Munich Cluster for Systems Neurology
print


Breadcrumb Navigation


Content

Press Release: Coronavirus - Neuropilin-1 could open the door to the inside of the cell

How the virus enters the cell: The protein neuropilin-1 facilitates SARS CoV-2 cell entry. A research team including SyNergy member Prof. Mikael Simons of the Technical University of Munich (TUM) recently published these findings in the journal "Science". Because neuropilin-1 is expressed in the mucous membranes of the olfactory and respiratory tract, the findings may be important for understanding the spreading of SARS CoV-2. components for this phenomenon have so far remained elusive.

20.10.2020

The degree to which a virus spreads depends on its infectivity. While the coronavirus SARS-CoV-2 has led to severe pandemic, a related virus, SARS-CoV, led to a much smaller outbreak in 2003, possibly because the infection was limited to the lower respiratory system. SARS-CoV-2, in contrast, infects the upper portions of the respiratory tract, including the nasal mucous membrane and, in consequence, spreads rapidly through active viral shedding. Researchers at TUM, the German Center for Neurodegenerative Diseases (DZNE), the University Clinic Universitätsmedizin Göttingen and the University of Helsinki have investigated the nature of SARS-CoV-2 infectivity.

Press release TUM

Press release DZNE

 

Coronavirus: Neuropilin-1 könnte Türöffner ins Zellinnere sein. Wie das Virus in die Zellen gelangt.

Das Protein Neuropilin-1 erleichtert den Eintritt von SARS-CoV-2 ins Innere der Zellen. Dies hat ein Forschungsteam unter Beteiligung von SyNergy-Mitglied Prof. Mikael Simons von der Technischen Universität München (TUM) mit einer im Fachjournal „Science“ erschienenen Publikation gezeigt. Da Neuropilin-1 in den Schleimhäuten der Atemwege und der Nase zu finden ist, könnte diese Erkenntnis für das Verständnis der Ausbreitung von SARS-CoV-2 wichtig sein.

Pressemitteilung TUM

Pressemitteilung DZNE