Multiple sclerosis meets systems immunology.
Lancet Neurol. 2021 Nov;20(11):887-888. doi: 10.1016/S1474-4422(21)00325-2. PMID: 34687627.
In their Review,1 Amit Bar-Or and Rui Li argue that autoimmune diseases like multiple sclerosis arise from perturbations of cellular networks, resulting in a disbalance of proinflammatory and anti-inflammatory mechanisms. Such a disbalance potentially enables both spontaneous stabilisation and exacerbation of disease activity, as observed in relapsing multiple sclerosis. The underlying immune processes are partly stochastic, yet shaped by a multitude of genetic and environmental influences.