Munich Cluster for Systems Neurology

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Curriculum vitae Prof. Dr. Dominik Paquet


    • 1999 - 2004 Studies of Biology (summa cum laude), University of Tuebingen, Germany
    • 2004 - 2005 Diploma Thesis, MRC Centre for Developmental Genetics, University of Sheffield, UK
    • 2005 - 2009 PhD Thesis (summa cum laude), Department of Biochemistry, Adolf-Butenandt-Institute, Ludwig-Maximilians University (LMU), Munich
    • 2009 - 2011 Postdoctoral Fellow, German Center for Neurodegenerative Diseases (DZNE), Munich
    • 2011 - 2016 Postdoctoral Fellow, Laboratory for Brain Development and Repair, The Rockefeller University, New York, USA

Academic positions & appointments

    • since 2016 Professor for Neurobiology, Institute for Stroke- and Dementia Research (ISD) & SyNergy, Ludwig-Maximilians University (LMU), Munich

Research  coordiantion

    • 2012 - 2016 research coordinator of the Tessier-Lavigne lab for the Lawrence Ellison Foundation Senior Scholar Award in Aging
    • 2012 - 2014 research coordinator of the Tessier-Lavigne lab for the Cure Alzheimer's Fund Research Grant

Awards & honors

    • 2004 - 2005 Diploma Thesis Fellowship, Department of Biomedical Sciences, University of Sheffield, UK
    • 2004 - 2005 Diploma Thesis Fellowship, German academic exchange service (DAAD)
    • 2007 Travel award, The Lindau Nobel Laureate Meeting
    • 2007 - 2009 PhD-Fellowship, Universität Bayern e.V. (Graduiertenförderung nach dem Bayerischen Eliteförderungsgesetz)
    • 2008 1st Young Investigator Award of the Universität Bayern e.V.
    • 2009 Best talk award, Interact-Meeting Munich
    • 2009 International Leda-Hanin-Award of the Cornelli Foundation, AD/PD-Meeting
    • 2009 International Verum Award of the Verum Foundation
    • 2010 Award for 'Intelligible Science’, Helmholtz Zentrum Geesthacht
    • 2010 Finalist at Deutscher Studienpreis, Körber-Stiftung
    • 2011 - 2014 Postdoctoral Fellowship, German Academy of Sciences Leopoldina
    • 2014 - 2016 Druckenmiller Postdoctoral Fellowship, The New York Stem Cell Foundation
    • 2015 Best talk award, The New York Stem Cell Foundation Innovators Retreat
    • 2016 Best poster award, The New York Stem Cell Foundation Innovators Retreat

10 key papers

    • Kwart D*, Paquet D*, Teo S, Tessier-Lavigne M. Precise and efficient scarless genome editing in stem cells using CORRECT. Nature Protocols 12:329-54 (2017). *equal first authors
    • Paquet D*, Kwart D*, Chen A, Sproul AA, Jacob S, Teo S, Olsen KM, Gregg A, Noggle S & Tessier-Lavigne M. Efficient introduction of specific homo- and heterozygous mutations with CRISPR/Cas9. Nature 533: 125–9 (2016). *equal first authors
    • Engerer P, Plucińska G, Thong R, Trovò L, Paquet D, Godinho L. Imaging subcellular structures in the living zebrafish embryo. Journal of Visualized Experiments 110:e53456 (2015).
    • Paquet D, Plucińska G, Misgeld T. In vivo imaging of mitochondria in intact zebrafish larvae. Methods in enzymology 547: 151–164 (2014).
    • Giustiniani J, Chambraud B, Sardin E, Dounane O, Guillemeau K, Nakatani H, Paquet D, Kamah A, Landrieu I, Lippens G, Baulieu EE, Tawk M. Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy. Proc Natl Acad Sci USA 111: 4584–4589 (2014).
    • Plucińska G*, Paquet D*, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T. In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. Journal of Neuroscience 32: 16203–16212 (2012). *equal first authors
    • Fett M, Pilsl A, Paquet D, Haass C, Tatzelt J, Schmid B, Winklhofer K. Parkin is protective against proteotoxic stress in a transgenic zebrafish model. PLoS ONE 5: e11783 (2010).
    • VanBebber F, Paquet D, Hruscha A, Schmid B, Haass C. Methylene Blue fails to inhibit Tau and Polygluta-mine Protein dependent Toxicity in Zebrafish. Neurobiology of Disease 39: 265–271 (2010).
    • Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. Journal of Clinical Investigation 119: 1382–1395 (2009).
    • Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. Journal of Neuroscience 27: 12413–12418 (2007).

Responsible for content: Prof. Dr. Dominik Paquet