Publications Misgeld

2022

• Düking T, Spieth L, Berghoff SA, Piepkorn L, Schmidke AM, Mitkovski M, Kannaiyan N, Hosang L, Scholz P, Shaib AH, Schneider LV, Hesse D, Ruhwedel T, Sun T, Linhoff L, Trevisiol A, Köhler S, Pastor AM, Misgeld T, Sereda M, Hassouna I, Rossner MJ, Odoardi F, Ischebeck T, de Hoz L, Hirrlinger J, Jahn O, Saher G (2022)
  Ketogenic diet uncovers differential metabolic plasticity of brain cells.
  Sci Adv. 2022 Sep 16;8(37):eabo7639. doi: 10.1126/sciadv.abo7639. Epub 2022 Sep 16. PMID: 36112685; PMCID: PMC9481126.
• Herwerth M, Kenet S, Schifferer M, Winkler A, Weber M, Snaidero N, Wang M, Lohrberg M, Bennett JL, Stadelmann C, Hemmer B, Misgeld T (2022)
  A new form of axonal pathology in a spinal model of neuromyelitis optica.
  Brain. 2022 Feb 24:awac079. doi: 10.1093/brain/awac079. Epub ahead of print. PMID: 35202467.
• Kalluri SR, Srivastava R, Kenet S, Tanti GK, Dornmair K, Bennett JL, Misgeld T, Hemmer B, Wyss MT, Herwerth M (2022)
  P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica : P2R Inhibitors Prevent Autoantibody Injury.
  Neurotherapeutics. 2022 Jul 12. doi: 10.1007/s13311-022-01269-w. Epub ahead of print. PMID: 35821382.
• Kerschensteiner M, Misgeld T (2022)
  A less painful transfer of power.
  Neuron. 2022 Feb 16;110(4):559-561. doi: 10.1016/j.neuron.2022.01.021. PMID: 35176237.
• Khalin I, Adarsh N, Schifferer M, Wehn A, Groschup B, Misgeld T, Klymchenko A, Plesnila N (2022)
  Size-Selective Transfer of Lipid Nanoparticle-Based Drug Carriers Across the Blood Brain Barrier Via Vascular Occlusions Following Traumatic Brain Injury.
  Small. 2022 Apr 5:e2200302. doi: 10.1002/smll.202200302. Epub ahead of print. PMID: 35384294.
• Liesche-Starnecker F, Schifferer M, , Schlegel J, Vollmuth Y, Rubbenstroth D, Delbridge C, Gempt J, Lorenzl S, Schnurbus L, Misgeld T, , Rosati M, Beer M, Matiasek K, Wunderlich S, Finck T (2022)
  Hemorrhagic lesion with detection of infected endothelial cells in human bornavirus encephalitis
  Acta Neuropathol. 2022 Jun 3:1–3. doi: 10.1007/s00401-022-02442-3. Epub ahead of print. PMID: 35657496; PMCID: PMC9164175.
• Wang M, Misgeld T, Brill MS (2022)
  Neural labeling and manipulation by neonatal intraventricular viral injection in mic
  STAR Protoc. 2022 Jan 10;3(1):101081. doi: 10.1016/j.xpro.2021.101081. PMID: 35059654; PMCID: PMC8760487.

2021

• Eira J, Magalhães J, Macedo N, Pero ME, Misgeld T, Sousa MM, Bartolini F, Liz MA (2021)
  Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation.
  Front Cell Dev Biol. 2021 Nov 8;9:747699. doi: 10.3389/fcell.2021.747699. PMID: 34820375; PMCID: PMC8606651.
• Engerer P, Petridou E, Williams PR, Suzuki SC, Yoshimatsu T, Portugues R, Misgeld T, Godinho L (2021)
  Notch-mediated re-specification of neuronal identity during central nervous system development.
  Curr Biol. 2021 Sep 7:S0960-9822(21)01185-4. doi: 10.1016/j.cub.2021.08.049. Epub ahead of print. PMID: 34534440.
• Hiltensperger M, Beltrán E, Kant R, Tyystjärvi S, Lepennetier G, Domínguez Moreno H, Bauer IJ, Grassmann S, Jarosch S, Schober K, Buchholz VR, Kenet S, Gasperi C, Öllinger R, Rad R, Muschaweckh A, Sie C, Aly L, Knier B, Garg G, Afzali AM, Gerdes LA, Kümpfel T, Franzenburg S, Kawakami N, Hemmer B, Busch DH, Misgeld T, Dornmair K, Korn T (2021)
  Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity.
  Nat Immunol. 2021 Jun 7. doi: 10.1038/s41590-021-00948-8. Epub ahead of print. PMID: 34099917.
• Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M (2021)
  Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
  Nat Neurosci. 2021 Jan 25. doi: 10.1038/s41593-020-00780-7. Epub ahead of print. PMID: 33495636.
• Schifferer M, Snaidero N, Djannatian M, Kerschensteiner M, Misgeld T (2021)
  Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology.
  Front Neuroanat. 2021 Oct 13;15:732506. doi: 10.3389/fnana.2021.732506. PMID: 34720890; PMCID: PMC8548362.
• Wang M, Kleele T, Xiao Y, Plucinska G, Avramopoulos P, Engelhardt S, Schwab MH, Kneussel M, Czopka T, Sherman DL, Brophy PJ, Misgeld T, Brill MS (2021)
  Completion of neuronal remodeling prompts myelination along developing motor axon branches.
  J Cell Biol. 2021 Apr 5;220(4):e201911114. doi: 10.1083/jcb.201911114. PMID: 33538762.

