Munich Cluster for Systems Neurology
print


Breadcrumb Navigation


Content

Tandem Projects

Tandem Projects are highly collaborative research projects aimed at improving our understanding of degenerative, inflammatory and glio-vascular disease. The projects combine expertise across traditional pathomechanisms, as well as systems biology and systems neuroscience tools. Furthermore, in many projects research efforts of basic scientists and clinicians are bundled. This allows us to combine approaches that range from in vitro models to investigator initiated trials. Four Research Areas have therefore been specified. Importantly, the portfolio of projects within the cluster is not static, but allows for addition of new projects and investigators as topics and techniques in systems neurology emerge. The current SyNergy tandem projects are as follows:

A1
TREM2 dependent microglial function and dysfunction in Alzheimer's disease
Haass*, Simons*, Herms, Lichtenthaler, Feederle

A2
Neuronal pathology and its compensation in the inflamed nervous system
Kerschensteiner*, Misgeld*, Bareyre, Konnerth, Portugues

A3
Neuronal metabolic dysfunction in neuroninflammation
Misgeld*, Kerschensteiner*, Perocchi

B1
Systems neurology of cell-type specific mitochondrial pathology in neurodegeneration
Misgeld*, Perocchi*, Harbauer

B2
Identifying key regulators of neuronal replacement after neurodegeneration and stroke
Götz*, Liesz*, Dichgans, Ninkovic

B3
Small vessel disease (SVD) – multiscale imaging from models to patients
Dichgans*, Plesnila*, Ertürk, Düring

B4
Role of proteostasis network dynamics in neurodegenerative diseases
Behrends*, Hartl*, Edbauer, Götz

B5
Cellular mechanisms of prolonged functional impairment after transient ischemic attacks
Liebscher*, Liesz*

C1
Myeloid derived suppressor cells - regulation of CNS entry and functions in CNS inflammation
Korn*, Lichtenthaler*, Misgeld

C2
Lipid metabolism, phagocyte function and remyelination
Simons*, Hemmer*, Haass

C3
Exploring disorders of the neuro-glio-vascular unit in isogenic human iPSC-derived in vitro models
Paquet*, Dichgans*, Plesnila

C4
Glia-neuron crosstalk governing systemic metabolism
Haass*, García-Cáceres*, Tschöp, Götz, Simons

C5
Pharmacological inhibition of HDAC9 for atheroprotection and its effects on neuroprotection
Dichgans*, Weber*, Liesz, Bernhagen, Plesnila

D1
Microglial activity markers: from mouse models to humans
Haass*, Lichtenthaler*, Bartenstein, Perneczky, Diehl-Schmid

D2
Environmental and immunological disease triggers in the German National Twin Cohort
Kerschensteiner*, Hemmer*, Hohlfeld, Korn, Simons, Düring

D3
Therapeutic modulation of TREM2
Haass*, Simons*, Herms, Lichtenthaler, Feederle

D4
Identify TDP-43 epitopes to block aggregation and spreading for immunotherapy in mice
Edbauer*, Klopstock*, Dieterich

 

*coordinating PI/AI