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Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination.

Front Neurol. 2022 Feb 2;12:820049. doi: 10.3389/fneur.2021.820049. PMID: 35185757; PMCID: PMC8847228.

Authors/Editors: Ancau M, Liesche-Starnecker F, Niederschweiberer J, Krieg SM, Zimmer C, Lingg C, Kumpfmüller D, Ikenberg B, Ploner M, Hemmer B, Wunderlich S, Mühlau M, Knier B.
Publication Date: 2022


We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.


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