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Two types of functionally distinct Ca2+ stores in hippocampal neurons.

Nat Commun. 2019 Jul 19;10(1):3223. doi: 10.1038/s41467-019-11207-8.

Authors/Editors: Chen-Engerer HJ, Hartmann J, Karl RM, Yang J, Feske S, Konnerth A.
Publication Date: 2019



It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.

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