Content
Publications
2021
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Alexopoulos P, Papanastasiou AD, Εconomou P, Beis P, Niforas M, Dassios TG, Kormpaki A, Zarkadis IK, Reichel M, Kornhuber J Perneczky R, Gourzis P
(2021)
Associations between APOE-, COMT Val108/158Met- and BDNF Val66Met polymorphisms and variations in depressive and anxiety symptoms, sense of coherence and vital exhaustion in the real-life setting of mandatory basic military training
J Neural Transm (Vienna). 2021 Jan 4. doi: 10.1007/s00702-020-02280-1. Epub ahead of print. PMID: 33394176.
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Benussi A, Premi E, Gazzina S, Brattini C, Bonomi E, Alberici A, Jiskoot L, van Swieten JC, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Masellis M, Tartaglia C, Rowe JB, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Frisoni G, Ghidoni R, Sorbi S, Le Ber I, Pasquier F, Peakman G, Todd E, Bocchetta M, Rohrer JD, Borroni B; Genetic FTD Initiative (GENFI)
(2021)
Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia.
JAMA Netw Open. 2021 Jan 4;4(1):e2030194. doi: 10.1001/jamanetworkopen.2020.30194. PMID: 33404617.
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Boeckh-Behrens T, Golkowski D, Ikenberg B, Schlegel J, Protzer U, Schulz C, Novotny J, Kreiser K, Zimmer C, Hemmer B, Wunderlich S
(2021)
COVID-19-associated Large Vessel Stroke in a 28-year-old Patient : NETs and Platelets Possible Key Players in Acute Thrombus Formation.
Clin Neuroradiol. 2021 Jan 29:1–4. doi: 10.1007/s00062-020-00992-1. Epub ahead of print. PMID: 33512534; PMCID: PMC7844783.
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Boltze J, Aronowski JA, Badaut J, Buckwalter MS, Caleo M, Chopp M, Dave KR, Didwischus N, Dijkhuizen RM, Doeppner TR, Dreier JP, Fouad K, Gelderblom M, Gertz K, Golubczyk D, Gregson BA, Hamel E, Hanley DF, Härtig W, Hummel FC, Ikhsan M, Janowski M, Jolkkonen J, Karuppagounder SS, Keep RF, Koerte IK, Kokaia Z, Li P, Liu F, Lizasoain I, Ludewig P, Metz GAS, Montagne A, Obenaus A, Palumbo A, Pearl M, Perez-Pinzon M, Planas AM, Plesnila N, Raval AP, Rueger MA, Sansing LH, Sohrabji F, Stagg CJ, Stetler RA, Stowe AM, Sun D, Taguchi A, Tanter M, Vay SU, Vemuganti R, Vivien D, Walczak P, Wang J, Xiong Y, Zille M
(2021)
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.
Front Aging Neurosci. 2021 Jan 28;13:623751. doi: 10.3389/fnagi.2021.623751. PMID: 33584250; PMCID: PMC7876251.
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Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W
(2021)
DGK and DZHK position paper on genome editing: basic science applications and future perspective
Basic Res Cardiol. 2021 Jan 15;116(1):2. doi: 10.1007/s00395-020-00839-3. PMID: 33449167.
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Burgess S, Malik R, Liu B, Mason AM, Georgakis MK, Dichgans M, Gill D
(2021)
Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.
Diabetologia. 2021 Jan 26. doi: 10.1007/s00125-020-05377-0. Epub ahead of print. PMID: 33495845.
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Dangond F, Donnelly A, Hohlfeld R, Gourzis PLubetzki C, Kohlhaas S, Leocani L, Ciccarelli O, Stankoff B, Sormani MP, Chataway J, Bozzoli F, Cucca F, Melton L, Coetzee T, Salvetti M
(2021)
Facing the urgency of therapies for progressive MS - a Progressive MS Alliance proposal.
Nat Rev Neurol. 2021 Jan 22. doi: 10.1038/s41582-020-00446-9. Epub ahead of print. PMID: 33483719.
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Delgado de la Herran HC, Cheng Y, Perocchi F
(2021)
Towards a systems-level understanding of mitochondrial biology.
Cell Calcium. 2021 Feb 1;95:102364. doi: 10.1016/j.ceca.2021.102364. Epub ahead of print. PMID: 33601101.
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Dobersch S, Rubio K, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Günther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D, Barreto G
(2021)
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation.
Nat Commun. 2021 Feb 16;12(1):1072. doi: 10.1038/s41467-021-21227-y. PMID: 33594057.
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Ertl M, Zu Eulenburg P, Woller M, Dieterich M
(2021)
The role of delta and theta oscillations during ego-motion in healthy adult volunteers.
Exp Brain Res. 2021 Feb 3. doi: 10.1007/s00221-020-06030-3. Epub ahead of print. PMID: 33534022.
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Feil K, Herzberg M, Dorn F, Tiedt S, Küpper C, Thunstedt DC, Papanagiotou P, Meyer L, Kastrup A, Dimitriadis K, Liebig T, Dieterich M, Kellert L; GSR investigators [i.a. Dichgans M ]
(2021)
Tandem Lesions in Anterior Circulation Stroke: Analysis of the German Stroke Registry-Endovascular Treatment.
