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Transcriptome signature of miRNA-26b KO mouse model suggests novel targets.

BMC Genom Data. 2021 Jun 30;22(1):23. doi: 10.1186/s12863-021-00976-1. PMID: 34193044; PMCID: PMC8243710.

Authors/Editors: van der Vorst EPC, Pepe MAA, Peters LJF, Haberbosch M, Jansen Y, Nauman R, Stathopoulos GT, Weber C, Bidzhekov K.
Publication Date: 2021

Abstract

MicroRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. One of the miRNAs that has been shown to play a role in various pathologies like cancer, neurological disorders and cardiovascular diseases is miRNA-26b. However, these studies only demonstrated rather ambiguous associations without revealing a causal relationship. Therefore, the aim of this study is to establish and validate a mouse model which enables the elucidation of the exact role of miRNA-26b in various pathologies.

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