2020

• Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B (2020)
  Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
  Nat Immunol. 2020 May;21(5):555-566. doi: 10.1038/s41590-020-0666-9. Epub 2020 Apr 23.
• Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T, Schifferer M (2020)
  Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution.
  iScience. 2020;23(7):101290. doi:10.1016/j.isci.2020.101290 [published online ahead of print, 2020 Jun 20]
• Kislinger G, Gnägi H, Kerschensteiner M, Simons M, Misgeld T (2020)
  ATUM-FIB microscopy for targeting and multiscale imaging of rare events in mouse cortex.
  STAR Protoc. 2020 Dec 16;1(3):100232. doi: 10.1016/j.xpro.2020.100232. PMID: 33377119; PMCID: PMC7757728.
• LaClair KD, Zhou Q, Michaelsen M, Wefers B, Brill MS, Janjic A, Rathkolb B, Farny D, Cygan M, de Angelis MH, Wurst W, Neumann M, Enard W, Misgeld T, Arzberger T, Edbauer D (2020)
  Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS.
  Acta Neuropathol. 2020;10.1007/s00401-020-02176-0. doi:10.1007/s00401-020-02176-0 [published online ahead of print, 2020 Jun 19].
• Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Luehmann MM, Knobeloch KP, Prinz M (2020)
  Novel Hexb-based tools for studying microglia in the CNS.
  Nat Immunol. 2020;21(7):802-815. doi:10.1038/s41590-020-0707-4
• Mieskes F, Wehnekamp F, Plucińska G, Thong R, Misgeld T, Lamb DC (2020)
  Trajectory data of antero- and retrograde movement of mitochondria in living zebrafish larvae.
  Data Brief. 2020 Feb 13;29:105280. doi: 10.1016/j.dib.2020.105280. eCollection 2020 Apr.
• Snaidero N, Schifferer M, Mezydlo A, Zalc B, Kerschensteiner M, Misgeld T (2020)
  Myelin replacement triggered by single-cell demyelination in mouse cortex.
  Nat Commun. 2020 Sep 29;11(1):4901. doi: 10.1038/s41467-020-18632-0. PMID: 32994410.
• Ziak J, Weissova R, Jeřábková K, Janikova M, Maimon R, Petrasek T, Pukajova B, Kleisnerova M, Wang M, Brill MS, Kasparek P, Zhou X, Alvarez-Bolado G, Sedlacek R, Misgeld T, Stuchlik A, Perlson E, Balastik M (2020)
  CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling.
  EMBO Rep. 2020 Jan 9:e48512. doi: 10.15252/embr.201948512. [Epub ahead of print]

