Tandem Projects
Tandem Projects are highly collaborative research projects aimed at improving our understanding of degenerative, inflammatory and glio-vascular disease. The projects combine expertise across traditional pathomechanisms, as well as systems biology and systems neuroscience tools. Furthermore, in many projects research efforts of basic scientists and clinicians are bundled. This allows us to combine approaches that range from in vitro models to investigator initiated trials. Four Research Areas have therefore been specified. Importantly, the portfolio of projects within the cluster is not static, but allows for addition of new projects and investigators as topics and techniques in systems neurology emerge. The current SyNergy tandem projects are as follows:
A1
TREM2 dependent microglial function and dysfunction in Alzheimer's disease
Haass*, Simons*, Herms, Lichtenthaler, Feederle
A2
Neuronal pathology and its compensation in the inflamed nervous system
Kerschensteiner*, Misgeld*, Bareyre, Konnerth, Portugues
A4
Axonal mitophagy – local quality control to restrict inflammation
Behrends*, Harbauer*
A5
Investigating pathogenic protein seeding in human iPSC-derived models of AD and FTD
Paquet*, Herms*, Hartl, Haass
A6
Trio infernal: The role of glia-glia-neuron interaction in ALS/FTD pathology
Edbauer*, Liebscher*, Ninkovic
B1
Systems neurology of cell-type specific mitochondrial pathology in neurodegeneration
Misgeld*, Perocchi*, Harbauer
B2
Identifying key regulators of neuronal replacement after neurodegeneration and stroke
Götz*, Liesz*, Dichgans, Ninkovic
B3
Small vessel disease (SVD) – multiscale imaging from models to patients
Dichgans*, Plesnila*, Ertürk
B4
Exploring and exploiting proteostasis network dynamics for treatment and repair
Behrends*, Hartl*, Edbauer, Götz
B5
Cellular mechanisms of prolonged functional impairment after transient ischemic attacks
Liebscher*, Liesz*
B6
Cellular mechanisms of β-amyloid dependent astrocytic dysfunction in vivo
Konnerth*, Misgeld*, Haass
B7
Neural circuit remodeling after acute hearing loss
Grothe*, Liebscher*, Ninkovic
B8
Systems-wide characterization of astrocyte-neuron crosstalk - relevance for Parkinson’s
disease
Burbulla*, Perocchi*, Lichtenthaler, Misgeld
C2
Lipid metabolism, phagocyte function and remyelination
Simons*, Hemmer*, Haass
C3
Exploring neurovascular disorders in isogenic human iPSC-derived in vitro models involving APP, Notch3, and Foxf2 mutations
Paquet*, Dichgans*, Plesnila
C4
Glia-neuron-vascular crosstalk governing systemic metabolism
García-Cáceres*, Tschöp*, Götz, Misgeld, Perocchi
C5
Pharmacological inhibition of HDAC9 for atheroprotection and its effects on neuroprotection
Dichgans*, Weber*, Liesz, Bernhagen, Plesnila
C6
Role of Sensory Neuroimmune Cardiovascular Interfaces in Atherosclerosis
Weber*, Dichgans*, Bernhagen*, Lichtenthaler, Herms
C7
IL-6 signaling in T cell subsets - Advanced models
Korn*, Lichtenthaler*
C8
Cell-type specific mitochondrial plasticity in neural cells of the inflamed CNS
Misgeld*, Kerschensteiner*, Perocchi, Harbauer
D1
Microglial activity markers: from mouse models to humans
Haass*, Lichtenthaler*, Brendel, Perneczky
D2
Environmental and immunological disease triggers in the German National Twin Cohort
Kerschensteiner*, Hemmer*, Gerdes, Korn, Simons
D3
Therapeutic modulation of TREM2
Haass*, Simons*, Herms, Lichtenthaler, Feederle
D6
PET radiotracer development for in vivo imaging of neurodegeneration, neuroinflammation and neurovascular diseases
Brendel*, Haass*
D7
Preparing for clinical trials of immunotherapy and nucleoside analogs in C9orf72 ALS
Edbauer*, Klopstock*, Levin, Lingor
*coordinating PI/AI