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Stars Are Not in Outer Space: Astrocytes Respond to Environmental Cues.

Cell. 2019 Jan 24;176(3):416-418. doi: 10.1016/j.cell.2018.12.025.

Authors/Editors: Korn T.
Publication Date: 2019



By in vivo screening in zebrafish larvae, Wheeler et al. identify environmental agents that directly modulate transcriptional programs of astrocytes. The herbicide linuron exploits the unfolded protein response pathway to induce a pro-inflammatory program in reactive astrocytes that potentiates inflammatory tissue damage in the CNS.


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