Shedding of BAFF/APRIL Receptors Controls B Cells.
Trends Immunol. 2018 Jul 30. pii: S1471-4906(18)30126-1. doi: 10.1016/j.it.2018.07.002. [Epub ahead of print]
|Authors/Editors:||Meinl E, Thaler FS, Lichtenthaler SF.|
Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma.