FG-nucleoporins caught in the act of liquid-liquid phase separation.
J Cell Biol. 2020 Jan 6;219(1). pii: e201910211. doi: 10.1083/jcb.201910211.
The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol.https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid–liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs.