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Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

Nat Neurosci. 2013 Sep 1. doi: 10.1038/nn.3503. [Epub ahead of print]

Authors/Editors: Viganò F, Möbius W, Götz M, Dimou L.
Publication Date: 2013



To examine the role of gray and white matter niches for oligodendrocyte differentiation, we used homo- and heterotopic transplantations into the adult mouse cerebral cortex. White matter–derived cells differentiated into mature oligodendrocytes in both niches with equal efficiency, whereas gray matter–derived cells did not. Thus, white matter promotes oligodendrocyte differentiation, and cells from this niche differentiate more easily, even in the less supportive gray matter environment.

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