Munich Cluster for Systems Neurology
print


Breadcrumb Navigation


Content

Frontotemporal dementia: from molecular mechanisms to therapy

J Neurochem. 2016 Aug;138 Suppl 1:3-5. doi: 10.1111/jnc.13619.

Authors/Editors: Haass C, Neumann M.
Publication Date: 2016

2016_11_haass

Abstract

Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome characterized by frontotemporal lobar degeneration (FTLD). Neuropathologically, FTLD is characterized by abnormal protein deposits and almost all cases can now be classified into three major molecular subgroups based on specific accumulating proteins with the most common being FTLD-tau and FTLD-TDP (accounting for ~40% and 50%, respectively) and FTLD-FET (accounting for ~5-10%). In this special issue, the molecular and genetic basics as well as clinical approaches and therapeutics are reviewed in a series of articles. This article is part of the Frontotemporal Dementia special issue.

Related Links