Stroke. 2021 Feb 16:STROKEAHA120031797. doi: 10.1161/STROKEAHA.120.031797. Epub ahead of print. PMID: 33588589.
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Feil K, Herzberg M, Dorn F, Tiedt S, Küpper C, Thunstedt DC, Hinske LC, Mühlbauer K, Goss S, Liebig T, Dieterich M, Bayer A, Kellert L; GSR Investigators [i.a. Dichgans M ]
(2021)
General Anesthesia versus Conscious Sedation in Mechanical Thrombectomy.
J Stroke. 2021 Jan;23(1):103-112. doi: 10.5853/jos.2020.02404. Epub 2021 Jan 31. PMID: 33600707.
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Gencer S, Evans BR, van der Vorst EPC, Döring Y, Weber C
(2021)
Inflammatory Chemokines in Atherosclerosis.
Cells. 2021 Jan 25;10(2):226. doi: 10.3390/cells10020226. PMID: 33503867.
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Gengatharan A, Malvaut S, Marymonchyk A, Ghareghani M, Snapyan M, Fischer-Sternjak J, Ninkovic J, Götz M, Saghatelyan A
(2021)
Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.
Cell. 2021 Jan 13:S0092-8674(20)31748-7. doi: 10.1016/j.cell.2020.12.026. Epub ahead of print. PMID: 33482084.
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Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
(2021)
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Neurology. 2021 Jan 25:10.1212/WNL.0000000000011555. doi: 10.1212/WNL.0000000000011555. Epub ahead of print. PMID: 33495378.
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Gill D, Karhunen V, Malik R, Dichgans M, Sofat N
(2021)
Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.
Osteoarthritis Cartilage. 2021 Jan 7:S1063-4584(21)00001-7. doi: 10.1016/j.joca.2020.12.015. Epub ahead of print. PMID: 33422704.
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Gronewold J, Kropp R, Lehmann N, Stang A, Mahabadi A, Weimar C, Dichgans M, Moebus S, Kröger K, Hoffmann B, Jöckel KH, Erbel R, Hermann D; Heinz Nixdorf Recall Study Investigative Group
(2021)
Population impact of different hypertension management guidelines based on the prospective population-based Heinz Nixdorf Recall study.
BMJ Open. 2021 Feb 17;11(2):e039597. doi: 10.1136/bmjopen-2020-039597. PMID: 33597131.
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Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
(2021)
Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Stroke. 2021 Feb 4:STROKEAHA120031710. doi: 10.1161/STROKEAHA.120.031710. Epub ahead of print. PMID: 33535786.
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Hartmann J, Roßmeier C, Riedl L, Dorn B, Fischer J, Slawik T, Fleischhaker M, Hartmann F, Egert-Schwender S, Kehl V, Haller B, Schneider-Schelte H, Dinkel A, Jox RJ, Diehl-Schmid J
(2021)
Quality of Life in Advanced Dementia with Late Onset, Young Onset, and Very Young Onset.
J Alzheimers Dis. 2021 Jan 25. doi: 10.3233/JAD-201302. Epub ahead of print. PMID: 33523011.
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Heinrichs D, Brandt EF, Fischer P, Köhncke J, Wirtz TH, Guldiken N, Djudjaj S, Boor P, Kroy D, Weiskirchen R, Bucala R, Wasmuth HE, Strnad P, Trautwein C, Bernhagen J, Berres ML
(2021)
Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations.
Cells. 2021 Jan 28;10(2):252. doi: 10.3390/cells10020252. PMID: 33525493.
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Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M
(2021)
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Nat Neurosci. 2021 Jan 25. doi: 10.1038/s41593-020-00780-7. Epub ahead of print. PMID: 33495636.
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Joseph-Mathurin N, Wang G, Kantarci K, Jack CR Jr, McDade E, Hassenstab J, Blazey TM, Gordon BA, Su Y, Chen G, Massoumzadeh P, Hornbeck RC, Allegri RF, Ances BM, Berman SB, Brickman AM, Brooks WS, Cash DM, Chhatwal JP, Chui HC, Correia S, Cruchaga C, Farlow MR, Fox NC, Fulham M, Ghetti B, Graff-Radford NR, Johnson KA, Karch CM, Laske C, Lee AKW, Levin J, Masters CL, Noble JM, O'Connor A, Perrin RJ, Preboske GM, Ringman JM, Rowe CC, Salloway S, Saykin AJ, Schofield PR, Shimada H, Shoji M, Suzuki K, Villemagne VL, Xiong C, Yakushev I, Morris JC, Bateman RJ, Benzinger TLS; Dominantly Inherited Alzheimer Network
(2021)
Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease.
Neurology. 2021 Jan 25:10.1212/WNL.0000000000011542. doi: 10.1212/WNL.0000000000011542. Epub ahead of print. PMID: 33495373.
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Kreuzer A, Sauerbeck J, Scheifele M, Stockbauer A, Schönecker S, Prix C, Wlasich E, Loosli SV, M Kazmierczak P, Unterrainer M, Catak C, Janowitz D, Pogarell O, Palleis C, Perneczky R, Albert NL, Bartenstein P, Danek A, Buerger K, Levin J, Zwergal A, Rominger A, Brendel M, Beyer L
(2021)
Detection Gap of Right-Asymmetric Neuronal Degeneration by CERAD Test Battery in Alzheimer's Disease.
