Content
2021
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Abudu YP, Shrestha BK, Zhang W, Palara A, Brenne HB, Larsen KB, Wolfson DL, Dumitriu G, Øie CI, Ahluwalia BS, Levy G, Behrends C, Tooze SA, Mouilleron S, Lamark T, Johansen T
(2021)
SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components.
J Cell Biol. 2021 Aug 2;220(8):e202009092. doi: 10.1083/jcb.202009092. Epub 2021 May 26. PMID: 34037656.
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Alexopoulos P, Papanastasiou AD, Εconomou P, Beis P, Niforas M, Dassios TG, Kormpaki A, Zarkadis IK, Reichel M, Kornhuber J Perneczky R, Gourzis P
(2021)
Associations between APOE-, COMT Val108/158Met- and BDNF Val66Met polymorphisms and variations in depressive and anxiety symptoms, sense of coherence and vital exhaustion in the real-life setting of mandatory basic military training
J Neural Transm (Vienna). 2021 Jan 4. doi: 10.1007/s00702-020-02280-1. Epub ahead of print. PMID: 33394176.
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Alexopoulos P, Frounta M, Perneczky R
(2021)
The multidimensional beneficial effect of physical exercise on symptoms of neurocognitive disorder.
Int Psychogeriatr. 2021 May 14:1-4. doi: 10.1017/S1041610221000703. Epub ahead of print. PMID: 33985612.
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Aly L, Strauß EM, Feucht N, Weiß I, Berthele A, Mitsdoerffer M, Haass C, Hemmer B, Maier M, Korn T, Knier B
(2021)
Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders.
Mult Scler. 2021 Jul 14:13524585211028831. doi: 10.1177/13524585211028831. Epub ahead of print. PMID: 34259579.
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Arduino DM, Goh V, Mokranjac D, Perocchi F
(2021)
Drug Discovery Assay to Identify Modulators of the Mitochondrial Ca2+ Uniporter.
Methods Mol Biol. 2021;2277:69-89. doi: 10.1007/978-1-0716-1270-5_5. PMID: 34080145.
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Aschenbrenner AJ, Baksh RA, Benejam B, Beresford-Webb JA, Coppus A, Fortea J, Handen BL, Hartley S, Head E, Jaeger J, Levin J, Loosli SV, Rebillat AS, Sacco S, Schmitt FA, Thurlow KE, Zaman S, Hassenstab J, Strydom A
(2021)
Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease.
Alzheimers Dement (Amst). 2021 May 2;13(1):e12184. doi: 10.1002/dad2.12184. PMID: 33969175; PMCID: PMC8088591.
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Aswendt M, Green C, Sadler R, Llovera G, Dzikowski L, Heindl S, Gomez de Agüero M, Diedenhofen M, Vogel S, Wieters F, Wiedermann D, Liesz A, Hoehn M
(2021)
The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia.
iScience. 2021 Sep 9;24(10):103095. doi: 10.1016/j.isci.2021.103095. PMID: 34622150; PMCID: PMC8479691.
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Auffenberg E, Hedrich UB, Barbieri R, Miely D, Groschup B, Wuttke TV, Vogel N, Lührs P, Zanardi I, Bertelli S, Spielmann N, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Pusch M, Dichgans M, Lerche H, Gavazzo P, Plesnila N, Freilinger T
(2021)
Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.
J Clin Invest. 2021 Sep 21:e142202. doi: 10.1172/JCI142202. Epub ahead of print. PMID: 34546973.
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Baade I, Hutten S, Sternburg EL, Pörschke M, Hofweber M, Dormann D, Kehlenbach RH
(2021)
The RNA-binding protein FUS is chaperoned and imported into the nucleus by a network of import receptors.
J Biol Chem. 2021 Apr 12:100659. doi: 10.1016/j.jbc.2021.100659. Epub ahead of print. PMID: 33857479.
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Baier B, Cuvenhaus H, Müller N, Birklein F, Dieterich M
(2021)
Vestibular compensation of otolith graviceptive dysfunction in stroke patients.
Eur J Neurol. 2021 Nov 22. doi: 10.1111/ene.15193. Epub ahead of print. PMID: 34808013.
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Ballarini T, Melo van Lent D, Brunner J, Schröder A, Wolfsgruber S, Altenstein S, Brosseron F, Buerger K, Dechent P, Dobisch L, Duzel E, Ertl-Wagner B, Fliessbach K, Freiesleben SD, Frommann I, Glanz W, Hauser D, Haynes JD, Heneka MT, Janowitz D, Kilimann I, Laske C, Maier F, Metzger CD, Munk M, Perneczky R, Peters O, Priller J, Ramirez A, Rauchmann B, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Vukovich R, Wiltfang J, Jessen F, Wagner M; DELCODE study group
(2021)
Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age.
Neurology. 2021 May 5:10.1212/WNL.0000000000012067. doi: 10.1212/WNL.0000000000012067. Epub ahead of print. PMID: 33952652.
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Benussi A, Premi E, Gazzina S, Brattini C, Bonomi E, Alberici A, Jiskoot L, van Swieten JC, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Masellis M, Tartaglia C, Rowe JB, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Frisoni G, Ghidoni R, Sorbi S, Le Ber I, Pasquier F, Peakman G, Todd E, Bocchetta M, Rohrer JD, Borroni B; Genetic FTD Initiative (GENFI)
(2021)
Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia.
JAMA Netw Open. 2021 Jan 4;4(1):e2030194. doi: 10.1001/jamanetworkopen.2020.30194. PMID: 33404617.
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Bernhagen J
(2021)
A new cytokine target for chronic obstructive pulmonary disease?
EBioMedicine. 2021 Jul 9;69:103479. doi: 10.1016/j.ebiom.2021.103479. Epub ahead of print. PMID: 34252695.
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Biagosch CA, Vidali S, Faerberboeck M, Hensler SV, Becker L, Amarie OV, Aguilar-Pimentel A, Garrett L, Klein-Rodewald T, Rathkolb B, Zanuttigh E, Calzada-Wack J, da Silva-Buttkus P, Rozman J, Treise I, Fuchs H, Gailus-Durner V, de Angelis MH, Janik D, Wurst W. Mayr JA, Klopstock T. eitinger T, Prokisch H, Iuso A
(2021)
A comprehensive phenotypic characterization of a whole-body Wdr45 knock-out mouse.
Mamm Genome. 2021 May 27. doi: 10.1007/s00335-021-09875-3. Epub ahead of print. PMID: 34043061.
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Biechele G, Sebastian Monasor L, Wind K, Blume T, Parhizkar S, Arzberger T, Sacher C, Beyer L, Eckenweber F, Gildehaus FJ, von Ungern-Sternberg B, Willem M, Bartenstein P, Cumming P, Rominger A, Herms J, Lichtenthaler S, Haass C, Tahirovic S, Brendel M
(2021)
Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease.
J Nucl Med. 2021 May 20:jnumed.120.261858. doi: 10.2967/jnumed.120.261858. Epub ahead of print. PMID: 34016733.
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Biechele G, Blume T, Deussing M, Zott B, Shi Y, Xiang X, Franzmeier N, Kleinberger G, Peters F, Ochs K, Focke C, Sacher C, Wind K, Schmidt C, Lindner S, Gildehaus FJ, Eckenweber F, Beyer L, von Ungern-Sternberg B, Bartenstein P, Baumann K, Dorostkar MM, Rominger A, Cumming P, Willem M, Adelsberger H, Herms J, Brendel M
(2021)
Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.
Theranostics. 2021 Aug 19;11(18):8964-8976. doi: 10.7150/thno.64022. PMID: 34522221; PMCID: PMC8419052.
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Biel D, Brendel M, Rubinski A, Buerger K, Janowitz D, Dichgans M, Franzmeier N; Alzheimer’s Disease Neuroimaging Initiative (ADNI)
(2021)
Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals.
Alzheimers Res Ther. 2021 Aug 12;13(1):137. doi: 10.1186/s13195-021-00880-x. PMID: 34384484; PMCID: PMC8361801.
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Biousse V, Newman NJ, Yu-Wai-Man P, Carelli V, Moster ML, Vignal-Clermont C, Klopstock T, Sadun AA, Sergott RC, Hage R, Esposti S, La Morgia C, Priglinger C, Karanja R, Blouin L, Taiel M, Sahel JA
(2021)
Long-Term Follow-Up After Unilateral Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy
The RESTORE Study. J Neuroophthalmol. 2021 Sep 1;41(3):309-315. doi: 10.1097/WNO.0000000000001367. PMID: 34415265; PMCID: PMC8366761.
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Bischof H, Burgstaller S, Springer A, Matt L, Rauter T, Bachkönig OA, Schmidt T, Groschner K, Schindl R, Madl T, Plesnila N, Lukowski R, Graier WF, Malli R
(2021)
Potassium ions promote hexokinase-II dependent glycolysis.
iScience. 2021 Mar 22;24(4):102346. doi: 10.1016/j.isci.2021.102346. PMID: 33870140; PMCID: PMC8047173.
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Bleilevens C, Soppert J, Hoffmann A, Breuer T, Bernhagen J, Martin L, Stiehler L, Marx G, Dreher M, Stoppe C, Simon TP
(2021)
Macrophage Migration Inhibitory Factor (MIF) Plasma Concentration in Critically Ill COVID-19 Patients: A Prospective Observational Study.
Diagnostics (Basel). 2021 Feb 17;11(2):332. doi: 10.3390/diagnostics11020332. PMID: 33671433; PMCID: PMC7922575.
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Blumenstock S, Sun F, Klaus C, Marinković P, Sgobio C, Paeger L, Liebscher S, Herms J
(2021)
Cortical circuit dysfunction in a mouse model of alpha-synucleinopathy in vivo.
Brain Commun. 2021 Nov 15;3(4):fcab273. doi: 10.1093/braincomms/fcab273. PMID: 34877534; PMCID: PMC8643497.
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Bocchetta M, Todd EG, Peakman G, Cash DM, Convery RS, Russell LL, Thomas DL, Iglesias JE, van Swieten JC, Jiskoot LC, Seelaar H, Borroni B, Galimberti D, Sanchez-Valle R, Laforce R Jr, Moreno F, Synofzik M, Graff C, Masellis M, Tartaglia MC, Rowe JB, Vandenberghe R, Finger E, Tagliavini F, de Mendonça A, Santana I, Butler CR, Ducharme S, Gerhard A, Danek A, Levin J, Otto M, Sorbi S, Le Ber I, Pasquier F, Rohrer JD; Genetic Frontotemporal dementia Initiative (GENFI).
(2021)
Differential early subcortical involvement in genetic FTD within the GENFI cohort.
Neuroimage Clin. 2021 Mar 29;30:102646. doi: 10.1016/j.nicl.2021.102646. Epub ahead of print. PMID: 33895632.
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Boeckh-Behrens T, Golkowski D, Ikenberg B, Schlegel J, Protzer U, Schulz C, Novotny J, Kreiser K, Zimmer C, Hemmer B, Wunderlich S
(2021)
COVID-19-associated Large Vessel Stroke in a 28-year-old Patient : NETs and Platelets Possible Key Players in Acute Thrombus Formation.
Clin Neuroradiol. 2021 Jan 29:1–4. doi: 10.1007/s00062-020-00992-1. Epub ahead of print. PMID: 33512534; PMCID: PMC7844783.
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Boegle R, Gerb J, Kierig E, Becker-Bense S, Ertl-Wagner B, Dieterich M, Kirsch V
(2021)
Intravenous Delayed Gadolinium-Enhanced MR Imaging of the Endolymphatic Space: A Methodological Comparative Study.
Front Neurol. 2021 Apr 22;12:647296. doi: 10.3389/fneur.2021.647296. PMID: 33967941; PMCID: PMC8100585.
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Boehmer DFR, Formisano S, de Oliveira Mann CC, Mueller SA, Kluge M, Metzger P, Rohlfs M, Hörth C, Kocheise L, Lichtenthaler SF Hopfner KP, Endres S, Rothenfusser S, Friedel CC, Duewell P, Schnurr M, Koenig LM
(2021)
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
Sci Immunol. 2021 Jul 16;6(61):eabe2550. doi: 10.1126/sciimmunol.abe2550. PMID: 34272227.
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Boltze J, Aronowski JA, Badaut J, Buckwalter MS, Caleo M, Chopp M, Dave KR, Didwischus N, Dijkhuizen RM, Doeppner TR, Dreier JP, Fouad K, Gelderblom M, Gertz K, Golubczyk D, Gregson BA, Hamel E, Hanley DF, Härtig W, Hummel FC, Ikhsan M, Janowski M, Jolkkonen J, Karuppagounder SS, Keep RF, Koerte IK, Kokaia Z, Li P, Liu F, Lizasoain I, Ludewig P, Metz GAS, Montagne A, Obenaus A, Palumbo A, Pearl M, Perez-Pinzon M, Planas AM, Plesnila N, Raval AP, Rueger MA, Sansing LH, Sohrabji F, Stagg CJ, Stetler RA, Stowe AM, Sun D, Taguchi A, Tanter M, Vay SU, Vemuganti R, Vivien D, Walczak P, Wang J, Xiong Y, Zille M
(2021)
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases.
Front Aging Neurosci. 2021 Jan 28;13:623751. doi: 10.3389/fnagi.2021.623751. PMID: 33584250; PMCID: PMC7876251.
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Bonfiglio CA, Weber C, Atzler D, Lutgens E
(2021)
Immunotherapy and cardiovascular diseases (CVD): novel avenues for immunotherapeutic approaches.
QJM. 2021 Jul 22:hcab207. doi: 10.1093/qjmed/hcab207. Epub ahead of print. PMID: 34293177.
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Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, Simons M
(2021)
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination.
Nat Metab. 2021 Feb;3(2):211-227. doi: 10.1038/s42255-021-00341-7. Epub 2021 Feb 18. PMID: 33619376.
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Bosmans LA, Shami A, Atzler D, Weber C, Gonçalves I, Lutgens E
(2021)
Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.
Vascul Pharmacol. 2021 Jun 5:106884. doi: 10.1016/j.vph.2021.106884. Epub ahead of print. PMID: 34102305.
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Brand RM, Friedrich V, Diddens J, Pfaller M, Romana de Franchis F, Radbruch H, Hemmer B, Steiger K, Lehmann-Horn K
(2021)
Anti-CD20 Depletes Meningeal B Cells but Does Not Halt the Formation of Meningeal Ectopic Lymphoid Tissue.
Neurol Neuroimmunol Neuroinflamm. 2021 May 21;8(4):e1012. doi: 10.1212/NXI.0000000000001012. PMID: 34021057; PMCID: PMC8143698.
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Brand RM, Diddens J, Friedrich V, Pfaller M, Radbruch H Hemmer B, Steiger K, Lehmann-Horn K
(2021)
Siponimod Inhibits the Formation of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis.
Neurol Neuroimmunol Neuroinflamm. 2021 Dec 15;9(1):e1117. doi: 10.1212/NXI.0000000000001117. PMID: 34911793; PMCID: PMC8674936.PMC8172942.
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Brandes RP, Dueck A, Engelhardt S, Kaulich M, Kupatt C, De Angelis MT, Leisegang MS, le Noble F, Moretti A, Müller OJ, Skryabin BV, Thum T, Wurst W
(2021)
DGK and DZHK position paper on genome editing: basic science applications and future perspective
Basic Res Cardiol. 2021 Jan 15;116(1):2. doi: 10.1007/s00395-020-00839-3. PMID: 33449167.
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Brändle SM, Cerina M, Weber S, Held K, Menke AF, Alcalá C, Gebert D, Herrmann AM, Pellkofer H, Gerdes LA, Bittner S, Leypoldt F, Teegen B, Komorowski L, Kümpfel T, Hohlfeld R, Meuth SG, Casanova B, Melzer N, Beltrán E, Dornmair K
(2021)
Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABAA receptor encephalitis.
Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e1916337118. doi: 10.1073/pnas.1916337118. PMID: 33619082.
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Brosseron F, Maass A, Kleineidam L, Ravichandran KA, González PG, McManus RM, Ising C, Santarelli F, Kolbe CC, Häsler LM, Wolfsgruber S, Marquié M, Boada M, Orellana A, de Rojas I, Röske S, Peters O, Cosma NC, Cetindag A, Wang X, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Schott BH, Bürger K, Janowitz D, Dichgans M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Göerß D, Laske C, Munk MH, Düzel E, Yakupov R, Dobisch L, Metzger CD, Glanz W, Ewers M, Dechent P, Haynes JD, Scheffler K, Roy N, Rostamzadeh A, Teunissen CE, Marchant NL, Spottke A, Jucker M, Latz E, Wagner M, Mengel D, Synofzik M, Jessen F, Ramirez A, Ruiz A, Heneka MT; DELCODE study group
(2021)
Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer’s disease
Neuron. 2021 Dec 31:S0896-6273(21)01033-3. doi: 10.1016/j.neuron.2021.12.016. Epub ahead of print. PMID: 34995486.
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Brunet T, Jech R, Brugger M, Kovacs R, Alhaddad B, Leszinski G, Riedhammer KM, Westphal DS, Mahle I, Mayerhanser K, Skorvanek M, Weber S, Graf E, Berutti R, Necpál J, Havránková P, Pavelekova P, Hempel M, Weber S, Graf E, Berutti R, Necpál J, Havránková P, Pavelekova P, Hempel M, Kotzaeridou U, Hoffmann GF, Leiz S, Makowski C, Roser T, Schroeder SA, Steinfeld R, Strobl-Wildemann G, Hoefele J, Borggraefe I, Distelmaier F, Strom TM, Winkelmann J, Meitinger T, Zech M, Wagner M
(2021)
De novo variants in neurodevelopmental disorders-experiences from a tertiary care center.
Clin Genet. 2021 Feb 22. doi: 10.1111/cge.13946. Epub ahead of print. PMID: 33619735.
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Buckles VD, Xiong C, Bateman RJ, Hassenstab J, Allegri R, Berman SB, Chhatwal JP, Danek A, Fagan AM, Ghetti B, Goate A, Graff-Radford N, Jucker M, Levin J, Marcus DS, Masters CL, McCue L, McDade E, Mori H, Moulder KL, Noble JM, Paumier K, Preische O, Ringman JM, Fox NC, Salloway S, Schofield PR, Martins R, Vöglein J, Morris JC; Dominantly Inherited Alzheimer's Network
(2021)
Different rates of cognitive decline in autosomal dominant and late-onset Alzheimer disease.
Alzheimers Dement. 2021 Dec 2. doi: 10.1002/alz.12505. Epub ahead of print. PMID: 34854530.
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Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D
(2021)
Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models.
JCI Insight. 2021 Oct 8;6(19):e148649. doi: 10.1172/jci.insight.148649. PMID: 34622801.
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Burgess S, Malik R, Liu B, Mason AM, Georgakis MK, Dichgans M, Gill D
(2021)
Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.
