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RAN translation down.

Nat Neurosci. 2019 Sep;22(9):1379-1380. doi: 10.1038/s41593-019-0482-4.

Authors/Editors: Hutten S, Dormann D.
Publication Date: 2019

Abstract

Repeat-associated non-AUG (RAN) translation generates toxic repeat proteins from pathological repeat expansions found in certain neurodegenerative disorders, including amyotrophic lateral sclerosis and frontotemporal dementia. How to suppress RAN translation has so far been unknown. A new study now reports a selective regulator of RAN translation identified in a genetic screen in yeast.

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