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When Separation Causes Activation: Biophysical Control of Bulk Autophagy Initiation.

Mol Cell. 2020 Jan 22. pii: S1097-2765(19)30958-X. doi: 10.1016/j.molcel.2019.12.028. [Epub ahead of print]

Authors/Editors: Bhattacharya D, Behrends C.
Publication Date: 2020

05_bhattacharya

Abstract

Fujioka et al. (2020) uncovered liquid-liquid phase separation of the PAS, a key driver of autophagosome formation in yeast. Moreover, the authors demonstrated that liquid-like PAS controls autophagic kinase activation and is itself regulated by the phosphorylation status of its constituents.

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