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Hemorrhagic lesion with detection of infected endothelial cells in human bornavirus encephalitis

Acta Neuropathol. 2022 Jun 3:1–3. doi: 10.1007/s00401-022-02442-3. Epub ahead of print. PMID: 35657496; PMCID: PMC9164175.

Authors/Editors: Liesche-Starnecker F, Schifferer M, , Schlegel J, Vollmuth Y, Rubbenstroth D, Delbridge C, Gempt J, Lorenzl S, Schnurbus L, Misgeld T, , Rosati M, Beer M, Matiasek K, Wunderlich S, Finck T.
Publication Date: 2022


Even though the number of confirmed cases of bornavirus
encephalitis (BE) rises constantly, the epidemiological risk
of this fatal disease is still underrecognized. Human infec-
tion with Borna disease virus 1 (BoDV-1) was first proven
in 2018 [3, 6] and the neuropathology of BE described in a
systematic analysis of autopsies briefly thereafter [4].
Herein, we report on a BE patient exhibiting brain hemor-
rhage that was detected in magnet resonance imaging (MRI)
and confirmed by histopathology post mortem. Moreover,
we demonstrate that encephalic vessels can be infected by


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