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[Pathomechanismen und klinische Aspekte der frontotemporalen Lobärdegeneration] [Article in German]

Nervenarzt. 2016 Dec 20. doi: 10.1007/s00115-016-0259-x. [Epub ahead of print]

Authors/Editors: Bürger K, Arzberger T, Stephan J, Levin J, Edbauer D.
Publication Date: 2016



Frontotemporal lobar degeneration (FTLD) includes a spectrum of heterogeneous clinical and neuropathological diseases. In a strict sense this includes the behavioral variant of frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA) and both variants can be associated with amyotrophic lateral sclerosis (FTD-ALS). In a broader sense FTLD also includes progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In recent years the strong genetic component of FTLD has become increasingly clear.

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