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Age-related myelin degradation burdens the clearance function of microglia during aging

Nature Neuroscience. 2016 June 13. DOI: 10.1038/nn.4325. [Epub ahead of print]

Authors/Editors: Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger A L, Jung S, Rossner M J, Simons M
Publication Date: 2016

2016_06_safaiyan

Abstract

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

 

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