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Voxel-based morphometry delineates the role of the cerebellar tonsil in physiological upbeat nystagmus

J Neurol. 2017 Mar 9. doi: 10.1007/s00415-017-8421-3. [Epub ahead of print]

Authors/Editors: Ruehl RM, Stephan T, Dieterich M, Eulenburg PZ.
Publication Date: 2017



A few video-oculography (VOG) studies have reported a constant spontaneous upbeat nystagmus (UBN) in the absence of fixation in a number of healthy subjects [2, 6]. These oscillations of the vertical gaze system are thought to be under the influence of the gravitational force vector and have been shown to be modulated by otolith input [4]. The phenomenon is therefore termed a vestibular nystagmus. The neural basis of UBN and whether structural differences can be attributed to it have not been investigated to date. In a combined voxel-based morphometry (VBM) imaging and VOG approach within the context of a vestibular stimulation study, we aimed to investigate the neuroanatomical substrate of this UBN.

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