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Cytokine aerobics: Oxidation controls cytokine dynamics and function.

Structure. 2022 Jun 2;30(6):787-790. doi: 10.1016/j.str.2022.05.005. PMID: 35660241

Authors/Editors: Brandhofer M, Bernhagen J,
Publication Date: 2022

Abstract

In this issue of Structure, Skeens et al. provide insights into the structure and dynamics of an oxidized form of the atypical cytokine macrophage migration-inhibitory factor (MIF). The study unveils a surprising conformational susceptibility of MIF to ambient redox alterations and identifies redox-sensitive residues and latent allostery sites with functional relevance.

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