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Genetics, Genomics, and Precision Medicine.

Stroke. 2021 Sep 2:STROKEAHA121033966. doi: 10.1161/STROKEAHA.121.033966. Epub ahead of print. PMID: 34470485.

Authors/Editors: Meschia JF, Dichgans M.
Publication Date: 2021

Abstract

Ever more refined and statistically powerful genomewide association studies continue to advance our understanding of the relationship between genetic variations and stroke risk. A study involving >7000 patients with Mendelian randomization (MR)-confirmed lacunar stroke found 5 loci that were associated with the lacunar stroke phenotype and an additional 7 associated loci in a multi-trait analysis including cerebral white matter hyperintensities (WMH).1 Two loci contained genes causing monogenic disorders (COL42A and HTRA1).

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