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NMOSD triggered by yellow fever vaccination - An unusual clinical presentation with segmental painful erythema

Mult Scler Relat Disord. 2017 Jan;11:43-44. doi: 10.1016/j.msard.2016.11.009. Epub 2016 Nov 27.

Authors/Editors: Schöberl F, Csanadi E, Eren O, Dieterich M, Kümpfel T.
Publication Date: 2017


Neuromyelitis Optica Spectrum Disorder (NMOSD) is an immune-mediated disease of the central nervous system with the presence of aquaporin 4-antibodies (AQP4-abs) in most cases. We describe a patient who developed NMOSD after a yellow fever vaccination. He presented to us with an unusual painful erythema Th7-9 triggered by touch in the respective skin area due to a cervical spinal cord lesion affecting the dorsolateral parts of C6/7. To our knowledge, this is the first case of NMOSD with such a clinical presentation expanding the clinical spectrum of NMOSD. It is important to be aware of that a yellow fever vaccination can trigger NMOSD.

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