SyNergy Seminar
Susanne Wegmann: Autoimmune-induced tauopathies: new ways of understanding Tau pathobiology.
Phosphorylation, "missorting", and aggregation are hallmark pathological changes in Tauopathies, including Alzheimer’s disease. SImilar Tau changes also occurr during neuronal stress reactions. To understand how, and what for, Tau phospohrylation and missorting occur, we utilize autoimmune-antibodies that trigger Tau pathology, e.g. in IgLON5 disease. Our findings reveal a role of neuronal hyperactivity as inducer of Tau changes that later can manisfest as Tau pathology. A similar mechanism is suggested for AD. Our data therefore suggest that mis-tuning of neuronal network activity is common path to Tau pathology across neurological disease spectra, and that autoimmune antibodies offer a well-controlled experimental system to study Tau ‚reactions‘ in this context.
Date
25.04.2024
Time
16:00 - 17:00
Location
Hybrid: Center for Stroke and Dementia Research Large Seminar Room 8G U1 155 Feodor-Lynen-Str. 17, 81377 Munich https://lmu-munich.zoom-x.de/j/64966463825?pwd=OHo4UkkvTkVPU0lFVVlLTWlldnQvZz09 Passwort: 137471 MeetingID: 649 6646 3825
Host
Dominik Paquet