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Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Atherosclerosis. 2014 Mar 14;234(1):214-217. doi: 10.1016/j.atherosclerosis.2014.03.002. [Epub ahead of print]

Authors/Editors: Mäkelä KM, Traylor M, Oksala N, Kleber ME, Seppälä I, Lyytikäinen LP, Hernesniemi JA, Kähönen M, Bevan S, Rothwell PM, Sudlow C, Dichgans M.
Publication Date: 2014

Abstract

BACKGROUND AND PURPOSE:
Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD).

METHODS:
The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N = 3548 cases, 5972 controls).

RESULTS:
In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p = 0.030; odds ratio = 1.29 [95% confidence interval 1.03‒1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke.

CONCLUSIONS:
The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

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