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Editorial: Circuit Mechanisms of Neurodegenerative Diseases.

Front Neurosci. 2020 Sep 30;14:593329. doi: 10.3389/fnins.2020.593329. PMID: 33100966; PMCID: PMC7554591.

Authors/Editors: Saxena S, Liebscher S.
Publication Date: 2020

Editorial on the Research Topic
Circuit Mechanisms of Neurodegenerative Diseases

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), or Amyotrophic lateral sclerosis (ALS) are histopathologically characterized by the formation of protein aggregates and the selective death of a defined population of neurons. These diseases have traditionally been viewed as being caused by the selective dysfunction of those vulnerable neurons via cell autonomous mechanisms. Current evidence, however, strongly implicates a causal involvement of altered neuronal circuit function in triggering and perpetuating the degenerative cascade.

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