Diabetologia. 2021 Jan 26. doi: 10.1007/s00125-020-05377-0. Epub ahead of print. PMID: 33495845.
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Burgstaller S, Bischof H, Rauter T, Schmidt T, Schindl R, Patz S, Groschup B, Filser S, van den Boom L, Sasse P, Lukowski R, Plesnila N, Graier WF, Malli R
(2021)
Immobilization of Recombinant Fluorescent Biosensors Permits Imaging of Extracellular Ion Signals.
ACS Sens. 2021 Nov 9. doi: 10.1021/acssensors.1c01369. Epub ahead of print. PMID: 34752056.
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Bussas M, Grahl S, Pongratz V, Berthele A, Gasperi C, Andlauer T, Gaser C, Kirschke JS, Wiestler B, Zimmer C, Hemmer B, Mühlau M
(2021)
Gray matter atrophy in relapsing-remitting multiple sclerosis is associated with white matter lesions in connecting fibers.
Mult Scler. 2021 Sep 30:13524585211044957. doi: 10.1177/13524585211044957. Epub ahead of print. PMID: 34591698.
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Calsolaro V, Matthews PM, Donat CK, Livingston NR, Femminella GD, Guedes SS, Myers J, Fan Z, Tyacke RJ, Venkataraman AV, Perneczky R, Gunn R, Rabiner EA, Gentleman S, Parker CA, Murphy PS, Wren PB, Hinz R, Sastre M, Nutt DJ, Edison P
(2021)
Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load.
Mol Psychiatry. 2021 Jul 15. doi: 10.1038/s41380-021-01193-z. Epub ahead of print. PMID: 34267329.
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Carinci M, Testa B, Bordi M, Milletti G, Bonora M, Antonucci L, Ferraina C, Carro M, Kumar M, Ceglie D, Eck F, Nardacci R, le Guerroué F, Petrini S, Soriano ME, Caruana I, Doria V, Manifava M, Peron C, Lambrughi M, Tiranti V, Behrends C, Papaleo E, Pinton P, Giorgi C, Ktistakis NT, Locatelli F, Nazio F, Cecconi F
(2021)
TFG binds LC3C to regulate ULK1 localization and autophagosome formation.
EMBO J. 2021 May 1:e103563. doi: 10.15252/embj.2019103563. Epub ahead of print. PMID: 33932238.
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Carmona-Iragui M, Alcolea D, Barroeta I, Videla L, Muñoz L, Van Pelt KL, Schmitt FA, Lightner DD, Koehl LM, Jicha G, Sacco S, Mircher C, Pape SE, Hithersay R, Clare ICH, Holland AJ, Nübling G, Levin J, Zaman SH, Strydom A, Rebillat AS, Head E, Blesa R, Lleó A, Fortea J
(2021)
Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study
Lancet Neurol. 2021 Aug;20(8):605-614. doi: 10.1016/S1474-4422(21)00129-0. PMID: 34302785.
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Carreca AP, Pravatà VM, D'Apolito D, Bonelli S, Calligaris M, Monaca E, Müller SA, Lichtenthaler SF. Scilabra SD
(2021)
Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates.
Int J Mol Sci. 2021 Feb 27;22(5):2392. doi: 10.3390/ijms22052392. PMID: 33673623.
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Cathiard L, Fraulob V, Lam DD, Torres M, Winkelmann J, Krężel W
(2021)
Investigation of dopaminergic signalling in Meis homeobox 1 (Meis1) deficient mice as an animal model of restless legs syndrome.
J Sleep Res. 2021 May 18:e13311. doi: 10.1111/jsr.13311. Epub ahead of print. PMID: 34008292.
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Chen S, Mao X, Lin X, Wehn A, Hu S, Mamrak U, Khalin I, Wostrack M, Ringel F, Plesnila N, Terpolilli NA
(2021)
Acid-ion sensing channel 1a deletion reduces chronic brain damage and neurological deficits after experimental traumatic brain injury.
J Neurotrauma. 2021 Mar 27. doi: 10.1089/neu.2020.7568. Epub ahead of print. PMID: 33779289.
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Chen Y, Kassam I, Lau SH, Kooner JS, Wilson R, Peters A, Winkelmann J, Chambers JC, Chow VT, Khor CC, van Dam RM, Teo YY, Loh M, Sim X
(2021)
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals.
Clin Epigenetics. 2021 Oct 20;13(1):195. doi: 10.1186/s13148-021-01162-x. PMID: 34670603; PMCID: PMC8527674.
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Chovsepian A, Berchtold D, Winek K, Mamrak U, Ramírez Álvarez I, Dening Y, Golubczyk D, Weitbrecht L, Dames C, Aillery M, Fernandez-Sanz C, Gajewski Z, Dieterich M, Janowski M, Falkai P, Walczak P, Plesnila N, Meisel A, Pan-Montojo F
(2021)
A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium-Mediated Excitotoxicity.
Adv Sci (Weinh). 2021 Dec 14:e2103265. doi: 10.1002/advs.202103265. Epub ahead of print. PMID: 34904402.
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Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B Rothhammer V
(2021)
The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm. 2021 Jul 23;8(5):e1043. doi: 10.1212/NXI.0000000000001043. PMID: 34301821; PMCID: PMC8312279.
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Claudi F, Tyson AL, Petrucco L, Margrie TW, Portugues R, Branco T
(2021)
Visualizing anatomically registered data with Brainrender.
Elife. 2021 Mar 19;10:e65751. doi: 10.7554/eLife.65751. Epub ahead of print. PMID: 33739286.
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Colombo A, Dinkel L, Müller SA, Sebastian Monasor L, Schifferer M, Cantuti-Castelvetri L, König J, Vidatic L, Bremova-Ertl T, Lieberman AP, Hecimovic S, Simons M, Lichtenthaler SF, Strupp M, Schneider SA, Tahirovic S
(2021)
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.
Nat Commun. 2021 Feb 24;12(1):1158. doi: 10.1038/s41467-021-21428-5. PMID: 33627648.
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Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, Benakis C, Dichgans M, Steiner H, Giera M, Haass C, Tahirovic S, Liesz A
(2021)
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition.
Elife. 2021 Apr 13;10:e59826. doi: 10.7554/eLife.59826. PMID: 33845942.
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Conrad J, Habs M, Ruehl M, Boegle R, Ertl M, Kirsch V, Eren O, Becker-Bense S, Stephan T, Wollenweber F, Duering M, Dieterich M, Eulenburg PZ
(2021)
Structural reorganization of the cerebral cortex after vestibulo-cerebellar stroke.
Neuroimage Clin. 2021 Feb 23;30:102603. doi: 10.1016/j.nicl.2021.102603. Epub ahead of print. PMID: 33676164; PMCID: PMC7933782.
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Cordts I, Hecker JS, Gauck D, Park J, Härtl J, Günthner R, Hammitzsch A, Schoser B, Abeck D, Götze KS, Haack TB, Deschauer M, Moog P, Hemmer B
(2021)
Successful treatment with azacitidine in VEXAS syndrome with prominent myofasciitis.
Rheumatology (Oxford). 2021 Dec 11:keab866. doi: 10.1093/rheumatology/keab866. Epub ahead of print. PMID: 34894213.
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Cousin MA, Creighton BA, Breau KA, Spillmann RC, Torti E, Dontu S, Tripathi S, Ajit D, Edwards RJ, Afriyie S, Bay JC, Harper KM, Beltran AA, Munoz LJ, Falcon Rodriguez L, Stankewich MC, Person RE, Si Y, Normand EA, Blevins A, May AS, Bier L, Aggarwal V, Mancini GMS, van Slegtenhorst MA, Cremer K, Becker J, Engels H, Aretz S, MacKenzie JJ, Brilstra E, van Gassen KLI, van Jaarsveld RH, Oegema R, Parsons GM, Mark P, Helbig I, McKeown SE, Stratton R, Cogne B, Isidor B, Cacheiro P, Smedley D, Firth HV, Bierhals T, Kloth K, Weiss D, Fairley C, Shieh JT, Kritzer A, Jayakar P, Kurtz-Nelson E, Bernier RA, Wang T, Eichler EE, van de Laar IMBH, McConkie-Rosell A, McDonald MT, Kemppainen J, Lanpher BC, Schultz-Rogers LE, Gunderson LB, Pichurin PN, Yoon G, Zech M, Jech R, Winkelmann J ; Undiagnosed Diseases Network; Genomics England Research Consortium, Beltran AS, Zimmermann MT, Temple B, Moy SS, Klee EW, Tan QK, Lorenzo DN
(2021)
athogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome.
Nat Genet. 2021 Jul 1. doi: 10.1038/s41588-021-00886-z. Epub ahead of print. PMID: 34211179.
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Dangond F, Donnelly A, Hohlfeld R, Gourzis PLubetzki C, Kohlhaas S, Leocani L, Ciccarelli O, Stankoff B, Sormani MP, Chataway J, Bozzoli F, Cucca F, Melton L, Coetzee T, Salvetti M
(2021)
Facing the urgency of therapies for progressive MS - a Progressive MS Alliance proposal.
Nat Rev Neurol. 2021 Jan 22. doi: 10.1038/s41582-020-00446-9. Epub ahead of print. PMID: 33483719.
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Davidson SM, Padró T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C
(2021)
Progress in cardiac research - from rebooting cardiac regeneration to a complete cell atlas of the heart.
Cardiovasc Res. 2021 Jun 11:cvab200. doi: 10.1093/cvr/cvab200. Epub ahead of print. PMID: 34114614.
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Delgado de la Herran HC, Cheng Y, Perocchi F
(2021)
Towards a systems-level understanding of mitochondrial biology.
Cell Calcium. 2021 Feb 1;95:102364. doi: 10.1016/j.ceca.2021.102364. Epub ahead of print. PMID: 33601101.
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de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernández I, Montrreal L, Antúnez C, Antonell A, Tankard RM, Bis JC, Sims R, Bellenguez C, Quintela I, González-Perez A, Calero M, Franco-Macías E, Macías J, Blesa R, Cervera-Carles L, Menéndez-González M, Frank-García A, Royo JL, Moreno F, Huerto Vilas R, Baquero M, Diez-Fairen M, Lage C, García-Madrona S, García-González P, Alarcón-Martín E, Valero S, Sotolongo-Grau O, Ullgren A, Naj AC, Lemstra AW, Benaque A, Pérez-Cordón A, Benussi A, Rábano A, Padovani A, Squassina A, de Mendonça A, Arias Pastor A, Kok AAL, Meggy A, Pastor AB, Espinosa A, Corma-Gómez A, Martín Montes A, Sanabria Á, DeStefano AL, Schneider A, Haapasalo A, Kinhult Ståhlbom A, Tybjærg-Hansen A, Hartmann AM, Spottke A, Corbatón-Anchuelo A, Rongve A, Borroni B, Arosio B, Nacmias B, Nordestgaard BG, Kunkle BW, Charbonnier C, Abdelnour C, Masullo C, Martínez Rodríguez C, Muñoz-Fernandez C, Dufouil C, Graff C, Ferreira CB, Chillotti C, Reynolds CA, Fenoglio C, Van Broeckhoven C, Clark C, Pisanu C, Satizabal CL, Holmes C, Buiza-Rueda D, Aarsland D, Rujescu D, Alcolea D, Galimberti D, Wallon D, Seripa D, Grünblatt E, Dardiotis E, Düzel E, Scarpini E, Conti E, Rubino E, Gelpi E, Rodriguez-Rodriguez E, Duron E, Boerwinkle E, Ferri E, Tagliavini F, Küçükali F, Pasquier F, Sanchez-Garcia F, Mangialasche F, Jessen F, Nicolas G, Selbæk G, Ortega G, Chêne G, Hadjigeorgiou G, Rossi G, Spalletta G, Giaccone G, Grande G, Binetti G, Papenberg G, Hampel H, Bailly H, Zetterberg H, Soininen H, Karlsson IK, Alvarez I, Appollonio I, Giegling I, Skoog I, Saltvedt I, Rainero I, Rosas Allende I, Hort J, Diehl-Schmid J, Van Dongen J, Vidal JS, Lehtisalo J, Wiltfang J, Thomassen JQ, Kornhuber J, Haines JL, Vogelgsang J, Pineda JA, Fortea J, Popp J, Deckert J, Buerger K, Morgan K, Fließbach K, Sleegers K, Molina-Porcel L, Kilander L, Weinhold L, Farrer LA, Wang LS, Kleineidam L, Farotti L, Parnetti L, Tremolizzo L, Hausner L, Benussi L, Froelich L, Ikram MA, Deniz-Naranjo MC, Tsolaki M, Rosende-Roca M, Löwenmark M, Hulsman M, Spallazzi M, Pericak-Vance MA, Esiri M, Bernal Sánchez-Arjona M, Dalmasso MC, Martínez-Larrad MT, Arcaro M, Nöthen MM, Fernández-Fuertes M, Dichgans M, Ingelsson M, Herrmann MJ, Scherer M, Vyhnalek M, Kosmidis MH, Yannakoulia M, Schmid M, Ewers M, Heneka MT, Wagner M, Scamosci M, Kivipelto M, Hiltunen M, Zulaica M, Alegret M, Fornage M, Roberto N, van Schoor NM, Seidu NM, Banaj N, Armstrong NJ, Scarmeas N, Scherbaum N, Goldhardt O, Hanon O, Peters O, Skrobot OA, Quenez O, Lerch O, Bossù P, Caffarra P, Dionigi Rossi P, Sakka P, Hoffmann P, Holmans PA, Fischer P, Riederer P, Yang Q, Marshall R, Kalaria RN, Mayeux R, Vandenberghe R, Cecchetti R, Ghidoni R, Frikke-Schmidt R, Sorbi S, Hägg S, Engelborghs S, Helisalmi S, Botne Sando S, Kern S, Archetti S, Boschi S, Fostinelli S, Gil S, Mendoza S, Mead S, Ciccone S, Djurovic S, Heilmann-Heimbach S, Riedel-Heller S, Kuulasmaa T, Del Ser T, Lebouvier T, Polak T, Ngandu T, Grimmer T, Bessi V, Escott-Price V, Giedraitis V, Deramecourt V, Maier W, Jian X, Pijnenburg YAL; EADB contributors [i.a. Perneczky R, ]; GR@ACE study group; DEGESCO consortium; IGAP (ADGC, CHARGE, EADI, GERAD); PGC-ALZ consortia, Kehoe PG, Garcia-Ribas G, Sánchez-Juan P, Pastor P, Pérez-Tur J, Piñol-Ripoll G, Lopez de Munain A, García-Alberca JM, Bullido MJ, Álvarez V, Lleó A, Real LM, Mir P, Medina M, Scheltens P, Holstege H, Marquié M, Sáez ME, Carracedo Á, Amouyel P, Schellenberg GD, Williams J, Seshadri S, van Duijn CM, Mather KA, Sánchez-Valle R, Serrano-Ríos M, Orellana A, Tárraga L, Blennow K, Huisman M, Andreassen OA, Posthuma D, Clarimón J, Boada M, van der Flier WM, Ramirez A, Lambert JC, van der Lee SJ, Ruiz A
(2021)
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
Nat Commun. 2021 Jun 7;12(1):3417. doi: 10.1038/s41467-021-22491-8. PMID: 34099642; PMCID: PMC8184987.
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d'Errico P, Ziegler-Waldkirch S, Aires V, Hoffmann P, Mezö C, Erny D, Monasor LS, Liebscher S, Ravi VM, Joseph K, Schnell O, Kierdorf K, Staszewski O, Tahirovic S, Prinz M, Meyer-Luehmann M
(2021)
Microglia contribute to the propagation of Aβ into unaffected brain tissue.
Nat Neurosci. 2021 Nov 22. doi: 10.1038/s41593-021-00951-0. Epub ahead of print. PMID: 34811521.
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Dichgans M, Beaufort N, Debette S, Anderson CD
(2021)
Stroke Genetics: Turning Discoveries into Clinical Applications.
Stroke. 2021 Aug;52(9):2974-2982. doi: 10.1161/STROKEAHA.121.032616. Epub 2021 Aug 17. PMID: 34399583; PMCID: PMC8384143.
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Dichgans M, Sandset EC, Kelly P
(2021)
Organizational Update From the European Stroke Organisation.
Stroke. 2021 Aug;52(8):e517-e519. doi: 10.1161/STROKEAHA.121.035358. Epub 2021 Jul 26. PMID: 34310179.
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Dobersch S, Rubio K, Singh I, Günther S, Graumann J, Cordero J, Castillo-Negrete R, Huynh MB, Mehta A, Braubach P, Cabrera-Fuentes H, Bernhagen J, Chao CM, Bellusci S, Günther A, Preissner KT, Kugel S, Dobreva G, Wygrecka M, Braun T, Papy-Garcia D, Barreto G
(2021)
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation.
Nat Commun. 2021 Feb 16;12(1):1072. doi: 10.1038/s41467-021-21227-y. PMID: 33594057.
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Dominko K, Rastija A, Sobocanec S, Vidatic L, Meglaj S, Lovincic Babic A, Hutter-Paier B, Colombo AV, Lichtenthaler SF, Tahirovic S, Hecimovic S
(2021)
Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation.
Int J Mol Sci. 2021 Dec 9;22(24):13256. doi: 10.3390/ijms222413256. PMID: 34948052; PMCID: PMC8705785.
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Dordevic M, Sulzer S, Barche D, Dieterich M, Arens C, Müller NG
(2021)
Chronic, Mild Vestibulopathy Leads to Deficits in Spatial Tasks that Rely on Vestibular Input While Leaving Other Cognitive Functions and Brain Volumes Intact
Life (Basel). 2021 Dec 9;11(12):1369. doi: 10.3390/life11121369. PMID: 34947900; PMCID: PMC8707705.
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Dyrba M, Hanzig M, Altenstein S, Bader S, Ballarini T, Brosseron F, Buerger K, Cantré D, Dechent P, Dobisch L, Düzel E, Ewers M, Fliessbach K, Glanz W, Haynes JD, Heneka MT, Janowitz D, Keles DB, Kilimann I, Laske C, Maier F, Metzger CD, Munk MH, Perneczky R, Peters O, Preis L, Priller J, Rauchmann B, Roy N, Scheffler K, Schneider A, Schott BH, Spottke A, Spruth EJ, Weber MA, Ertl-Wagner B, Wagner M, Wiltfang J, Jessen F, Teipel SJ; ADNI, AIBL, DELCODE study groups
(2021)
Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer's disease.
Alzheimers Res Ther. 2021 Nov 23;13(1):191. doi: 10.1186/s13195-021-00924-2. PMID: 34814936; PMCID: PMC8611898.
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Dzinovic I, Serranová T, Prouteau C, Colin E, Ziegler A, Winkelmann J, Jech R, Zech M
(2021)
Myoclonic dystonia phenotype related to a novel calmodulin-binding transcription activator 1 sequence variant.