Front Aging Neurosci. 2021 Feb 2;13:611595. doi: 10.3389/fnagi.2021.611595. PMID: 33603657; PMCID: PMC7884314.
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Kupatt C, Windisch A, Moretti A, Wolf E, Wurst W, Walter MC
(2021)
Genome editing for Duchenne muscular dystrophy: a glimpse of the future?
Gene Ther. 2021 Feb 2. doi: 10.1038/s41434-021-00222-4. Epub ahead of print. PMID: 33531685.
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Luckett PH, McCullough A, Gordon BA, Strain J, Flores S, Dincer A, McCarthy J, Kuffner T, Stern A, Meeker KL, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, Salloway S, Schofield PR, Brickman AM, Brooks WS, Cash DM, Fulham MJ, Ghetti B, Jack CR Jr, Vöglein J, Klunk W, Koeppe R, Oh H, Su Y, Weiner M, Wang Q, Swisher L, Marcus D, Koudelis D, Joseph-Mathurin N, Cash L, Hornbeck R, Xiong C, Perrin RJ, Karch CM, Hassenstab J, McDade E, Morris JC, Benzinger TLS, Bateman RJ, Ances BM; Dominantly Inherited Alzheimer Network (DIAN)
(2021)
Modeling autosomal dominant Alzheimer's disease with machine learning.
Alzheimers Dement. 2021 Jan 21. doi: 10.1002/alz.12259. Epub ahead of print. PMID: 33480178.
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Newman NJ, Yu-Wai-Man P, Carelli V, Moster ML, Biousse V, Vignal-Clermont C, Sergott RC, Klopstock T, Sadun AA, Barboni P, DeBusk AA, Girmens JF, Rudolph G, Karanjia R, Taiel M, Blouin L, Smits G, Katz B, Sahel JA; LHON Study Group
(2021)
Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset.
Ophthalmology. 2021 Jan 12:S0161-6420(20)31187-8. doi: 10.1016/j.ophtha.2020.12.012. Epub ahead of print. PMID: 33451738.
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Ostkamp P, Salmen A, Pignolet B, Görlich D, Andlauer TFM, Schulte-Mecklenbeck A, Gonzalez-Escamilla G, Bucciarelli F, Gennero I, Breuer J, Antony G, Schneider-Hohendorf T, Mykicki N, Bayas A, Then Bergh F, Bittner S, Hartung HP, Friese MA, Linker RA, Luessi F, Lehmann-Horn K, Mühlau M, Paul F, Stangel M, Tackenberg B, Tumani H, Warnke C, Weber F, Wildemann B, Zettl UK, Ziemann U, Müller-Myhsok B, Kümpfel T, Klotz L, Meuth SG, Zipp F, Hemmer B, Hohlfeld R, Brassat D, Gold R, Gross CC, Lukas C, Groppa S, Loser K, Wiendl H, Schwab N; German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network
(2021)
Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity.
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2018457118. doi: 10.1073/pnas.2018457118. PMID: 33376202.
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Pavelekova P, Jech R, Zech M, Krepelova A, Han V, Mosejova A, Liba Z, Urgosik D, Gdovinova Z, Havrankova P, Fecikova A, Winkelmann J, Skorvanek M
(2021)
Atypical presentations of DYT1 dystonia with acute craniocervical onset.
Parkinsonism Relat Disord. 2021 Jan 13;83:54-55. doi: 10.1016/j.parkreldis.2020.12.019. Epub ahead of print. PMID: 33476878.
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Reinert MC, Pacheu-Grau D, Catarino CB, Klopstock T, Ohlenbusch A, Schittkowski M, Wilichowski E, Rehling P, Brockmann K
(2021)
Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy.
Orphanet J Rare Dis. 2021 Feb 4;16(1):64. doi: 10.1186/s13023-021-01690-y. PMID: 33541401; PMCID: PMC7860214.
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Safaiyan S, Besson-Girard S, Kaya T, Cantuti-Castelvetri L, Liu L, Ji H, Schifferer M, Gouna G, Usifo F, Kannaiyan N, Fitzner D, Xiang X, Rossner MJ, Brendel M, Gokce O, Simons M
(2021)
White matter aging drives microglial diversity.
Neuron. 2021 Feb 11:S0896-6273(21)00073-8. doi: 10.1016/j.neuron.2021.01.027. Epub ahead of print. PMID: 33606969.
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Santovito D, Toto L, De Nardis V, Marcantonio P, D'Aloisio R, Mastropasqua A, De Cesare D, Bucci M, Paganelli C, Natarelli L, Weber C, Consoli A, Mastropasqua R, Cipollone F
(2021)
Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes.
Sci Rep. 2021 Feb 18;11(1):4136. doi: 10.1038/s41598-021-83047-w. PMID: 33602976.
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Schindler L, Zwissler L, Krammer C, Hendgen-Cotta U, Rassaf T, Hampton MB, Dickerhof N, Bernhagen J
(2021)
Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells.
