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Association of Retinal Architecture, Intrathecal Immunity, and Clinical Course in Multiple Sclerosis

JAMA Neurol. 2017 May 1. doi: 10.1001/jamaneurol.2017.0377. [Epub ahead of print]

Authors/Editors: Knier B, Leppenetier G, Wetzlmair C, Aly L, Hoshi MM, Pernpeintner V, Biberacher V, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T.
Publication Date: 2017


Importance: Biomarkers to estimate long-term outcomes in patients with multiple sclerosis (MS) and to assign patients to individual treatment regimens are urgently needed.

Objective: To assess whether retinal layer volumes are correlated with immune cell subsets and immunoglobulin indices in the cerebrospinal fluid and whether retinal layer volumes alone or in combination with intrathecal variables are associated with worsening of disease in patients with relapsing-remitting MS.

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