News | 31/01/2024 | Research Spotlight
Replacing lost neurons: Influence of dysfunctional mitochondria on direct neuronal reprogramming uncovered
Mitochondria account for essential cellular processes – from energy production (ATP) to nucleotide metabolism. Dysfunction of mitochondria can lead to neurological disorders and contribute to developing diseases associated with aging. Researchers have now uncovered the role of dysfunctional mitochondria in direct neuronal reprogramming, the process of converting an astrocyte into a neuron to repair or replace damaged neurons. They identified and successfully addressed two hurdles caused by dysfunctional mitochondria during this process: the unfolded protein response (UPR) and integrated stress response (ISR). This discovery unravels possible novel therapeutic strategies for treating mitochondrial disorders and replacing functional neurons.