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Role of the immune system for conditioning in cerebrovascular diseases.

Cond Med. 2021 Feb;4(1):1-2. PMID: 34095776; PMCID: PMC8177088.

Authors/Editors: Stowe AM, Bernhagen J.
Publication Date: 2021

Abstract

The philosopher Friedrich Nietzsche wrote “what doesn’t kill me, makes me stronger” (Wohns 2020), a fact that is hard for any of us to ignore at work, with trauma, or following an illness. How many times in life has a new reality been reached – achieved through struggle and stress and previously difficult to imagine but nonetheless manageable. This adaptation to stress underlies the concept of conditioning, and specifically the studies by which resistance phenotypes can be achieved in cells, organs, tissues, or organisms. Thus, conditioning is integral to life- it is the response to stress and the subsequent change by an organism that drives adaptation and resilience. Often overlooked in the concept of conditioning are the pleiotropic effects of responses within an organism. Effects from a single systemic conditioning stimulus can induce changes to multiple organ systems and/or confer resilience to many types of injury or disease.

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