J Leukoc Biol. 2021 Feb 10. doi: 10.1002/JLB.3A0420-242RRR. Epub ahead of print. PMID: 33565160.
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Schöberl F, Pradhan C, Grosch M, Brendel M, Jostes F, Obermaier K, Sowa C, Jahn K, Bartenstein P, Brandt T, Dieterich M, Zwergal A
(2021)
Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space.
Sci Rep. 2021 Jan 29;11(1):2695. doi: 10.1038/s41598-021-82427-6. PMID: 33514827; PMCID: PMC7846808.
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Stenton SL, Sheremet NL, Catarino CB, Andreeva N, Assouline Z, Barboni P, Barel O, Berutti R, Bychkov IO, Caporali L, Capristo M, Carbonelli M, Cascavilla ML, Charbel Issa P, Freisinger P, Gerber S, Ghezzi D, Graf E, Heidler J, Hempel M, Heon E, Itkis YS, Javasky E, Kaplan J, Kopajtich R, Kornblum C, Kovacs-Nagy R, Krylova T, Kunz WS, La Morgia C, Lamperti C, Ludwig C, Malacarne PF, Maresca A, Mayr JA, Meisterknecht J, Nevinitsyna T, Palombo F, Pode-Shakked B, Shmelkova MS, Strom TM, Tagliavini F, Tzadok M, van der Ven AT, Vignal-Clermont C, Wagner M, Zakharova E, Zhorzholadze N, Rozet JM, Carelli V, Tsygankova P, Klopstock T, Wittig I, Prokisch H
(2021)
Impaired complex I repair causes recessive Leber's hereditary optic neuropathy.
J Clin Invest. 2021 Jan 19:138267. doi: 10.1172/JCI138267. Epub ahead of print. PMID: 33465056.
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Wang M, Kleele T, Xiao Y, Plucinska G, Avramopoulos P, Engelhardt S, Schwab MH, Kneussel M, Czopka T, Sherman DL, Brophy PJ, Misgeld T, Brill MS
(2021)
Completion of neuronal remodeling prompts myelination along developing motor axon branches.
J Cell Biol. 2021 Apr 5;220(4):e201911114. doi: 10.1083/jcb.201911114. PMID: 33538762.
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Weisheit I, Kroeger JA, Malik R, Wefers B, Lichtner P, Wurst W, Dichgans M, Paquet D
(2021)
Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping.
Nat Protoc. 2021 Feb 17. doi: 10.1038/s41596-020-00481-2. Epub ahead of print. PMID: 33597771.
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Zellner S, Schifferer M, Behrends C
(2021)
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Mol Cell. 2021 Jan 28:S1097-2765(21)00009-5. doi: 10.1016/j.molcel.2021.01.009. Epub ahead of print. PMID: 33545068.
2020
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Abo-Rady M, Kalmbach N, Pal A, Schludi C, Janosch A, Richter T, Freitag P, Bickle M, Kahlert AK, Petri S, Stefanov S, Glass H, Staege S, Just W, Bhatnagar R, Edbauer D, Hermann A, Wegner F, Sterneckert JL
(2020)
Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins.
Stem Cell Reports. 2020 Feb 5. pii: S2213-6711(20)30031-X. doi: 10.1016/j.stemcr.2020.01.010. [Epub ahead of print]
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Ahmadi SA, Vivar G, Navab N, Möhwald K, Maier A, Hadzhikolev H, Brandt T, Grill E, Dieterich M, Jahn K, Zwergal A
(2020)
Modern machine-learning can support diagnostic differentiation of central and peripheral acute vestibular disorders.
J Neurol. 2020;10.1007/s00415-020-09931-z. doi:10.1007/s00415-020-09931-z [published online ahead of print, 2020 Jun 11]
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Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M, Badimon L, Cosentino F, De Carlo M, Weber C, Wilkinson F, Bochaton-Piallat ML, Evans PC
(2020)
Endothelial function in cardiovascular precision medicine: a position paper on behalf of the european society of cardiology.
Cardiovasc Res. 2020 Apr 13. pii: cvaa085. doi: 10.1093/cvr/cvaa085. [Epub ahead of print]
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Altmann A, Cash DM, Bocchetta M, Heller C, Reynolds R, Moore K, Convery RS, Thomas DL, van Swieten JC, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Frisoni G, Ghidoni R, Sorbi S, Otto M, Ryten M, Rohrer JD; Genetic FTD Initiative, GENFI
(2020)
Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia.
Brain Commun. 2020 Aug 19;2(2):fcaa122. doi: 10.1093/braincomms/fcaa122. PMID: 33210084; PMCID: PMC7667525.
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Aly L, Havla J, Lepennetier G, Andlauer TFM, Sie C, Strauß EM, Hoshi MM, Kümpfel T, Hiltensperger M, Mitsdoerffer M, Mühlau M, Zimmer C, Hemmer B, Korn T, Knier B
(2020)
Inner retinal layer thinning in radiologically isolated syndrome predicts conversion to multiple sclerosis.
Eur J Neurol. 2020;10.1111/ene.14416. doi:10.1111/ene.14416 [published online ahead of print, 2020 Jun 26].
