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Catching filopodia: Exosomes surf on fast highways to enter cells

J Cell Biol. 2016 Apr 25;213(2):143-5. doi: 10.1083/jcb.201604024. Epub 2016 Apr 25.

Authors/Editors: Schneider A, Simons M.
Publication Date: 2016

Abstract

The mechanisms of exosomal uptake and their intracellular itinerary are not understood. In this issue, Heusermann et al. (2016. J Cell. Biol. http://dx.doi.org/10.1083/jcb.201506084) show that exosomes surf filopodia and are endocytosed in a process reminiscent to virus entry. Intraendosomal exosomes travel to the ER and are distributed to lysosomal compartments.

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