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Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

Neuron. 2019 Feb 20;101(4):557-559. doi: 10.1016/j.neuron.2019.01.058.

Authors/Editors: Haass C, Willem M.
Publication Date: 2019



The amyloid precursor protein (APP) is not only processed to the neurotoxic amyloid-β peptide but also to various types of secreted APP variants. In a recent issue of Science, Rice et al. (2019) now demonstrate that secreted APP functions as a modulator of synaptic transmission by binding to GABABR1a.

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