2019

• Djannatian M, Timmler S, Arends M, Luckner M, Weil MT, Alexopoulos I, Snaidero N, Schmid B, Misgeld T, Möbius W, Schifferer M, Peles E, Simons M (2019)
  Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS.
  Nat Commun. 2019 Oct 22;10(1):4794. doi: 10.1038/s41467-019-12789-z.
• Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T (2019)
  Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
  Nat Neurosci. 2019 Sep 9. doi: 10.1038/s41593-019-0479-z. [Epub ahead of print]
• Schumacher AM, Misgeld T, Kerschensteiner M, Snaidero N (2019)
  Imaging the execution phase of neuroinflammatory disease models.
  Exp Neurol. 2019 May 29:112968. doi: 10.1016/j.expneurol.2019.112968. [Epub ahead of print]
• Sigmund F, Pettinger S, Kube M, Schneider F, Schifferer M, Schneider S, Efremova MV, Pujol-Martí J, Aichler M, Walch A, Misgeld T, Dietz H, Westmeyer GG (2019)
  Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters.
  ACS Nano. 2019 Jun 13. doi: 10.1021/acsnano.9b03140. [Epub ahead of print].
• Wehnekamp F, Plucińska G, Thong R, Misgeld T, Lamb DC (2019)
  Nanoresolution real-time 3D orbital tracking for studying mitochondrial trafficking in vertebrate axons in vivo.
  Elife. 2019 Jun 10;8. pii: e46059. doi: 10.7554/eLife.46059.
• Witte ME, Schumacher AM, Mahler CF, Bewersdorf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M (2019)
  Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis.
  Neuron. 2019 Jan 6. pii: S0896-6273(18)31123-1. doi: 10.1016/j.neuron.2018.12.023. [Epub ahead of print]

2018

• Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF (2018)
  Non-cell-autonomous function of DR6 in Schwann cell proliferation
  EMBO J. 2018 Feb 19. pii: e97390. doi: 10.15252/embj.201797390. [Epub ahead of print]
• Kiss A, Fischer I, Kleele T, Misgeld T, Propst F (2018)
  Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization.
  Front Cell Neurosci. 2018 Jul 17;12:195. doi: 10.3389/fncel.2018.00195. eCollection 2018.

2017

• Akassoglou K, Merlini M, Rafalski VA, Real R, Liang L, Jin Y, Dougherty SE, De Paola V, Linden DJ, Misgeld T, Zheng B (2017)
  In Vivo Imaging of CNS Injury and Disease
  J Neurosci. 2017 Nov 8;37(45):10808-10816. doi: 10.1523/JNEUROSCI.1826-17.2017.
• Engerer P, Suzuki SC, Yoshimatsu T, Chapouton P, Obeng N, Odermatt B, Williams PR, Misgeld T, Godinho L (2017)
  Uncoupling of neurogenesis and differentiation during retinal development
  EMBO J. 2017 Mar 3. pii: e201694230. doi: 10.15252/embj.201694230. [Epub ahead of print]
• Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, Butovsky O, Haass C (2017)
  TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
  EMBO Rep. 2017 May 8. pii: e201743922. doi: 10.15252/embr.201743922. [Epub ahead of print]
• Misgeld T, Schwarz TL (2017)
  Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture.
  Neuron. 2017 Nov 1;96(3):651-666. doi: 10.1016/j.neuron.2017.09.055.

2016

• Bert B, Chmielewska J, Bergmann S, Busch M, Driever W, Finger-Baier K, Hößler J, Köhler A, Leich N, Misgeld T, Nöldner T, Reiher A, Schartl M, Seebach-Sproedt A, Thumberger T, Schönfelder G, Grune B (2016)
  Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish
  EMBO J. 2016 Apr 22. pii: e201694448. [Epub ahead of print]
• Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat T, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T (2016)
  Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.
  Neuron. 2016 Oct 18. pii: S0896-6273(16)30654-7. doi: 10.1016/j.neuron.2016.09.049. [Epub ahead of print]
• Engerer P, Fecher C, Misgeld T. (2016)
  Super-resolution microscopy writ large.
  Nat Biotechnol. 2016 Sep 8;34(9):928-30. doi: 10.1038/nbt.3669.
• Fujikawa Y, Roma LP, Sobotta MC, Rose AJ, Diaz MB, Locatelli G, Breckwoldt MO, Misgeld T, Kerschensteiner M, Herzig S, Müller-Decker K, Dick TP (2016)
  Mouse redox histology using genetically encoded probes
  Sci Signal. 2016 Mar 15;9(419):rs1. doi: 10.1126/scisignal.aad3895.
• Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T (2016)
  Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells
  Nat Immunol. 2016 Nov 28. doi: 10.1038/ni.3632. [Epub ahead of print]
• Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B (2016)
  In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology
  Ann Neurol. 2016 Mar 6. doi: 10.1002/ana.24630. [Epub ahead of print]
• Plucińska G, Misgeld T (2016)
  Imaging of neuronal mitochondria in situ
  Curr Opin Neurobiol. 2016 Jul 22;39:152-163. doi: 10.1016/j.conb.2016.06.006. [Epub ahead of print]
• Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M (2016)
  Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
  Nat Commun. 2016 Nov 16;7:13275. doi: 10.1038/ncomms13275

2015

• Breckwoldt MO, Wittmann C, Misgeld T, Kerschensteiner M, Grabher C (2015)
  Redox imaging using genetically encoded redox indicators in zebrafish and mice
  Biol Chem. 2015 Jan 29. pii: /j/bchm.just-accepted/hsz-2014-0294/hsz-2014-0294.xml. doi: 10.1515/hsz-2014-0294. [Epub ahead of print]
• Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K (2015)
  αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features
  Neurol Neuroimmunol Neuroinflamm. 2015 May 7;2(4):e107. doi: 10.1212/NXI.0000000000000107. eCollection 2015.