Neurogenetics. 2021 Mar 6. doi: 10.1007/s10048-021-00637-6. Epub ahead of print. PMID: 33677721.
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Dzinovic I, Škorvánek M, Pavelekova P, Zhao C, Keren B, Whalen S, Bakhtiari S, Chih Jin S, Kruer MC, Jech R, Winkelmann J, Zech M
(2021)
Variant recurrence confirms the existence of a FBXO31-related spastic-dystonic cerebral palsy syndrome.
Ann Clin Transl Neurol. 2021 Mar 6. doi: 10.1002/acn3.51335. Epub ahead of print. PMID: 33675180.
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Dzinovic I, Škorvánek M, Necpál J, Boesch S, Švantnerová J, Wagner M, Havránková P, Pavelekova P, Haň V, Janzarik WG, Berweck S, Diebold I, Kuster A, Jech R, Winkelmann J, Zech M
(2021)
Dystonia as a prominent presenting feature in developmental and epileptic encephalopathies: A case series
Parkinsonism Relat Disord. 2021 Aug 11;90:73-78. doi: 10.1016/j.parkreldis.2021.08.007. Epub ahead of print. PMID: 34399161.
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Earley AM, Burbulla LF. Krainc D, Awatramani R
(2021)
Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons.
Sci Rep. 2021 Nov 15;11(1):22257. doi: 10.1038/s41598-021-01366-4. PMID: 34782629; PMCID: PMC8593045.
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Egea V, Kessenbrock K, Lawson D, Bartelt A, Weber C, Ries C
(2021)
Let-7f miRNA regulates SDF-1α- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release.
Cell Death Dis. 2021 May 20;12(6):516. doi: 10.1038/s41419-021-03789-3. PMID: 34016957.
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Egle M, Hilal S, Tuladhar AM, Pirpamer L, Hofer E, Duering M, Wason J, Morris RG, Dichgans M, Schmidt R, Tozer D, Chen C, de Leeuw FE, Markus HS
(2021)
Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration.
J Neurol Neurosurg Psychiatry. 2021 Sep 11:jnnp-2021-326571. doi: 10.1136/jnnp-2021-326571. Epub ahead of print. PMID: 34509999.
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Egle M, Hilal S, Tuladhar AM, Pirpamer L, Hofer E, Duering M, Wason J, Morris RG, Dichgans M, Schmidt R, Tozer D, Chen C, de Leeuw FE, Markus HS
(2021)
Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration.
J Neurol Neurosurg Psychiatry. 2021 Sep 11:jnnp-2021-326571. doi: 10.1136/jnnp-2021-326571. Epub ahead of print. PMID: 34509999.
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Eira J, Magalhães J, Macedo N, Pero ME, Misgeld T, Sousa MM, Bartolini F, Liz MA
(2021)
Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation.
Front Cell Dev Biol. 2021 Nov 8;9:747699. doi: 10.3389/fcell.2021.747699. PMID: 34820375; PMCID: PMC8606651.
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Elstner M, Olszewski K, Prokisch H, Klopstock T, Murgia M
(2021)
Multi-Omics Approach to Mitochondrial DNA Damage in Human Muscle Fibers
Int J Mol Sci. 2021 Oct 14;22(20):11080. doi: 10.3390/ijms222011080. PMID: 34681740; PMCID: PMC8537949.
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Emes D, Hüls A, Baumer N, Dierssen M, Puri S, Russell L, Sherman SL, Strydom A, Bargagna S, Brandão AC, Costa ACS, Feany PT, Chicoine BA, Ghosh S, Rebillat AS, Sgandurra G, Valentini D, Rohrer TR, Levin J, Lakhanpaul M, On Behalf Of The Trisomy Research Society Covid-Initiative Study Group
(2021)
COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey.
J Clin Med. 2021 Oct 31;10(21):5125. doi: 10.3390/jcm10215125. PMID: 34768645; PMCID: PMC8584980.
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Engerer P, Petridou E, Williams PR, Suzuki SC, Yoshimatsu T, Portugues R, Misgeld T, Godinho L
(2021)
Notch-mediated re-specification of neuronal identity during central nervous system development.
Curr Biol. 2021 Sep 7:S0960-9822(21)01185-4. doi: 10.1016/j.cub.2021.08.049. Epub ahead of print. PMID: 34534440.
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Ertl M, Zu Eulenburg P, Woller M, Dieterich M
(2021)
The role of delta and theta oscillations during ego-motion in healthy adult volunteers.
Exp Brain Res. 2021 Feb 3. doi: 10.1007/s00221-020-06030-3. Epub ahead of print. PMID: 33534022.
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Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C
(2021)
THE YEAR IN BASIC VASCULAR BIOLOGY RESEARCH: FROM MECHANORECEPTORS AND NETS TO SMARTPHONE DATA AND OMICS.
Cardiovasc Res. 2021 Mar 21:cvab105. doi: 10.1093/cvr/cvab105. Epub ahead of print. PMID: 33744925.
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Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, Hassenstab J, Gordon BA, Chhatwal JP, Levin J, Schofield P, Benzinger TLS, Morris JC, Goate A, Karch CM, Fagan AM, McDade E, Allegri R, Berman S, Chui H, Cruchaga C, Farlow M, Graff-Radford N, Jucker M, Lee JH, Martins RN, Mori H, Perrin R, Xiong C, Rossor M, Fox NC, O'Connor A, Salloway S, Danek A, Buerger K, Bateman RJ, Habeck C, Stern Y, Franzmeier N; Alzheimer’s Disease Neuroimaging Initiative and the Dominantly Inherited Alzheimer Network
(2021)
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease.
Brain. 2021 Mar 16:awab112. doi: 10.1093/brain/awab112. Epub ahead of print. PMID: 33725114.
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Feil K, Adrion C, Boesch S, Doss S, Giordano I, Hengel H, Jacobi H, Klockgether T, Klopstock T, Nachbauer W, Schöls L, Steiner KM, Stendel C, Timmann D, Naumann I, Mansmann U, Strupp M; ALCAT Study Group
(2021)
Safety and Efficacy of Acetyl-DL-Leucine in Certain Types of Cerebellar Ataxia: The ALCAT Randomized Clinical Crossover Trial.
JAMA Netw Open. 2021 Dec 1;4(12):e2135841. doi: 10.1001/jamanetworkopen.2021.35841. PMID: 34905009.
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Feil K, Herzberg M, Dorn F, Tiedt S, Küpper C, Thunstedt DC, Papanagiotou P, Meyer L, Kastrup A, Dimitriadis K, Liebig T, Dieterich M, Kellert L; GSR investigators [i.a. Dichgans M ]
(2021)
Tandem Lesions in Anterior Circulation Stroke: Analysis of the German Stroke Registry-Endovascular Treatment.
Stroke. 2021 Feb 16:STROKEAHA120031797. doi: 10.1161/STROKEAHA.120.031797. Epub ahead of print. PMID: 33588589.
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Feil K, Herzberg M, Dorn F, Tiedt S, Küpper C, Thunstedt DC, Hinske LC, Mühlbauer K, Goss S, Liebig T, Dieterich M, Bayer A, Kellert L; GSR Investigators [i.a. Dichgans M ]
(2021)
General Anesthesia versus Conscious Sedation in Mechanical Thrombectomy.
J Stroke. 2021 Jan;23(1):103-112. doi: 10.5853/jos.2020.02404. Epub 2021 Jan 31. PMID: 33600707.
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Findeiss E, Schwarz SC, Evsyukov V, Rösler TW, Höllerhage M, Chakroun T, Nykänen NP, Shen Y, Wurst W. Kohl M, Tost J, Höglinger GU
(2021)
Comprehensive miRNome-Wide Profiling in a Neuronal Cell Model of Synucleinopathy Implies Involvement of Cell Cycle Genes.
Front Cell Dev Biol. 2021 Mar 4;9:561086. doi: 10.3389/fcell.2021.561086. PMID: 33748099; PMCID: PMC7969723.
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Fourneau J, Bareyre FM
(2021)
Semaphorin7A: its role in the control of serotonergic circuits and functional recovery following spinal cord injury.
Neural Regen Res. 2022 May;17(5):959-962. doi: 10.4103/1673-5374.324828. PMID: 34558508.
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Franklin HD, Russell LL, Peakman G, Greaves CV, Bocchetta M, Nicholas J, Poos J, Convery RS, Cash DM, van Swieten J, Jiskoot L, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Le Ber I, Pasquier F, Rohrer JD; Genetic FTD Initiative, GENFI
(2021)
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort.
Alzheimers Res Ther. 2021 Jul 12;13(1):127. doi: 10.1186/s13195-021-00865-w. PMID: 34253227; PMCID: PMC8276486.
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Franzmeier N, Ossenkoppele R, Brendel M, Rubinski A, Smith R, Kumar A, Mattsson-Carlgren N, Strandberg O, Duering M, Buerger K, Dichgans M, Hansson O, Ewers M; Alzheimer's Disease Neuroimaging Initiative (ADNI)* and the Swedish BioFINDER study
(2021)
The BIN1 rs744373 Alzheimer's disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline.
Alzheimers Dement. 2021 Jun 1. doi: 10.1002/alz.12371. Epub ahead of print. PMID: 34060233.
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Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M
(2021)
Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study.
Stroke. 2021 Dec 16:STROKEAHA121036306. doi: 10.1161/STROKEAHA.121.036306. Epub ahead of print. PMID: 34911345.
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Garrett L, Da Silva-Buttkus P, Rathkolb B, Gerlini R, Becker L, Sanz-Moreno A, Seisenberger C, Zimprich A, Aguilar-Pimentel A, Amarie OV, Cho YL, Kraiger M, Spielmann N, Calzada-Wack J, Marschall S, Busch D, Schmitt-Weber C, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, Hölter SM, de Angelis MH
(2021)
Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
Dis Model Mech. 2021 Dec 29:dmm.049205. doi: 10.1242/dmm.049205. Epub ahead of print. PMID: 34964047.
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Gasperi C, Hapfelmeier A, Daltrozzo T, Schneider A, Donnachie E, Hemmer B
(2021)
Systematic Assessment of Medical Diagnoses Preceding the First Diagnosis of Multiple Sclerosis.
Neurology. 2021 Apr 26:10.1212/WNL.0000000000012074. doi: 10.1212/WNL.0000000000012074. Epub ahead of print. PMID: 33903190.
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Gencer S, Evans BR, van der Vorst EPC, Döring Y, Weber C
(2021)
Inflammatory Chemokines in Atherosclerosis.
Cells. 2021 Jan 25;10(2):226. doi: 10.3390/cells10020226. PMID: 33503867.
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Gencer S, Döring Y, Jansen Y, Bayasgalan S, Schengel O, Müller M, Peters LJF, Weber C, van der Vorst EPC
(2021)
Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue.
Biomedicines. 2021 Apr 6;9(4):394. doi: 10.3390/biomedicines9040394. PMID: 33917642; PMCID: PMC8067615.
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Gengatharan A, Malvaut S, Marymonchyk A, Ghareghani M, Snapyan M, Fischer-Sternjak J, Ninkovic J, Götz M, Saghatelyan A
(2021)
Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.
Cell. 2021 Jan 13:S0092-8674(20)31748-7. doi: 10.1016/j.cell.2020.12.026. Epub ahead of print. PMID: 33482084.
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Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
(2021)
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study.
Neurology. 2021 Jan 25:10.1212/WNL.0000000000011555. doi: 10.1212/WNL.0000000000011555. Epub ahead of print. PMID: 33495378.
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Georgakis MK, Malik R, Li X, Gill D, Levin MG, Vy HMT, Judy R, Ritchie M, Verma SS; Regeneron Genetics Center, Nadkarni GN, Damrauer SM, Theodoratou E, Dichgans M
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Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile: A Phenome-Wide Association Study.
Circulation. 2021 Mar 16;143(11):1177-1180. doi: 10.1161/CIRCULATIONAHA.120.052604. Epub 2021 Mar 15. PMID: 33720771.
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Georgakis MK, van der Laan SW, Asare Y, Mekke JM, Haitjema S, Schoneveld AH, de Jager SCA, Nurmohamed NS, Kroon J, Stroes ESG, de Kleijn DPV, de Borst GJ, Maegdefessel L, Soenhlein O, Pasterkamp G, Dichgans M
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Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability.
Arterioscler Thromb Vasc Biol. 2021 Apr 8:ATVBAHA121316091. doi: 10.1161/ATVBAHA.121.316091. Epub ahead of print. PMID: 33827260.
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Gill D, Georgakis MK, Walker VM, Schmidt AF, Gkatzionis A, Freitag DF, Finan C, Hingorani AD, Howson JMM, Burgess S, Swerdlow DI, Davey Smith G, Holmes MV, Dichgans M. Scott RA, Zheng J, Psaty BM, Davies NM
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Mendelian randomization for studying the effects of perturbing drug targets.
Wellcome Open Res. 2021 Feb 10;6:16. doi: 10.12688/wellcomeopenres.16544.2. PMID: 33644404; PMCID: PMC7903200.
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Gill D, Karhunen V, Malik R, Dichgans M, Sofat N
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Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study.
Osteoarthritis Cartilage. 2021 Jan 7:S1063-4584(21)00001-7. doi: 10.1016/j.joca.2020.12.015. Epub ahead of print. PMID: 33422704.
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Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A
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Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice.
Cardiovasc Res. 2021 Dec 13:cvab359. doi: 10.1093/cvr/cvab359. Epub ahead of print. PMID: 34897380.
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Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, Gauthier S, Benzinger TLS, Morris JC, Bateman RJ, Breitner JCS, Poirier J, Vachon-Presseau E, Villeneuve S; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Dominantly Inherited Alzheimer Network (DIAN) Study Group; Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
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Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Nat Commun. 2021 Sep 9;12(1):5346. doi: 10.1038/s41467-021-25492-9. PMID: 34504080.
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Gouna G, Klose C, Bosch-Queralt M, Liu L, Gokce O, Schifferer M, Cantuti-Castelvetri L, Simons M
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TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination
J Exp Med. 2021 Oct 4;218(10):e20210227. doi: 10.1084/jem.20210227. Epub 2021 Aug 23. PMID: 34424266.
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Grahl S, Bussas M, Wiestler B, Eichinger P, Gaser C, Kirschke J, Zimmer C, Berthele A, Hemmer B, Mühlau M
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Differential Effects of Fingolimod and Natalizumab on Magnetic Resonance Imaging Measures in Relapsing-Remitting Multiple Sclerosis.
Neurotherapeutics. 2021 Sep 24. doi: 10.1007/s13311-021-01118-2. Epub ahead of print. PMID: 34561843.
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Gronewold J, Kropp R, Lehmann N, Stang A, Mahabadi A, Weimar C, Dichgans M, Moebus S, Kröger K, Hoffmann B, Jöckel KH, Erbel R, Hermann D; Heinz Nixdorf Recall Study Investigative Group
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Population impact of different hypertension management guidelines based on the prospective population-based Heinz Nixdorf Recall study.
BMJ Open. 2021 Feb 17;11(2):e039597. doi: 10.1136/bmjopen-2020-039597. PMID: 33597131.
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Grosch M, Beyer L, Lindner M, Kaiser L, Ahmadi SA, Stockbauer A, Bartenstein P, Dieterich M, Brendel M, Zwergal A, Ziegler S
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Metabolic connectivity-based single subject classification by multi-regional linear approximation in the rat.
Neuroimage. 2021 Apr 5:118007. doi: 10.1016/j.neuroimage.2021.118007. Epub ahead of print. PMID: 33831550.
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Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C
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Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
Cell Metab. 2021 Apr 30:S1550-4131(21)00173-X. doi: 10.1016/j.cmet.2021.04.007. Epub ahead of print. PMID: 33951475.
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Gruner K, Leissing F, Sinitski D, Thieron H, Axstmann C, Baumgarten K, Reinstädler A, Winkler P, Altmann M, Flatley A, Jaouannet M, Zienkiewicz K, Feussner I, Keller H, Coustau C, Falter-Braun P, Feederle R. Bernhagen J. Panstruga R
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Chemokine-like MDL proteins modulate flowering time and innate immunity in plants.
J Biol Chem. 2021 Mar 30:100611. doi: 10.1016/j.jbc.2021.100611. Epub ahead of print. PMID: 33798552.
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Loss of TREM2 facilitates tau accumulation, spreading, and brain atrophy, but only in the presence of amyloid pathology.
Neuron. 2021 Apr 21;109(8):1243-1245. doi: 10.1016/j.neuron.2021.03.029. PMID: 33887187.
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Haeckert J, Brendel M, Beyer L, Barthel H, Sabri O, Hasan A, Perneczky R
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Effective Valproic Acid Treatment in a Patient With Delusional Parasitosis Due to Corticobasal Syndrome and Alzheimer Disease.
J Clin Psychopharmacol. 2021 Mar 12. doi: 10.1097/JCP.0000000000001378. Epub ahead of print. PMID: 33734170.
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Hansen J, von Melchner H, Wurst W
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Mutant non-coding RNA resource in mouse embryonic stem cells.
Dis Model Mech. 2021 Feb 5;14(2):dmm047803. doi: 10.1242/dmm.047803. PMID: 33729986; PMCID: PMC7875499.
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Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS
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Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.
Stroke. 2021 Feb 4:STROKEAHA120031710. doi: 10.1161/STROKEAHA.120.031710. Epub ahead of print. PMID: 33535786.
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Hartmann J, Roßmeier C, Riedl L, Dorn B, Fischer J, Slawik T, Fleischhaker M, Hartmann F, Egert-Schwender S, Kehl V, Haller B, Schneider-Schelte H, Dinkel A, Jox RJ, Diehl-Schmid J
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Quality of Life in Advanced Dementia with Late Onset, Young Onset, and Very Young Onset.
J Alzheimers Dis. 2021 Jan 25. doi: 10.3233/JAD-201302. Epub ahead of print. PMID: 33523011.
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Hartmann J, Chen-Engerer HJ, Konnerth A
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Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca2+ signals in dendritic spines to regulate working and associative memory".
Cell Calcium. 2021 Feb 17;96:102372. doi: 10.1016/j.ceca.2021.102372. Epub ahead of print. PMID: 33640627.
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Havla J, Schultz Y, Zimmermann H, Hohlfeld R, Danek A, Kümpfel T
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First manifestation of multiple sclerosis after immunization with the Pfizer-BioNTech COVID-19 vaccine.
J Neurol. 2021 Jun 11:1–4. doi: 10.1007/s00415-021-10648-w. Epub ahead of print. PMID: 34115170; PMCID: PMC8193159.
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He YY, Xie XM, Zhang HD, Ye J, Gencer S, van der Vorst EPC, Döring Y, Weber C, Pang XB, Jing ZC, Yan Y, Han ZY
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Identification of Hypoxia Induced Metabolism Associated Genes in Pulmonary Hypertension.
