Catching filopodia: Exosomes surf on fast highways to enter cells
J Cell Biol. 2016 Apr 25;213(2):143-5. doi: 10.1083/jcb.201604024. Epub 2016 Apr 25.
|Authors/Editors:||Schneider A, Simons M.|
The mechanisms of exosomal uptake and their intracellular itinerary are not understood. In this issue, Heusermann et al. (2016. J Cell. Biol. http://dx.doi.org/10.1083/jcb.201506084) show that exosomes surf filopodia and are endocytosed in a process reminiscent to virus entry. Intraendosomal exosomes travel to the ER and are distributed to lysosomal compartments.