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CSF Protein Concentration Shows No Correlation With Brain Volume Measures

Front Neurol. 2019 May 3;10:463. doi: 10.3389/fneur.2019.00463. eCollection 2019.

Authors/Editors: Wuschek A, Grahl S, Pongratz V, Korn T, Kirschke J, Zimmer C, Hemmer B, Mühlau M.
Publication Date: 2019


Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations.

Objective: To determine the relation between CSF protein concentrations and brain volume.

Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied.

Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex.

Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.

Keywords: albumin, brain volume, CSF, protein, MRI

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