Front Pharmacol. 2021 Nov 5;12:753727. doi: 10.3389/fphar.2021.753727. PMID: 34803695; PMCID: PMC8602807.
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Heger LM, Wise RM, Hees JT, Harbauer AB, Burbulla LF
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Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.
Cells. 2021 Dec 7;10(12):3436. doi: 10.3390/cells10123436. PMID: 34943944; PMCID: PMC8699816.
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Heindl S, Ricci A, Carofiglio O, Zhou Q, Arzberger T, Lenart N, Franzmeier N, Hortobagyi T, Nelson PT, Stowe AM, Denes A, Edbauer D, Liesz A
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Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
J Exp Med. 2021 Aug 2;218(8):e20202411. doi: 10.1084/jem.20202411. Epub 2021 May 26. PMID: 34037669.
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Heinrichs D, Brandt EF, Fischer P, Köhncke J, Wirtz TH, Guldiken N, Djudjaj S, Boor P, Kroy D, Weiskirchen R, Bucala R, Wasmuth HE, Strnad P, Trautwein C, Bernhagen J, Berres ML
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Unexpected Pro-Fibrotic Effect of MIF in Non-Alcoholic Steatohepatitis Is Linked to a Shift in NKT Cell Populations.
Cells. 2021 Jan 28;10(2):252. doi: 10.3390/cells10020252. PMID: 33525493.
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Held F, Kalluri SR, Berthele A, Klein AK, Reindl M, Hemmer B
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Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients.
Mult Scler J Exp Transl Clin. 2021 Jun 25;7(2):20552173211022767. doi: 10.1177/20552173211022767. PMID: 34262784; PMCID: PMC8246507.
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Henderson JM, Weber C, Santovito D
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Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis.
Cells. 2021 Mar 11;10(3):625. doi: 10.3390/cells10030625. PMID: 33799835; PMCID: PMC7998923.
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Implications of immune responses for stroke injury and recovery.
Brain Behav Immun. 2021 May 20:S0889-1591(21)00217-8. doi: 10.1016/j.bbi.2021.05.020. Epub ahead of print. PMID: 34023355.
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Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB, Cooper MA, Groß O, Krane M, Weber C, Koenig W, Soehnlein O, Adamstein NH, Ridker P, Schunkert H, Libby P, Kessler T, Sager HB
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Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis.
Cardiovasc Res. 2021 Oct 28:cvab337. doi: 10.1093/cvr/cvab337. Epub ahead of print. PMID: 34718444.
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Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.
Nat Immunol. 2021 Jun 7. doi: 10.1038/s41590-021-00948-8. Epub ahead of print. PMID: 34099917.
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Hinterdobler J, Schott S, Jin H, Meesmann A, Steinsiek AL, Zimmermann AS, Wobst J, Müller P, Mauersberger C, Vilne B, Baecklund A, Chen CS, Moggio A, Braster Q, Molitor M, Krane M, Kempf WE, Ladwig KH, Hristov M, Hulsmans M, Hilgendorf I, Weber C, Wenzel P, Scheiermann C, Maegdefessel L, Soehnlein O, Libby P, Nahrendorf M, Schunkert H, Kessler T, Sager HB
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Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis.
Eur Heart J. 2021 Jul 19:ehab371. doi: 10.1093/eurheartj/ehab371. Epub ahead of print. PMID: 34279021.
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Hofmann E, Soppert J, Ruhl T, Gousopoulos E, Gerra S, Storti G, Tian Y, Brandhofer M, Schweizer R, Song SY, Lindenblatt N, Pallua N, Bernhagen J, Kim BS
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The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia.
Front Physiol. 2021 Jul 21;12:638448. doi: 10.3389/fphys.2021.638448. PMID: 34366876; PMCID: PMC8334873.
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Correcting gut dysbiosis can ameliorate inflammation and promote remyelination in multiple sclerosis - Commentary.
Mult Scler. 2021 May 28:13524585211018990. doi: 10.1177/13524585211018990. Epub ahead of print. PMID: 34047222.
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Hohlfeld R
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Lancet Neurol. 2021 Nov;20(11):887-888. doi: 10.1016/S1474-4422(21)00325-2. PMID: 34687627.
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Hohlfeld R
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Mesenchymal stem cells for multiple sclerosis: hype or hope?
Lancet Neurol. 2021 Nov;20(11):881-882. doi: 10.1016/S1474-4422(21)00324-0. PMID: 34687621.
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Hsia HE, Tüshaus J, Feng X, Hofmann LI, Wefers B, Marciano DK, Wurst W, Lichtenthaler S
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Endoglycan (PODXL2) is proteolytically processed by ADAM10 (a disintegrin and metalloprotease 10) and controls neurite branching in primary neurons
FASEB J. 2021 Sep;35(9):e21813. doi: 10.1096/fj.202100475R. PMID: 34390512.
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Iankova V, Karin I, Klopstock T, Schneider SA
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Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders.
Front Neurol. 2021 Apr 15;12:629414. doi: 10.3389/fneur.2021.629414. PMID: 33935938; PMCID: PMC8082061.
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Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, akib MS, Kerimolgu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka MT, Janowitz D, Kilimann I, Kleinedam L, Laske C, Metzger CD, Munk MH, Perneczky R, Peters O, Priller J, Rauchmann BS, Roy N, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Wagner M, Wiltfang J, Düzel E, Jessen F; Delcode Study Group, Rizzoli SO, Zimmermann WH, Schulze TG, Falkai P, Sananbenesi F, Fischer A
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A microRNA signature that correlates with cognition and is a target against cognitive decline.
EMBO Mol Med. 2021 Oct 11:e13659. doi: 10.15252/emmm.202013659. Epub ahead of print. PMID: 34633146.
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Ives A, Le Roy D, Théroude C, Bernhagen J, Roger T, Calandra T
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Macrophage migration inhibitory factor promotes the migration of dendritic cells through CD74 and the activation of the Src/PI3K/myosin II pathway.
FASEB J. 2021 May;35(5):e21418. doi: 10.1096/fj.202001605R. PMID: 33774873.
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Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M
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Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Nat Neurosci. 2021 Jan 25. doi: 10.1038/s41593-020-00780-7. Epub ahead of print. PMID: 33495636.
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Joseph-Mathurin N, Wang G, Kantarci K, Jack CR Jr, McDade E, Hassenstab J, Blazey TM, Gordon BA, Su Y, Chen G, Massoumzadeh P, Hornbeck RC, Allegri RF, Ances BM, Berman SB, Brickman AM, Brooks WS, Cash DM, Chhatwal JP, Chui HC, Correia S, Cruchaga C, Farlow MR, Fox NC, Fulham M, Ghetti B, Graff-Radford NR, Johnson KA, Karch CM, Laske C, Lee AKW, Levin J, Masters CL, Noble JM, O'Connor A, Perrin RJ, Preboske GM, Ringman JM, Rowe CC, Salloway S, Saykin AJ, Schofield PR, Shimada H, Shoji M, Suzuki K, Villemagne VL, Xiong C, Yakushev I, Morris JC, Bateman RJ, Benzinger TLS; Dominantly Inherited Alzheimer Network
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Longitudinal Accumulation of Cerebral Microhemorrhages in Dominantly Inherited Alzheimer Disease.
Neurology. 2021 Jan 25:10.1212/WNL.0000000000011542. doi: 10.1212/WNL.0000000000011542. Epub ahead of print. PMID: 33495373.
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Joshi P, Riffel F, Satoh K, Enomoto M, Qamar S, Scheiblich H, Villacampa N, Kumar S, Theil S, Parhizkar S, Haass C, Heneka MT, Fraser PE, St George-Hyslop P, Walter J
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Differential interaction with TREM2 modulates microglial uptake of modified Aβspecies
Glia. 2021 Aug 24. doi: 10.1002/glia.24077. Epub ahead of print. PMID: 34427354.
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Joshi P, Riffel F, Kumar S, Villacampa N, Theil S, Parhizkar S, Haass C, Colonna M, Heneka MT, Arzberger T, Herms J, Walter J
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TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits.
Acta Neuropathol Commun. 2021 Oct 18;9(1):168. doi: 10.1186/s40478-021-01263-x. PMID: 34663480; PMCID: PMC8522217.
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Jüschke C, Klopstock T, Catarino CB, Owczarek-Lipska M, Wissinger B, Neidhardt J
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Autosomal dominant optic atrophy: A novel treatment for OPA1 splice defects using U1 snRNA adaption.
Mol Ther Nucleic Acids. 2021 Oct 21;26:1186-1197. doi: 10.1016/j.omtn.2021.10.019. PMID: 34853716; PMCID: PMC8604756.
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Kappos L, Fox RJ, Burcklen M, Freedman MS, Havrdová EK, Hennessy B, Hohlfeld R, Lublin F, Montalban X, Pozzilli C, Scherz T, D'Ambrosio D, Linscheid P, Vaclavkova A, Pirozek-Lawniczek M, Kracker H, Sprenger T
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Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized Clinical Trial.
JAMA Neurol. 2021 Mar 29. doi: 10.1001/jamaneurol.2021.0405. Epub ahead of print. PMID: 33779698.
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Karin I, Büchner B, Gauzy F, Klucken A, Klopstock T
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Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)-An International Network on Care and Research for Patients With Neurodegeneration With Brain Iron Accumulation (NBIA).
Front Neurol. 2021 Feb 22;12:642228. doi: 10.3389/fneur.2021.642228. PMID: 33692746; PMCID: PMC7937633.
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Kempf J, Knelles K, Hersbach BA, Petrik D, Riedemann T, Bednarova V, Janjic A, Simon-Ebert T, Enard W, Smialowski P, Götz M, Masserdotti G
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Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
Cell Rep. 2021 Jul 20;36(3):109409. doi: 10.1016/j.celrep.2021.109409. Erratum in: Cell Rep. 2021 Aug 17;36(7):109571. PMID: 34289357; PMCID: PMC8316252.
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Khalin I, Severi C, Heimburger D, Wehn A, Hellal F, Reisch A, Klymchenko AS, Plesnila N
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Dynamic tracing using ultra-bright labelling and multi-photon microscopy identifies endothelial uptake of poloxamer 188 coated poly(lactic-co-glycolic acid) nano-carriers in vivo.
Nanomedicine. 2021 Dec 13:102511. doi: 10.1016/j.nano.2021.102511. Epub ahead of print. PMID: 34915181.
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Role of IL-6 in the commitment of T cell subsets.
Cytokine. 2021 Jul 26;146:155654. doi: 10.1016/j.cyto.2021.155654. Epub ahead of print. PMID: 34325116.
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Korzhova V, Marinković P, Njavro JR, Goltstein PM, Sun F, Tahirovic S, Herms J, Liebscher S
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Long-term dynamics of aberrant neuronal activity in awake Alzheimer's disease transgenic mice.
Commun Biol. 2021 Dec 7;4(1):1368. doi: 10.1038/s42003-021-02884-7. PMID: 34876653.
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Kreuzer A, Sauerbeck J, Scheifele M, Stockbauer A, Schönecker S, Prix C, Wlasich E, Loosli SV, M Kazmierczak P, Unterrainer M, Catak C, Janowitz D, Pogarell O, Palleis C, Perneczky R, Albert NL, Bartenstein P, Danek A, Buerger K, Levin J, Zwergal A, Rominger A, Brendel M, Beyer L
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Detection Gap of Right-Asymmetric Neuronal Degeneration by CERAD Test Battery in Alzheimer's Disease.
Front Aging Neurosci. 2021 Feb 2;13:611595. doi: 10.3389/fnagi.2021.611595. PMID: 33603657; PMCID: PMC7884314.
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Kupatt C, Windisch A, Moretti A, Wolf E, Wurst W, Walter MC
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Genome editing for Duchenne muscular dystrophy: a glimpse of the future?
Gene Ther. 2021 Feb 2. doi: 10.1038/s41434-021-00222-4. Epub ahead of print. PMID: 33531685.
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Kurgyis Z, Vornholz L, Pechloff K, Kemény LV, Wartewig T, Muschaweckh A, Joshi A, Kranen K, Hartjes L, Möckel S, Steiger K, Hameister E, Volz T, Mellett M, French LE, Biedermann T, Korn T, Ruland J
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Keratinocyte-intrinsic BCL10/MALT1 activity initiates and amplifies psoriasiform skin inflammation.
Sci Immunol. 2021 Nov 26;6(65):eabi4425. doi: 10.1126/sciimmunol.abi4425. Epub 2021 Nov 26. PMID: 34826258.
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Kurz C, Walker L, Rauchmann BS, Perneczky R
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Dysfunction of the blood-brain barrier in Alzheimer's disease: evidence from human studies.
Neuropathol Appl Neurobiol. 2021 Nov 25. doi: 10.1111/nan.12782. Epub ahead of print. PMID: 34823269.
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Lacy M, Bürger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E
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Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.
Nat Commun. 2021 Jun 18;12(1):3754. doi: 10.1038/s41467-021-23909-z. PMID: 34145241.
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Lam DD, Nikolic AA, Zhao C, Mirza-Schreiber N, Krężel W, Oexle K, Winkelmann J
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Intronic elements associated with insomnia and restless legs syndrome exhibit cell type-specific epigenetic features contributing to MEIS1 regulation.
Hum Mol Genet. 2021 Dec 9:ddab355. doi: 10.1093/hmg/ddab355. Epub ahead of print. PMID: 34888668.
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Lam DD, Williams RH, Lujan E, Tanabe K, Huber G, Saw NL, Merl-Pham J, Salminen AV, Lohse D, Spendiff S, Plastini MJ, Zech M, Lochmüller H, Geerlof A, Hauck SM, Shamloo M, Wernig M, Winkelmann J
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Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation.
J Neurosci. 2021 Dec 22:JN-RM-0962-21. doi: 10.1523/JNEUROSCI.0962-21.2021. Epub ahead of print. PMID: 34965974.
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Ethical use of off-label disease-modifying therapies for multiple sclerosis.
Mult Scler. 2021 Jul 26:13524585211030207. doi: 10.1177/13524585211030207. Epub ahead of print. PMID: 34304636.
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Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation
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Levin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM; VA Million Veteran Program
(2021)
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease.
Circulation. 2021 Jun 18. doi: 10.1161/CIRCULATIONAHA.121.053797. Epub ahead of print. PMID: 34139859.
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Levin J, Nübling G, Giese A, Janzen A, Oertel W
(2021)
Neuroprotektive Therapien bei idiopathischen, genetischen und atypischen Parkinson-Syndromen mit α-Synuklein – Pathologie [Neuroprotective treatment of idiopathic, genetic and atypical Parkinson's disease with alpha-synuclein-Pathology].
Nervenarzt. 2021 Nov 4. German. doi: 10.1007/s00115-021-01220-y. Epub ahead of print. PMID: 34735584.
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Levin J, Oertel W
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Proteinbezogene Therapien neurodegenerativer Erkrankungen [Protein-related treatment of neurodegenerative diseases].
Nervenarzt. 2021 Dec;92(12):1217-1218. German. doi: 10.1007/s00115-021-01218-6. Epub 2021 Dec 6. PMID: 34870714.
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Lichtenthaler SF, Tschirner SK, Steiner H
(2021)
Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.
Curr Opin Neurobiol. 2021 Oct 21;72:101-110. doi: 10.1016/j.conb.2021.09.003. Epub ahead of print. PMID: 34689040.
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Limburg K, Radziej K, Sattel H, Henningsen P, Dieterich M, Probst T, Dale R, Lahmann C
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A Randomized Controlled Trial Evaluating Integrative Psychotherapeutic Group Treatment Compared to Self-Help Groups in Functional Vertigo/Dizziness.
J Clin Med. 2021 May 20;10(10):2215. doi: 10.3390/jcm10102215. PMID: 34065517; PMCID: PMC8161006.
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Liu H, Schwarting J, Terpolilli NA, Nehrkorn K, Plesnila N
(2021)
Scavenging Free Iron Reduces Arteriolar Microvasospasms After Experimental Subarachnoid Hemorrhage.
Stroke. 2021 Nov 9:STROKEAHA120033472. doi: 10.1161/STROKEAHA.120.033472. Epub ahead of print. PMID: 34749506.
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Liu L, Besson-Girard S, Ji H, Gehring K, Bulut B, Kaya T, Usifo F, Simons M, Gokce O
(2021)
Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing.
STAR Protoc. 2021 Jun 10;2(2):100590. doi: 10.1016/j.xpro.2021.100590. PMID: 34159323; PMCID: PMC8196224.
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Liu S, Hossinger A, Heumüller SE, Hornberger A, Buravlova O, Konstantoulea K, Müller SA, Paulsen L, Rousseau F, Schymkowitz J, Lichtenthaler SF, Neumann M, Denner P, Vorberg IM
(2021)
Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions.
Nat Commun. 2021 Oct 19;12(1):5739. doi: 10.1038/s41467-021-25855-2. PMID: 34667166; PMCID: PMC8526834.
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Llovera G, Pinkham K, Liesz A
(2021)
Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis.
J Vis Exp. 2021 May 6;(171). doi: 10.3791/62536. PMID: 34028443.
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Llovera G, Simats A, Liesz A
(2021)
Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery.
J Vis Exp. 2021 May 24;(171). doi: 10.3791/62573. PMID: 34096920.
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Lo EH, Albers GW, >Dichgans M>, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžić S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM
(2021)
Circadian Biology and Stroke.
Stroke. 2021 May 4:STROKEAHA120031742. doi: 10.1161/STROKEAHA.120.031742. Epub ahead of print. PMID: 33940951.
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Lombardi J, Mayer B, Semler E, Anderl-Straub S, Uttner I, Kassubek J, Diehl-Schmid J, Danek A, Levin J, Fassbender K, Fliessbach K, Schneider A, Huppertz HJ, Jahn H, Volk A, Kornhuber J, Landwehrmeyer B, Lauer M, Prudlo J, Wiltfang J, Schroeter ML, Ludolph A, Otto M; FTLD consortium
(2021)
Quantifying progression in primary progressive aphasia with structural neuroimaging.
Alzheimers Dement. 2021 Mar 30. doi: 10.1002/alz.12323. Epub ahead of print. PMID: 33787063.
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Loosli SV, Schmidt L, Nübling G, Wlasich E, Prix C, Danek A, Levin J
(2021)
Kognition bei Down-Syndrom: Entwicklung über die Lebensspanne und neuropsychologische Diagnostik im Erwachsenenalter [Cognition in Down's Syndrome: Development across the Life Span and Neuropsychological Assessment in Adults].
Fortschr Neurol Psychiatr. 2021 Mar 1. German. doi: 10.1055/a-1362-9868. Epub ahead of print. PMID: 33647991.
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Lora J, Weskamp G, Li TM, Maretzky T, Shola DTN, Monette S, Lichtenthaler SF, Lu TT, Yang C, Blobel CP
(2021)
Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.
