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COVID-19-associated Large Vessel Stroke in a 28-year-old Patient : NETs and Platelets Possible Key Players in Acute Thrombus Formation.

Clin Neuroradiol. 2021 Jan 29:1–4. doi: 10.1007/s00062-020-00992-1. Epub ahead of print. PMID: 33512534; PMCID: PMC7844783.

Authors/Editors: Boeckh-Behrens T, Golkowski D, Ikenberg B, Schlegel J, Protzer U, Schulz C, Novotny J, Kreiser K, Zimmer C, Hemmer B, Wunderlich S.
Publication Date: 2021



COVID-19 (corona virus disease-19) is associated with acute stroke in up to 5% of all cases [1] and was initially reported in patients with typical risk factors; however, recent reports also described large vessel occlusions (LVOs) in younger patients with no pre-existing conditions and only mildly affected by COVID-19 [2, 3].

We report the case of a 28-year-old female patient with COVID-19-associated large vessel stroke and the results of the tissue analyses of the extracted clot. Although COVID-19-associated diffuse thrombosis of the microvascular bed has been reported [4], we believe this may be the first reported detailed analysis of extracted clot tissue of a COVID-19-associated LVO beyond mere clinical observations.


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