News | 12/02/2024 | Research Spotlight
Changes in synapses related to protein 43 (GAP-43) speed up the spread of tau in Alzheimer’s disease
A combined neuroimaging and biofluid biomarker study investigated whether synaptic changes are associated with accelerated tau spreading in Alzheimer’s disease (AD). They found that higher levels of the presynaptic protein GAP-43 speed up the spread of tau in AD. These findings are relevant for developing treatments to slow down the progression of the disease.