J Biol Chem. 2021 May 3:100733. doi: 10.1016/j.jbc.2021.100733. Epub ahead of print. PMID: 33957124.
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Luckett PH, McCullough A, Gordon BA, Strain J, Flores S, Dincer A, McCarthy J, Kuffner T, Stern A, Meeker KL, Berman SB, Chhatwal JP, Cruchaga C, Fagan AM, Farlow MR, Fox NC, Jucker M, Levin J, Masters CL, Mori H, Noble JM, Salloway S, Schofield PR, Brickman AM, Brooks WS, Cash DM, Fulham MJ, Ghetti B, Jack CR Jr, Vöglein J, Klunk W, Koeppe R, Oh H, Su Y, Weiner M, Wang Q, Swisher L, Marcus D, Koudelis D, Joseph-Mathurin N, Cash L, Hornbeck R, Xiong C, Perrin RJ, Karch CM, Hassenstab J, McDade E, Morris JC, Benzinger TLS, Bateman RJ, Ances BM; Dominantly Inherited Alzheimer Network (DIAN)
(2021)
Modeling autosomal dominant Alzheimer's disease with machine learning.
Alzheimers Dement. 2021 Jan 21. doi: 10.1002/alz.12259. Epub ahead of print. PMID: 33480178.
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Macrini C, Gerhards R, Winklmeier S, Bergmann L, Mader S, Spadaro M, Vural A, Smolle M, Hohlfeld R, Kümpfel T, Lichtenthaler SF. Franquelim HG, Jenne D, Meinl E
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Features of MOG required for recognition by patients with MOG antibody-associated disorders.
Brain. 2021 Mar 11:awab105. doi: 10.1093/brain/awab105. Epub ahead of print. PMID: 33704436.
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Mahler C, Schumacher AM, Unterrainer M, Kaiser L, Höllbacher T, Lindner S, Havla J, Ertl-Wagner B, Patzig M, Seelos K, Neitzel J, Mäurer M, Krumbholz M, Metz I, Brück W, Stadelmann C, Merkler D, Gass A, Milenkovic V, Bartenstien P, Albert NL, Kümpfel T, Kerschensteiner M
(2021)
TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy.
Brain. 2021 Mar 23:awab127. doi: 10.1093/brain/awab127. Epub ahead of print. PMID: 33757118.
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Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D
(2021)
Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses.
Hypertension. 2021 Apr 5:HYPERTENSIONAHA12016534. doi: 10.1161/HYPERTENSIONAHA.120.16534. Epub ahead of print. PMID: 33813844.
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Malik R, Georgakis MK, Neitzel J, Rannikmäe K, Ewers M, Seshadri S, Sudlow CLM, Dichgans M
(2021)
Midlife vascular risk factors and risk of incident dementia: Longitudinal cohort and Mendelian randomization analyses in the UK Biobank.
Alzheimers Dement. 2021 Mar 22. doi: 10.1002/alz.12320. Epub ahead of print. PMID: 33749976.
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Malik R, Beaufort N, Frerich S, Gesierich B, Georgakis MK, Rannikmäe K, Ferguson AC, Haffner C, Traylor M, Ehrmann M, Sudlow CLM, Dichgans M
(2021)
Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities.
Brain. 2021 Oct 9:awab253. doi: 10.1093/brain/awab253. Epub ahead of print. PMID: 34626176.
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Marignier R, Hacohen Y, Cobo-Calvo A, Pröbstel AK, Aktas O, Alexopoulos H, Amato MP, Asgari N, Banwell B, Bennett J, Brilot F, Capobianco M, Chitnis T, Ciccarelli O, Deiva K, De Sèze J, Fujihara K, Jacob A, Kim HJ, Kleiter I, Lassmann H, Leite MI, Linington C, Meinl E, Palace J, Paul F, Petzold A, Pittock S, Reindl M, Sato DK, Selmaj K, Siva A, Stankoff B, Tintore M, Traboulsee A, Waters P, Waubant E, Weinshenker B, Derfuss T, Vukusic S, Hemmer B
(2021)
Myelin-oligodendrocyte glycoprotein antibody-associated disease
Lancet Neurol. 2021 Sep;20(9):762-772. doi: 10.1016/S1474-4422(21)00218-0. PMID: 34418402.
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Markov DA, Petrucco L, Kist AM, Portugues R
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A cerebellar internal model calibrates a feedback controller involved in sensorimotor control.
Nat Commun. 2021 Nov 18;12(1):6694. doi: 10.1038/s41467-021-26988-0. PMID: 34795244; PMCID: PMC8602262.
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Martín-de-Saavedra MD, Dos Santos M, Culotta L, Varea O, Spielman BP, Parnell E, Forrest MP, Gao R, Yoon S, McCoig E, Jalloul HA, Myczek K, Khalatyan N, Hall EA, Turk LS, Sanz-Clemente A, Comoletti D, Lichtenthaler SF, Burgdorf JS, Barbolina MV, Savas JN, Penzes P
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Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2.
Neuron. 2021 Dec 16:S0896-6273(21)00986-7. doi: 10.1016/j.neuron.2021.11.025. Epub ahead of print. PMID: 34921780.
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Matías-García PR, Ward-Caviness CK, Raffield LM, Gao X, Zhang Y, Wilson R, Gào X, Nano J, Bostom A, Colicino E, Correa A, Coull B, Eaton C, Hou L, Just AC, Kunze S, Lange L, Lange E, Lin X, Liu S, Nwanaji-Enwerem JC, Reiner A, Shen J, Schöttker B, Vokonas P, Zheng Y, Young B, Schwartz J, Horvath S, Lu A, Whitsel EA, Koenig W, Adamski J, Winkelmann J, Brenner H, Baccarelli AA, Gieger C, Peters A, Franceschini N, Waldenberger M
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DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.
Clin Epigenetics. 2021 Jun 2;13(1):121. doi: 10.1186/s13148-021-01082-w. PMID: 34078457; PMCID: PMC8170969.
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McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF
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The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.
Nat Rev Neurol. 2021 Sep 21. doi: 10.1038/s41582-021-00545-1. Epub ahead of print. PMID: 34548654.
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Megas IF, Simons D, Kim BS, Stoppe C, Piatkowski A, Fikatas P, Fuchs PC, Bastiaanse J, Pallua N, Bernhagen J, Grieb G
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Macrophage Migration Inhibitory Factor-An Innovative Indicator for Free Flap Ischemia after Microsurgical Reconstruction.
Healthcare (Basel). 2021 May 21;9(6):616. doi: 10.3390/healthcare9060616. PMID: 34063809.
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Meinl E, Hohlfeld R
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CD20+ T cells as pathogenic players and therapeutic targets in MS.
Ann Neurol. 2021 Sep 29. doi: 10.1002/ana.26232. Epub ahead of print. PMID: 34585761.
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Meschia JF, Dichgans M
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Genetics, Genomics, and Precision Medicine.
Stroke. 2021 Sep 2:STROKEAHA121033966. doi: 10.1161/STROKEAHA.121.033966. Epub ahead of print. PMID: 34470485.
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Mirza-Schreiber N, Zech M, Wilson R, Brunet T, Wagner M, Jech R, Boesch S, Škorvánek M, Necpál J, Weise D, Weber S, Mollenhauer B, Trenkwalder C, Maier EM, Borggraefe I, Vill K, Hackenberg A, Pilshofer V, Kotzaeridou U, Schwaibold EMC, Hoefele J, Waldenberger M, Gieger C, Peters A, Meitinger T, Schormair B, Winkelmann J, Oexle K
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Blood DNA methylation provides an accurate biomarker of KMT2B-related dystonia and predicts onset.
Brain. 2021 Sep 30:awab360. doi: 10.1093/brain/awab360. Epub ahead of print. PMID: 34590685.
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Mitsdörffer M, Di Liberto G, Dötsch S, Sie C, Wagner I, Pfaller M, Kreutzfeldt M, Fräßle S, Aly L, Knier B, Busch DH, Merkler D, Korn T
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Formation and immunomodulatory function of meningeal B-cell aggregates in progressive CNS autoimmunity.
Brain. 2021 Mar 9:awab093. doi: 10.1093/brain/awab093. Epub ahead of print. PMID: 33693558.
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Monfrini E, Zech M, Steel D, Kurian MA, Winkelmann J, Di Fonzo A
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HOPS-associated neurological disorders (HOPSANDs): linking endolysosomal dysfunction to the pathogenesis of dystonia
Brain. 2021 Apr 19:awab161. doi: 10.1093/brain/awab161. Epub ahead of print. PMID: 33871597.
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Mori K, Gotoh S, Yamashita T, Uozumi R, Kawabe Y, Tagami S, Kamp F, Nuscher B, Edbauer D, Haass C, Nagai Y, Ikeda M
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The porphyrin TMPyP4 inhibits elongation during the non-canonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene
J Biol Chem. 2021 Aug 24:101120. doi: 10.1016/j.jbc.2021.101120. Epub ahead of print. PMID: 34450161.
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Mortazavi M, Hizarci Ö, Gerdes LA, Havla J, Kümpfel T, Hohlfeld R, Stöcklein S, Keeser D, Ertl-Wagner B
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Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk: A scoping review of MRI studies.
Neuroimage Clin. 2021 Jun 18;31:102734. doi: 10.1016/j.nicl.2021.102734. Epub ahead of print. PMID: 34171607; PMCID: PMC8234346.
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Moster ML, Sergott RC, Newman NJ, Yu-Wai-Man P, Carelli V, Bryan MS, Smits G, Biousse V, Vignal-Clermont C, Klopstock T, Sadun AA, DeBusk AA, Carbonelli M, Hage R, Priglinger S, Karanjia R, Blouin L, Taiel M, Katz B, Sahel JA; LHON study group
(2021)
Cross-Sectional Analysis of Baseline Visual Parameters in Subjects Recruited Into the RESCUE and REVERSE ND4-LHON Gene Therapy Studies.
J Neuroophthalmol. 2021 Jul 23. doi: 10.1097/WNO.0000000000001316. Epub ahead of print. PMID: 34310464.
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Mueller-Sarnowski F, Sollmann N, Schröder A, Houri L, Ille S, Grimmer T, Krieg SM, Diehl-Schmid J
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Neuronavigated repetitive transcranial magnetic stimulation as novel mapping technique provides insights into language function in primary progressive aphasia.
Brain Imaging Behav. 2021 Dec 28. doi: 10.1007/s11682-021-00605-6. Epub ahead of print. PMID: 34964088.
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Murali Mahadevan H, Hashemiaghdam A, Ashrafi G, Harbauer AB
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Mitochondria in Neuronal Health: From Energy Metabolism to Parkinson's Disease.
Adv Biol (Weinh). 2021 Aug 11:e2100663. doi: 10.1002/adbi.202100663. Epub ahead of print. PMID: 34382382.
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Musacchio T, Zech M, Reich MM, Winkelmann J, Volkmann J
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A recurrent EIF2AK2 missense variant causes autosomal-dominant isolated dystonia.
Ann Neurol. 2021 Apr 18. doi: 10.1002/ana.26081. Epub ahead of print. PMID: 33866603.
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Nash A, Gijsen HJM, Hrupka BJ, Teng KS, Lichtenthaler SF, Takeshima H, Gunnersen JM, Munro KM
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BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.
Sci Rep. 2021 Jul 23;11(1):15084. doi: 10.1038/s41598-021-94369-0. PMID: 34302009; PMCID: PMC8302682.
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Natarelli L, Parca L, Mazza T, Weber C, Virgili F, Fratantonio D
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MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2.
Noncoding RNA. 2021 Feb 18;7(1):14. doi: 10.3390/ncrna7010014. PMID: 33670580; PMCID: PMC7931055.
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Natarelli L, Virgili F, Weber C
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SARS-CoV-2, Cardiovascular Diseases, and Noncoding RNAs: A Connected Triad.
Int J Mol Sci. 2021 Nov 12;22(22):12243. doi: 10.3390/ijms222212243. PMID: 34830125; PMCID: PMC8620514.
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Necpál J, Zech M, Winkelmann J, Jech R
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Trisomy X syndrome with dystonia and a pathogenic SATB1 variant.
Neurol Sci. 2021 May 24. doi: 10.1007/s10072-021-05320-0. Epub ahead of print. PMID: 34031799.
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Neilson DE, Zech M, Hufnagel RB, Slone J, Wang X, Homan S, Gutzwiller LM, Leslie EJ, Leslie ND, Xiao J, Hedera P, LeDoux MS, Gebelein B, Wilbert F, Eckenweiler M, Winkelmann J, Gilbert DL, Huang T
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A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia.
Mov Disord. 2021 Oct 11. doi: 10.1002/mds.28821. Epub ahead of print. PMID: 34636445.
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Neitzel J, Franzmeier N, Rubinski A, Dichgans M, Brendel M; Alzheimer’s Disease Neuroimaging Initiative (ADNI), Malik R, Ewers M
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KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
Nat Commun. 2021 Jun 22;12(1):3825. doi: 10.1038/s41467-021-23755-z. PMID: 34158479.
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Neuser S, Brechmann B, Heimer G, Brösse I, Schubert S, O'Grady L, Zech M, Srivastava S, Sweetser DA, Dincer Y, Mall V, Winkelmann J, Behrends C, Darras BT, Graham RJ, Jayakar P, Byrne B, El Bar-Aluma B, Haberman Y, Szeinberg A, Aldhalaan HM, Hashem M, Tenaiji AA, Ismayl O, Al Nuaimi AE, Maher K, Ibrahim S, Khan F, Houlden H, Ramakumaran VS, Pagnamenta AT, Posey JE, Lupski JR, Tan WH, ElGhazali G, Herman I, Muñoz T, Repetto GM, Seitz A, Krumbiegel M, Cecilia Poli M, Kini U, Efthymiou S, Meiler J, Maroofian R, Alkuraya FS, Jamra RA, Popp B, Ben-Zeev B, Ebrahimi-Fakhari D
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Clinical, neuroimaging and molecular spectrum of TECPR2-associated hereditary sensory and autonomic neuropathy with intellectual disability.
Hum Mutat. 2021 Apr 13. doi: 10.1002/humu.24206. Epub ahead of print. PMID: 33847017.
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Newman NJ, Yu-Wai-Man P, Carelli V, Moster ML, Biousse V, Vignal-Clermont C, Sergott RC, Klopstock T, Sadun AA, Barboni P, DeBusk AA, Girmens JF, Rudolph G, Karanjia R, Taiel M, Blouin L, Smits G, Katz B, Sahel JA; LHON Study Group
(2021)
Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset.
Ophthalmology. 2021 Jan 12:S0161-6420(20)31187-8. doi: 10.1016/j.ophtha.2020.12.012. Epub ahead of print. PMID: 33451738.
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Newman NJ, Yu-Wai-Man P, Carelli V, Biousse V, Moster ML, Vignal-Clermont C, Sergott RC, Klopstock T, Sadun AA, Girmens JF, La Morgia C, DeBusk AA, Jurkute N, Priglinger C, Karanjia R, Josse C, Salzmann J, Montestruc F, Roux M, Taiel M, Sahel JA
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Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison.
Front Neurol. 2021 May 24;12:662838. doi: 10.3389/fneur.2021.662838. PMID: 34108929; PMCID: PMC8181419.
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Ng YS, Bindoff LA, Gorman GS, Klopstock T, Kornblum C, Mancuso M, McFarland R, Sue CM, Suomalainen A, Taylor RW, Thorburn DR, Turnbull DM
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Mitochondrial disease in adults: recent advances and future promise.
Lancet Neurol. 2021 Jul;20(7):573-584. doi: 10.1016/S1474-4422(21)00098-3. PMID: 34146515.
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Nguyen TT, Nam GS, Kang JJ, Han GC, Kim JS, Dieterich M, Oh SY
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Galvanic Vestibular Stimulation Improves Spatial Cognition After Unilateral Labyrinthectomy in Mice
Front Neurol. 2021 Jul 29;12:716795. doi: 10.3389/fneur.2021.716795. PMID: 34393985; PMCID: PMC8358680.
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Nguyen TN, Padman BS, Zellner S, Khuu G, Uoselis L, Lam WK, Skulsuppaisarn M, Lindblom RSJ, Watts EM, Behrends C, Lazarou M
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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.
Mol Cell. 2021 Mar 25:S1097-2765(21)00169-6. doi: 10.1016/j.molcel.2021.03.001. Epub ahead of print. PMID: 33773106.
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Nguyen TT, Nam GS, Kang JJ, Han GC, Kim JS, Dieterich M, Oh SY
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The Differential Effects of Acute Right- vs. Left-Sided Vestibular Deafferentation on Spatial Cognition in Unilateral Labyrinthectomized Mice.
Front Neurol. 2021 Dec 8;12:789487. doi: 10.3389/fneur.2021.789487. PMID: 34956067; PMCID: PMC8692718.
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Nuebling GS, Prix C, Brendel M, Beyer L, Wlasich E, Loosli SV, Barthel H, Sabri O, Bartenstein P, Vöglein J, Danek A, Rominger A, Edbauer D, Haass C, Levin J
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Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease.
Neurobiol Aging. 2021 Feb 28:S0197-4580(21)00076-2. doi: 10.1016/j.neurobiolaging.2021.02.021. Epub ahead of print. PMID: 33789815.
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Odstrcil I, Petkova MD, Haesemeyer M, Boulanger-Weill J, Nikitchenko M, Gagnon JA, Oteiza P, Schalek R, Peleg A, Portugues R, Lichtman JW, Engert F
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Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish.
Curr Biol. 2021 Nov 17:S0960-9822(21)01530-X. doi: 10.1016/j.cub.2021.11.007. Epub ahead of print. PMID: 34822765.
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Oh SY, Dieterich M, Lee BN, Boegle R, Kang JJ, Lee NR, Gerb J, Hwang SB, Kirsch V
(2021)
Endolymphatic Hydrops in Patients With Vestibular Migraine and Concurrent Meniere's Disease.
Front Neurol. 2021 Mar 11;12:594481. doi: 10.3389/fneur.2021.594481. PMID: 33776877; PMCID: PMC7991602.
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O'Neill TJ, Seeholzer T, Gewies A, Gehring T, Giesert F, Hamp I, Graß C, Schmidt H, Kriegsmann K, Tofaute MJ, Demski K, Poth T, Rosenbaum M, Schnalzger T, Ruland J, Göttlicher M, Kriegsmann M, Naumann R, Heissmeyer V, Plettenburg O, Wurst W, Krappmann D
(2021)
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
Sci Immunol. 2021 Nov 12;6(65):eabh2095. doi: 10.1126/sciimmunol.abh2095. Epub 2021 Nov 12. PMID: 34767456.
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Ong-Pålsson E, Njavro JR, Wilson Y, Pigoni M, Schmidt A, Müller SA, Meyer M, Hartmann J, Busche MA, Gunnersen JM, Munro KM, Lichtenthaler SF
(2021)
The β-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice.