2014

• Bishop D, Nikic I, Kerschensteiner M, Misgeld T (2014)
  The use of a laser for correlating light and electron microscopic images in thick tissue specimens
  Methods Cell Biol. 2014;124:323-37. doi: 10.1016/B978-0-12-801075-4.00015-X
• Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T (2014)
  Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo
  Nat Med. 2014 Apr 20. doi: 10.1038/nm.3520. [Epub ahead of print]
• Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T, Konnerth A (2014)
  STIM1 Controls Neuronal Ca(2+) Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior
  Neuron. 2014 May 7;82(3):635-44. doi: 10.1016/j.neuron.2014.03.027.
• Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T (2014)
  An assay to image neuronal microtubule dynamics in mice
  Nat Commun. 2014 Sep 12;5:4827. doi: 10.1038/ncomms5827
• Mar FM, Simões AR, Leite S, Morgado MM, Santos TE, Rodrigo IS, Teixeira CA, Misgeld T, Sousa MM (2014)
  CNS axons globally increase axonal transport after peripheral conditioning
  J Neurosci. 2014 Apr 23;34(17):5965-70. doi: 10.1523/JNEUROSCI.4680-13.2014.
• Paquet D, Plucińska G, Misgeld T (2014)
  In vivo imaging of mitochondria in intact zebrafish larvae
  Methods Enzymol. 2014;547:151-64. doi: 10.1016/B978-0-12-801415-8.00009-6.
• Simons M, Misgeld T, Kerschensteiner M (2014)
  A unified cell biological perspective on axon-myelin injury
  J Cell Biol. 2014 Aug 4;206(3):335-345
• Sorbara CD, Wagner NE, Ladwig A, Nikić I, Merkler D, Kleele T, Marinković P, Naumann R, Godinho L, Bareyre FM, Bishop D, Misgeld T, Kerschensteiner M (2014)
  Pervasive Axonal Transport Deficits in Multiple Sclerosis Models
  Neuron. 2014 Nov 25. pii: S0896-6273(14)01006-X. doi: 10.1016/j.neuron.2014.11.006. [Epub ahead of print]
• Wang K, Milkie DE, Saxena A, Engerer P, Misgeld T, Bronner ME, Mumm J, Betzig E (2014)
  Rapid adaptive optical recovery of optimal resolution over large volumes
  Nat Methods. 2014 Apr 13. doi: 10.1038/nmeth.2925. [Epub ahead of print]
• Williams PR, Marincu BN, Sorbara CD, Mahler CF, Schumacher AM, Griesbeck O, Kerschensteiner M, Misgeld T (2014)
  A recoverable state of axon injury persists for hours after spinal cord contusion in vivo
  Nat Commun. 2014 Dec 16;5:5683. doi: 10.1038/ncomms6683.

2013

• Brill MS, Marinković P, Misgeld T (2013)
  Sequential Photo-bleaching to Delineate Single Schwann Cells at the Neuromuscular Junction
  J Vis Exp. 11(71) (2013)
• Kreutzfeldt M, Bergthaler A, Fernandez M, Brück W, Steinbach K, Vorm M, Coras R, Blümcke I, Bonilla WV, Fleige A, Forman R, Müller W, Becher B, Misgeld T, Kerschensteiner M, Pinschewer DD, Merkler D (2013)
  Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss
  J Exp Med. 2013 Sep 2. [Epub ahead of print]
• Misgeld T, Lichtenthaler SF, Dichgans M (2013)
  Between new genetic discoveries and large randomized trials-neurological research in the era of systems medicine
  EMBO Rep. 2013 May 14. doi: 10.1038/embor.2013.70. [Epub ahead of print]
• Romanelli E, Sorbara CD, Nikić I, Dagkalis A, Misgeld T, Kerschensteiner M (2013)
  Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes
  Nat Protoc. 8(3):481-90 (2013)

2012

• Plucińska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T (2012)
  In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system
  J Neurosci. 32(46):16203-12 (2012)