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PARP1 and CBP lose their footing in cancer

Nat Struct Mol Biol. 2014 Nov 5;21(11):947-8. doi: 10.1038/nsmb.2913

Authors/Editors: Timinszky G, Ladurner AG.
Publication Date: 2014



The human histone macroH2A.1.1 recruits activated PARP1 enzyme to chromatin through its poly(ADP-ribose)-binding macrodomain. New work shows that PARP1 and CBP can be displaced from chromatin in cancer cells that have lost macroH2A.1.1, thus leading to changes in histone H2B acetylation at cancer-relevant genes.

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