Mol Neurobiol. 2021 Dec 27. doi: 10.1007/s12035-021-02660-y. Epub ahead of print. PMID: 34958451.
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Ortner M, Riedl L, Jox RJ, Hartmann J, Roßmeier C, Dorn B, Kehl V, Egert-Schwender S, Fischer J, Diehl-Schmid J
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Suicidal Ideations and Behavior in Patients With Young and Late Onset Dementia.
Front Neurol. 2021 Jul 27;12:647396. doi: 10.3389/fneur.2021.647396. PMID: 34385968; PMCID: PMC8353362.
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Ostkamp P, Salmen A, Pignolet B, Görlich D, Andlauer TFM, Schulte-Mecklenbeck A, Gonzalez-Escamilla G, Bucciarelli F, Gennero I, Breuer J, Antony G, Schneider-Hohendorf T, Mykicki N, Bayas A, Then Bergh F, Bittner S, Hartung HP, Friese MA, Linker RA, Luessi F, Lehmann-Horn K, Mühlau M, Paul F, Stangel M, Tackenberg B, Tumani H, Warnke C, Weber F, Wildemann B, Zettl UK, Ziemann U, Müller-Myhsok B, Kümpfel T, Klotz L, Meuth SG, Zipp F, Hemmer B, Hohlfeld R, Brassat D, Gold R, Gross CC, Lukas C, Groppa S, Loser K, Wiendl H, Schwab N; German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network
(2021)
Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity.
Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2018457118. doi: 10.1073/pnas.2018457118. PMID: 33376202.
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Ostrozovicova M, Jech R, Steel D, Pavelekova P, Han V, Gdovinova Z, Lichtner P, Kurian MA, Wiethoff S, Houlden H, Havránková P, Winkelmann J, Zech M, Skorvanek M
(2021)
A Recurrent VPS16 p.Arg187* Nonsense Variant in Early-Onset Generalized Dystonia.
Mov Disord. 2021 May 17. doi: 10.1002/mds.28647. Epub ahead of print. PMID: 33998058.
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Pagnon de la Vega M, Giedraitis V, Michno W, Kilander L, Güner G, Zielinski M, Löwenmark M, Brundin R, Danfors T, Söderberg L, Alafuzoff I, Nilsson LNG, Erlandsson A, Willbold D, Müller SA, Schröder GF, Hanrieder J, Lichtenthaler SF, Lannfelt L, Sehlin D, Ingelsson M
(2021)
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.
Sci Transl Med. 2021 Aug 11;13(606):eabc6184. doi: 10.1126/scitranslmed.abc6184. PMID: 34380771.
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Palleis C, Brendel M, Finze A, Weidinger E, Bötzel K, Danek A, Beyer L, Nitschmann A, Kern M, Biechele G, Rauchmann BS, Häckert J, Höllerhage M, Stephens AW, Drzezga A, van Eimeren T, Villemagne VL, Schildan A, Barthel H, Patt M, Sabri O; German Imaging Initiative for Tauopathies (GII4T), Bartenstein P, Perneczky R, Haass C, Levin J, Höglinger GU
(2021)
Cortical [18 F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes.
Mov Disord. 2021 May 5. doi: 10.1002/mds.28624. Epub ahead of print. PMID: 33951244.
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Papadopoulos A, Palaiopanos K, Björkbacka H, Peters A, de Lemos JA, Seshadri S, Dichgans M, Georgakis MK
(2021)
Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies.
Neurology. 2021 Dec 30:10.1212/WNL.0000000000013274. doi: 10.1212/WNL.0000000000013274. Epub ahead of print. PMID: 34969940.
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Pavelekova P, Jech R, Zech M, Krepelova A, Han V, Mosejova A, Liba Z, Urgosik D, Gdovinova Z, Havrankova P, Fecikova A, Winkelmann J, Skorvanek M
(2021)
Atypical presentations of DYT1 dystonia with acute craniocervical onset.
Parkinsonism Relat Disord. 2021 Jan 13;83:54-55. doi: 10.1016/j.parkreldis.2020.12.019. Epub ahead of print. PMID: 33476878.
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Peakman G, Russell LL, Convery RS, Nicholas JM, Van Swieten JC, Jiskoot LC, Moreno F, Sanchez-Valle R, Laforce R, Graff C, Masellis M, Tartaglia MC, Rowe JB, Borroni B, Finger E, Synofzik M, Galimberti D, Vandenberghe R, de Mendonça A, Butler CR, Gerhard A, Ducharme S, Le Ber I, Tagliavini F, Santana I, Pasquier F, Levin J, Danek A, Otto M, Sorbi S, Rohrer JD; Genetic FTD Initiative (GENFI)
(2021)
Comparison of clinical rating scales in genetic frontotemporal dementia within the GENFI cohort.
J Neurol Neurosurg Psychiatry. 2021 Aug 5:jnnp-2021-326868. doi: 10.1136/jnnp-2021-326868. Epub ahead of print. PMID: 34353857.
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Penkert H, Bertrand A, Tiwari V, Breimann S, Müller SA, Jordan PM, Gerl MJ, Klose C, Cantuti-Castelvetri L, Bosch-Queralt M, Levental I, Lichtenthaler SF, Werz O, Simons M
(2021)
Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery.
Cell Rep. 2021 Oct 26;37(4):109898. doi: 10.1016/j.celrep.2021.109898. PMID: 34706241.
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Perna L, Trares K, Perneczky R, Tato M, Stocker H, Möllers T, Holleczek B, Schöttker B, Brenner H
(2021)
Risk of Late-Onset Depression and Cognitive Decline: Results From Inflammatory Proteome Analyses in a Prospective Population-Based Cohort Study.
Am J Geriatr Psychiatry. 2021 Dec 3:S1064-7481(21)00553-4. doi: 10.1016/j.jagp.2021.12.001. Epub ahead of print. PMID: 34961662.
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Peseschkian T, Cordts I, Günther R, Stolte B, Zeller D, Schröter C, Weyen U, Regensburger M, Wolf J, Schneider I, Hermann A, Metelmann M, Kohl Z, Linker RA, Koch JC, Büchner B, Weiland U, Schönfelder E, Heinrich F, Osmanovic A, Klopstock T, Dorst J, Ludolph AC, Boentert M, Hagenacker T, Deschauer M, Lingor P, Petri S, Schreiber-Katz O
(2021)
A Nation-Wide, Multi-Center Study on the Quality of Life of ALS Patients in Germany.
Brain Sci. 2021 Mar 14;11(3):372. doi: 10.3390/brainsci11030372. PMID: 33799476; PMCID: PMC7998410.
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Pfeiffer S, Tomašcová A, Mamrak U, Haunsberger SJ, Connolly NMC, Resler A, Düssmann H, Weisová P, Jirström E, D'Orsi B, Chen G, Cremona M, Hennessy BT, Plesnila N, Prehn JHM
(2021)
AMPK-regulated miRNA-210-3p is activated during ischaemic neuronal injury and modulates PI3K-p70S6K signalling.
J Neurochem. 2021 Mar 11. doi: 10.1111/jnc.15347. Epub ahead of print. PMID: 33694332.
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Poos JM, Russell LL, Peakman G, Bocchetta M, Greaves CV, Jiskoot LC, van der Ende EL, Seelaar H, Papma JM, van den Berg E, Pijnenburg YAL, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia C, Finger E, Vandenberghe R, de Medonça A, Tagliavini F, Butler CR, Santana I, Ber IL, Gerhard A, Ducharme S, Levin J, Danek A, Otto M, Sorbi S, Pasquier F, van Swieten JC, Rohrer JD; Genetic FTD Initiative, GENF
(2021)
Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study.
Alzheimers Dement (Amst). 2021 May 13;13(1):e12185. doi: 10.1002/dad2.12185. PMID: 34027016; PMCID: PMC8116844.
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Portaccio E, Fonderico M, Hemmer B, Derfuss T, Stankoff B, Selmaj K, Tintorè M, Amato MP
(2021)
Impact of COVID-19 on multiple sclerosis care and management: Results from the European Committee for Treatment and Research in Multiple Sclerosis survey.
Mult Scler. 2021 Mar 25:13524585211005339. doi: 10.1177/13524585211005339. Epub ahead of print. PMID: 33764197.
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Rabenstein A, Catarino CB, Rampeltshammer V, Schindler D, Gallenmüller C, Priglinger C, Pogarell O, Rüther T, Klopstock T
(2021)
Smoking and alcohol, health-related quality of life and psychiatric comorbidities in Leber's Hereditary Optic Neuropathy mutation carriers: a prospective cohort study.
Orphanet J Rare Dis. 2021 Mar 11;16(1):127. doi: 10.1186/s13023-021-01724-5. PMID: 33706792; PMCID: PMC7953635.
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Rauchmann BS, Schneider-Axmann T, Perneczky R ; Alzheimer's Disease Neuroimaging Initiative (ADNI)
(2021)
Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition.
J Neurol Neurosurg Psychiatry. 2021 Jun 29:jnnp-2020-325537. doi: 10.1136/jnnp-2020-325537. Epub ahead of print. PMID: 34187867.
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Rauchmann BS, Ersoezlue E, Stoecklein S, Keeser D, Brosseron F, Buerger K, Dechent P, Dobisch L, Ertl-Wagner B, Fliessbach K, Haynes JD, Heneka MT, Incesoy EI, Janowitz D, Kilimann I, Laske C, Metzger CD, Munk MH, Peters O, Priller J, Ramirez A, Roeske S, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Vukovich R, Wagner M, Wiltfang J, Yakupov R, Duezel E, Jessen F, Perneczky R ; DELCODE study group and the Alzheimer's Disease Neuroimaging Initiative (ADNI)
(2021)
Resting-State Network Alterations Differ between Alzheimer's Disease Atrophy Subtypes.
Cereb Cortex. 2021 Jun 3:bhab130. doi: 10.1093/cercor/bhab130. Epub ahead of print. PMID: 34080613.
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Rausch L, Lutz K, Schifferer M, inheim E, Gruber R, Oesterhaus EF, Rinke L, Hellmuth JC, Scherer C, Muenchhoff M, Mandel C, Bergwelt-Baildon M, Simons M, Straub T, Krug AB, Kranich J, Brocker T
(2021)
Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients.
J Extracell Vesicles. 2021 Dec;10(14):e12173. doi: 10.1002/jev2.12173. PMID: 34854246; PMCID: PMC8636722.
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Reber S, Jutzi D, Lindsay H, Devoy A, Mechtersheimer J, Levone BR, Domanski M, Bentmann E, Dormann D, Mühlemann O, Barabino SML, Ruepp MD
(2021)
The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation.
Nucleic Acids Res. 2021 Jul 7:gkab582. doi: 10.1093/nar/gkab582. Epub ahead of print. PMID: 34233002.
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Reetz K, Dogan I, Hilgers RD, Giunti P, Parkinson MH, Mariotti C, Nanetti L, Durr A, Ewenczyk C, Boesch S, Nachbauer W, Klopstock T, Stendel C, Rodríguez de Rivera Garrido FJ, Rummey C, Schöls L, Hayer SN, Klockgether T, Giordano I, Didszun C, Rai M, Pandolfo M, Schulz JB; EFACTS study group
(2021)
Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 4-year cohort study.
Lancet Neurol. 2021 Mar 23:S1474-4422(21)00027-2. doi: 10.1016/S1474-4422(21)00027-2. Epub ahead of print. PMID: 33770527.
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Reidler P, Brehm A, Sporns PB, Burbano VG, Stueckelschweiger L, Broocks G, Liebig T, Psychogios MN, Ricke J, Dimitriadis K, Dichgans M, Kunz WG, Tiedt S
(2021)
Circadian rhythm of ischaemic core progression in human stroke.
J Neurol Neurosurg Psychiatry. 2021 May 26:jnnp-2021-326072. doi: 10.1136/jnnp-2021-326072. Epub ahead of print. PMID: 34039629.
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Reinert MC, Pacheu-Grau D, Catarino CB, Klopstock T, Ohlenbusch A, Schittkowski M, Wilichowski E, Rehling P, Brockmann K
(2021)
Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy.
Orphanet J Rare Dis. 2021 Feb 4;16(1):64. doi: 10.1186/s13023-021-01690-y. PMID: 33541401; PMCID: PMC7860214.
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Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, Yu L, Khinikar A, Sivasankaran R, Kieloch A, Valentin MA, Karydas AM, Mitic LL, Pearlman R, Kornak J, Kramer JH, Miller BL, Kantarci K, Knopman DS, Graff-Radford N, Petrucelli L, Rademakers R, Irwin DJ, Grossman M, Ramos EM, Coppola G, Mendez MF, Bordelon Y, Dickerson BC, Ghoshal N, Huey ED, Mackenzie IR, Appleby BS, Domoto-Reilly K, Hsiung GR, Toga AW, Weintraub S, Kaufer DI, Kerwin D, Litvan I, Onyike CU, antelyat A, Roberson ED, Tartaglia MC, Foroud T, Chen W, Czerkowicz J, Graham DL, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Cash DM, Convery RS, Bocchetta M, Foiani M, Caroline V G, Peakman G, Russell L, Swift I, Todd E, Rohrer JD, Boeve BF, Rosen HJ, Boxer AL
(2021)
Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.
Neurology. 2021 Apr 7:10.1212/WNL.0000000000011848. doi: 10.1212/WNL.0000000000011848. Epub ahead of print. PMID: 33827960.
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Roth S, Cao J, Singh V, Tiedt S, Hundeshagen G, Li T, Boehme JD, Chauhan D, Zhu J, Ricci A, Gorka O, Asare Y, Yang J, Lopez MS, Rehberg M, Bruder D, Zhang S, Groß O, Dichgans M, Hornung V, Liesz A
(2021)
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade.
Immunity. 2021 Mar 1:S1074-7613(21)00070-4. doi: 10.1016/j.immuni.2021.02.004. Epub ahead of print. PMID: 33667383.
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Rujeedawa T, Carrillo Félez E, Clare ICH, Fortea J, Strydom A, Rebillat AS, Coppus A, Levin J, Zaman SH
(2021)
The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease.
J Clin Med. 2021 Oct 3;10(19):4582. doi: 10.3390/jcm10194582. PMID: 34640600; PMCID: PMC8509365.
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Sachs M, Wetzel S, Reichelt J, Sachs W, Schebsdat L, Zielinski S, Seipold L, Heintz L, Müller SA, Kretz O, Lindenmeyer M, Wiech T, Huber TB, Lüllmann-Rauch R, Lichtenthaler SF, Saftig P, Meyer-Schwesinger C
(2021)
ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage.
J Am Soc Nephrol. 2021 Mar 30:ASN.2020081213. doi: 10.1681/ASN.2020081213. Epub ahead of print. PMID: 33785583.
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Safaiyan S, Besson-Girard S, Kaya T, Cantuti-Castelvetri L, Liu L, Ji H, Schifferer M, Gouna G, Usifo F, Kannaiyan N, Fitzner D, Xiang X, Rossner MJ, Brendel M, Gokce O, Simons M
(2021)
White matter aging drives microglial diversity.
Neuron. 2021 Feb 11:S0896-6273(21)00073-8. doi: 10.1016/j.neuron.2021.01.027. Epub ahead of print. PMID: 33606969.
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Sander P, Feng M, Schweitzer MK, Wilting F, Gutenthaler SM, Arduino DM, Fischbach S, Dreizehnter L, Moretti A, Gudermann T, Perocchi F, Schredelseker J
(2021)
Approved drugs ezetimibe and disulfiram enhance mitochondrial Ca2+ uptake and suppress cardiac arrhythmogenesis.
Br J Pharmacol. 2021 Jul 21. doi: 10.1111/bph.15630. Epub ahead of print. PMID: 34287836.
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Santovito D, Toto L, De Nardis V, Marcantonio P, D'Aloisio R, Mastropasqua A, De Cesare D, Bucci M, Paganelli C, Natarelli L, Weber C, Consoli A, Mastropasqua R, Cipollone F
(2021)
Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes.
Sci Rep. 2021 Feb 18;11(1):4136. doi: 10.1038/s41598-021-83047-w. PMID: 33602976.
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Santovito D, Weber C
(2021)
Not all myocardial infarctions are created equal: The potential of circulating microRNAs to discern coronary artery dissection.
EBioMedicine. 2021 May 6;67:103366. doi: 10.1016/j.ebiom.2021.103366. Epub ahead of print. PMID: 33965874.
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Scekic-Zahirovic J, Sanjuan-Ruiz I, Kan V, Megat S, De Rossi P, Dieterlé S, Cassel R, Jamet M, Kessler P, Wiesner D, Tzeplaeff L, Demais V, Sahadevan S, Hembach KM, Muller HP, Picchiarelli G, Mishra N, Antonucci S, Dirrig-Grosch S, Kassubek J, Rasche V, Ludolph A, Boutillier AL, Roselli F, Polymenidou M, Lagier-Tourenne C, Liebscher S, Dupuis L
(2021)
Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.
Nat Commun. 2021 May 21;12(1):3028. doi: 10.1038/s41467-021-23187-9. PMID: 34021132.
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Schaffernicht G, Shang Q, Stievenard A, Bötzel K, Dening Y, Kempe R, Toussaint M, Gündel D, Kranz M, Reichmann H, Vanbesien-Mailliot C, Brust P, Dieterich M, Funk RHW, Ravens U, Pan-Montojo F
(2021)
Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease.
Front Neurol. 2021 Mar 22;12:642604. doi: 10.3389/fneur.2021.642604. PMID: 33841309; PMCID: PMC8030242.
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Schafflick D, Wolbert J, Heming M, Thomas C, Hartlehnert M, Börsch AL, Ricci A, Martín-Salamanca S, Li X, Lu IN, Pawlak M, Minnerup J, Strecker JK, Seidenbecher T, Meuth SG, Hidalgo A, Liesz A, Wiendl H, Meyer Zu Horste G
(2021)
Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges.
Nat Neurosci. 2021 Jul 12. doi: 10.1038/s41593-021-00880-y. Epub ahead of print. PMID: 34253922.
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Schänzer A, Achleitner M, Trümbach D, Hubert L, Munnich A, Ahlemeyer B, AlAbdulrahim MM, Greif PA, Vosberg S, Hummer B, Feichtinger RG, Mayr JA, Wortmann SB, Aichner H, Rudnik-Schöneborn S, Ruiz A, Gabau E, Sánchez JP, Ellard S, Homfray T, Stals KL, Wurst W, Neubauer BA, Acker T, Bohlander SK, Asensio C, Besmond C, Alkuraya FS, AlSayed MD, Hahn A, Weber A
(2021)
Mutations in HID1 cause syndromic infantile encephalopathy and hypopituitarism.
Ann Neurol. 2021 May 17. doi: 10.1002/ana.26127. Epub ahead of print. PMID: 33999436.
