Munich Cluster for Systems Neurology

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Curriculum vitae Prof. Dr. Franz-Ulrich Hartl

    • Date of Birth: March 10, 1957


    • 1982 M.D., University of Heidelberg
    • 1985 Dr. med., University of Heidelberg, Institute of Biochemistry
    • 1990 Dr. med habil., University of Munich, Institute of Physiological Chemistry
    • 1985 - 1986 Post-doctoral Fellow with Prof. W. Neupert, Ludwig-Maximilians-Universität München
    • 1989 - 1990 Post-doctoral Fellow with Prof. W. Wickner, University of California at Los Angeles

Academic positions & appointments

    • 1987 - 1995 Group leader, Institute of Physiological Chemistry, University of Munich
    • 1991 - 1992 Associate Member, Program in Cellular Biochemistry & Biophysics, Sloan-Kettering Institute, New York
    • 1993 - 1997 Member (with tenure), Program in Cellular Biochemistry and Biophysics, Sloan-Kettering Institute, New York
    • 1994 - 1997 Associate Investigator, Howard Hughes Medical Institute
    • since 1997 Director, Max-Planck-Institut für Biochemie, Martinsried, Germany

Research coordination

    • 2004 - 2009 Project Coordinator of “Interaction Proteome” (EU Sixth Framework Program)
    • 2005 - 2016 Speaker of the Steering Committee of the International Max Planck Research School

Membership in Editorial Boards

    • since 1996 Journal of Cell Biology
    • since 1999 EMBO Journal
    • since 2004 Annual Review of Biochemistry
    • since 2006 Molecular Cell
    • since 2012 Proceedings of the National Academy of Sciences (PNAS)
    • since 2009 Chairman of Scientific Advisory Board, Proteomics Therapeutics, USA
    • since 2008 Member Prize Committee of the Ernst Jung Foundation, Hamburg
    • since 2013 Member Selection Committee for the Shaw Prize in Life Science and Medicine

Awards & honors

    • 1997 Lipmann Award of the American Society of Biochemistry and Molecular Biology
    • 1997 Honorary Professor, Ludwig-Maximilians-Universität München
    • 1998 EMBO Member
    • 2002 Gottfried Wilhelm Leibniz-Prize of the Deutsche Forschungsgemeinschaft
    • 2002 Member Leopoldina, German Academy of Sciences
    • 2004 Gairdner Foundation International Award, Canada
    • 2005 Ernst Jung-Prize for Medicine
    • 2006 Koerber European Science Award
    • 2007 Wiley Prize in Biomedical Sciences, Rockefeller University, USA
    • 2008 Lewis S. Rosenstiel Award, Brandeis University, USA
    • 2008 Louisa Gross Horwitz Prize, Columbia University, USA
    • 2009 Otto Warburg Medal of the German Society for Biochemistry and Molecular Biology
    • 2010 The Dr H.P. Heineken Prize for Biochemistry and Biophysics
    • 2011 Albert Lasker Award for Basic Medical Research 2011
    • 2011 Foreign Associate of the National Academy of Sciences, USA
    • 2013 ERC Synergy grant
    • 2016 Ernst Schering-Prize
    • 2016 Albany Medical Center Prize
    • 2017 Wilson Medal, American Society of Cell Biology

10 key papers

    • Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU*, Baumeister W*, Fernández-Busnadiego R. In situ architecture and cellular interactions of polyQ inclusions. Cell 171:179-87 (2017) (* co-corresponding authors)
    • Choe Y-J, Park S-H, Hassemer T, Körner R, Vincenz-Donnelly L, Hayer-Hartl M, Hartl FU. Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature 531:191-5 (2016)
    • Kim YE, Hosp F, Frottin F, Ge H, Mann M, Hayer-Hartl M, Hartl FU. Soluble oligomers of polyQ-expanded huntingtin target a multiplicity of key cellular factors. Mol Cell 63:951-64 (2016)
    • Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU*, Hipp MS*. Cytoplasmic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA. Science 351:173-6 (2016)
    • Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread proteome remodeling and aggregation in aging C. elegans. Cell 161:919-32 (2015)
    • Raychaudhuri S, Löw C, Körner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU. Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1. Cell 156:975-85 (2014)
    • Park S-H, Kukushkin Y, Chen T, Gupta R, Konagai A, Hipp MS, Hayer-Hartl M, Hartl FU. PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone. Cell 154:134-45 (2013)
    • Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, Vendruscolo M, Hayer-Hartl M, Hartl FU & Vabulas RM. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 144:67-78 (2011)
    • Hartl FU, Bracher A, Hayer-Hartl M. Molecular chaperones in protein folding and proteostasis. Nature 475:324-32 (2011)
    • Chakraborty K, Chatila M, Sinha J, Shi Q, Poschner BC, Sikor M, Jiang G, Lamb DC, Hartl FU, Hayer-Hartl M. Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell 142:112-22 (2010)
    • Behrends C, Langer CA, Boteva R, Böttcher U, Stemp MJ, Schaffar G, Vasudeva Rao B, Giese A, Kretzschmar H, Siegers K, Hartl FU. Chaperonin TRiC promotes the assembly of polyQ expansion proteins into non-toxic oligomers. Mol Cell 23:887-97 (2006)

Responsible for content: Prof. Dr. Franz-Ulrich Hartl