miRNAs Identify Shared Pathways in Alzheimer's and Parkinson's Diseases.
Trends Mol Med. 2019 Jun 17. pii: S1471-4914(19)30123-6. doi: 10.1016/j.molmed.2019.05.006. [Epub ahead of print]
|Authors/Editors:||Sadlon A, Takousis P, Alexopoulos P, Evangelou E, Prokopenko I, Perneczky R.|
Despite the identification of several dozens of common genetic variants associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD), most of the genetic risk remains uncharacterised. Therefore, it is important to understand the role of regulatory elements, such as miRNAs. Dysregulated miRNAs are implicated in AD and PD, with potential value in dissecting the shared pathophysiology between the two disorders. miRNAs relevant to both neurodegenerative diseases are related to axonal guidance, apoptosis, and inflammation, therefore, AD and PD likely arise from similar underlying biological pathway defects. Furthermore, pathways regulated by APP, L1CAM, and genes of the caspase family may represent promising therapeutic miRNA targets in AD and PD since they are targeted by dysregulated miRNAs in both disorders.