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In vivo imaging of retinal neurodegeneration at the single cell level in humans

Brain. 2017 Jun 1;140(6):1542-1543. doi: 10.1093/brain/awx100.

Authors/Editors: Herms J, Schön C.
Publication Date: 2017


This scientific commentary refers to ‘Real-time imaging of single neuronal cell apoptosis in patients with glaucoma’, by Cordeiro et al. (doi:10.1093/brain/awx088).

Glaucoma is a multifactoral retinal disorder that affects more than 60 million patients worldwide (Tham et al., 2014). The disease is mostly asymptomatic until late stages when visual problems arise. Vision loss from glaucoma cannot be recovered and as a consequence, 8.4 million patients are bilaterally blind (Quigley, 2011). Visual field loss and optic disc damage are characteristic for the disease and occur due to a progressive loss of retinal ganglion cells (RGCs) and their axons.

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