Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms.
J Neurol Sci. 2020;418:117090. doi:10.1016/j.jns.2020.117090 [published online ahead of print, 2020 Aug 11]
|Authors/Editors:||Neumann B, Schmidbauer ML, Dimitriadis K, Otto S, Knier B, Niesen WD, Hosp JA, Günther A, Lindemann S, Nagy G, Steinberg T, Linker RA, Hemmer B, Bösel J.|
• Largest cohort of patients with COVID-19 and neurological symptoms who underwent LP.
• In all 30 cases, RT-PCR for SARS-CoV-2 from CSF was negative.
• CSF analysis findings, including WBC, were normal in most patients with COVID-19.
• Neurological symptoms in COVID-19 seem to be caused mainly by indirect mechanism.
Keywords: SARS-CoV-2, COVID-19, Cerebrospinal fluid, Neurological symptoms
Abbreviations: PANDEMIC, Pooled Analysis of Neurologic DisordErs Manifesting in Intensive care of COVID-19; IGNITE, Initiative of German NeuroIntensive Trial Engagement; CSF, cerebrospinal fluid; LP, lumbar puncture; RT-PCR, reverse-transcriptase–polymerase-chain-reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; WBC, white blood cell count