Cytokine aerobics: Oxidation controls cytokine dynamics and function.
Structure. 2022 Jun 2;30(6):787-790. doi: 10.1016/j.str.2022.05.005. PMID: 35660241
| Authors/Editors: | Brandhofer M, Bernhagen J, |
|---|---|
| Publication Date: | 2022 |
Abstract
In this issue of Structure, Skeens et al. provide insights into the structure and dynamics of an oxidized form of the atypical cytokine macrophage migration-inhibitory factor (MIF). The study unveils a surprising conformational susceptibility of MIF to ambient redox alterations and identifies redox-sensitive residues and latent allostery sites with functional relevance.
