Remodelers tap into nucleosome plasticity
Nat Struct Mol Biol. 2017 Apr 6;24(4):341-343. doi: 10.1038/nsmb.3394.
|Authors/Editors:||Singh HR, Murawska M, Ladurner AG.|
Chromatin-remodeling enzymes perform the formidable task of reorganizing the structure of a stable macromolecular assembly, the nucleosome. Recently published work demonstrates that the SNF2H chromatin remodeler distorts the histone octamer structure upon binding to the nucleosome, then taps into this induced plasticity to productively achieve nucleosome sliding.