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Schifferer M, Snaidero N, Djannatian M, Kerschensteiner M, Misgeld T
(2021)
Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology.
Front Neuroanat. 2021 Oct 13;15:732506. doi: 10.3389/fnana.2021.732506. PMID: 34720890; PMCID: PMC8548362.
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Schindler L, Zwissler L, Krammer C, Hendgen-Cotta U, Rassaf T, Hampton MB, Dickerhof N, Bernhagen J
(2021)
Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells.
J Leukoc Biol. 2021 Feb 10. doi: 10.1002/JLB.3A0420-242RRR. Epub ahead of print. PMID: 33565160.
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Schindler L, Smyth LCD, Bernhagen J, Hampton MB, Dickerhof N
(2021)
Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils.
Redox Biol. 2021 Mar 30;41:101946. doi: 10.1016/j.redox.2021.101946. Epub ahead of print. PMID: 33823474.
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Schischlevskij P, Cordts I, Günther R, Stolte B, Zeller D, Schröter C, Weyen U, Regensburger M, Wolf J, Schneider I, Hermann A, Metelmann M, Kohl Z, Linker RA, Koch JC, Stendel C, Müschen LH, Osmanovic A, Binz C, Klopstock T, Dorst J, Ludolph AC, Boentert M, Hagenacker T, Deschauer M, Lingor P, Petri S, Schreiber-Katz O
(2021)
Informal Caregiving in Amyotrophic Lateral Sclerosis (ALS): A High Caregiver Burden and Drastic Consequences on Caregivers' Lives.
Brain Sci. 2021 Jun 4;11(6):748. doi: 10.3390/brainsci11060748. PMID: 34200087; PMCID: PMC8228206.
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Schlosser P, Tin A, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Weihs A, Yu Z, Hoppmann A, Grundner-Culemann F, Min JL, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Breteler MMB, Carmeli C, Chaker L, Chambers JC, Cole SA, Coresh J, Corre T, Correa A, Cox SR, de Klein N, Delgado GE, Domingo-Relloso A, Eckardt KU, Ekici AB, Endlich K, Evans KL, Floyd JS, Fornage M, Franke L, Fraszczyk E, Gao X, Gào X, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Jarvelin MR, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kramer H, Kronenberg F, Kühnel B, Lehtimäki T, Lind L, Liu D, Liu Y, Lloyd-Jones DM, Lohman K, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Navas-Acien A, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Rosas SE, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, Tellez-Plaza M, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Verweij N, Walker RM, Wielscher M, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y; Estonian Biobank Research Team; Genetics of DNA Methylation Consortium, Loh M, Snieder H, Levy D, Waldenberger M, Susztak K, Köttgen A, Teumer A
(2021)
Meta-analyses identify DNA methylation associated with kidney function and damage.
Nat Commun. 2021 Dec 9;12(1):7174. doi: 10.1038/s41467-021-27234-3. PMID: 34887417.
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Schmitt J, Palleis C, Sauerbeck J, Unterrainer M, Harris S, Prix C, Weidinger E, Katzdobler S, Wagemann O, Danek A, Beyer L, Rauchmann BS, Rominger A, Simons M, Bartenstein P, Perneczky R, Haass C Levin J, Höglinger GU, Brendel M; German Imaging Initiative for Tauopathies (GII4T)
(2021)
Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome.
Front Aging Neurosci. 2021 May 13;13:661284. doi: 10.3389/fnagi.2021.661284. PMID: 34054506; PMCID: PMC8155727.
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Schneider MM, Gautam S, Herling TW, Andrzejewska E, Krainer G, Miller AM, Trinkaus VA, Peter QAE, Ruggeri FS, Vendruscolo M, Bracher A, Dobson CM Hartl FU
(2021)
The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Nat Commun. 2021 Oct 14;12(1):5999. doi: 10.1038/s41467-021-25966-w. PMID: 34650037.
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Schöberl F, Pradhan C, Grosch M, Brendel M, Jostes F, Obermaier K, Sowa C, Jahn K, Bartenstein P, Brandt T, Dieterich M, Zwergal A
(2021)
Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space.
Sci Rep. 2021 Jan 29;11(1):2695. doi: 10.1038/s41598-021-82427-6. PMID: 33514827; PMCID: PMC7846808.
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Schwarting J, Nehrkorn K, Liu H, Plesnila N, Terpolilli NA
(2021)
Role of Pial Microvasospasms and Leukocyte Plugging for Parenchymal Perfusion after Subarachnoid Hemorrhage Assessed by In Vivo Multi-Photon Microscopy
Int J Mol Sci. 2021 Aug 6;22(16):8444. doi: 10.3390/ijms22168444. PMID: 34445151; PMCID: PMC8395146.
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Seker FB, Fan Z, Gesierich B, Gaubert M, Sienel RI, Plesnila N
(2021)
Neurovascular Reactivity in the Aging Mouse Brain Assessed by Laser Speckle Contrast Imaging and 2-Photon Microscopy: Quantification by an Investigator-Independent Analysis Tool.
Front Neurol. 2021 Nov 11;12:745770. doi: 10.3389/fneur.2021.745770. PMID: 34858312; PMCID: PMC8631776.
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Sitron CS, Hartl FU
(2021)
A new way of D/Ealing with protein misfolding.
Mol Cell. 2021 Oct 21;81(20):4114-4115. doi: 10.1016/j.molcel.2021.09.025. PMID: 34686313.
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Skorvanek M, Rektorova I, Mandemakers W, Wagner M, Steinfeld R, Orec L, Han V, Pavelekova P, Lackova A, Kulcsarova K, Ostrozovicova M, Gdovinova Z, Plecko B, Brunet T, Berutti R, Kuipers DJS, Boumeester V, Havrankova P, Tijssen MAJ, Kaiyrzhanov R, Rizig M, Houlden H, Winkelmann J, Bonifati V, Zech M, Jech R
(2021)
WARS2 mutations cause dopa-responsive early-onset parkinsonism and progressive myoclonus ataxia.
Parkinsonism Relat Disord. 2021 Dec 2;94:54-61. doi: 10.1016/j.parkreldis.2021.11.030. Epub ahead of print. PMID: 34890876.
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Soldati C, Lopez-Fabuel I, Wanderlingh LG, Garcia-Macia M, Monfregola J, Esposito A, Napolitano G, Guevara-Ferrer M, Scotto Rosato A, Krogsaeter EK, Paquet D, Grimm CM, Montefusco S, Braulke T, Storch S, Mole SE, De Matteis MA, Ballabio A, Sampaio JL, McKay T, Johannes L, Bolaños JP, Medina DL
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Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
EMBO Mol Med. 2021 Aug 19:e13742. doi: 10.15252/emmm.202013742. Epub ahead of print. PMID: 34411438.
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Song M, Beyer L, Kaiser L, Barthel H, van Eimeren T, Marek K, Nitschmann A, Scheifele M, Palleis C, Respondek G, Kern M, Biechele G, Hammes J, Bischof G, Barbe M, Onur Ö, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Barret O, Madonia J, Russell DS, Stephens AW, Mueller A, Roeber S, Herms J, Bötzel K, Danek A, Levin J, Classen J, Höglinger GU, Bartenstein P, Villemagne V, Drzezga A, Seibyl J, Sabri O, Boening G, Ziegler S, Brendel M
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Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET.
J Cereb Blood Flow Metab. 2021 May 27:271678X211018904. doi: 10.1177/0271678X211018904. Epub ahead of print. PMID: 34044665.
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Song M, Scheifele M, Barthel H, van Eimeren T, Beyer L, Marek K, Eckenweber F, Palleis C, Kaiser L, Finze A, Kern M, Nitschmann A, Biechele G, Katzdobler S, Bischof G, Hammes J, Jessen F, Saur D, Schroeter ML, Rumpf JJ, Rullmann M, Schildan A, Patt M, Neumaier B, Stephens AW, Rauchmann BS, Perneczky R, Levin J, Classen J, Höglinger GU, Bartenstein P, Boening G, Ziegler S, Villemagne V, Drzezga A, Seibyl J, Sabri O, Brendel M; German Imaging Initiative for Tauopathies (GII4T)
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Feasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy.
Eur J Nucl Med Mol Imaging. 2021 May 22. doi: 10.1007/s00259-021-05391-3. Epub ahead of print. PMID: 34021393.
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Song B, Kang CY, Han JH, Kano M, Konnerth A, Bae S
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In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors.
Comput Struct Biotechnol J. 2021 Apr 25;19:2477-2485. doi: 10.1016/j.csbj.2021.04.051. PMID: 34025938; PMCID: PMC8113754.
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Staiger A, Schroeter ML, Ziegler W, Schölderle T, Anderl-Straub S, Danek A, Duning T, Fassbender K, Fliessbach K, Jahn H, Kasper E, Kornhuber J, Landwehrmeyer B, Lauer M, Lombardi J, Ludolph A, Müller-Sarnowski F, Polyakova M, Prix C, Prudlo J, Regenbrecht F, Roßmeier C, Schneider A, Wiltfang J, Otto M; German FTLD Consortium, Diehl-Schmid J
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Motor speech disorders in the nonfluent, semantic and logopenic variants of primary progressive aphasia.
Cortex. 2021 Apr 2;140:66-79. doi: 10.1016/j.cortex.2021.03.017. Epub ahead of print. PMID: 33933931.
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Stavsky A, Stoler O, Kostic M, Katoshevsky T, Assali EA, Savic I, Amitai Y, Prokisch H, Leiz S, Daumer-Haas C, Fleidervish I, Perocchi F, Gitler D, Sekler I
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Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation.
Commun Biol. 2021 Jun 2;4(1):666. doi: 10.1038/s42003-021-02114-0. Erratum in: Commun Biol. 2021 Jun 14;4(1):755. PMID: 34079053; PMCID: PMC8172942.
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Steffens H, Mott AC, Li S, Wegner W, Švehla P, Kan VWY, Wolf F, Liebscher S, Willig KI
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Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity.
Sci Adv. 2021 Jun 9;7(24):eabf2806. doi: 10.1126/sciadv.abf2806. PMID: 34108204.
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Steiner T, Dichgans M, Norrving B, Aamodt AH, Berge E, Christensen H, Fuentes B, Khatri P, Korompoki E, Martí-Fabregas J, Quinn T, Toni D, Zedde M, Sacco S, Turc G
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European Stroke Organisation (ESO) standard operating procedure for the preparation and publishing of guidelines.
Eur Stroke J. 2021 Sep;6(3):CXXII-CXXXIV. doi: 10.1177/23969873211024143. Epub 2021 Sep 24. PMID: 34746429; PMCID: PMC8564158.
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Stenton SL, Sheremet NL, Catarino CB, Andreeva N, Assouline Z, Barboni P, Barel O, Berutti R, Bychkov IO, Caporali L, Capristo M, Carbonelli M, Cascavilla ML, Charbel Issa P, Freisinger P, Gerber S, Ghezzi D, Graf E, Heidler J, Hempel M, Heon E, Itkis YS, Javasky E, Kaplan J, Kopajtich R, Kornblum C, Kovacs-Nagy R, Krylova T, Kunz WS, La Morgia C, Lamperti C, Ludwig C, Malacarne PF, Maresca A, Mayr JA, Meisterknecht J, Nevinitsyna T, Palombo F, Pode-Shakked B, Shmelkova MS, Strom TM, Tagliavini F, Tzadok M, van der Ven AT, Vignal-Clermont C, Wagner M, Zakharova E, Zhorzholadze N, Rozet JM, Carelli V, Tsygankova P, Klopstock T, Wittig I, Prokisch H
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Impaired complex I repair causes recessive Leber's hereditary optic neuropathy.
J Clin Invest. 2021 Jan 19:138267. doi: 10.1172/JCI138267. Epub ahead of print. PMID: 33465056.
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Stowe AM, Bernhagen J
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Role of the immune system for conditioning in cerebrovascular diseases.
Cond Med. 2021 Feb;4(1):1-2. PMID: 34095776; PMCID: PMC8177088.
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Sullivan R, Kilaru A, Hemmer B, Campbell Cree BA, Greenberg BM, Kundu U, Hach T, DeLasHeras V, Ward BJ, Berger J
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COVID-19 Infection in Fingolimod- or Siponimod-Treated Patients: Case Series.
Neurol Neuroimmunol Neuroinflamm. 2021 Nov 30;9(1):e1092. doi: 10.1212/NXI.0000000000001092. PMID: 34848501.
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Sun F, Salinas AG, Filser S, Blumenstock S, Medina-Luque J, Herms J, Sgobio C
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Impact of α-synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology.
Brain Pathol. 2021 Nov 21:e13036. doi: 10.1111/bpa.13036. Epub ahead of print. PMID: 34806235.
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Sundararaman SS, Peters LJF, Jansen Y, Gencer S, Yan Y, Nazir S, Bonnin Marquez A, Kahles F, Lehrke M, Biessen EAL, Jankowski J, Weber C, Döring Y, van der Vorst EPC
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Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe-/- mice.
Sci Rep. 2021 May 17;11(1):10409. doi: 10.1038/s41598-021-89893-y. PMID: 34001955; PMCID: PMC8128899.
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Tang Q, Gao P, Arzberger T, Höllerhage M, Herms J, Höglinger G, Koeglsperger T
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Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion.
Cell Death Dis. 2021 Sep 17;12(10):854. doi: 10.1038/s41419-021-04138-0. PMID: 34535638.
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Thakur N, Klopstock T. Jackowski S, Kuscer E, Tricta F, Videnovic A, Jinnah HA
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Rational Design of Novel Therapies for Pantothenate Kinase-Associated Neurodegeneration.
Mov Disord. 2021 May 18. doi: 10.1002/mds.28642. Epub ahead of print. PMID: 34002881.
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Thompson AJ, Carroll W, Ciccarelli O, Comi G, Cross A, Donnelly A, Feinstein A, Fox RJ, Helme A, Hohlfeld R, Hyde R, Kanellis P, Landsman D, Lubetzki C, Marrie RA, Morahan J, Montalban X, Musch B, Rawlings S, Salvetti M, Sellebjerg F, Sincock C, Smith KE, Strum J, Zaratin P, Coetzee T
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Charting a global research strategy for progressive MS-An international progressive MS Alliance proposal.
Mult Scler. 2021 Dec 1:13524585211059766. doi: 10.1177/13524585211059766. Epub ahead of print. PMID: 34850641.
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Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R
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MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.
J Clin Invest. 2021 Dec 1;131(23):e127171. doi: 10.1172/JCI127171. PMID: 34850744; PMCID: PMC8631602.
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Tin A, Schlosser P, Matias-Garcia PR, Thio CHL, Joehanes R, Liu H, Yu Z, Weihs A, Hoppmann A, Grundner-Culemann F, Min JL, Kuhns VLH, Adeyemo AA, Agyemang C, Ärnlöv J, Aziz NA, Baccarelli A, Bochud M, Brenner H, Bressler J, Breteler MMB, Carmeli C, Chaker L, Coresh J, Corre T, Correa A, Cox SR, Delgado GE, Eckardt KU, Ekici AB, Endlich K, Floyd JS, Fraszczyk E, Gao X, Gào X, Gelber AC, Ghanbari M, Ghasemi S, Gieger C, Greenland P, Grove ML, Harris SE, Hemani G, Henneman P, Herder C, Horvath S, Hou L, Hurme MA, Hwang SJ, Kardia SLR, Kasela S, Kleber ME, Koenig W, Kooner JS, Kronenberg F, Kühnel B, Ladd-Acosta C, Lehtimäki T, Lind L, Liu D, Lloyd-Jones DM, Lorkowski S, Lu AT, Marioni RE, März W, McCartney DL, Meeks KAC, Milani L, Mishra PP, Nauck M, Nowak C, Peters A, Prokisch H, Psaty BM, Raitakari OT, Ratliff SM, Reiner AP, Schöttker B, Schwartz J, Sedaghat S, Smith JA, Sotoodehnia N, Stocker HR, Stringhini S, Sundström J, Swenson BR, van Meurs JBJ, van Vliet-Ostaptchouk JV, Venema A, Völker U, Winkelmann J, Wolffenbuttel BHR, Zhao W, Zheng Y; Estonian Biobank Research Team; Genetics of DNA Methylation Consortium, Loh M, Snieder H, Waldenberger M, Levy D, Akilesh S, Woodward OM, Susztak K, Teumer A, Köttgen A
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Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
Nat Commun. 2021 Dec 9;12(1):7173. doi: 10.1038/s41467-021-27198-4. PMID: 34887389.
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Traschütz A, Reich S, Adarmes AD, Anheim M, Ashrafi MR, Baets J, Basak AN, Bertini E, Brais B, Gagnon C, Gburek-Augustat J, Hanagasi HA, Heinzmann A, Horvath R, de Jonghe P, Kamm C, Klivenyi P, Klopstock T, Minnerop M, Münchau A, Renaud M, Roxburgh RH, Santorelli FM, Schirinzi T, Sival DA, Timmann D, Vielhaber S, Wallner M, van de Warrenburg BP, Zanni G, Zuchner S, Klockgether T, Schüle R, Schöls L; PREPARE Consortium, Synofzik M
(2021)
The ARCA Registry: A Collaborative Global Platform for Advancing Trial Readiness in Autosomal Recessive Cerebellar Ataxias.
Front Neurol. 2021 Jun 25;12:677551. doi: 10.3389/fneur.2021.677551. PMID: 34248822; PMCID: PMC8267795.
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Traylor M, Persyn E, Tomppo L, Klasson S, Abedi V, Bakker MK, Torres N, Li L, Bell S, Rutten-Jacobs L, Tozer DJ, Griessenauer CJ, Zhang Y, Pedersen A, Sharma P, Jimenez-Conde J, Rundek T, Grewal RP, Lindgren A, Meschia JF, Salomaa V, Havulinna A, Kourkoulis C, Crawford K, Marini S, Mitchell BD, Kittner SJ, Rosand J, Dichgans M, Jern C, Strbian D, Fernandez-Cadenas I, Zand R, Ruigrok Y, Rost N, Lemmens R, Rothwell PM, Anderson CD, Wardlaw J, Lewis CM, Markus HS; Helsinki Stroke, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group; National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network; UK DNA Lacunar Stroke Study Investigators; International Stroke Genetics Consortium
(2021)
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies.
Lancet Neurol. 2021 Mar 25:S1474-4422(21)00031-4. doi: 10.1016/S1474-4422(21)00031-4. Epub ahead of print. PMID: 33773637.
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Traylor M, Malik R, Gesierich B, Dichgans M
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The BS variant of C4 protects against age-related loss of white matter microstructural integrity.
Brain. 2021 Aug 6:awab261. doi: 10.1093/brain/awab261. Epub ahead of print. PMID: 34358307.
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Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R
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In situ architecture of neuronal α-Synuclein inclusions.
Nat Commun. 2021 Apr 14;12(1):2110. doi: 10.1038/s41467-021-22108-0. PMID: 33854052.
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Tripathi-Giesgen I, Behrends C
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The ubiquitin ligation machinery in the defense against bacterial pathogens.
EMBO Rep. 2021 Sep 13:e52864. doi: 10.15252/embr.202152864. Epub ahead of print. PMID: 34515402.
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Tüshaus J, Müller SA, Shrouder J, Arends M, Simons M, Plesnila N, Blobel CP, Lichtenthaler SF
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The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.
FASEB J. 2021 Nov;35(11):e21962. doi: 10.1096/fj.202100936R. PMID: 34613632.
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Tuzlak S, Dejean AS, Iannacone M, Quintana FJ, Waisman A, Ginhoux F, Korn T, Becher B
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Repositioning TH cell polarization from single cytokines to complex help.
Nat Immunol. 2021 Oct;22(10):1210-1217. doi: 10.1038/s41590-021-01009-w. Epub 2021 Sep 20. PMID: 34545250.
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Unger F, Konnerth A, Zott B
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Population imaging of synaptically released glutamate in mouse hippocampal slices.
STAR Protoc. 2021 Nov 9;2(4):100877. doi: 10.1016/j.xpro.2021.100877. PMID: 34816125; PMCID: PMC8591355.
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Vandebergh M, Andlauer TFM, Zhou Y, Mallants K, Held F, Aly L, Taylor BV, Hemmer B, Dubois B, Goris A
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Genetic variation in WNT9B increases relapse hazard in multiple sclerosis.
Ann Neurol. 2021 Mar 11. doi: 10.1002/ana.26061. Epub ahead of print. PMID: 33704824.
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van der Ende EL, Morenas-Rodriguez E, McMillan C, Grossman M, Irwin D, Sanchez-Valle R, Graff C, Vandenberghe R, Pijnenburg YAL, Laforce R, Ber IL, Lleo A, Haass C, Suarez-Calvet M, van Swieten JC, Seelaar H
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CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia.
Neurobiol Aging. 2021 Mar 4:S0197-4580(21)00079-8. doi: 10.1016/j.neurobiolaging.2021.02.024. Epub ahead of print. PMID: 33896652.
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van der Ende EL, Bron EE, Poos JM, Jiskoot LC, Panman JL, Papma JM, Meeter LH, Dopper EGP, Wilke C, Synofzik M, Heller C, Swift IJ, Sogorb-Esteve A, Bouzigues A, Borroni B, Sanchez-Valle R, Moreno F, Graff C, Laforce R, Galimberti D, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, Rowe JB, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Pijnenburg YAL, Sorbi S, Zetterberg H, Niessen WJ, Rohrer JD, Klein S, van Swieten JC, Venkatraghavan V, Seelaar H; GENFI consortium
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A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia.
Brain. 2021 Oct 11:awab382. doi: 10.1093/brain/awab382. Epub ahead of print. PMID: 34633446.
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van der Vorst EPC, Pepe MAA, Peters LJF, Haberbosch M, Jansen Y, Nauman R, Stathopoulos GT, Weber C, Bidzhekov K
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Transcriptome signature of miRNA-26b KO mouse model suggests novel targets.
BMC Genom Data. 2021 Jun 30;22(1):23. doi: 10.1186/s12863-021-00976-1. PMID: 34193044; PMCID: PMC8243710.
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Van Steenbergen V, Bareyre FM
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Chemogenetic approaches to unravel circuit wiring and related behavior after spinal cord injury
Exp Neurol. 2021 Aug 10;345:113839. doi: 10.1016/j.expneurol.2021.113839. Epub ahead of print. PMID: 34389362.
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Vettermann FJ, Harris S, Schmitt J, Unterrainer M, Lindner S, Rauchmann BS, Palleis C, Weidinger E, Beyer L, Eckenweber F, Schuster S, Biechele G, Ferschmann C, Milenkovic VM, Wetzel CH, Rupprecht R, Janowitz D, Buerger K, Perneczky R, Höglinger GU, Levin J, Haass C, Tonn JC, Niyazi M, Bartenstein P, Albert NL, Brendel M
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Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders.
Life (Basel). 2021 May 26;11(6):484. doi: 10.3390/life11060484. PMID: 34073557.
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Vöglein J, Kostova I, Arzberger T, Röber S, Schmitz P, Simons M, Ruf V, Windl O, Herms J, Dieterich M, Danek A, Höglinger GU, Giese A, Levin J
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First symptom guides diagnosis and prognosis in neurodegenerative diseases - a retrospective study of autopsy proven cases.
Eur J Neurol. 2021 Mar 4. doi: 10.1111/ene.14800. Epub ahead of print. PMID: 33662165.
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Vöglein J, Levin J, Forbrig R, Liebig T, Dieterich M, Danek A
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Amphetamin induzierte zerebrale Vaskulitis – ein Fallbericht [Amphetamine-induced cerebral vasculitis-a case report].
Nervenarzt. 2021 Apr 29. German. doi: 10.1007/s00115-021-01125-w. Epub ahead of print. PMID: 33914110.
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Vöglein J, Kostova I, Arzberger T, Noachtar S, Dieterich M, Herms J, Schmitz P, Ruf V, Windl O, Roeber S, Simons M, Höglinger GU, Danek A, Giese A, Levin J
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Seizure prevalence in neurodegenerative diseases - a study of autopsy proven cases.
Eur J Neurol. 2021 Sep 2. doi: 10.1111/ene.15089. Epub ahead of print. PMID: 34472165.PMC8161006.
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von Hundelshausen P, Lorenz R, Siess W, Weber C
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Vaccine-induced immune thrombotic thrombocytopenia (VITT): targeting pathomechanisms with Bruton tyrosine kinase inhibitors.
Thromb Haemost. 2021 Apr 13. doi: 10.1055/a-1481-3039. Epub ahead of print. PMID: 33851389.
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Wagner M, Lorenz G, Volk AE, Brunet T, Edbauer D, Berutti R, Zhao C, Anderl-Straub S, Bertram L, Danek A, Deschauer M, Dill V, Fassbender K, Fliessbach K, Götze KS, Jahn H, Kornhuber J, Landwehrmeyer B, Lauer M, Obrig H, Prudlo J, Schneider A, Schroeter ML, Uttner I, Vukovich R, Wiltfang J, Winkler AS, Zhou Q, Ludolph AC; German FTLD consortium, Oexle K, Otto M, Diehl-Schmid J, Winkelmann J
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Clinico-genetic findings in 509 frontotemporal dementia patients.
Mol Psychiatry. 2021 Sep 24. doi: 10.1038/s41380-021-01271-2. Epub ahead of print. PMID: 34561610.
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Influence of Organic Solvents on Secondary Brain Damage after Experimental Traumatic Brain Injury.
Neurotrauma Rep. 2020 Nov 6;1(1):148-156. doi: 10.1089/neur.2020.0029. PMID: 34223539; PMCID: PMC8240898.
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Wang M, Kleele T, Xiao Y, Plucinska G, Avramopoulos P, Engelhardt S, Schwab MH, Kneussel M, Czopka T, Sherman DL, Brophy PJ, Misgeld T, Brill MS
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Completion of neuronal remodeling prompts myelination along developing motor axon branches.
J Cell Biol. 2021 Apr 5;220(4):e201911114. doi: 10.1083/jcb.201911114. PMID: 33538762.
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Wehn AC, Khalin I, Duering M, Hellal F, Culmsee C, Vandenabeele P, Plesnila N, Terpolilli NA
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RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury
Acta Neuropathol Commun. 2021 Aug 17;9(1):138. doi: 10.1186/s40478-021-01236-0. PMID: 34404478; PMCID: PMC8369637.
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Weisheit I, Kroeger JA, Malik R, Wefers B, Lichtner P, Wurst W, Dichgans M, Paquet D
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Simple and reliable detection of CRISPR-induced on-target effects by qgPCR and SNP genotyping.
Nat Protoc. 2021 Feb 17. doi: 10.1038/s41596-020-00481-2. Epub ahead of print. PMID: 33597771.
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Wicklein R, Heidegger S, Verbeek M, Eiz-Vesper B, Maecker-Kolhoff B, Kirschke JS, Page A, Korn T, Hemmer B, Deschauer M
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Combined Treatment With Pembrolizumab and Allogenic BK Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy: A Case Report.
Neurol Neuroimmunol Neuroinflamm. 2021 Jul 20;8(5):e1042. doi: 10.1212/NXI.0000000000001042. PMID: 34285093; PMCID: PMC8293283.
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Wicklein R, Wauschkuhn J, Giglhuber K, Kümpfel T, Hemmer B, Havla J, Knier B
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Association of Peripapillary Hyper-Reflective Ovoid Masslike Structures and Disease Duration in Primary Progressive Multiple Sclerosis.
Eur J Neurol. 2021 Aug 9. doi: 10.1111/ene.15056. Epub ahead of print. PMID: 34374178.
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Wiegand TLT, Sollmann N, Bonke EM, Umeasalugo KE, Sobolewski KR, Plesnila N, Shenton ME, Lin AP, Koerte IK
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Translational neuroimaging in mild traumatic brain injury.
J Neurosci Res. 2021 Mar 31. doi: 10.1002/jnr.24840. Epub ahead of print. PMID: 33789358.
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Wilke C, Reich S, van Swieten JC, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler CR, Gerhard A, Levin J, Danek A, Otto M, Frisoni G, Ghidoni R, Sorbi S, Bocchetta M, Todd E, Kuhle J, Barro C; Genetic Frontotemporal dementia Initiative (GENFI), Rohrer JD, Synofzik M
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Stratifying the presymptomatic phase of genetic frontotemporal dementia by serum NfL and pNfH: a longitudinal multicentre study.
Ann Neurol. 2021 Nov 7. doi: 10.1002/ana.26265. Epub ahead of print. PMID: 34743360.
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Willroider M, Roeber S, Horn AKE, Arzberger T, Scheifele M, Respondek G, Sabri O, Barthel H, Patt M, Mishchenko O, Schildan A, Mueller A, Koglin N, Stephens A, Levin J, Höglinger GU, Bartenstein P, Herms J, Brendel M, Beyer L
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Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for in vitro Assessment of Progressive Supranuclear Palsy Tau Pathology With [ 18 F]PI-2620.
Front Neurol. 2021 Jul 2;12:684523. doi: 10.3389/fneur.2021.684523. PMID: 34276540; PMCID: PMC8282895.
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Winter B, Krämer J, Meinhardt T, Berner D, Alt K, Wenzel M, Winkelmann J, Zech M
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NR4A2 and Dystonia with Dopa Responsiveness.
Mov Disord. 2021 Jun 21. doi: 10.1002/mds.28701. Epub ahead of print. PMID: 34155693.
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Wirtz TH, Saal A, Bergmann I, Fischer P, Heinrichs D, Brandt EF, Koenen MT, Djudjaj S, Schneider KM, Boor P, Bucala R, Weiskirchen R, Bernhagen J, Trautwein C, Berres ML
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Macrophage migration inhibitory factor exerts pro-proliferative and anti-apoptotic effects via CD74 in murine hepatocellular carcinoma.
Br J Pharmacol. 2021 Jul 11. doi: 10.1111/bph.15622. Epub ahead of print. PMID: 34250589.
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Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, Palleis C, Rauchmann BS, Gildehaus FJ, Lindner S, Spitz C, Franzmeier N, Baumann K, Rominger A, Bartenstein P, Ziegler S, Drzezga A, Respondek G, Buerger K, Perneczky R, Levin J, Höglinger GU, Herms J, Haass C, Brendel M
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Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Sci Transl Med. 2021 Oct 13;13(615):eabe5640. doi: 10.1126/scitranslmed.abe5640. Epub 2021 Oct 13. PMID: 34644146.
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Yan Y, Thakur M, van der Vorst EPC, Weber C, Döring Y
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Targeting the chemokine network in atherosclerosis.
Atherosclerosis. 2021 Jun 29:S0021-9150(21)01197-7. doi: 10.1016/j.atherosclerosis.2021.06.912. Epub ahead of print. PMID: 34247863.
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Young AL, Bocchetta M, Russell LL, Convery RS, Peakman G, Todd E, Cash DM, Greaves CV, van Swieten J, Jiskoot L, Seelaar H, Moreno F, Sanchez-Valle R, Borroni B, Laforce R Jr, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Sorbi S, Williams SC, Alexander DC, Rohrer JD; Genetic FTD Initiative (GENFI)
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Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling. Neurology.
2021 Jun 22:10.1212/WNL.0000000000012410. doi: 10.1212/WNL.0000000000012410. Epub ahead of print. PMID: 34158384.
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Yuan S, Burgess S, Laffan M, Mason AM, Dichgans M, Gill D, Larsson SC
(2021)
Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study.
J Am Heart Assoc. 2021 Apr 9:e019644. doi: 10.1161/JAHA.120.019644. Epub ahead of print. PMID: 33834859.
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Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU
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The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Nat Commun. 2021 Aug 11;12(1):4863. doi: 10.1038/s41467-021-25060-1. PMID: 34381050.
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Zech M, Boesch S, Škorvánek M, Necpál J, Švantnerová J, Wagner M, Dincer Y, Sadr-Nabavi A, Serranová T, Rektorová I, Havránková P, Ganai S, Mosejová A, Příhodová I, Šarláková J, Kulcsarová K, Ulmanová O, Bechyně K, Ostrozovičová M, Haň V, Ventosa JR, Shariati M, Shoeibi A, Weber S, Mollenhauer B, Trenkwalder C, Berutti R, Strom TM, Ceballos-Baumann A, Mall V, Haslinger B, Jech R, Winkelmann J
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Clinically relevant copy-number variants in exome sequencing data of patients with dystonia.
Parkinsonism Relat Disord. 2021 Feb 12;84:129-134. doi: 10.1016/j.parkreldis.2021.02.013. Epub ahead of print. PMID: 33611074.
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Zech M, Jech R, Boesch S, Škorvánek M, Necpál J, Švantnerová J, Wagner M, Sadr-Nabavi A, Distelmaier F, Krenn M, Serranová T, Rektorová I, Havránková P, Mosejová A, Příhodová I, Šarláková J, Kulcsarová K, Ulmanová O, Bechyně K, Ostrozovičová M, Haň V, Ventosa JR, Brunet T, Berutti R, Shariati M, Shoeibi A, Schneider SA, Kuster A, Baumann M, Weise D, Wilbert F, Janzarik WG, Eckenweiler M, Mall V, Haslinger B, Berweck S, Winkelmann J, Oexle K
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Scoring Algorithm-Based Genomic Testing in Dystonia: A Prospective Validation Study.
Mov Disord. 2021 May 5. doi: 10.1002/mds.28614. Epub ahead of print. PMID: 33949708.
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Zech M, Seibt A, Zumbaum B, Klee D, Meitinger T, Winkelmann J, Mayatpepek E, Wagner M, Distelmaier F
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MATR3 haploinsufficiency and early-onset neurodegeneration.
Brain. 2021 Jun 26:awab240. doi: 10.1093/brain/awab240. Epub ahead of print. PMID: 34173818.
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Zech M, Kumar KR, Reining S, Reunert J, Tchan M, Riley LG, Drew AP, Adam RJ, Berutti R, Biskup S, Derive N, Bakhtiari S, Jin SC, Kruer MC, Bardakjian T, Gonzalez-Alegre P, Keller Sarmiento IJ, Mencacci NE, Lubbe SJ, Kurian MA, Clot F, Méneret A, de Sainte Agathe JM, Fung VSC, Vidailhet M, Baumann M, Marquardt T, Winkelmann J, Boesch S
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Biallelic AOPEP Loss-of-Function Variants Cause Progressive Dystonia with Prominent Limb Involvement.
Mov Disord. 2021 Oct 1. doi: 10.1002/mds.28804. Epub ahead of print. PMID: 34596301.
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Zech M, Kopajtich R, Steinbrücker K, Bris C, Gueguen N, Feichtinger RG, Achleitner MT, Duzkale N, Périvier M, Koch J, Engelhardt H, Freisinger P, Wagner M, Brunet T, Berutti R, Smirnov D, Navaratnarajah T, Rodenburg RJT, Pais LS, Austin-Tse C, O'Leary M, Boesch S, Jech R, Bakhtiari S, Jin SC, Wilbert F, Kruer MC, Wortmann SB, Eckenweiler M, Mayr JA, Distelmaier F, Steinfeld R, Winkelmann J, Prokisch H
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Variants in mitochondrial ATP synthase cause variable neurologic phenotypes.
Ann Neurol. 2021 Dec 26. doi: 10.1002/ana.26293. Epub ahead of print. PMID: 34954817.
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Zellner S, Schifferer M, Behrends C
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Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Mol Cell. 2021 Jan 28:S1097-2765(21)00009-5. doi: 10.1016/j.molcel.2021.01.009. Epub ahead of print. PMID: 33545068.
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Zellner S, Nalbach K, Behrends C
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Autophagosome content profiling using proximity biotinylation proteomics coupled to protease digestion in mammalian cells.
STAR Protoc. 2021 Apr 27;2(2):100506. doi: 10.1016/j.xpro.2021.100506. PMID: 33997820; PMCID: PMC8102175.
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Zellner S, Behrends C
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Autophagosome content profiling reveals receptor-specific cargo candidates.
Autophagy. 2021 Apr 5:1-3. doi: 10.1080/15548627.2021.1909410. Epub ahead of print. PMID: 33779494.
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Zhang K, Förster R, He W, Liao X, Li J, Yang C, Qin H, Wang M, Ding R, Li R, Jian T, Wang Y, Zhang J, Yang Z, Jin W, Zhang Y, Qin S, Lu Y, Chen T, Stobart J, Weber B, Adelsberger H, Konnerth A, Chen X
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Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence.
Nat Neurosci. 2021 Nov 15. doi: 10.1038/s41593-021-00949-8. Epub ahead of print. PMID: 34782794.
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Zhang H, Bussmann J, Huhnke FH, Devoldere J, Minnaert AK, Jiskoot W, Serwane F, Spatz J, Röding M, De Smedt SC, Braeckmans K, Remaut K
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Together is Better: mRNA Co-Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co-Delivery and Protein Expression on the Single Cell Level.
Adv Sci (Weinh). 2021 Dec 16:e2102072. doi: 10.1002/advs.202102072. Epub ahead of print. PMID: 34913603.
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Zhang Y, Liesz A, Li
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Coming to the Rescue: Regulatory T Cells for Promoting Recovery After Ischemic Stroke.
Stroke. 2021 Dec;52(12):e837-e841. doi: 10.1161/STROKEAHA.121.036072. Epub 2021 Nov 22. PMID: 34807742.
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Zhu J, Cao J, Liesz A, Roth S
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A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR Protoc. 2021 Dec 1;2(4):100983. doi: 10.1016/j.xpro.2021.100983. PMID: 34927092; PMCID: PMC8646263.