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Redox imaging using genetically encoded redox indicators in zebrafish and mice

Biol Chem. 2015 Jan 29. pii: /j/bchm.just-accepted/hsz-2014-0294/hsz-2014-0294.xml. doi: 10.1515/hsz-2014-0294. [Epub ahead of print]

Authors/Editors: Breckwoldt MO, Wittmann C, Misgeld T, Kerschensteiner M, Grabher C.
Publication Date: 2015

Abstract

Abstract Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this review we summarize recent advances in the generation of genetically encoded redox indicators (GERIs), introduce new redox imaging strategies and highlight key publications in the field of vertebrate redox imaging. We also discuss the limitations and future potential of in vivo redox imaging in zebrafish and mice.

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