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Only solid waste, please!

Mol Cell. 2022 Apr 21;82(8):1408-1410. doi: 10.1016/j.molcel.2022.04.003. PMID: 35452612.

Authors/Editors: Dormann D, Behrends C.
Publication Date: 2022


Transfer between cells is an unexpected addition to the mitochondrial life cycle. In this issue of Neuron, Van der Vlist et al. now provide evidence that M2-macrophages infiltrating sensory ganglia resolve pain by transferring particles containing mitochondria to neurons—tTo elucidate the mechanism driving selective autophagy of protein aggregates, or “aggrephagy,” Ma et al. (2022) identify chaperonin TRiC subunit CCT2 as a receptor that specifically promotes the clearance of solid aggregates, but not liquid-like condensates, in a ubiquitin-independent manner.hus boosting nociceptors back to normal function.

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