Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues.
Cell. 2019 Jan 24;176(3):416-418. doi: 10.1016/j.cell.2018.12.025.
By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.