Munich Cluster for Systems Neurology

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Tandem Projects

Tandem Projects are highly collaborative research projects aimed at improving our understanding of degenerative, inflammatory and glio-vascular disease. The projects combine expertise across traditional pathomechanisms, as well as systems biology and systems neuroscience tools. Furthermore, in many projects research efforts of basic scientists and clinicians are bundled. This allows us to combine approaches that range from in vitro models to investigator initiated trials. Three Research Areas have therefore been specified. Importantly, the portfolio of projects within the cluster is not static, but allows for addition of new projects and investigators as topics and techniques in systems neurology emerge. The current SyNergy tandem projects are as follows:

Identification of molecular markers and development of functional reporters of mitochondrial pathology in degenerative and inflammatory neurological diseases
Misgeld*, Kerschensteiner, Herms, Lichtenthaler, Perocchi

Correlates and consequences of microglial/macrophage activation in multiple sclerosis
Hohlfeld*, Kerschensteiner*, Bartenstein, Reiser

Compensatory plasticity after neuroinflammatory/‐ degenerative injury
Misgeld, Kerschensteiner*, Bareyre, Konnerth

Long term provenance mapping of cell recruitment to the CNS
Misgeld*, Korn*

Mechanisms of axonal pathology in a model of NMO-related astrocyte toxicity
Misgeld*, Hemmer*

Transcriptional regulation of HDAC9 ‐ a risk factor for stroke and myocardial infarction
Dichgans*, Mann

Degeneration and plasticity of connected areas after cortical ischemia
Kerschensteiner, Dichgans, Plesnila*, Bareyre*

Role of the stroke‐relevant HDAC9 gene in the cellular proteome & acetylome
Dichgans, Ladurner*

Impact of the ALS/FTLD gene TDP-43 on vascular formation and growth
Haass, Pohl*, Schmid

NG2-reaction in spinal cord injury
Dimou*, Bareyre

Long non-coding RNAs involved in loss of dendritic spines and synapses
Scheuermann*, Ertuerk*

Characterization of a Lipid-ApoE-Complement Axis in Alzheimer´s Disease and Atherosclerosis
Weber*, Herms

Cellular mechanisms of prolonged functional impairment after transient ischemic attacks
Liebscher*, Liesz*

Stem Cell Reaction of astrocytes in demyelinating disease
Hemmer, Korn, Götz*, Grothe

In situ mass spectrometry of regenerating brain
Götz, Imhof*

In vivo imaging of activity dependent-assembly of myelin in zebrafish
Czopka, Misgeld, Simons*

Core 1
Modulation of TREM2 function, a microglial risk factor for neurodegeneration
Haass*, Hartl, Herms

Core 2
Longitudinal assessment of amyloid deposition in APP-Swe mice treated with a γ-secretase modulator using [18F]florbetaben PET
Haass*, Herms, Rominger

Core 3
Neuronal and vascular dysfunction in ALS/FTLD: from molecules to patients
Edbauer*, Haass, Meitinger, Schmid, Dieterich

Core 4
Soluble BAFF/APRIL receptors in neuroinflammation
Hohlfeld/Meinl*, Lichtenthaler

Core 5
Transmission of human synucleinopathy to an animal model – implications for pathophysiology, strain specificity and therapeutic approaches
Höglinger, Dieterich*

Core 6
Development of novel methodology for the joint analysis of –omics data
Dichgans, Müller-Myhsok*

Core 7
Generation of animal models to study lysosomal dysfunction in FTLD/ALS
Haass, Misgeld, Wurst*, Lichtenthaler, Schmid

Core 8
Analysis of large-scale neuronal circuits in mouse models of Alzheimer´s disease
Busche, Misgeld, Konnerth*

Core 10
Analysis of RNA granules and mRNA transport in novel cellular and animal models of ALS-FUS
Dormann*, Wurst

Core 11
Longitudinal dynamics of the neural correlates of local neurodegeneration
Sirota*, Herms

Core 12
Genetic analysis of cases with familial Fronto Temporal Dementia
Winkelmann*, Edbauer

Core 13
Detection of a Pro--2-oxidized variant of the chemokine MIF in vascular disease
Bernhagen*, Feederle

Identification and validation of novel Eph/Ephrinclustering and signaling modulators
Hartl, Klein*


*corresponding PI/AI