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Reparative inflammation in multiple sclerosis

Semin Immunol. 2022 Jun 21:101630. doi: 10.1016/j.smim.2022.101630. Epub ahead of print. PMID: 35750551.

Authors/Editors: Cantuti-Castelvetri L, Gokce O, Simons M,
Publication Date: 2022

Abstract 

Multiple sclerosis is a chronic inflammatory disease, in which repeated episodes of acute auto-inflammatory attacks trigger demye- linating injury in the central nervous system. Whereas our understand- ing of the disease-causing immune activation is constantly increasing, much less is known about the injury-induced reparative innate immune responses. Here, we discuss the essential function of microglia and monocyte-derived macrophages in orchestrating debris clearance and regeneration. Dampening reparative inflammation can result in insuf- ficient clearance and, thus, to persisting damage, with the consequences of prolonged inflammation. Thus, an understanding of the entire spec- trum of inflammatory responses is essential for the prevention of injury- inducing and the stimulation of repair promoting functions of the immune system.

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