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Andlauer TFM, Link J, Martin D, Ryner M, Hermanrud C, Grummel V, Auer M, Hegen H, Aly L, Gasperi C, Knier B, Müller-Myhsok B, Jensen PEH, Sellebjerg F, Kockum I, Olsson T, Pallardy M, Spindeldreher S, Deisenhammer F, Fogdell-Hahn A, Hemmer B; ABIRISK consortium
(2020)
Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS.
BMC Med. 2020 Nov 4;18(1):298. doi: 10.1186/s12916-020-01769-6. PMID: 33143745; PMCID: PMC7641861.
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Arloth J, Eraslan G, Andlauer TFM, Martins J, Iurato S, Kühnel B, Waldenberger M, Frank J, Gold R, Hemmer B, Luessi F, Nischwitz S, Paul F, Wiendl H, Gieger C, Heilmann-Heimbach S, Kacprowski T, Laudes M, Meitinger T, Peters A, Rawal R, Strauch K, Lucae S, Müller-Myhsok B, Rietschel M, Theis FJ, Binder EB, Mueller NS
(2020)
DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning.
PLoS Comput Biol. 2020 Feb 3;16(2):e1007616. doi: 10.1371/journal.pcbi.1007616. eCollection 2020 Feb.
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Armstrong NJ, Mather KA, Sargurupremraj M, Knol MJ, Malik R, Satizabal CL, Yanek LR, Wen W, Gudnason VG, Dueker ND, Elliott LT, Hofer E, Bis J, Jahanshad N, Li S, Logue MA, Luciano M, Scholz M, Smith AV, Trompet S, Vojinovic D, Xia R, Alfaro-Almagro F, Ames D, Amin N, Amouyel P, Beiser AS, Brodaty H, Deary IJ, Fennema-Notestine C, Gampawar PG, Gottesman R, Griffanti L, Jack CR Jr, Jenkinson M, Jiang J, Kral BG, Kwok JB, Lampe L, C M Liewald D, Maillard P, Marchini J, Bastin ME, Mazoyer B, Pirpamer L, Rafael Romero J, Roshchupkin GV, Schofield PR, Schroeter ML, Stott DJ, Thalamuthu A, Trollor J, Tzourio C, van der Grond J, Vernooij MW, Witte VA, Wright MJ, Yang Q, Morris Z, Siggurdsson S, Psaty B, Villringer A, Schmidt H, Haberg AK, van Duijn CM, Jukema JW, Dichgans M, Sacco RL, Wright CB, Kremen WS, Becker LC, Thompson PM, Mosley TH, Wardlaw JM, Ikram MA, Adams HHH, Seshadri S, Sachdev PS, Smith SM, Launer L, Longstreth W, DeCarli C, Schmidt R, Fornage M, Debette S, Nyquist PA
(2020)
Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.
Stroke. 2020;STROKEAHA119027544. doi:10.1161/STROKEAHA.119.027544 [published online ahead of print, 2020 Jun 10]
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Arrambide G, Iacobaeus E, Amato MP, Derfuss T, Vukusic S, Hemmer B, Brundin L, Tintore M
(2020)
Aggressive multiple sclerosis (2): Treatment.
Mult Scler. 2020;1352458520924595. doi:10.1177/1352458520924595 [published online ahead of print, 2020 Jun 12]
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Asare Y, Campbell-James TA, Bokov Y, Yu LL, Prestel M, El Bounkari O, Roth S, Megens RT, Straub T, Thomas K, Yan G, Schneider M, Ziesch N, Tiedt S, Silvestre-Roig C, Braster Q, Huang Y, Schneider M, Malik R, Haffner C, Liesz A, Soehnlein O, Bernhagen J, Dichgans M
(2020)
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Circ Res. 2020;10.1161/CIRCRESAHA.120.316743. doi:10.1161/CIRCRESAHA.120.316743 [published online ahead of print, 2020 Jun 17].
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Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease.
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In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.
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The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients.
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Associations of schizophrenia risk genes ZNF804A and CACNA1C with schizotypy and modulation of attention in healthy subjects.
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Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
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GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.
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The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
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Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, Japtok J, Hermann A, Sommacal A, Weber M; German Consortium for Frontotemporal Lobar Degeneration; Bavarian Brain Banking Alliance, Kamp F, Nuscher B, Edbauer D, Haass C
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Optimal Inter-Eye Difference Thresholds by OCT in MS: An International Study.
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Action Plan for Stroke in Europe 2018–2030.
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Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis.
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Genome-wide association study identifies 30 loci associated with bipolar disorder.
Nat Genet. 2019 May;51(5):793-803. doi: 10.1038/s41588-019-0397-8. Epub 2019 May 1.
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Steinbach K, Vincenti I, Egervari K, Kreutzfeldt M, van der Meer F, Page N, Klimek B, Rossitto-Borlat I, Di Liberto G, Muschaweckh A, Wagner I, Hammad K, Stadelmann C, Korn T, Hartley O, Pinschewer DD, Merkler D
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Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice.
Sci Transl Med. 2019 Jun 26;11(498). pii: eaav5519. doi: 10.1126/scitranslmed.aav5519.
