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Balanced sex distribution in patients with Menière's disease.

J Neurol. 2019 Apr 10. doi: 10.1007/s00415-019-09301-4. [Epub ahead of print]

Authors/Editors: Becker-Bense S, Wittmann C, Dieterich M,
Publication Date: 2019


Dear Sirs,
Menière’s disease (MD) is an inner ear disorder characterized by spontaneous attacks of vertigo, unilateral fluctuating hearing loss, aural fullness, and tinnitus. With the exception of two very early reports, previous studies over the last five decades consistently reported a more or less distinct female-to-male preponderance in patients with MD (female:male ratio between 1.13:1 and 4.33:1, mean over all studies 1.63:1), with considerable methodological differences. These earlier studies (a) used different study designs and recruitment strategies (e.g., academic specialized neurology/otology centers/general hospitals/general practitioners, regional/cross-regional population register based, clinical retrospective cohort analyses), (b) referred to varying populations (different ages, ethnic groups, sample sizes, inpatients and outpatients), and (c) applied different diagnostic criteria (e.g., due to changing diagnostic guidelines over time). Most of the studies focused on epidemiologic evaluation of prevalence or incidence rates on the basis of population-based surveys or retrospective clinical case series. Gender distribution was often not the primary focus of their evaluation. Thus, we evaluated the sex distribution in a large MD patient population, carefully diagnosed in a tertiary interdisciplinary dizziness clinic jointly run by ENT doctors and neurologists.

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