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Shedding of BAFF/APRIL Receptors Controls B Cells.

Trends Immunol. 2018 Jul 30. pii: S1471-4906(18)30126-1. doi: 10.1016/ [Epub ahead of print]

Authors/Editors: Meinl E, Thaler FS, Lichtenthaler SF.
Publication Date: 2018



Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma.


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