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Stendel C, Wagner M, Rudolph G, Klopstock T
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Gillespie's Syndrome with Minor Cerebellar Involvement and No Intellectual Disability Associated with a Novel ITPR1 Mutation: Report of a Case and Literature Review.
Neuropediatrics. 2019 Jul 24. doi: 10.1055/s-0039-1693150. [Epub ahead of print]
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Strohm L, Behrends C
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Glia-specific autophagy dysfunction in ALS.
Semin Cell Dev Biol. 2019 May 28. pii: S1084-9521(19)30020-5. doi: 10.1016/j.semcdb.2019.05.024. [Epub ahead of print]
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Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology.
Mol Neurodegener. 2019 Jan 10;14(1):1. doi: 10.1186/s13024-018-0301-5.
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Sun D, Tiedt S, Yu B, Jian X, Gottesman RF, Mosley TH, Boerwinkle E, Dichgans M, Fornage M
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A prospective study of serum metabolites and risk of ischemic stroke.
Neurology. 2019 Mar 13. pii: 10.1212/WNL.0000000000007279. doi: 10.1212/WNL.0000000000007279. [Epub ahead of print]
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Takousis P, Sadlon A, Schulz J, Wohlers I, Dobricic V, Middleton L, Lill CM, Perneczky R, Bertram L
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Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid.
Alzheimers Dement. 2019 Sep 5. pii: S1552-5260(19)35119-2. doi: 10.1016/j.jalz.2019.06.4952. [Epub ahead of print]
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Tan Y, Sgobio C, Arzberger T, Machleid F, Tang Q, Findeis E, Tost J, Chakroun T, Gao P, Höllerhage M, Bötzel K, Herms J, Höglinger G, Koeglsperger T
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Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease.
Acta Neuropathol. 2019 Nov 25. doi: 10.1007/s00401-019-02099-5. [Epub ahead of print]
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Tanti GK, Srivastava R, Kalluri SR, Nowak C, Hemmer B
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Isolation, Culture and Functional Characterization of Glia and Endothelial Cells From Adult Pig Brain.
Front Cell Neurosci. 2019 Jul 23;13:333. doi: 10.3389/fncel.2019.00333. eCollection 2019.
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Ter Telgte A, Wiegertjes K, Gesierich B, Marques JP, Huebner M, de Klerk JJ, Schreuder FHBM, Araque Caballero MA, Kuijf HJ, Norris DG, Klijn CJM, Dichgans M, Tuladhar AM, Duering M, de Leeuw FE
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The contribution of acute infarcts to cerebral small vessel disease progression.
Ann Neurol. 2019 Jul 24. doi: 10.1002/ana.25556. [Epub ahead of print]
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Thaler FS, Thaller AL, Biljecki M, Schuh E, Winklmeier S, Mahler CF, Gerhards R, Völk S, Schnorfeil F, Subklewe M, Hohlfeld R, Kümpfel T, Meinl E
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Abundant GAD-reactive B cells in GAD-antibody-associated neurological disorders.
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Thrippleton MJ, Backes WH, Sourbron S, Ingrisch M, van Osch MJP, Dichgans M, Fazekas F, Ropele S, Frayne R, van Oostenbrugge RJ, Smith EE, Wardlaw JM
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Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations.
Alzheimers Dement. 2019 Apr 25. pii: S1552-5260(19)30045-7. doi: 10.1016/j.jalz.2019.01.013. [Epub ahead of print]
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Tiedt S, Herzberg M, Küpper C, Feil K, Kellert L, Dorn F, Liebig T, Alegiani A, Dichgans M, Wollenweber FA; GSR Investigators
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Stroke Etiology Modifies the Effect of Endovascular Treatment in Acute Stroke.
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Tilch E, Schormair B, Zhao C, Salminen AV, Antic Nikolic A, Holzknecht E, Högl B, Poewe W, Bachmann CG, Paulus W, Trenkwalder C, Oertel WH, Hornyak M, Fietze I, Berger K, Lichtner P, Gieger C, Peters A, Müller-Myhsok B, Hoischen A, Winkelmann J, Oexle K
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Identification of Restless Legs Syndrome Genes by Mutational Load Analysis.
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Tilstam PV, Soppert J, Hemmers C, Harlacher E, Döring Y, van der Vorst EPC, Schulte C, Alampour-Rajabi S, Theelen W, Asare Y, de Winther MPJ, Lawrence T, Bernhagen J, Schober A, Zernecke A, Jankowski J, Weber C, Noels H
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Timmler S, Simons M
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In Vivo Functional Mapping of a Cortical Column at Single-Neuron Resolution
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Traylor M, Tozer DJ, Croall ID, Lisiecka Ford DM, Olorunda AO, Boncoraglio G, Dichgans M, Lemmens R, Rosand J, Rost NS, Rothwell PM, Sudlow CLM, Thijs V, Rutten-Jacobs L, Markus HS; International Stroke Genetics Consortium
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Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226).
