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Disentangling the manifold functions of RORγt

Nat Immunol. 2017 Sep 19;18(10):1059-1060. doi: 10.1038/ni.3831.

Authors/Editors: Korn T
Publication Date: 2017


A two-amino-acid substitution in the transcription factor RORγt disrupts its effect in establishing the transcriptional program of TH17 cells while leaving its function in the development of thymocytes and lymphoid-tissue–inducer cells largely intact.

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