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Immunity in Stroke: The Next Frontier

Thromb Haemost. 2022 Jun 10. doi: 10.1055/s-0042-1748890. Epub ahead of print. PMID: 35688450.

Authors/Editors: Li T, Liesz A,
Publication Date: 2022

Abstract

Translational stroke research has long been focusing on neuroprotective strategies to
prevent secondary tissue injury and promote recovery after acute ischemic brain injury.
The inflammatory response to stroke has more recently emerged as a key pathophysi-
ological pathway contributing to stroke outcome. It is now accepted that the
inflammatory response is functionally involved in all phases of the ischemic stroke
pathophysiology. The immune response is therefore considered a breakthrough target
for ischemic stroke treatment. On one side, stroke induces a local neuroinflammatory
response, in which the inflammatory activation of glial, endothelial and brain-invading
cells contributes to lesion progression after stroke. On the other side, ischemic brain
injury perturbs systemic immune homeostasis and results in long-lasting changes of
systemic immunity. Here, we briefly summarize current concepts in local neuro-
inflammation and the systemic immune responses after stroke, and highlight two
promising therapeutic strategies for poststroke inflammation.

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