Neurology. 2019 Jan 18. pii: 10.1212/WNL.0000000000006952. doi: 10.1212/WNL.0000000000006952. [Epub ahead of print]
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Traylor M, Anderson CD, Rutten-Jacobs LCA, Falcone GJ, Comeau ME, Ay H, Sudlow CLM, Xu H, Mitchell BD, Cole JW, Rexrode K, Jimenez-Conde J, Schmidt R, Grewal RP, Sacco R, Ribases M, Rundek T, Rosand J, Dichgans M, Lee JM, Langefeld CD, Kittner SJ, Markus HS, Woo D, Malik R; NINDS Stroke Genetics Network (SiGN) and International Stroke Genetics Consortium (ISGC)
(2019)
Subtype Specificity of Genetic Loci Associated With Stroke in 16 664 Cases and 32 792 Controls.
Circ Genom Precis Med. 2019 Jul;12(7):e002338. doi: 10.1161/CIRCGEN.118.002338. Epub 2019 Jul 15.
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Traylor M, Amin Al Olama A, Lyytikäinen LP, Marini S, Chung J, Malik R, Dichgans M, Kähönen M, Lehtimäki T, Anderson CD, Raitakari OT, Markus HS
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Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke.
Hypertension. 2019 Dec 23:HYPERTENSIONAHA11913513. doi: 10.1161/HYPERTENSIONAHA.119.13513. [Epub ahead of print]
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Ukmar-Godec T, Hutten S, Grieshop MP, Rezaei-Ghaleh N, Cima-Omori MS, Biernat J, Mandelkow E, Söding J, Dormann D, Zweckstetter M
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Lysine/RNA-interactions drive and regulate biomolecular condensation.
Nat Commun. 2019 Jul 2;10(1):2909. doi: 10.1038/s41467-019-10792-y.
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van der Ende EL, Meeter LH, Poos JM, Panman JL, Jiskoot LC, Dopper EGP, Papma JM, de Jong FJ, Verberk IMW, Teunissen C, Rizopoulos D, Heller C, Convery RS, Moore KM, Bocchetta M, Neason M, Cash DM, Borroni B, Galimberti D, Sanchez-Valle R, Laforce R Jr, Moreno F, Synofzik M, Graff C, Masellis M, Carmela Tartaglia M, Rowe JB, Vandenberghe R, Finger E, Tagliavini F, de Mendonça A, Santana I, Butler C, Ducharme S, Gerhard A, Danek A, Levin J, Otto M, Frisoni GB, Cappa S, Pijnenburg YAL, Rohrer JD, van Swieten JC; Genetic Frontotemporal dementia Initiative (GENFI)
(2019)
Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study.
Lancet Neurol. 2019 Dec;18(12):1103-1111. doi: 10.1016/S1474-4422(19)30354-0.
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
Acta Neuropathol. 2019 May 27. doi: 10.1007/s00401-019-02026-8. [Epub ahead of print]
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A protein quality control pathway regulated by linear ubiquitination.
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Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.
Exp Eye Res. 2019 Apr 13. pii: S0014-4835(18)30702-4. doi: 10.1016/j.exer.2019.03.024. [Epub ahead of print]
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Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J
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Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.
Brain. 2019 Mar 20. pii: awz050. doi: 10.1093/brain/awz050. [Epub ahead of print]
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Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.
Neurobiol Aging. 2019 Sep 20. pii: S0197-4580(19)30320-3. doi: 10.1016/j.neurobiolaging.2019.08.034. [Epub ahead of print]
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Vollstedt EJ, Kasten M, Klein C; MJFF Global Genetic Parkinson's Disease Study Group (i.a. Winkelmann J
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Using global team science to identify genetic Parkinson's disease worldwide.
Ann Neurol. 2019 Jun 2. doi: 10.1002/ana.25514. [Epub ahead of print]
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Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
J Exp Med. 2019 May 24. pii: jem.20181762. doi: 10.1084/jem.20181762. [Epub ahead of print]
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von Siemens SM, Perneczky R, Vogelmeier CF, Behr J, Kauffmann-Guerrero D, Alter P, Trudzinski FC, Bals R, Grohé C, Söhler S, Waschki B, Lutter JI, Welte T, Jörres RA, Kahnert K; COSYCONET study group
(2019)
The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort.
Respir Res. 2019 Nov 14;20(1):257. doi: 10.1186/s12931-019-1217-5.
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Wagner M, Osborn DPS, Gehweiler I, Nagel M, Ulmer U, Bakhtiari S, Amouri R, Boostani R, Hentati F, Hockley MM, Hölbling B, Schwarzmayr T, Karimiani EG, Kernstock C, Maroofian R, Müller-Felber W, Ozkan E, Padilla-Lopez S, Reich S, Reichbauer J, Darvish H, Shahmohammadibeni N, Tafakhori A, Vill K, Zuchner S, Kruer MC, Winkelmann J, Jamshidi Y, Schüle R
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Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia.
Nat Commun. 2019 Oct 21;10(1):4790. doi: 10.1038/s41467-019-12620-9.
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Wardlaw JM, Smith C, Dichgans M
(2019)
Small vessel disease: mechanisms and clinical implications.
