahr H, Denecke B, Bernhagen J, Ludwig A (2016). Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells. Biochim Biophys Acta. 2016 Feb 4. pii: S0167-4889(16)30019-2. doi: 10.1016/j.bbamcr.2016.02.003. [Epub ahead of print]
- Przybyl L, Haase N, Golic M, Rugor J, Solano M E, Arck P C, Gauster M, Huppertz B, Emontzpohl C, Stoppe C, Bernhagen J, Leng L, Bucala R, Schulz H, Heuser A, Weedon-Fekjær M S, Johnson G M, Peetz D, Luft F C, Staff A C, Müller D N, Dechend R, Herse F (2016). CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia Circulation Research. 2016 May 19. pii: CIRCRESAHA.116.308304. DOI: 10.1161/CIRCRESAHA.116.308304. [Epub ahead of print]
- Rajasekaran D, Gröning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis E, Bernhagen J (2016). Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: Evidence for Partial Allosteric Agonism in Comparison to CXCL12. Journal of Biological Chemistry. 2016 May 19. pii: jbc.M116.717751. DOI: 10.1074/jbc.M116.717751. [Epub ahead of print]
- Roger T, Schneider A, Weier M, Sweep FC, Le Roy D, Bernhagen J, Calandra T, Giannoni E (2016). High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates. Proc Natl Acad Sci U S A. 2016 Feb 8. pii: 201514018. [Epub ahead of print]
- Rosello X, Burke N, Stoppe C, Bernhagen J, Davidson S D, Yellon D (2016). Exogenous administration of recombinant MIF at physiological concentrations failed to attenuate infarct size in a langendorff perfused isolated mouse heart model. Cardiovasc Drugs and Therapy. 2016 June 22. DOI: 10.1007/s10557-016-6673-2. [Epub ahead of print]