Lancet Neurol. 2019 May 13. pii: S1474-4422(19)30079-1. doi: 10.1016/S1474-4422(19)30079-1. [Epub ahead of print]
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Weaver NA, Zhao L, Biesbroek JM, Kuijf HJ, Aben HP, Bae HJ, Caballero MÁA, Chappell FM, Chen CPLH Dichgans M, Duering M, Georgakis MK, van der Giessen RS, Gyanwali B, Hamilton OKL, Hilal S, Vom Hofe EM, de Kort PLM, Koudstaal PJ, Lam BYK, Lim JS, Makin SDJ, Mok VCT, Shi L, Valdés Hernández MC, Venketasubramanian N, Wardlaw JM, Wollenweber FA, Wong A, Xin X; Meta VCI Map consortium, Biessels GJ
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The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.
Alzheimers Dement (Amst). 2019 Apr 12;11:310-326. doi: 10.1016/j.dadm.2019.02.007. eCollection 2019 Dec.
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Wehnekamp F, Plucińska G, Thong R, Misgeld T, Lamb DC
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Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo.
Elife. 2019 Jun 10;8. pii: e46059. doi: 10.7554/eLife.46059.
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Isolation and Culture of Oligodendrocytes.
Methods Mol Biol. 2019;1936:79-95. doi: 10.1007/978-1-4939-9072-6_5.
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Willacker L, Dowsett J, Dieterich M, Taylor PCJ
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Egocentric processing in the roll plane and dorsal parietal cortex: A TMS-ERP study of the subjective visual vertical.
Neuropsychologia. 2019 Mar 2;127:113-122. doi: 10.1016/j.neuropsychologia.2019.02.023. [Epub ahead of print]
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Winklmeier S, Schlüter M, Spadaro M, Thaler FS, Vural A, Gerhards R, Macrini C, Mader S, Kurne A, Inan B, Karabudak R, Özbay FG, Esendagli G, Hohlfeld R, Kümpfel T, Meinl E
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Identification of circulating MOG-specific B cells in patients with MOG antibodies.
Neurol Neuroimmunol Neuroinflamm. 2019 Oct 14;6(6):625. doi: 10.1212/NXI.0000000000000625. Print 2019 Nov.
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Wirtz TH, Fischer P, Backhaus C, Bergmann I, Brandt EF, Heinrichs D, Koenen MT, Schneider KM, Eggermann T, Kurth I, Stoppe C, Bernhagen J, Bruns T, Fischer J, Berg T, Trautwein C, Berres ML
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Genetic Variants in the Promoter Region of the Macrophage Migration Inhibitory Factor are Associated with the Severity of Hepatitis C Virus-Induced Liver Fibrosis.
Int J Mol Sci. 2019 Jul 31;20(15). pii: E3753. doi: 10.3390/ijms20153753.
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Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis.
Neuron. 2019 Jan 6. pii: S0896-6273(18)31123-1. doi: 10.1016/j.neuron.2018.12.023. [Epub ahead of print]
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Wollenweber FA, Opherk C, Zedde M, Catak C, Malik R, Duering M, Konieczny MJ, Pascarella R, Samões R, Correia M, Martí-Fàbregas J, Linn J, Dichgans M
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Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy.
Neurology. 2019 Jan 23. pii: 10.1212/WNL.0000000000006956. doi: 10.1212/WNL.0000000000006956. [Epub ahead of print]
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Wuschek A, Grahl S, Pongratz V, Korn T, Kirschke J, Zimmer C, Hemmer B, Mühlau M
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CSF Protein Concentration Shows No Correlation With Brain Volume Measures
Front Neurol. 2019 May 3;10:463. doi: 10.3389/fneur.2019.00463. eCollection 2019.
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Yates SC, Groeneboom NE, Coello C, Lichtenthaler SF, Kuhn PH, Demuth HU, Hartlage-Rübsamen M, Roßner S, Leergaard T, Kreshuk A, Puchades MA, Bjaalie JG
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QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain.
Front Neuroinform. 2019 Dec 3;13:75. doi: 10.3389/fninf.2019.00075. eCollection 2019.
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Yilmaz R, Müller K, Brenner D, Volk AE, Borck G, Hermann A, Meitinger T, Strom TM, Danzer KM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS Network MND-NET
(2019)
SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden.
Neurobiol Aging. 2019 Nov 2. pii: S0197-4580(19)30382-3. doi: 10.1016/j.neurobiolaging.2019.10.018. [Epub ahead of print]
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A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.
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Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy
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Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms
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COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls
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Trenkwalder C, Winkelmann J, Oertel W, Virgin G, Roubert B, Mezzacasa A; FCM-RLS Study Investigators
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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
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White LO, Ising M, von Klitzing K, Sierau S, Michel A, Klein AM, Müller-Myhsok B, Uhr M, Crowley MJ, Kirschbaum C, Stalder T
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Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.
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Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D
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Nat Commun. 2017 Jul 24;8(1):155. doi: 10.1038/s41467-017-00178-3.
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Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke
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Analysis of Locomotor Behavior in the German Mouse Clinic
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In Vivo Imaging of Glial Activation after Unilateral Labyrinthectomy in the Rat: A [18F]GE180-PET Study.
Front Neurol. 2017 Dec 11;8:665. doi: 10.3389/fneur.2017.00665. eCollection 2017.
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